KEGG   ORTHOLOGY: K16859Help
Entry
K16859                      KO                                     

Name
PGF
Definition
placenta growth factor
Pathway
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko05200  Pathways in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K16859  PGF; placenta growth factor
   04015 Rap1 signaling pathway
    K16859  PGF; placenta growth factor
   04010 MAPK signaling pathway
    K16859  PGF; placenta growth factor
   04151 PI3K-Akt signaling pathway
    K16859  PGF; placenta growth factor
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K16859  PGF; placenta growth factor
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K16859  PGF; placenta growth factor
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K16859  PGF; placenta growth factor
Cytokines and growth factors [BR:ko04052]
 Growth factors
  Growth factors (RTK binding)
   K16859  PGF; placenta growth factor
BRITE hierarchy
Genes
HSA: 5228(PGF)
PTR: 741830(PGF)
PPS: 100984147(PGF)
GGO: 101125053(PGF)
PON: 100440872(PGF)
NLE: 100600228(PGF)
MCC: 701219(PGF)
MCF: 102134620(PGF)
CSAB: 103229341(PGF)
RRO: 104677582(PGF)
RBB: 108534920(PGF)
CJC: 100386568(PGF)
SBQ: 101042551(PGF)
MMU: 18654(Pgf)
MCAL: 110307029(Pgf)
MPAH: 110324731(Pgf)
RNO: 94203(Pgf)
MUN: 110546968(Pgf)
CGE: 100754799(Pgf)
NGI: 103747350(Pgf)
HGL: 101725085(Pgf)
CCAN: 109694002(Pgf)
OCU: 100339515(PGF)
TUP: 102480300(PGF)
CFA: 100855780(PGF)
VVP: 112927283(PGF)
AML: 100480980(PGF)
UMR: 103671076(PGF)
UAH: 113270324(PGF)
ORO: 101369724(PGF)
ELK: 111148570
FCA: 101095904(PGF)
PTG: 102960599(PGF)
PPAD: 109253846(PGF)
AJU: 106974417(PGF)
BTA: 280894(PGF)
BOM: 102273440(PGF)
BIU: 109565356(PGF)
BBUB: 102389960(PGF)
CHX: 102169297(PGF)
OAS: 443245(PGF)
SSC: 100156404(PGF)
CFR: 102520919(PGF)
CDK: 105086095(PGF)
BACU: 103017555(PGF)
LVE: 103082053(PGF)
OOR: 101284353(PGF)
DLE: 111176246(PGF)
PCAD: 102979244(PGF)
ECB: 100051349(PGF)
EAI: 106827733(PGF)
MYB: 102243042(PGF)
MYD: 102761298(PGF)
MNA: 107533829(PGF)
HAI: 109381519(PGF)
DRO: 112311551(PGF)
PALE: 102889783(PGF)
RAY: 107504821(PGF)
MJV: 108399226(PGF)
LAV: 100674895(PGF)
TMU: 101355158
MDO: 100023623(PGF)
SHR: 100925473(PGF)
PCW: 110208321(PGF)
OAA: 100093060(PGF)
GGA: 771832(PGF)
MGP: 100542999(PGF)
CJO: 107315098(PGF)
NMEL: 110401232(PGF)
APLA: 101800933(PGF)
ACYG: 106038790(PGF)
TGU: 100221017(PGF)
LSR: 110477279(PGF)
SCAN: 103826914(PGF)
GFR: 102038207(PGF)
PHI: 102099617(PGF)
PMAJ: 107206015(PGF)
CCAE: 111929568(PGF)
CCW: 104688590(PGF)
ETL: 114056008(PGF)
FPG: 101920675(PGF)
FCH: 102059983(PGF)
CLV: 102097929(PGF)
EGZ: 104133226(PGF)
NNI: 104021035(PGF)
PADL: 103913044(PGF)
AAM: 106483053
ASN: 102386060(PGF)
AMJ: 102567693(PGF)
PSS: 102451883(PGF)
CMY: 102935251(PGF)
CPIC: 101934809(PGF) 101941746
ACS: 100552896(pgf)
PVT: 110075606 110079090(PGF)
PBI: 103050803 103067148(PGF)
PMUR: 107293072(PGF)
TSR: 106541647(PGF) 106551621
PMUA: 114591899(PGF) 114603133
GJA: 107118328(PGF) 107125835
DRE: 557468(pgfb)
IPU: 108258015 108270479(pgf)
PHYP: 113538606(pgf)
AMEX: 107197829
EEE: 113587029
LCO: 104919815
NCC: 104960941
MZE: 101474897(pgf) 101480538
ONL: 100695462 100703833(pgf)
OLA: 101161449
PRET: 103457897 103461058(pgf)
CVG: 107085608(pgf)
NFU: 107392368
KMR: 108236961(pgf)
ALIM: 106520837(pgf)
CSEM: 103396668(pgf)
SDU: 111225931(pgf) 111240400
SLAL: 111663130(pgf) 111672600
HCQ: 109513204
BPEC: 110155603
MALB: 109955230
ELS: 105017540 105026447(pgf)
SFM: 108941445(pgf)
PKI: 111852514(pgf)
LCM: 102359260(PGF) 102361405
CMK: 103190808
RTP: 109922076
MDE: 109612411
TCA: 103313153
PTEP: 107448099
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1924389
  Authors
Maglione D, Guerriero V, Viglietto G, Delli-Bovi P, Persico MG
  Title
Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor.
  Journal
Proc Natl Acad Sci U S A 88:9267-71 (1991)
DOI:10.1073/pnas.88.20.9267
  Sequence
[hsa:5228]
Reference
  Authors
De Falco S
  Title
The discovery of placenta growth factor and its biological activity.
  Journal
Exp Mol Med 44:1-9 (2012)
DOI:10.3858/emm.2012.44.1.025
Reference
  Authors
Rolny C, Mazzone M, Tugues S, Laoui D, Johansson I, Coulon C, Squadrito ML, Segura I, Li X, Knevels E, Costa S, Vinckier S, Dresselaer T, Akerud P, De Mol M, Salomaki H, Phillipson M, Wyns S, Larsson E, Buysschaert I, Botling J, Himmelreich U, Van Ginderachter JA, De Palma M, Dewerchin M, Claesson-Welsh L, Carmeliet P
  Title
HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF.
  Journal
Cancer Cell 19:31-44 (2011)
DOI:10.1016/j.ccr.2010.11.009
  Sequence
[hsa:5228]
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