KEGG   ORTHOLOGY: K16857Help
Entry
K16857                      KO                                     

Name
THBS1
Definition
thrombospondin 1
Pathway
ko04015  Rap1 signaling pathway
ko04115  p53 signaling pathway
ko04145  Phagosome
ko04151  PI3K-Akt signaling pathway
ko04350  TGF-beta signaling pathway
ko04510  Focal adhesion
ko04512  ECM-receptor interaction
ko05144  Malaria
ko05165  Human papillomavirus infection
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05219  Bladder cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K16857  THBS1; thrombospondin 1
   04350 TGF-beta signaling pathway
    K16857  THBS1; thrombospondin 1
   04151 PI3K-Akt signaling pathway
    K16857  THBS1; thrombospondin 1
  09133 Signaling molecules and interaction
   04512 ECM-receptor interaction
    K16857  THBS1; thrombospondin 1
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K16857  THBS1; thrombospondin 1
  09143 Cell growth and death
   04115 p53 signaling pathway
    K16857  THBS1; thrombospondin 1
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K16857  THBS1; thrombospondin 1
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K16857  THBS1; thrombospondin 1
   05205 Proteoglycans in cancer
    K16857  THBS1; thrombospondin 1
  09162 Cancer: specific types
   05219 Bladder cancer
    K16857  THBS1; thrombospondin 1
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    K16857  THBS1; thrombospondin 1
  09174 Infectious disease: parasitic
   05144 Malaria
    K16857  THBS1; thrombospondin 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K16857  THBS1; thrombospondin 1
  09183 Protein families: signaling and cellular processes
   00536 Glycosaminoglycan binding proteins
    K16857  THBS1; thrombospondin 1
Membrane trafficking [BR:ko04131]
 Endocytosis
  Phagocytosis
   Opsonins
    K16857  THBS1; thrombospondin 1
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Haparin
  Extracellular matrix molecules
   K16857  THBS1; thrombospondin 1
BRITE hierarchy
Genes
HSA: 7057(THBS1)
PTR: 453319(THBS1)
PPS: 100994890(THBS1)
GGO: 101135507(THBS1)
PON: 100453386(THBS1)
NLE: 100603886(THBS1)
MCC: 705413(THBS1)
MCF: 102130245(THBS1)
CSAB: 103245860(THBS1)
RRO: 104659681(THBS1)
RBB: 108526966(THBS1)
CJC: 100390178(THBS1)
SBQ: 101029602(THBS1)
MMU: 21825(Thbs1)
MCAL: 110310932(Thbs1)
MPAH: 110319023(Thbs1)
RNO: 445442(Thbs1)
MUN: 110564049(Thbs1)
CGE: 100760878(Thbs1)
NGI: 103727450(Thbs1)
HGL: 101701581(Thbs1)
CCAN: 109700113(Thbs1)
OCU: 100350430(THBS1)
TUP: 102497602(THBS1)
CFA: 487486(THBS1)
VVP: 112919933(THBS1)
AML: 100465724(THBS1)
UMR: 103673473(THBS1)
UAH: 113242050(THBS1)
ORO: 101376329(THBS1)
ELK: 111161597
FCA: 101092689(THBS1)
PTG: 102969748(THBS1)
PPAD: 109263182(THBS1)
AJU: 106979757(THBS1)
BTA: 281530(THBS1)
BOM: 102278109(THBS1)
BIU: 109564916(THBS1)
BBUB: 102401160(THBS1)
CHX: 100860971(THBS1)
OAS: 101106433(THBS1)
SSC: 492313(THBS1)
CFR: 102519986(THBS1)
CDK: 105096896(THBS1)
BACU: 103019307(THBS1)
LVE: 103080694(THBS1)
OOR: 101283920(THBS1)
DLE: 111181763(THBS1)
PCAD: 102995420(THBS1)
ECB: 100057478(THBS1)
EPZ: 103556716(THBS1)
EAI: 106835162(THBS1)
MYB: 102250983(THBS1)
MYD: 102758170(THBS1)
MNA: 107543012(THBS1)
HAI: 109384080(THBS1)
DRO: 112311111(THBS1)
PALE: 102898784(THBS1)
RAY: 107514453(THBS1)
MJV: 108400147(THBS1)
LAV: 100667431(THBS1)
TMU: 101344047
MDO: 100031767(THBS1)
SHR: 100926698(THBS1)
PCW: 110202873(THBS1)
OAA: 100092988(THBS1)
GGA: 373987(THBS1)
MGP: 100542373(THBS1)
CJO: 107314919(THBS1)
NMEL: 110401369(THBS1)
APLA: 101793322(THBS1)
ACYG: 106031773(THBS1)
TGU: 100230636(THBS1)
LSR: 110475265(THBS1)
SCAN: 103826589(THBS1)
GFR: 102031762(THBS1)
FAB: 101818592(THBS1)
PHI: 102103663(THBS1)
PMAJ: 107206295(THBS1)
CCAE: 111930312(THBS1)
CCW: 104684025(THBS1)
ETL: 114063733(THBS1)
FPG: 101915773(THBS1)
FCH: 102054866(THBS1)
CLV: 102091738(THBS1)
EGZ: 104122092(THBS1)
NNI: 104020294(THBS1)
ACUN: 113480732(THBS1)
PADL: 103914353(THBS1)
AAM: 106482797(THBS1)
ASN: 102374383(THBS1)
AMJ: 102568233(THBS1)
PSS: 102447926(THBS1)
CMY: 102943153(THBS1)
CPIC: 101940307(THBS1)
ACS: 100552734(thbs1)
PVT: 110080127(THBS1)
PBI: 103054107(THBS1)
PMUR: 107296464(THBS1)
TSR: 106542050(THBS1)
PMUA: 114593635(THBS1)
GJA: 107119648(THBS1)
XLA: 379508(thbs1.S) 779026(thbs2.L)
XTR: 100170153(thbs1)
NPR: 108796832(THBS1)
DRE: 561901(thbs1b)
IPU: 108257932(thbs1) 108270370
PHYP: 113530102(thbs1) 113531877
AMEX: 103029184(thbs1) 103031445
TRU: 101061772(thbs1) 101062487
NCC: 104957017(thbs1) 104963041
ONL: 100533981(thbs1a) 100533982(thbs1b)
OLA: 100302438 100302441(thbs1)
XMA: 102222883 102236898(thbs1)
PRET: 103457638 103458518(thbs1)
NFU: 107377820 107392441(thbs1)
KMR: 108233501(thbs1) 108236340
ALIM: 106522431(thbs1) 106535463
HCQ: 109516072 109523753(thbs1)
MALB: 109962404 109967980(thbs1)
SFM: 108919589(thbs1)
PKI: 111838851(thbs1)
LCM: 102358103(THBS1)
CMK: 103175202(thbs1)
RTP: 109918114(thbs1)
CIN: 619278
SPU: 577806
APLC: 110979481
SKO: 100375408
PDAM: 113669517
AQU: 100632678
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2430973
  Authors
Lawler J, Hynes RO
  Title
The structure of human thrombospondin, an adhesive glycoprotein with multiple calcium-binding sites and homologies with several different proteins.
  Journal
J Cell Biol 103:1635-48 (1986)
DOI:10.1083/jcb.103.5.1635
  Sequence
[hsa:7057]
Reference
  Authors
Christopherson KS, Ullian EM, Stokes CC, Mullowney CE, Hell JW, Agah A, Lawler J, Mosher DF, Bornstein P, Barres BA
  Title
Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis.
  Journal
Cell 120:421-33 (2005)
DOI:10.1016/j.cell.2004.12.020
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