KEGG   ORTHOLOGY: K17447Help
Entry
K17447                      KO                                     

Name
SHC2
Definition
SHC-transforming protein 2
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko04012  ErbB signaling pathway
ko04014  Ras signaling pathway
ko04062  Chemokine signaling pathway
ko04072  Phospholipase D signaling pathway
ko04370  VEGF signaling pathway
ko04510  Focal adhesion
ko04650  Natural killer cell mediated cytotoxicity
ko04722  Neurotrophin signaling pathway
ko04910  Insulin signaling pathway
ko04915  Estrogen signaling pathway
ko04917  Prolactin signaling pathway
ko04926  Relaxin signaling pathway
ko05034  Alcoholism
ko05100  Bacterial invasion of epithelial cells
ko05214  Glioma
ko05220  Chronic myeloid leukemia
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K17447  SHC2; SHC-transforming protein 2
   04012 ErbB signaling pathway
    K17447  SHC2; SHC-transforming protein 2
   04370 VEGF signaling pathway
    K17447  SHC2; SHC-transforming protein 2
   04072 Phospholipase D signaling pathway
    K17447  SHC2; SHC-transforming protein 2
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K17447  SHC2; SHC-transforming protein 2
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K17447  SHC2; SHC-transforming protein 2
   04062 Chemokine signaling pathway
    K17447  SHC2; SHC-transforming protein 2
  09152 Endocrine system
   04910 Insulin signaling pathway
    K17447  SHC2; SHC-transforming protein 2
   04915 Estrogen signaling pathway
    K17447  SHC2; SHC-transforming protein 2
   04917 Prolactin signaling pathway
    K17447  SHC2; SHC-transforming protein 2
   04926 Relaxin signaling pathway
    K17447  SHC2; SHC-transforming protein 2
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K17447  SHC2; SHC-transforming protein 2
 09160 Human Diseases
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K17447  SHC2; SHC-transforming protein 2
   05226 Gastric cancer
    K17447  SHC2; SHC-transforming protein 2
   05214 Glioma
    K17447  SHC2; SHC-transforming protein 2
   05220 Chronic myeloid leukemia
    K17447  SHC2; SHC-transforming protein 2
   05224 Breast cancer
    K17447  SHC2; SHC-transforming protein 2
  09165 Substance dependence
   05034 Alcoholism
    K17447  SHC2; SHC-transforming protein 2
  09171 Infectious disease: bacterial
   05100 Bacterial invasion of epithelial cells
    K17447  SHC2; SHC-transforming protein 2
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K17447  SHC2; SHC-transforming protein 2
   01522 Endocrine resistance
    K17447  SHC2; SHC-transforming protein 2
BRITE hierarchy
Genes
HSA: 25759(SHC2)
PTR: 749831(SHC2)
PPS: 100974798(SHC2)
GGO: 101129046(SHC2)
PON: 100445042(SHC2)
NLE: 100591489(SHC2)
MCC: 721021(SHC2)
MCF: 102125325(SHC2)
CSAB: 103233559(SHC2)
RRO: 104655312 104673873(SHC2)
RBB: 108531776(SHC2) 108533994
CJC: 100415083(SHC2)
SBQ: 101048523(SHC2)
MMU: 216148(Shc2)
MCAL: 110303444(Shc2)
MPAH: 110326457(Shc2)
RNO: 314612(Shc2)
MUN: 110551355(Shc2)
CGE: 100761269(Shc2)
NGI: 103737407(Shc2)
HGL: 101723930(Shc2)
CCAN: 109686083(Shc2)
TUP: 102481863(SHC2)
CFA: 611955(SHC2)
VVP: 112935467(SHC2)
AML: 100480694(SHC2)
UMR: 103681753(SHC2)
UAH: 113242690(SHC2)
ORO: 101384118(SHC2)
FCA: 101083489(SHC2)
PTG: 102954336(SHC2)
AJU: 106978092(SHC2)
BTA: 533455(SHC2)
BOM: 102281047(SHC2)
BIU: 109561056(SHC2)
BBUB: 102389953(SHC2)
PHD: 102315889(SHC2)
CHX: 102169956(SHC2)
OAS: 101113847(SHC2)
SSC: 110259382(SHC2)
CFR: 102506382
CDK: 105093416(SHC2)
BACU: 103006868(SHC2)
LVE: 103088833(SHC2)
OOR: 101275665(SHC2)
DLE: 111170483(SHC2)
PCAD: 102974315(SHC2)
ECB: 100146209(SHC2)
EPZ: 103542441(SHC2)
EAI: 106834253(SHC2)
MYB: 102251506(SHC2)
MYD: 102752087(SHC2)
MNA: 107538554(SHC2)
HAI: 109390676(SHC2)
RSS: 109437064(SHC2)
DRO: 112312297(SHC2)
PALE: 102885958(SHC2)
RAY: 107500961(SHC2)
TMU: 101359726
SHR: 100917745(SHC2)
PCW: 110223483(SHC2)
OAA: 100081397(SHC2)
GGA: 770341(SHC2)
MGP: 100538500(SHC2)
CJO: 107325668(SHC2)
NMEL: 110389019(SHC2)
APLA: 101803969(SHC2)
ACYG: 106049094(SHC2)
TGU: 100217581(SHC2)
LSR: 110475781(SHC2)
SCAN: 103822026(SHC2)
GFR: 102034643(SHC2)
FAB: 101815242(SHC2)
PHI: 102100749(SHC2)
PMAJ: 107215430(SHC2)
CCAE: 111940286(SHC2)
CCW: 104697005(SHC2)
ETL: 114066416(SHC2)
FPG: 101924524(SHC2)
FCH: 102049085(SHC2)
CLV: 102088882(SHC2)
EGZ: 104124436(SHC2)
NNI: 104016320(SHC2)
PADL: 103923470(SHC2)
AAM: 106486386(SHC2)
ASN: 102383911(SHC2)
AMJ: 102565747(SHC2)
PSS: 102462610(SHC2)
CMY: 102933759(SHC2)
CPIC: 101944228(SHC2)
ACS: 100553545(shc2)
PVT: 110079278(SHC2)
PBI: 103061599(SHC2)
GJA: 107110440(SHC2)
XLA: 108706896(shc2.S) 108713169(shc2.L)
XTR: 100487416(shc2)
NPR: 108790334(SHC2)
DRE: 562011(shc2)
SANH: 107676975(shc2) 107699410
IPU: 108270761(shc2)
PHYP: 113547084(shc2)
AMEX: 103026451
EEE: 113587209(shc2)
TRU: 101071160(shc2)
LCO: 104918475(shc2)
NCC: 104958981(shc2)
MZE: 101463941
OLA: 101156242(shc2)
XMA: 102216631
XCO: 114150293
PRET: 103463557(shc2)
NFU: 107393200(shc2)
KMR: 108230757
AOCE: 111573492(shc2)
CSEM: 103398231
POV: 109625730(shc2)
LCF: 108881424(shc2)
SDU: 111232138
HCQ: 109532226
BPEC: 110167820(shc2)
MALB: 109964050
ELS: 105011583(shc2)
SFM: 108919768(shc2)
PKI: 111860152(shc2)
LCM: 102355047(SHC2)
CMK: 103182043(shc2)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9507002
  Authors
Nakamura T, Muraoka S, Sanokawa R, Mori N
  Title
N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling.
  Journal
J Biol Chem 273:6960-7 (1998)
DOI:10.1074/jbc.273.12.6960
  Sequence
[hsa:25759]
Reference
  Authors
Sasaki H, Emi M, Iijima H, Ito N, Sato H, Yabe I, Kato T, Utsumi J, Matsubara K
  Title
Copy number loss of (src homology 2 domain containing)-transforming protein 2 (SHC2) gene: discordant loss in monozygotic twins and frequent loss in patients with multiple system atrophy.
  Journal
Mol Brain 4:24 (2011)
DOI:10.1186/1756-6606-4-24
  Sequence
[hsa:25759]
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