KEGG   ORTHOLOGY: K23605Help
Entry
K23605                      KO                                     

Name
SMAD3
Definition
mothers against decapentaplegic homolog 3
Pathway
ko04068  FoxO signaling pathway
ko04110  Cell cycle
ko04144  Endocytosis
ko04218  Cellular senescence
ko04350  TGF-beta signaling pathway
ko04371  Apelin signaling pathway
ko04390  Hippo signaling pathway
ko04520  Adherens junction
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04659  Th17 cell differentiation
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05161  Hepatitis B
ko05166  Human T-cell leukemia virus 1 infection
ko05200  Pathways in cancer
ko05210  Colorectal cancer
ko05212  Pancreatic cancer
ko05220  Chronic myeloid leukemia
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
ko05321  Inflammatory bowel disease (IBD)
Disease
H00800  Loeys-Dietz syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    K23605  SMAD3; mothers against decapentaplegic homolog 3
   04390 Hippo signaling pathway
    K23605  SMAD3; mothers against decapentaplegic homolog 3
   04371 Apelin signaling pathway
    K23605  SMAD3; mothers against decapentaplegic homolog 3
   04068 FoxO signaling pathway
    K23605  SMAD3; mothers against decapentaplegic homolog 3
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K23605  SMAD3; mothers against decapentaplegic homolog 3
  09143 Cell growth and death
   04110 Cell cycle
    K23605  SMAD3; mothers against decapentaplegic homolog 3
   04218 Cellular senescence
    K23605  SMAD3; mothers against decapentaplegic homolog 3
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K23605  SMAD3; mothers against decapentaplegic homolog 3
   04550 Signaling pathways regulating pluripotency of stem cells
    K23605  SMAD3; mothers against decapentaplegic homolog 3
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    K23605  SMAD3; mothers against decapentaplegic homolog 3
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K23605  SMAD3; mothers against decapentaplegic homolog 3
  09162 Cancer: specific types
   05210 Colorectal cancer
    K23605  SMAD3; mothers against decapentaplegic homolog 3
   05212 Pancreatic cancer
    K23605  SMAD3; mothers against decapentaplegic homolog 3
   05225 Hepatocellular carcinoma
    K23605  SMAD3; mothers against decapentaplegic homolog 3
   05226 Gastric cancer
    K23605  SMAD3; mothers against decapentaplegic homolog 3
   05220 Chronic myeloid leukemia
    K23605  SMAD3; mothers against decapentaplegic homolog 3
  09163 Immune disease
   05321 Inflammatory bowel disease (IBD)
    K23605  SMAD3; mothers against decapentaplegic homolog 3
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K23605  SMAD3; mothers against decapentaplegic homolog 3
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K23605  SMAD3; mothers against decapentaplegic homolog 3
   05161 Hepatitis B
    K23605  SMAD3; mothers against decapentaplegic homolog 3
BRITE hierarchy
Other DBs
GO: 0070410
Genes
HSA: 4088(SMAD3)
PTR: 748161(SMAD3)
PPS: 100993322(SMAD3)
GGO: 109025264(SMAD3)
PON: 100448249(SMAD3)
NLE: 100583279(SMAD3)
MCC: 711355(SMAD3)
MCF: 102146086(SMAD3)
CSAB: 103245436(SMAD3)
RRO: 104662580(SMAD3)
RBB: 108514714(SMAD3)
CJC: 100393808(SMAD3)
SBQ: 101039593(SMAD3)
MMU: 17127(Smad3)
MCAL: 110301346(Smad3)
MPAH: 110327577(Smad3)
RNO: 25631(Smad3)
MUN: 110557885
CGE: 100759220(Smad3)
NGI: 103736807(Smad3)
HGL: 101713378(Smad3)
CCAN: 109701514(Smad3)
OCU: 100346303(SMAD3)
TUP: 102473158(SMAD3)
CFA: 610902(SMAD3)
VVP: 112929830(SMAD3)
AML: 100479304(SMAD3)
UAH: 113240893(SMAD3)
ORO: 101367515(SMAD3)
ELK: 111153179
FCA: 101101387(SMAD3)
PTG: 102971888(SMAD3)
PPAD: 109262802(SMAD3)
AJU: 106980367(SMAD3)
BTA: 515125(SMAD3)
BOM: 102282627(SMAD3)
BIU: 109564704(SMAD3)
BBUB: 102400710(SMAD3)
CHX: 102169293(SMAD3)
OAS: 443169(SMAD3)
SSC: 397260(SMAD3)
CDK: 105093274(SMAD3)
BACU: 103019152(SMAD3)
LVE: 103085090(SMAD3)
OOR: 101288074(SMAD3)
DLE: 111177751(SMAD3)
PCAD: 102989819(SMAD3)
ECB: 100033845(SMAD3)
EPZ: 103549637(SMAD3)
EAI: 106840608(SMAD3)
MYB: 102259468(SMAD3)
MYD: 102769241(SMAD3)
HAI: 109385242(SMAD3)
PALE: 102895268(SMAD3)
RAY: 107508935(SMAD3)
MJV: 108404778(SMAD3)
TMU: 101344857
MDO: 100018703(SMAD3)
SHR: 100923201(SMAD3)
PCW: 110205871(SMAD3)
OAA: 100085963(SMAD3)
GGA: 395132(SMAD3)
MGP: 100544037(SMAD3)
CJO: 107318915(SMAD3)
NMEL: 110403531(SMAD3)
APLA: 101801230(SMAD3)
ACYG: 106043666(SMAD3)
LSR: 110483002(SMAD3)
SCAN: 103816118(SMAD3)
FAB: 101806307(SMAD3)
PHI: 102110827(SMAD3)
PMAJ: 107209417(SMAD3)
CCAE: 111933962(SMAD3)
CCW: 104683877(SMAD3)
ETL: 114065087
FPG: 101924726(SMAD3)
FCH: 102053568(SMAD3)
CLV: 102095468(SMAD3)
EGZ: 104125236(SMAD3)
NNI: 104017045(SMAD3)
ACUN: 113484131(SMAD3)
PADL: 103914749(SMAD3)
ASN: 102379863(SMAD3)
AMJ: 102564680(SMAD3)
PSS: 102449871(SMAD3)
CMY: 102946629(SMAD3)
CPIC: 101949856(SMAD3)
PBI: 103067237(SMAD3)
PMUR: 107283914(SMAD3)
TSR: 106547616
PMUA: 114584162(SMAD3)
GJA: 107105564(SMAD3)
XLA: 108712801(smad3) 378633(smad3.L)
XTR: 493272(smad3)
NPR: 108784107(SMAD3)
DRE: 326283(smad3b) 58092(smad3a)
IPU: 108259569(SMAD3) 108264458
PHYP: 113534580(smad3) 113540926
TRU: 101074868
LCO: 104922325(smad3) 104927744
NCC: 104949845 104967854(smad3)
ONL: 100692385 100695277(smad3)
OLA: 101169523
XMA: 102218118(smad3) 102235393
XCO: 114142996 114156401(smad3)
CVG: 107097788 107100800(smad3)
NFU: 107388715(smad3)
KMR: 108230182(smad3) 108237917
ALIM: 106512958 106521204(smad3)
AOCE: 111573031 111573169(smad3)
CSEM: 103379082 103380246(smad3)
POV: 109624649(smad3) 109637282
LCF: 108886506(smad3) 108887878
SDU: 111228425(smad3) 111238627
SLAL: 111661150 111666993(smad3)
HCQ: 109514412 109519458(smad3)
BPEC: 110174509(smad3)
MALB: 109963341 109971207(smad3)
OTW: 112235777
ELS: 105005850(smad3) 105013596
SFM: 108934681(smad3)
PKI: 111845594(smad3)
LCM: 102356317(SMAD3)
CMK: 103189587(smad3)
RTP: 109936169(smad3)
CIN: 100178575
SPU: 577345(Sp-Smad2/3)
APLC: 110975164
SKO: 100313734(Smad2/3)
DME: Dmel_CG2262(Smox)
DER: 6550310
DSI: Dsimw501_GD24642(Dsim_GD24642)
DSR: 110179736
DPE: 6598361
DMN: 108153411
DWI: 6649109
DAZ: 108617946
DNV: 108655431
DHE: 111595002
MDE: 101890260
LCQ: 111674919
AAG: 5570959
BIM: 100740756
BTER: 100646575
CCAL: 108630351
OBB: 114879806
SOC: 105193574
AEC: 105152835
ACEP: 105624937
PBAR: 105424505
VEM: 105566971
HST: 105184734
DQU: 106747646
CFO: 105256957
LHU: 105679381
PGC: 109857096
OBO: 105279483
PCF: 106785004
NVI: 100114895(Smox)
CSOL: 105366782
MDL: 103579049
TCA: 662450
DPA: 109536357
ATD: 109598083
NVL: 108567240
BMOR: 101738552
BMAN: 114245695
PMAC: 106709465
PRAP: 110993832
HAW: 110369607
TNL: 113500333
PXY: 105380548
RMD: 113559507
BTAB: 109042301
CLEC: 106664471
ZNE: 110837117
FCD: 110849299
CSCU: 111619055
PTEP: 107446655
TSP: Tsp_05943
PCAN: 112558140
CRG: 105337984
OBI: 106878050
LAK: 106179664
EPA: 110238115
ADF: 107337755(AdiSmad2/3)
AMIL: 114955849
PDAM: 113667438
SPIS: 111337190
DGT: 114525388
AQU: 105312557
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9464505
  Authors
Arai T, Akiyama Y, Okabe S, Ando M, Endo M, Yuasa Y
  Title
Genomic structure of the human Smad3 gene and its infrequent alterations in colorectal cancers.
  Journal
Cancer Lett 122:157-63 (1998)
DOI:10.1016/s0304-3835(97)00384-4
  Sequence
[hsa:4088]
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