KEGG   ORTHOLOGY: K17718
Entry
K17718                      KO                                     

Name
CYP2C8
Definition
cytochrome P450 family 2 subfamily C polypeptide 8 [EC:1.14.14.1]
Pathway
ko00590  Arachidonic acid metabolism
ko00591  Linoleic acid metabolism
ko00830  Retinol metabolism
ko00982  Drug metabolism - cytochrome P450
ko01100  Metabolic pathways
ko04726  Serotonergic synapse
ko05204  Chemical carcinogenesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C polypeptide 8
   00591 Linoleic acid metabolism
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C polypeptide 8
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C polypeptide 8
  09111 Xenobiotics biodegradation and metabolism
   00982 Drug metabolism - cytochrome P450
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C polypeptide 8
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C polypeptide 8
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C polypeptide 8
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C polypeptide 8
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K17718  CYP2C8; cytochrome P450 family 2 subfamily C polypeptide 8
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K17718  CYP2C8; cytochrome P450 family 2 subfamily C polypeptide 8
Other DBs
RN: R07042 R07043 R07048 R07050 R07055 R07056 R08312 R08390 R08392
Genes
HSA: 1558(CYP2C8)
PTR: 450909(CYP2C8)
PPS: 100967379
GGO: 101127173
PON: 100447840
NLE: 100602226
MCC: 678683(CYP2C8) 702239
MCF: 102117212(CYP2C20)
CSAB: 103216303(CYP2C8)
RRO: 104665592
RBB: 108541196
CJC: 100390915(CYP2C8)
SBQ: 101041387
 » show all
Reference
PMID:3500169
  Authors
Okino ST, Quattrochi LC, Pendurthi UR, McBride OW, Tukey RH
  Title
Characterization of multiple human cytochrome P-450 1 cDNAs. The chromosomal localization of the gene and evidence for alternate RNA splicing.
  Journal
J Biol Chem 262:16072-9 (1987)
  Sequence
[hsa:1558]
Reference
  Authors
Iliff JJ, Jia J, Nelson J, Goyagi T, Klaus J, Alkayed NJ
  Title
Epoxyeicosanoid signaling in CNS function and disease.
  Journal
Prostaglandins Other Lipid Mediat 91:68-84 (2010)
DOI:10.1016/j.prostaglandins.2009.06.004
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