KEGG ORTHOLOGY: K16531

ORTHOLOGY: K16531

Entry

K16531                      KO

Symbol

BBS4

Name

Bardet-Biedl syndrome 4 protein

Disease

H00418

Bardet-Biedl syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K16531  BBS4; Bardet-Biedl syndrome 4 protein
  09183 Protein families: signaling and cellular processes
   03037 Cilium and associated proteins
    K16531  BBS4; Bardet-Biedl syndrome 4 protein
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Centrosome formation proteins
   Pericentriolar materials (PCM)
    Centriolar satellite
     K16531  BBS4; Bardet-Biedl syndrome 4 protein
Cilium and associated proteins [BR:ko03037]
Primary cilia and associated proteins
  BBSome
   K16531  BBS4; Bardet-Biedl syndrome 4 protein

Other DBs

GO:

0034464

Genes

HSA:

585(BBS4)

PTR:	453726(BBS4)

PPS:	100988031(BBS4)

GGO:	101139659(BBS4)

PON:	100443076(BBS4)

NLE:	100593615 100603433(BBS4)

HMH:	116482627(BBS4) 116810272

MCC:	704508(BBS4)

MCF:	101925626(BBS4)

MTHB:

126958159

MNI:	105463789(BBS4)

CSAB:

103245367(BBS4)

CATY:

105573489(BBS4)

PANU:

101013336(BBS4)

TGE:	112627833(BBS4)

MLEU:

105537333(BBS4)

RRO:	104673838(BBS4)

RBB:	108520405(BBS4)

TFN:	117070315 117070397(BBS4)

PTEH:

111526990(BBS4)

CANG:

105505192(BBS4)

CJC:	100415623(BBS4)

SBQ:	101051187(BBS4)

CIMI:

108317515(BBS4)

CSYR:

103275472(BBS4)

MMUR:

105873382(BBS4)

LCAT:

123623994(BBS4)

PCOQ:

105807300(BBS4)

OGA:	100963057(BBS4)

MMU:	102774(Bbs4)

MCAL:

110301246(Bbs4)

MPAH:

110327721(Bbs4)

RNO:	300754(Bbs4)

MCOC:

116072295(Bbs4)

ANU:	117699108(Bbs4)

MUN:	110549568(Bbs4)

CGE:	100755264(Bbs4)

MAUA:

101823803(Bbs4)

PROB:

127231826(Bbs4)

PLEU:

114708930(Bbs4)

MORG:

121466096(Bbs4)

MFOT:

126507437

AAMP:

119809726(Bbs4)

NGI:	103736850(Bbs4)

HGL:	101707988(Bbs4)

CPOC:

100716676

CCAN:

109687666(Bbs4)

DORD:

105982457(Bbs4)

DSP:	122122961(Bbs4)

PLOP:

125338892(Bbs4)

NCAR:

124976233

MMMA:

107137962(Bbs4)

OCU:

100347284

OPI:	101520456(BBS4)

TUP:	102488254(BBS4)

GVR:	103595884(BBS4)

CFA:	487634(BBS4)

CLUD:

112675632(BBS4)

VVP:	112921696 112935101(BBS4)

VLG:	121472879 121482205(BBS4)

NPO:	129506452(BBS4)

AML:	100473881(BBS4)

UMR:	103679014(BBS4)

UAH:	113240942(BBS4)

UAR:	123790704(BBS4)

ELK:

111153170

LLV:

125103780

MPUF:

101675335(BBS4)

MNP:	131999190(BBS4)

MLK:	131835805(BBS4)

NVS:	122894321(BBS4)

ORO:	101379112(BBS4)

EJU:	114206551(BBS4)

ZCA:	113909540(BBS4)

MLX:	118003747(BBS4) 118019080

NSU:	110580583 110583728(BBS4)

LWW:	102741841 102745850(BBS4)

FCA:	101090871(BBS4)

PYU:	121041958(BBS4)

PCOO:

112855281(BBS4)

PBG:	122468461(BBS4)

PVIV:

125168562(BBS4)

LRUF:

124508958

PTG:	102960443(BBS4)

PPAD:

109262728(BBS4)

PUC:

125910116

AJU:

106974215

HHV:	120235494(BBS4)

BTA:	532120(BBS4)

BOM:	102285199(BBS4)

BIU:	109564748(BBS4)

BBUB:

102398214 102409949(BBS4)

BBIS:

104982064(BBS4)

CHX:	102180499(BBS4)

OAS:	101110416(BBS4)

BTAX:

128054021(BBS4)

ODA:	120853508(BBS4) 120868477

CCAD:

122443129(BBS4)

MBEZ:

129563539(BBS4)

SSC:	100513212(BBS4)

CFR:	102513657(BBS4)

CBAI:

105069212(BBS4)

CDK:	105087287(BBS4)

VPC:	102529070(BBS4)

BACU:

103005737 103020608(BBS4)

BMUS:

118891341(BBS4)

LVE:	103081788(BBS4)

OOR:	101278421(BBS4)

DLE:	111177798(BBS4)

PCAD:

102995413(BBS4)

PSIU:

116749604(BBS4)

NASI:

112410889(BBS4)

ECB:	100063282(BBS4)

EPZ:	103555466(BBS4)

EAI:

106836644

MYB:	102248309(BBS4)

MYD:	102751830(BBS4)

MMYO:

118675480(BBS4)

MLF:	102426161(BBS4)

PKL:	118729265(BBS4)

EFUS:

103304716(BBS4)

MNA:	107528395(BBS4)

DRO:	112301680(BBS4)

SHON:

118987778(BBS4)

AJM:	119050112(BBS4)

PDIC:

114493208(BBS4)

PHAS:

123825299(BBS4)

MMF:	118617195(BBS4)

PPAM:

129062693(BBS4)

HAI:	109391750(BBS4)

RFQ:	117022878(BBS4)

PALE:

102897862(BBS4)

PGIG:

120597886(BBS4)

PVP:	105302486(BBS4)

RAY:	107501103(BBS4)

MJV:	108409959(BBS4)

TOD:	119238821(BBS4)

SARA:

101546386(BBS4)

SETR:

126015145(BBS4)

LAV:	100662213(BBS4)

TMU:

101353553

ETF:	101654963(BBS4)

DNM:	101435042(BBS4)

MDO:	100028985(BBS4)

GAS:	123232983(BBS4)

SHR:	100921192(BBS4)

AFZ:

127552008

PCW:	110213899(BBS4)

OAA:	100077164(BBS4)

GGA:	415318(BBS4)

PCOC:

116244519(BBS4)

MGP:	104912758(BBS4)

CJO:	107318500(BBS4)

TPAI:

128075453(BBS4)

LMUT:

125698166(BBS4)

NMEL:

110403599(BBS4)

APLA:

101790080(BBS4)

ACYG:

106044205(BBS4)

CATA:

118258097(BBS4)

AFUL:

116493316(BBS4)

TGU:	100227428(BBS4)

LSR:	110483972(BBS4)

SCAN:

103816149(BBS4)

PMOA:

120508829(BBS4)

OTC:	121343387(BBS4)

PRUF:

121354341(BBS4)

GFR:	102039947(BBS4)

FAB:	101813118(BBS4)

OMA:	130257583(BBS4)

PHI:	102106982(BBS4)

PMAJ:

107209368(BBS4)

CCAE:

111934293(BBS4)

CCW:	104697532(BBS4)

CBRC:

103613508(BBS4)

ETL:	114059923(BBS4)

ZAB:	102061055(BBS4)

ACHL:

103807494(BBS4)

SVG:	106861069(BBS4)

MMEA:

130580934(BBS4)

HRT:	120758684(BBS4)

FPG:	101912612(BBS4)

FCH:	102052538(BBS4)

CLV:	102093228(BBS4)

EGZ:	104130825(BBS4)

NNI:	104016706(BBS4)

PCRI:

104032840(BBS4)

PLET:

104626170(BBS4)

EHS:	104503494(BBS4)

PCAO:

104046429(BBS4)

ACUN:

113483793(BBS4)

TALA:

104361951(BBS4)

PADL:

103913417(BBS4)

AFOR:

103898587(BBS4)

ACHC:

115341122(BBS4)

HALD:

104316914(BBS4)

HLE:	104834358(BBS4)

AGEN:

126043648

GCL:

127020822

CCRI:

104163384(BBS4)

CSTI:

104556344(BBS4)

CMAC:

104480026(BBS4)

MUI:	104546711(BBS4)

BREG:

104642390(BBS4)

FGA:	104084342(BBS4)

GSTE:

104260569(BBS4)

LDI:	104352642(BBS4)

MNB:	103779597(BBS4)

OHA:	104330621(BBS4)

NNT:	104410712(BBS4)

SHAB:

115612875(BBS4)

DPUB:

104306072(BBS4)

PGUU:

104470346(BBS4)

ACAR:

104525236 104529111

CPEA:

104396128(BBS4)

AVIT:

104270063(BBS4)

CVF:	104295768(BBS4)

RTD:	128914565(BBS4)

CUCA:

104066323(BBS4)

TEO:	104377120(BBS4)

BRHI:

104490839(BBS4)

AAM:	106486120(BBS4)

AROW:

112967284(BBS4)

NPD:	112952296(BBS4)

TGT:	104576861(BBS4)

DNE:	112992263(BBS4)

SCAM:

104144593(BBS4)

ASN:	102369015(BBS4)

AMJ:	102574478(BBS4)

CPOO:

109308845(BBS4)

GGN:	109288763(BBS4)

PSS:	102443817(BBS4)

CMY:	102942369(BBS4)

CCAY:

125643999(BBS4)

DCC:	119862595(BBS4)

CPIC:

101932371(BBS4)

TST:	117883708(BBS4)

CABI:

116839426(BBS4)

MRV:	120373251(BBS4)

ACS:	100567822(bbs4)

ASAO:

132762712(BBS4)

PVT:	110084387(BBS4)

SUND:

121933567(BBS4)

PBI:	103059429(BBS4)

PMUR:

107297690(BBS4)

CTIG:

120306349(BBS4)

TSR:

106548863

PGUT:

117674525(BBS4)

APRI:

131184634(BBS4)

PTEX:

113442409(BBS4)

NSS:	113425337(BBS4)

VKO:	123033756(BBS4)

PMUA:

114584221(BBS4)

PRAF:

128401808(BBS4)

ZVI:	118086443(BBS4)

HCG:	128334831(BBS4)

GJA:

107124050

STOW:

125424645(BBS4)

EMC:	129345429(BBS4)

XLA:	108712990(bbs4.S)

XTR:	549034(bbs4)

NPR:	108784037(BBS4)

RTEM:

120931509(BBS4)

BBUF:

120985633(BBS4)

BGAR:

122929702(BBS4)

MUO:	115457908(BBS4)

GSH:	117348313(BBS4)

DRE:	768303(bbs4)

SRX:	107745567 107754319

SANH:

107669039 107701057

SGH:	107549580(bbs4) 107569348

CCAR:

109070016 109078642(bbs4)

CAUA:

113077193 113098793

CGIB:

128014205

PTET:

122331180(bbs4)

LROH:

127157089(bbs4)

OMC:	131533908(bbs4)

PPRM:

120460433(bbs4)

RKG:	130106463(bbs4)

MAMB:

125247729(bbs4)

CIDE:

127507624

MASI:

127436064 127437115

TROS:

130549662(bbs4)

TDW:	130414045(bbs4)

MANU:

129434175(bbs4)

IPU:

108275068

IFU:	128618074(bbs4)

PHYP:

113529879(bbs4)

SMEO:

124392370(bbs4)

TFD:	113653956(bbs4)

TVC:	132856932(bbs4)

AMEX:

103021455(bbs4)

CMAO:

118811868(bbs4)

EEE:	113583569(bbs4)

CHAR:

105890612(bbs4)

TRU:	101073911(bbs4)

TFS:	130513871(bbs4)

TNG:	GSTEN00018149G001

LCO:	104922797(bbs4)

NCC:	104956329(bbs4)

TBEN:

117471530(bbs4)

CGOB:

115006443(bbs4)

PGEO:

117461227

GACU:

117549273(bbs4)

EMAC:

134862504(bbs4)

ELY:	117249614(bbs4)

EFO:	125901761(bbs4)

PLEP:

121946558(bbs4)

SLUC:

116043407(bbs4)

ECRA:

117950247(bbs4)

ESP:	116693621(bbs4)

PFLV:

114559016(bbs4)

GAT:	120813598(bbs4)

PPUG:

119195086(bbs4)

AFB:	129102253(bbs4)

CLUM:

117728724(bbs4)

PSWI:

130192913(bbs4)

MSAM:

119890073(bbs4)

SCHU:

122881688(bbs4)

CUD:	121506816(bbs4)

ALAT:

119018629(bbs4)

MZE:	101475868(bbs4)

ONL:	100692460(bbs4)

OAU:	116324011(bbs4)

OLA:	101165958(bbs4)

OML:	112161032(bbs4)

CSAI:

133459443(bbs4)

XMA:	102222455(bbs4)

XCO:	114143071(bbs4)

XHE:	116719077(bbs4)

PRET:

103462137(bbs4)

PFOR:

103135959(bbs4)

PLAI:

106946022(bbs4)

PMEI:

106925154(bbs4)

GAF:	122840888(bbs4)

PPRL:

129369681(bbs4)

CVG:	107086531(bbs4)

CTUL:

119786442(bbs4)

GMU:	124867424(bbs4)

NFU:	107381772(bbs4)

KMR:	108234803(bbs4)

ALIM:

106512986(bbs4)

NWH:	119430232(bbs4)

AOCE:

111567966(bbs4)

MCEP:

125004957(bbs4)

CSEM:

103398438(bbs4)

POV:	109637196(bbs4)

SSEN:

122772499(bbs4)

HHIP:

117759265(bbs4)

HSP:	118113883(bbs4)

SMAU:

118302255(bbs4)

LCF:

108887846

SDU:	111223992(bbs4)

SLAL:

111651813 111670110(bbs4)

XGL:	120789086(bbs4)

HCQ:	109525849(bbs4)

SSCV:

125967257

SBIA:

133498453(bbs4)

PEE:	133399146(bbs4)

PTAO:

133471497(bbs4)

BPEC:

110167082(bbs4)

MALB:

109963302(bbs4)

BSPL:

114852683(bbs4)

SJO:

128358005

SASA:

106560769 106595576

STRU:

115166816 115197148 115203509

OTW:	112218307(bbs4) 112263878

OMY:	110491610(bbs4) 110506956 110506961

OGO:	124019506 124027537 124040067(bbs4)

ONE:	115134562(bbs4)

OKI:	109867431 109886228

OKE:	118374594 118396363(bbs4)

SALP:

111962070(bbs4)

SNH:	120048865 120066557(bbs4)

CCLU:

121532086(bbs4) 121563798

ELS:	105013791 105018671

SFM:	108942354(bbs4)

PKI:	111857390(bbs4)

AANG:

118215000(bbs4)

LOC:	102687334(bbs4)

PSPA:

121294613 121299347

ARUT:

117428185 117429229

PSEX:

120541635(bbs4)

LCM:	102364699(BBS4)

CMK:	103188696(bbs4)

CPLA:

122542520(bbs4)

HOC:	132834797(bbs4)

LERI:

129713640(bbs4)

PMRN:

116945916(BBS4)

LRJ:	133340475(BBS4)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

AJC:

SKO:

DME:	Dmel_CG13232(BBS4)

DER:

6547254

DSE:

6608592

DSI:	Dsimw501_GD10768(Dsim_GD10768)

DYA:	Dyak_GE12854

DAN:

DSR:

DPO:

DPE:

DMN:	108158900 117194092

DWI:

6638217

DGR:

6560421

DMO:	Dmoj_GI19775

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:	119675110 119682328 119683857

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ006509 CpipJ_CPIJ006510

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:	115881823 115888044

AGRG:

ATD:

CSET:

AGB:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_209132

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

PGW:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM278770

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_331186

DMK:	116930450 123475912

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_F58A4.14(bbs-4)

CBR:	CBG_09893 CBG_10029

CRQ:	GCK72_009482

NAI:	NECAME_05770

BMY:	BM_BM4542(Bma-bbs-4)

LOA:	LOAG_10276

TSP:

Tsp_10250

HRO:	HELRODRAFT_188177

LGI:	LOTGIDRAFT_53377

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:	106171639 106172533

SMM:	Smp_029480

SHX:	MS3_00000023(BBS4)

OVI:	T265_14915

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

TAD:	TRIADDRAFT_18483

AQU:

100632475

CRE:	CHLRE_12g548650v5

VCN:	VOLCADRAFT_66874(Bbs4)

MNG:	MNEG_11706

MIS:	MICPUN_99142(BBS4)

MPP:	MICPUCDRAFT_50814(BBS4)

MBR:	MONBRDRAFT_23427

SRE:	PTSG_10970

TET:	TTHERM_01054280

PTM:	GSPATT00005292001

SMIN:

v1.2.006882.t1(symbB.v1.2.006882.t1)

AAF:	AURANDRAFT_1883

PIF:	PITG_02952

PSOJ:

PHYSODRAFT_309859

SPAR:

SPRG_09854 SPRG_16608

GTT:	GUITHDRAFT_160194

TBR:	Tb10.6k15.3940

TBG:	TbgDal_X8330

TCR:	510187.130

LMA:	LMJF_36_2280

LIF:	LINJ_36_2410

LDO:	LDBPK_362410

LMI:	LMXM_36_2280

LBZ:	LBRM_35_2520

LPAN:

LPMP_352370

NGR:	NAEGRDRAFT_28891

TVA:	TVAG_2v1045140

GLA:	GL50803_0010529

» show all

Reference

PMID:15107855

Authors

Kim JC, Badano JL, Sibold S, Esmail MA, Hill J, Hoskins BE, Leitch CC, Venner K, Ansley SJ, Ross AJ, Leroux MR, Katsanis N, Beales PL

Title

The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression.

Journal

Nat Genet 36:462-70 (2004)
DOI:10.1038/ng1352

Sequence

[hsa:585]

LinkDB

DBGET integrated database retrieval system