KEGG   ORTHOLOGY: K21421Help
Entry
K21421                      KO                                     

Name
NOX2, GP91, CYBB
Definition
NADPH oxidase 2 [EC:1.-.-.-]
Pathway
ko04066  HIF-1 signaling pathway
ko04145  Phagosome
ko04216  Ferroptosis
ko04217  Necroptosis
ko04621  NOD-like receptor signaling pathway
ko04670  Leukocyte transendothelial migration
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05140  Leishmaniasis
Disease
H00089  IFN-gamma/IL-12 axis
H00098  Chronic granulomatous disease
H01167  Gluconobacter infection
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
  09143 Cell growth and death
   04216 Ferroptosis
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
   04217 Necroptosis
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
   04670 Leukocyte transendothelial migration
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.-  
   1.-.-  
    1.-.-.-  
     K21421  NOX2, GP91, CYBB; NADPH oxidase 2
Membrane trafficking [BR:ko04131]
 Endocytosis
  Phagocytosis
   NADPH oxidase complex
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
 Others
  NADPH oxidases (Nox) and associated proteins
   NADPH oxidases
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
BRITE hierarchy
Other DBs
GO: 0016175
TC: 5.B.1.1.1
Genes
HSA: 1536(CYBB)
PTR: 465566(CYBB)
PPS: 100982531
GGO: 101144859
PON: 100459132
NLE: 100605123
MCC: 696542(CYBB)
MCF: 102122418
CSAB: 103247465(CYBB)
RRO: 104658069
RBB: 108522897
CJC: 100415466(CYBB)
SBQ: 101052306
MMU: 13058(Cybb)
MCAL: 110286646
MPAH: 110313555
RNO: 66021(Cybb)
CGE: 100760802
NGI: 103734151
HGL: 101709509
CCAN: 109698413
OCU: 100008801(CYBB)
TUP: 102468293
CFA: 491825(CYBB)
VVP: 112929967
AML: 100468223
UMR: 103668228
UAH: 113265816
ORO: 101379802
ELK: 111150330
FCA: 101086207
PTG: 102950901
AJU: 106982016
BTA: 281112(CYBB)
BOM: 102288244
BBUB: 102415288
CHX: 102175938
OAS: 100036757(CYBB)
SSC: 397108(GP91-PHOX)
CFR: 102517434
CDK: 105101594
BACU: 103009523
LVE: 103078741
OOR: 101279174
DLE: 111170450
PCAD: 102993493
ECB: 100050132(CYBB)
EPZ: 103540976
EAI: 106825146
MYB: 102244245
MYD: 102764112
MNA: 107540071
HAI: 109376547
DRO: 112307613
PALE: 102887189
RAY: 107503927
MJV: 108404285
LAV: 100655878
TMU: 101344219
MDO: 100017914
SHR: 100917667
OAA: 100082988
GGA: 418581(CYBB)
MGP: 100543754
CJO: 107324446
NMEL: 110404027
APLA: 101792171
ACYG: 106042157
TGU: 100225149
LSR: 110483221
SCAN: 103815785
GFR: 102043904
FAB: 101813268
PHI: 102103714
PMAJ: 107210624
CCAE: 111926769
CCW: 104686217
ETL: 114058998
FPG: 101920108
FCH: 102053609
CLV: 102091246
EGZ: 104133041
NNI: 104020081
ACUN: 113485490
PADL: 103912607
AAM: 106483650
ASN: 102373183
AMJ: 102572671
PSS: 102454753
CMY: 102945080
CPIC: 101949220
ACS: 100562545
PBI: 103064031
PMUR: 107294658
TSR: 106557320
PMUA: 114596171
GJA: 107113619
XLA: 444353(cybb.L)
XTR: 595081(cybb)
NPR: 108792287
DRE: 393386(cybb)
IPU: 108259374(CYBB)
PHYP: 113547443
AMEX: 103031151
EEE: 113578253
TRU: 445888(gp91phox)
LCO: 104937235
NCC: 104957581
MZE: 101485767
ONL: 100705711
OLA: 101157756
XMA: 102232835
XCO: 114140559
PRET: 103456660
CVG: 107096819
NFU: 107384631
KMR: 108251269
ALIM: 106527016
AOCE: 111573332
CSEM: 103389690
POV: 109645867
LCF: 108873164
SDU: 111234761
SLAL: 111672373
HCQ: 109528505
BPEC: 110156598
MALB: 109955650
SASA: 100270807(cybb) 106575674
SALP: 112077474
ELS: 105019694
SFM: 108933209
PKI: 111838198
LCM: 102363081
CMK: 103183733
CIN: 100169685(nox2)
SPU: 757329
APLC: 110974417
PCAN: 112565522
CRG: 105319325
MYI: 110449837
OBI: 106873617
LAK: 106150924
ADF: 107332213
HMG: 101236489
AQU: 100639820
DZI: 111302650
CQI: 110688502
NCR: NCU10775(nox-2)
NTE: NEUTE1DRAFT148131(NEUTE1DRAFT_148131)
SMP: SMAC_08741(putative nox2)
MGR: MGG_06559
SSCK: SPSK_07252
MAW: MAC_01488
MAJ: MAA_04914
CMT: CCM_01357
BFU: BCIN_02g04930(BcnoxB)
MBE: MBM_02981
ABE: ARB_07242
TVE: TRV_03949
PTE: PTT_13443
LBC: LACBIDRAFT_173015(LbNoxB)
ABP: AGABI1DRAFT60718(AGABI1DRAFT_60718)
ABV: AGABI2DRAFT194938(AGABI2DRAFT_194938)
DDI: DDB_G0289653(noxA)
DFA: DFA_11184(noxA)
SMIN: v1.2.014519.t1(symbB.v1.2.014519.t1)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2425263
  Authors
Royer-Pokora B, Kunkel LM, Monaco AP, Goff SC, Newburger PE, Baehner RL, Cole FS, Curnutte JT, Orkin SH
  Title
Cloning the gene for an inherited human disorder--chronic granulomatous disease--on the basis of its chromosomal location.
  Journal
Nature 322:32-8 (1986)
DOI:10.1038/322032a0
  Sequence
[hsa:1536]
LinkDB All DBs

DBGET integrated database retrieval system