KEGG ORTHOLOGY: K20064

ORTHOLOGY: K20064

Entry

K20064                      KO

Symbol

GRB10

Name

growth factor receptor-bound protein 10

Pathway

map04150

mTOR signaling pathway

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04150 mTOR signaling pathway
    K20064  GRB10; growth factor receptor-bound protein 10
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K20064  GRB10; growth factor receptor-bound protein 10
Membrane trafficking [BR:ko04131]
Endocytosis
  Clathrin-mediated endocytosis
   Receptor tyrosine kinase (RTK) adaptor proteins
    K20064  GRB10; growth factor receptor-bound protein 10

Other DBs

GO:	0005070 0005158

Genes

HSA:	2887(GRB10)

PTR:	463410(GRB10)

PPS:	100970376(GRB10)

GGO:	101147357(GRB10)

PON:	100434903(GRB10)

NLE:	100599409(GRB10)

HMH:	116812441(GRB10)

MCC:	694786(GRB10)

MCF:	102117572(GRB10)

MTHB:

126951469

MNI:	105492378(GRB10)

CSAB:

103226075(GRB10)

CATY:

105588285(GRB10)

PANU:

101012084(GRB10)

TGE:	112620824(GRB10)

MLEU:

105555260(GRB10)

RRO:	104657652(GRB10)

RBB:	108527367(GRB10)

TFN:	117073449(GRB10)

PTEH:

111555716(GRB10)

CANG:

105515690(GRB10)

CJC:	100402854(GRB10)

SBQ:	101042598(GRB10)

CIMI:

108293931 108296296(GRB10)

CSYR:

103258744(GRB10)

MMUR:

105855189(GRB10)

LCAT:

123647352(GRB10)

PCOQ:

105815471(GRB10)

OGA:	100943908(GRB10)

MMU:	14783(Grb10)

MCAL:

110305653(Grb10)

MPAH:

110330986(Grb10)

MCOC:

116068552(Grb10)

ANU:	117712626(Grb10)

MUN:	110554529(Grb10)

CGE:	100760784(Grb10)

MAUA:

101825261(Grb10)

PROB:

127233991(Grb10)

PLEU:

114702510(Grb10)

MORG:

121459526(Grb10)

MFOT:

126500872

AAMP:

119825177(Grb10)

NGI:	103746990(Grb10)

HGL:	101725734(Grb10)

CPOC:

100733471(Grb10)

CCAN:

109700613(Grb10)

DORD:

105991765(Grb10)

DSP:	122112139(Grb10)

PLOP:

125346753(Grb10)

NCAR:

124990259

MMMA:

107146255(Grb10)

OCU:

100355737

OPI:	101533322(GRB10)

TUP:	102498579(GRB10)

GVR:	103588247(GRB10)

CFA:	607755(GRB10)

CLUD:

112661532(GRB10)

VVP:	112925848(GRB10)

VLG:	121471759(GRB10)

NPO:	129494112(GRB10)

AML:	100476882(GRB10)

UMR:	103674552(GRB10)

UAH:	113257529(GRB10)

UAR:	123786263(GRB10)

ELK:

111157052

LLV:

125080998

MPUF:

101689448(GRB10)

MNP:	132016101(GRB10)

MLK:	131829157(GRB10)

NVS:	122904651(GRB10)

ORO:	101363885(GRB10)

EJU:	114213692(GRB10)

ZCA:	113910944(GRB10)

MLX:	118024529(GRB10)

NSU:	110592655(GRB10)

LWW:	102742290(GRB10)

FCA:	101083918(GRB10)

PYU:	121017005(GRB10)

PCOO:

112859698(GRB10)

PBG:	122487670(GRB10)

PVIV:

125155147(GRB10)

LRUF:

124524039

PTG:	102965932(GRB10)

PPAD:

109267971(GRB10)

PUC:

125929769

AJU:

106968216

HHV:	120234061(GRB10)

BTA:	407210(GRB10)

BOM:

102264736

BIU:	109558178(GRB10)

BBUB:

102404267(GRB10)

BBIS:

104981811(GRB10)

CHX:	102173910(GRB10)

OAS:	101111275(GRB10)

BTAX:

128046462(GRB10)

ODA:	120877828(GRB10)

CCAD:

122438048(GRB10)

MBEZ:

129552190(GRB10)

SSC:	100188977(GRB10)

CFR:	102512663(GRB10)

CBAI:

105065159(GRB10)

CDK:	105105291(GRB10)

VPC:	102539549(GRB10)

BACU:

102999267(GRB10)

BMUS:

118901006(GRB10)

LVE:	103080900(GRB10)

OOR:	101274856(GRB10) 101284329

DLE:	111184554(GRB10) 111187339

PCAD:

102993174

PSIU:

116748547 116759234(GRB10)

NASI:

112412696(GRB10) 112414965

ECB:	100052610(GRB10)

EPZ:	103563418(GRB10)

EAI:	106822902(GRB10)

MYB:	102242221(GRB10)

MYD:	102756714(GRB10)

MMYO:

118665898(GRB10)

MLF:	102440478(GRB10)

PKL:	118727768(GRB10)

EFUS:

103291166(GRB10)

MNA:	107525993(GRB10)

DRO:

112306975

SHON:

118983500(GRB10)

AJM:	119057348(GRB10)

PDIC:

114507582(GRB10)

PHAS:

123812198(GRB10)

MMF:	118620235(GRB10)

PPAM:

129068922(GRB10)

HAI:

109388354

RFQ:	117012293(GRB10)

PALE:

102898005(GRB10)

PGIG:

120602483(GRB10)

PVP:

105303564

RAY:	107512422(GRB10)

MJV:	108388515(GRB10)

TOD:	119231708(GRB10)

SARA:

101542165(GRB10)

SETR:

126014153(GRB10)

LAV:	100656282(GRB10)

TMU:

101346797

ETF:	101660567(GRB10)

DNM:	101441021(GRB10)

MDO:	100029986(GRB10)

GAS:	123243142(GRB10)

SHR:	100917313(GRB10)

AFZ:

127553444

PCW:	110205000(GRB10)

OAA:	100074527(GRB10)

GGA:	420948(GRB10)

PCOC:

116226325(GRB10)

MGP:	100542734(GRB10)

CJO:	107309486(GRB10)

TPAI:

128090837(GRB10)

LMUT:

125691202(GRB10)

NMEL:

110393206(GRB10)

APLA:

101796819(GRB10)

ACYG:

106036553(GRB10)

CATA:

118251063(GRB10)

AFUL:

116485911(GRB10)

TGU:	100224775(GRB10)

LSR:	110479518(GRB10)

SCAN:

103824524(GRB10)

PMOA:

120504878(GRB10)

OTC:	121339725(GRB10)

PRUF:

121358044(GRB10)

GFR:	102033131(GRB10)

FAB:	101812622(GRB10)

OMA:	130249104(GRB10)

PHI:	102104661(GRB10)

PMAJ:

107216263(GRB10)

CCAE:

111925378(GRB10)

CCW:	104685861(GRB10)

CBRC:

103618778(GRB10)

ETL:	114055149(GRB10)

ZAB:	102068869(GRB10)

ACHL:

103797221(GRB10)

SVG:	106850738(GRB10)

MMEA:

130576404(GRB10)

HRT:	120764233(GRB10)

FPG:	101922654(GRB10)

FCH:	102059502(GRB10)

CLV:	102084727(GRB10)

EGZ:	104126181(GRB10)

NNI:	104014790(GRB10)

PCRI:

104037457(GRB10)

PLET:

104621448

EHS:	104515989(GRB10)

ACUN:

113476494(GRB10)

TALA:

104361315(GRB10)

PADL:

103922340(GRB10)

AFOR:

103901927(GRB10)

ACHC:

115340159(GRB10)

HALD:

104317474(GRB10)

HLE:	104835748(GRB10)

AGEN:

126051250

GCL:

127013096

CCRI:

104155858(GRB10)

CSTI:

104561218

CMAC:

104484358(GRB10)

MUI:

104538368

BREG:

104643717(GRB10)

FGA:	104081734(GRB10)

GSTE:

104255341

LDI:	104345176(GRB10)

MNB:	103772104(GRB10)

OHA:	104335947(GRB10)

NNT:

104401835

SHAB:

115612342(GRB10)

DPUB:

104305681(GRB10)

ACAR:

104523483

CPEA:

104398269(GRB10)

AVIT:

104279262

CVF:	104285342(GRB10)

RTD:	128904902(GRB10)

CUCA:

104059208(GRB10)

TEO:	104376558(GRB10)

BRHI:

104500219(GRB10)

AAM:	106492880(GRB10)

AROW:

112969133(GRB10)

NPD:	112953302(GRB10)

TGT:	104573666(GRB10)

DNE:	112984443(GRB10)

SCAM:

104148660(GRB10)

ASN:	102375292(GRB10)

AMJ:	102567317(GRB10)

CPOO:

109314021(GRB10)

GGN:	109300132(GRB10)

PSS:	102449342(GRB10)

CMY:	102932294(GRB10)

CCAY:

125631873(GRB10)

DCC:	119851295(GRB10)

CPIC:

101939122(GRB10)

TST:	117872655(GRB10)

CABI:

116836615(GRB10)

MRV:	120397876(GRB10)

ACS:	100564990(grb10)

ASAO:

132778499(GRB10)

PVT:	110085762(GRB10)

PBI:	103055285(GRB10)

PMUR:

107287641(GRB10)

CTIG:

120305072(GRB10)

TSR:	106538956(GRB10)

PGUT:

117664942(GRB10)

APRI:

131196783(GRB10)

PTEX:

113437381(GRB10)

NSS:	113419107(GRB10)

VKO:	123035293(GRB10)

PMUA:

114582210(GRB10)

PRAF:

128400649(GRB10)

ZVI:	118095824(GRB10)

HCG:	128329375(GRB10)

GJA:	107121866(GRB10)

EMC:	129337479(GRB10)

XLA:	100381089(grb10.L) 108720011(grb10.S)

XTR:	100151701(grb10)

NPR:	108788304(GRB10)

RTEM:

120940441(GRB10)

BBUF:

121000774(GRB10)

BGAR:

122937794

MUO:	115471669(GRB10)

GSH:	117353931(GRB10)

DRE:	446167(grb10a) 562032(grb10b)

SRX:	107739542 107746967 107748738 107751877

SANH:

107656633 107657570 107667783 107684229 107704094

SGH:	107551212 107563712 107565574 107601668

CCAR:

109055682 109076381

CAUA:

113062361 113116176(grb10) 113120124

CGIB:

127935668 127974854 127978963

PTET:

122323614(grb10a) 122360233(grb10b)

LROH:

127177829(grb10b) 127181576(grb10a)

OMC:	131521285(grb10b) 131525303(grb10a)

PPRM:

120477501 120483549(grb10a)

RKG:	130076451(grb10a) 130089922(grb10b)

MAMB:

125243041(grb10b) 125275489(grb10a)

CIDE:

127496913 127501027

MASI:

127421409 127425678 127452563 127453615

TROS:

130557533(grb10b) 130567330(grb10a)

TDW:	130415348(grb10a) 130432603(grb10b)

MANU:

129447729(grb10b) 129455644(grb10a)

IPU:	108264732(grb10b) 108273075

IFU:	128605385(grb10b) 128615352(grb10a)

PHYP:

113534201(grb10) 113543760

SMEO:

124381931 124384411(grb10b)

TFD:	113641272(grb10a) 113663709(grb10b)

TVC:	132842863(grb10a) 132846449(grb10b)

AMEX:

103031323(grb10)

CMAO:

118806018(grb10a) 118821970(grb10b)

EEE:	113586566(grb10) 113589114

CHAR:

105905327(grb10a)

TRU:	101067016 101075382

TFS:	130518648 130532870(grb10b)

TNG:	GSTEN00017579G001 GSTEN00035404G001

LCO:	104934758 104937108

NCC:	104961436 104965467

TBEN:

117477722 117480092

CGOB:

115015558 115020824(grb10)

PGEO:

117454943 117460538

GACU:

117537443(grb10b) 117563045

EMAC:

134861576(grb10b) 134874777

ELY:	117263599 117265856(grb10b)

EFO:	125892900(grb10b) 125904552

PLEP:

121945454(grb10b) 121958200

SLUC:

116035241(grb10b) 116041221

ECRA:

117946625 117957011

ESP:	116691809 116701414

PFLV:

114556977 114567948

GAT:	120810687 120826229

PPUG:

119197528(grb10b) 119219466

AFB:	129097111 129109123(grb10b)

CLUM:

117739269 117745865(grb10b)

PSWI:

130200628 130212551

MSAM:

119897904(grb10b) 119906981

SCHU:

122865064 122881148(grb10b)

CUD:	121513442(grb10b) 121524148

ALAT:

119006002(grb10b) 119016729

MZE:	101472205 101472778

ONL:	100694675 100703704

OAU:	116313416 116322614(grb10b)

OLA:	101165586(grb10)

OML:	112136293 112143563(grb10b) 112159952

CSAI:

133426613(grb10b) 133460479

XMA:	102222201 102225386

XCO:	114141674 114155305

XHE:	116717152 116731263

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122831616(grb10b) 122844104

PPRL:

129367475 129376263

CVG:	107091852 107094114

CTUL:

119777078(grb10b) 119792939

GMU:	124865640(grb10b) 124879994

NFU:	107378763 107383188

KMR:	108232318(grb10b) 108238714

ALIM:

106514242 106518097

NWH:	119409513(grb10b) 119425684

AOCE:

111562437 111573420

MCEP:

125016123(grb10b) 125019646

CSEM:

103388767 103394723

POV:	109631798 109632221

SSEN:

122774664(grb10b) 122786315(grb10a)

HHIP:

117770307 117776721(grb10b)

HSP:	118113587 118124382

SMAU:

118299682(grb10b) 118311103

LCF:	108888828(grb10b) 108900407

SDU:	111223500 111227672

SLAL:

111655936 111671450

XGL:	120783750(grb10b) 120786129

HCQ:	109521916 109521964

SSCV:

125975277 125986788

SBIA:

133498755 133500552

PEE:	133396186 133401817

PTAO:

133471521 133480191

BPEC:

110167175 110171516

MALB:

109958271(grb10) 109971729

BSPL:

114842799(grb10b) 114865539(grb10a)

SJO:	128365983(grb10b) 128373975

SASA:

106570349 106579904 106588785 106605415

STRU:

115173834 115175628 115176393 115180502

OTW:	112222535 112228363 112238316 112264508

OMY:	110485935 110488100 110496474 110512801

OGO:	123997864 124005254 124012586 124042742

ONE:	115102810 115128596 115131395

OKI:	109901903 109901918 109904677 109907342

OKE:	118364064 118367718 118397657 118398971

SALP:

111955894 111958062

SNH:	120022070 120027049 120031018 120048490

CCLU:

121570069 121571880 121586245 121586598

ELS:	105012411 105025917(grb10)

SFM:	108919287 108940745

PKI:	111840898(grb10) 111852699

AANG:

118230375(grb10b) 118233866

LOC:	102697507(grb10)

PSPA:

121313364 121314797

ARUT:

117400277 117435483

PSEX:

120516081(grb10b)

LCM:	102352775(GRB10)

CMK:

103181196

RTP:

109911645

CPLA:

122549906

HOC:	132815731(grb10b)

LERI:

129710367(grb10b)

PMRN:

116938549 116948726

LRJ:	133346093 133349638

BFO:

BBEL:

CIN:

SCLV:

FVI:

MGEN:

NMEA:

LBD:

CGLO:

CCIN:

DSM:

NFB:

AROA:

CSET:

AGB:

PPYR:

HVI:

MQU:	128991898 128992069

FOC:

TPAL:

CSEC:

IEL:

PPOI:

LPOL:

NVE:

ADF:

AMIL:

PDAM:

SPIS:

HMG:

Reference

PMID:12493740

Authors

Wick KR, Werner ED, Langlais P, Ramos FJ, Dong LQ, Shoelson SE, Liu F

Title

Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor.

Journal

J Biol Chem 278:8460-7 (2003)
DOI:10.1074/jbc.M208518200

Sequence

[hsa:2887]

Reference

PMID:9360986

Authors

Dong LQ, Du H, Porter SG, Kolakowski LF Jr, Lee AV, Mandarino LJ, Fan J, Yee D, Liu F

Title

Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma.

Journal

J Biol Chem 272:29104-12 (1997)
DOI:10.1074/jbc.272.46.29104

Sequence

[hsa:2887]

LinkDB

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