KEGG   ORTHOLOGY: K17449Help
Entry
K17449                      KO                                     

Name
SHC4
Definition
SHC-transforming protein 4
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko04012  ErbB signaling pathway
ko04014  Ras signaling pathway
ko04062  Chemokine signaling pathway
ko04072  Phospholipase D signaling pathway
ko04510  Focal adhesion
ko04650  Natural killer cell mediated cytotoxicity
ko04722  Neurotrophin signaling pathway
ko04910  Insulin signaling pathway
ko04915  Estrogen signaling pathway
ko04917  Prolactin signaling pathway
ko04926  Relaxin signaling pathway
ko04935  Growth hormone synthesis, secretion and action
ko05034  Alcoholism
ko05100  Bacterial invasion of epithelial cells
ko05206  MicroRNAs in cancer
ko05214  Glioma
ko05220  Chronic myeloid leukemia
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K17449  SHC4; SHC-transforming protein 4
   04012 ErbB signaling pathway
    K17449  SHC4; SHC-transforming protein 4
   04072 Phospholipase D signaling pathway
    K17449  SHC4; SHC-transforming protein 4
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K17449  SHC4; SHC-transforming protein 4
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K17449  SHC4; SHC-transforming protein 4
   04062 Chemokine signaling pathway
    K17449  SHC4; SHC-transforming protein 4
  09152 Endocrine system
   04910 Insulin signaling pathway
    K17449  SHC4; SHC-transforming protein 4
   04915 Estrogen signaling pathway
    K17449  SHC4; SHC-transforming protein 4
   04917 Prolactin signaling pathway
    K17449  SHC4; SHC-transforming protein 4
   04926 Relaxin signaling pathway
    K17449  SHC4; SHC-transforming protein 4
   04935 Growth hormone synthesis, secretion and action
    K17449  SHC4; SHC-transforming protein 4
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K17449  SHC4; SHC-transforming protein 4
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K17449  SHC4; SHC-transforming protein 4
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K17449  SHC4; SHC-transforming protein 4
   05226 Gastric cancer
    K17449  SHC4; SHC-transforming protein 4
   05214 Glioma
    K17449  SHC4; SHC-transforming protein 4
   05220 Chronic myeloid leukemia
    K17449  SHC4; SHC-transforming protein 4
   05224 Breast cancer
    K17449  SHC4; SHC-transforming protein 4
  09165 Substance dependence
   05034 Alcoholism
    K17449  SHC4; SHC-transforming protein 4
  09171 Infectious disease: bacterial
   05100 Bacterial invasion of epithelial cells
    K17449  SHC4; SHC-transforming protein 4
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K17449  SHC4; SHC-transforming protein 4
   01522 Endocrine resistance
    K17449  SHC4; SHC-transforming protein 4
BRITE hierarchy
Genes
HSA: 399694(SHC4)
PTR: 453414(SHC4)
PPS: 100991042(SHC4)
GGO: 101154420(SHC4)
PON: 100431574(SHC4)
NLE: 100591644(SHC4)
MCC: 714611(SHC4)
MCF: 102130383(SHC4)
CSAB: 103245659(SHC4)
RRO: 104657941(SHC4)
RBB: 108530104(SHC4)
CJC: 100392220(SHC4)
SBQ: 101032627(SHC4)
MMU: 271849(Shc4)
MCAL: 110289726(Shc4)
MPAH: 110318126(Shc4)
RNO: 679845(Shc4)
MUN: 110550937(Shc4)
CGE: 100763505(Shc4)
NGI: 103733036(Shc4)
HGL: 101717788(Shc4)
CCAN: 109684252(Shc4)
OCU: 100350676(SHC4)
TUP: 102479734(SHC4)
CFA: 487546(SHC4)
VVP: 112920045(SHC4)
AML: 100475137(SHC4)
UMR: 103676722(SHC4)
UAH: 113269597(SHC4)
ORO: 101375729(SHC4)
ELK: 111162137
FCA: 101099050(SHC4)
PTG: 102955115(SHC4)
PPAD: 109263016(SHC4)
AJU: 106967221(SHC4)
BTA: 524734(SHC4)
BOM: 102284488(SHC4)
BIU: 109565147(SHC4)
BBUB: 102406154(SHC4)
CHX: 102179773(SHC4)
OAS: 101110241(SHC4)
SSC: 100526147(SHC4)
CFR: 102517753(SHC4)
CDK: 105104832(SHC4)
BACU: 102999132(SHC4)
LVE: 103088900(SHC4)
OOR: 101289594(SHC4)
DLE: 111181617(SHC4)
PCAD: 102988652(SHC4)
ECB: 100055699(SHC4)
EPZ: 103551857(SHC4)
EAI: 106838625(SHC4)
MYB: 102239285(SHC4)
MYD: 102762219(SHC4)
MNA: 107535558(SHC4)
HAI: 109394486(SHC4)
DRO: 112311774(SHC4)
PALE: 102888926(SHC4)
RAY: 107519965(SHC4)
MJV: 108402352(SHC4)
LAV: 100654827(SHC4)
TMU: 101355900
MDO: 100031128(SHC4)
SHR: 100927458(SHC4)
PCW: 110201503(SHC4)
GGA: 426482(SHC4)
MGP: 100541111(SHC4)
CJO: 107318783(SHC4)
NMEL: 110403695(SHC4)
APLA: 101797165(SHC4)
ACYG: 106033799(SHC4)
TGU: 100226451(SHC4)
LSR: 110474245(SHC4)
SCAN: 103816021(SHC4)
GFR: 102037367(SHC4)
FAB: 101809679(SHC4)
PHI: 102103363(SHC4)
PMAJ: 107209575(SHC4)
CCAE: 111934113(SHC4)
CCW: 104683990(SHC4)
ETL: 114059944(SHC4)
FPG: 101914295(SHC4)
FCH: 102053624(SHC4)
CLV: 102088829(SHC4)
EGZ: 104130918(SHC4)
NNI: 104017130(SHC4)
ACUN: 113484090(SHC4)
PADL: 103922748(SHC4)
AAM: 106496580(SHC4)
ASN: 102383468(SHC4)
AMJ: 102568049(SHC4)
PSS: 102455357(SHC4)
CMY: 102934651(SHC4)
CPIC: 101946426(SHC4)
ACS: 100560740(shc4)
PVT: 110077281(SHC4)
PBI: 103055438(SHC4)
PMUR: 107287682(SHC4)
TSR: 106548787
PMUA: 114584523(SHC4)
GJA: 107124453(SHC4)
XLA: 108711398(shc4.L) 108712318(shc4.S)
XTR: 100490718(shc4)
NPR: 108792188(SHC4)
LCO: 109136640(shc4)
MZE: 101474172(shc4)
ONL: 100701320(shc4)
OLA: 101170912(shc4)
XMA: 102222349(shc4)
XCO: 114142814(shc4)
PRET: 103462081(shc4)
CVG: 107085339(shc4)
NFU: 107381724(shc4)
AOCE: 111565759(shc4)
CSEM: 103379110(shc4)
POV: 109637245(shc4)
LCF: 108887900(shc4)
SDU: 111238681(shc4)
SLAL: 111661140(shc4)
HCQ: 109525729(shc4)
SFM: 108940860
PKI: 111844965(shc4)
LCM: 102354432(SHC4)
CMK: 103187006(shc4)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Fagiani E, Giardina G, Luzi L, Cesaroni M, Quarto M, Capra M, Germano G, Bono M, Capillo M, Pelicci P, Lanfrancone L
  Title
RaLP, a new member of the Src homology and collagen family, regulates cell migration and tumor growth of metastatic melanomas.
  Journal
Cancer Res 67:3064-73 (2007)
DOI:10.1158/0008-5472.CAN-06-2301
  Sequence
[hsa:399694]
Reference
  Authors
Jones N, Hardy WR, Friese MB, Jorgensen C, Smith MJ, Woody NM, Burden SJ, Pawson T
  Title
Analysis of a Shc family adaptor protein, ShcD/Shc4, that associates with muscle-specific kinase.
  Journal
Mol Cell Biol 27:4759-73 (2007)
DOI:10.1128/MCB.00184-07
  Sequence
[hsa:399694]
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