KEGG ORTHOLOGY: K24174

ORTHOLOGY: K24174

Entry

K24174                      KO

Symbol

METTL4

Name

N(6)-adenine-specific DNA methyltransferase [EC:2.1.1.72]

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis
    K24174  METTL4; N(6)-adenine-specific DNA methyltransferase
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.72  site-specific DNA-methyltransferase (adenine-specific)
     K24174  METTL4; N(6)-adenine-specific DNA methyltransferase
Messenger RNA biogenesis [BR:ko03019]
Eukaryotic type
  mRNA processing factors
   3' end processing
    N6-methyltransferase complex
     K24174  METTL4; N(6)-adenine-specific DNA methyltransferase

Other DBs

GO:

0009007

Genes

HSA:	64863(METTL4)

PTR:	468487(METTL4)

PPS:	100975333(METTL4)

GGO:	101153116(METTL4)

PON:	100455120(METTL4)

NLE:	100582926(METTL4)

HMH:	116468699(METTL4)

MCC:	696353(METTL4)

MCF:	102118174(METTL4)

MTHB:

126941154

MNI:	105478808(METTL4)

CSAB:

103222692(METTL4)

CATY:

105583954(METTL4)

PANU:

101019145(METTL4)

TGE:	112611522(METTL4)

MLEU:

105551178(METTL4)

RRO:	104654115(METTL4)

RBB:	108516708(METTL4)

TFN:	117064098(METTL4)

PTEH:

111553562(METTL4)

CANG:

105523096(METTL4)

CJC:	100385149(METTL4)

SBQ:	101031027(METTL4)

CIMI:

108302438(METTL4)

CSYR:

103277371(METTL4)

MMUR:

105861019(METTL4)

LCAT:

123621748(METTL4)

PCOQ:

105816596(METTL4)

MMU:	76781(Mettl4)

MCAL:

110284272

MPAH:

110335714 110336037(Mettl4)

RNO:	316731(Mettl4)

MCOC:

116088899(Mettl4)

ANU:	117693630(Mettl4)

MUN:	110558712(Mettl4)

CGE:	100752537(Mettl4)

MAUA:

101828400(Mettl4)

PROB:

127226796(Mettl4)

PLEU:

114696420(Mettl4)

MORG:

121434748 121458943

MFOT:

126496599

AAMP:

119803955(Mettl4)

NGI:	103735395(Mettl4)

HGL:	101724336(Mettl4)

CPOC:

100730430(Mettl4)

CCAN:

109681007(Mettl4)

DORD:

105993765(Mettl4)

DSP:	122104370(Mettl4)

PLOP:

125364210(Mettl4)

NCAR:

124965796

MMMA:

107139609(Mettl4)

OCU:

100343651

OPI:	105942716(METTL4)

TUP:	102467717(METTL4)

GVR:	103587641(METTL4)

CFA:	490534(METTL4)

CLUD:

112648006(METTL4)

VVP:	112925256(METTL4)

VLG:	121471420(METTL4)

NPO:	129508834(METTL4)

AML:	100467181(METTL4)

UMR:	103662717(METTL4)

UAH:	113253257(METTL4)

UAR:	123782035(METTL4)

ELK:

111142517

LLV:

125082502

MPUF:

101690502(METTL4)

MNP:	132023903(METTL4)

MLK:	131811505(METTL4)

NVS:	122903002(METTL4)

ORO:	101371332(METTL4)

EJU:	114200321(METTL4)

ZCA:	113913215(METTL4)

MLX:	118004772(METTL4)

NSU:	110576995(METTL4)

LWW:	102740830(METTL4)

FCA:	101088958(METTL4)

PYU:	121033133(METTL4)

PCOO:

112868367(METTL4)

PBG:	122470604(METTL4)

PVIV:

125149410(METTL4)

LRUF:

124517610

PTG:	102951516(METTL4)

PPAD:

109248575(METTL4)

PUC:

125914792

AJU:

106986077

HHV:	120239086(METTL4)

BTA:	521222(METTL4)

BOM:	102270858(METTL4)

BIU:	109577980(METTL4)

BBUB:

102393816(METTL4)

BBIS:

104983295(METTL4)

CHX:	102173246(METTL4)

OAS:	100913156(METTL4)

BTAX:

128067541(METTL4)

ODA:	120881105(METTL4)

CCAD:

122425549(METTL4)

MBEZ:

129549755(METTL4)

SSC:	110261174(METTL4)

CFR:	102512425(METTL4)

CBAI:

105071405(METTL4)

CDK:	105086132(METTL4)

VPC:	102541063(METTL4)

BACU:

103008394(METTL4)

BMUS:

118880349(METTL4)

LVE:	103086548(METTL4)

OOR:	101287480(METTL4)

DLE:	111162875(METTL4)

PCAD:

102987925(METTL4)

PSIU:

116739281(METTL4)

NASI:

112409055(METTL4)

ECB:	100061890(METTL4)

EPZ:	103562358(METTL4)

EAI:	106825897(METTL4)

MYB:	102259015(METTL4)

MYD:	102753492(METTL4)

MMYO:

118663329(METTL4)

MLF:	102440690(METTL4)

PKL:	118707450(METTL4)

EFUS:

103304674(METTL4)

MNA:	107535897(METTL4)

DRO:	112322974(METTL4)

SHON:

118997075(METTL4)

AJM:	119065946(METTL4)

PDIC:

114506985(METTL4)

PHAS:

123826126(METTL4)

MMF:	118619141(METTL4)

PPAM:

129078618(METTL4)

HAI:	109394731(METTL4)

RFQ:	117038747(METTL4)

PALE:

102882579(METTL4)

PGIG:

120588015(METTL4)

PVP:	105292294(METTL4)

RAY:	107516755(METTL4)

MJV:	108399492(METTL4)

TOD:	119243159(METTL4)

SARA:

101539238(METTL4)

SETR:

126003846(METTL4)

LAV:	100662083(METTL4)

TMU:

101353015

ETF:	101639204(METTL4)

DNM:	101417836(METTL4)

MDO:	100014396(METTL4)

GAS:	123231755(METTL4)

SHR:	111719076(METTL4)

AFZ:

127543980

PCW:	110197084(METTL4)

OAA:	100073599(METTL4)

GGA:	421056(METTL4)

PCOC:

116226175(METTL4)

MGP:

100547828

CJO:	107310056(METTL4)

TPAI:

128090810(METTL4)

LMUT:

125690844(METTL4)

NMEL:

110393981(METTL4)

APLA:

101796657(METTL4)

ACYG:

106034983(METTL4)

CATA:

118256764(METTL4)

AFUL:

116486897(METTL4)

TGU:	100227922(METTL4)

LSR:	110482347(METTL4)

SCAN:

103826913(METTL4)

PMOA:

120500843(METTL4)

OTC:	121333223(METTL4)

PRUF:

121359054(METTL4)

GFR:	102039858(METTL4)

FAB:	101820663(METTL4)

OMA:	130249410(METTL4)

PHI:	102102296(METTL4)

PMAJ:

107200665(METTL4)

CCAE:

111924001(METTL4)

CCW:	104687304(METTL4)

CBRC:

103618419(METTL4)

ETL:	114058732(METTL4)

ACHL:

103798342

SVG:	106850156(METTL4)

MMEA:

130572894(METTL4)

HRT:	120755232(METTL4)

FPG:	101923059(METTL4)

FCH:	102050048(METTL4)

CLV:	102084143(METTL4)

EGZ:	104134141(METTL4)

NNI:	104018122(METTL4)

PCRI:

104036810(METTL4)

PLET:

104622884(METTL4)

EHS:	104516295(METTL4)

PCAO:

104047431(METTL4)

ACUN:

113476486(METTL4)

TALA:

104361887(METTL4)

PADL:

103917775(METTL4)

AFOR:

103902994(METTL4)

ACHC:

115340183(METTL4)

HALD:

104312142(METTL4)

HLE:	104842501(METTL4)

AGEN:

126050715

GCL:

127013338

CCRI:

104157231(METTL4)

CSTI:

104556674(METTL4)

CMAC:

104473478(METTL4)

MUI:	104533860(METTL4)

BREG:

104629958(METTL4)

FGA:	104078829(METTL4)

GSTE:

104251473(METTL4)

LDI:	104353465(METTL4)

MNB:	103773078(METTL4)

OHA:	104326644(METTL4)

NNT:	104403007(METTL4)

SHAB:

115609748(METTL4)

DPUB:

104296577(METTL4)

PGUU:

104461554(METTL4)

ACAR:

104526675(METTL4)

CPEA:

104396936(METTL4)

AVIT:

104274223(METTL4)

CVF:	104287887(METTL4)

RTD:	128905963(METTL4)

CUCA:

104065520(METTL4)

TEO:	104370195(METTL4)

BRHI:

104491742(METTL4)

AAM:	106484667(METTL4)

AROW:

112968358(METTL4)

NPD:	112944107(METTL4)

TGT:	104575028(METTL4)

DNE:	112997022(METTL4)

SCAM:

104139093(METTL4)

ASN:	102377992(METTL4)

AMJ:	102569473(METTL4)

CPOO:

109317801(METTL4)

GGN:	109303692(METTL4)

PSS:	102460899(METTL4)

CMY:	102940616(METTL4)

CCAY:

125632349(METTL4)

DCC:	119851009(METTL4)

CPIC:

101941986(METTL4)

TST:	117873385(METTL4)

CABI:

116820203(METTL4)

MRV:	120399110(METTL4)

ACS:	100563991(mettl4)

ASAO:

132774744(METTL4)

PVT:	110079437(METTL4)

SUND:

121917288 121917328

PBI:	103055141(METTL4)

PMUR:

107285291(METTL4)

CTIG:

120311486(METTL4)

TSR:

106553772

PGUT:

117672679(METTL4)

APRI:

131195498(METTL4)

PTEX:

113435495(METTL4)

NSS:	113413858(METTL4)

VKO:	123020393(METTL4)

PMUA:

114600709(METTL4)

PRAF:

128417578(METTL4)

ZVI:	118090417(METTL4)

HCG:	128324482(METTL4)

GJA:	107112741(METTL4)

STOW:

125439232(METTL4)

EMC:	129334100(METTL4)

XLA:	108695256(mettl4.S)

XTR:	100379768(mettl4)

NPR:	108784650(METTL4)

RTEM:

120940900(METTL4)

BBUF:

121001751(METTL4)

BGAR:

122939116(METTL4)

MUO:	115460335(METTL4)

GSH:	117355880(METTL4)

DRE:	560686(mettl4)

SRX:	107745318(mettl4)

SANH:

107675397(mettl4)

SGH:	107559935(mettl4)

CCAR:

109070460(mettl4)

CAUA:

113051716(mettl4)

CGIB:

128016440

PTET:

122347866(mettl4)

LROH:

127167738(mettl4)

OMC:	131543295(mettl4)

PPRM:

120477379 120477381

RKG:	130090460(mettl4)

MAMB:

125265213(mettl4)

CIDE:

127516432

MASI:

127450290

TROS:

130555492(mettl4)

TDW:	130420000(mettl4)

MANU:

129453175(mettl4)

IPU:

108268346

IFU:	128609642(mettl4)

PHYP:

113539890(mettl4)

SMEO:

124388010(mettl4)

TFD:	113657617(mettl4)

TVC:	132848458(mettl4)

AMEX:

103044096(mettl4)

CMAO:

118826666(mettl4)

EEE:	113579287(mettl4)

CHAR:

105894743(mettl4)

TRU:	101063433(mettl4)

TFS:	130513659(mettl4)

TNG:	GSTEN00031779G001

LCO:	104929553(mettl4)

NCC:	104949663(mettl4)

TBEN:

117495618(mettl4)

CGOB:

115025409(mettl4)

PGEO:

117465540(mettl4)

GACU:

117544705(mettl4)

EMAC:

134884089(mettl4)

ELY:	117264630(mettl4)

EFO:	125881611(mettl4)

PLEP:

121960753(mettl4)

SLUC:

116045288(mettl4)

ECRA:

117938144(mettl4)

ESP:	116672382(mettl4)

PFLV:

114548874(mettl4)

GAT:	120812084(mettl4)

PPUG:

119198599(mettl4)

AFB:	129110517(mettl4)

CLUM:

117749766(mettl4)

PSWI:

130206090(mettl4)

MSAM:

119911244(mettl4)

SCHU:

122866919(mettl4)

CUD:	121527115(mettl4)

ALAT:

119008574(mettl4)

MZE:	101467065(mettl4)

ONL:

100697483

OAU:	116315975 120441825

OLA:	101158563(mettl4)

OML:	112151049(mettl4)

CSAI:

133423676(mettl4)

XMA:	102228532(mettl4)

XCO:	114137132(mettl4)

XHE:	116711883(mettl4)

PRET:

103456864(mettl4)

PFOR:

103140490(mettl4)

PLAI:

106962126(mettl4)

PMEI:

106915382(mettl4)

GAF:	122824137(mettl4)

PPRL:

129364513(mettl4)

CVG:	107102102(mettl4)

CTUL:

119791643(mettl4)

GMU:	124857665(mettl4)

NFU:	107382516(mettl4)

KMR:	108230327(mettl4)

ALIM:

106520960(mettl4)

NWH:	119426265(mettl4)

AOCE:

111569342(mettl4)

MCEP:

124995737(mettl4)

CSEM:

103377450(mettl4)

POV:	109629715(mettl4)

SSEN:

122781254(mettl4)

HHIP:

117753665(mettl4)

HSP:	118098613(mettl4)

SMAU:

118287720(mettl4)

LCF:

108895006

SDU:	111237832(mettl4)

SLAL:

111656570(mettl4)

XGL:	120789970(mettl4)

HCQ:	109517524(mettl4)

SSCV:

125986140

SBIA:

133492496(mettl4)

PEE:	133396777(mettl4)

PTAO:

133470376(mettl4)

BPEC:

110170103(mettl4)

BSPL:

114854666(mettl4)

SJO:

128382826

SASA:

106590139(mettl4)

STRU:

115195792(mettl4)

OTW:	112227967(mettl4)

OMY:	110489942(mettl4)

OGO:	124039786(mettl4)

ONE:	115130374(mettl4)

OKI:	109899486(mettl4)

OKE:	118373615(mettl4)

SALP:

111953540(mettl4)

SNH:	120051152(mettl4)

CCLU:

121569883(mettl4)

ELS:	105019345(mettl4)

SFM:	108937041(mettl4)

PKI:	111857742(mettl4)

AANG:

118225432(mettl4)

LOC:	102682782(mettl4)

PSPA:

121314494(mettl4)

ARUT:

117435743(mettl4)

PSEX:

120530379(mettl4)

LCM:	102348234(METTL4)

RTP:	109926704(mettl4)

CPLA:

122560766(mettl4)

HOC:	132825476(mettl4)

LERI:

129706828(mettl4)

PMRN:

116951896(METTL4)

LRJ:	133349163(METTL4)

BFO:

BBEL:

CIN:

SCLV:

DME:	Dmel_CG14906(Mettl4)

DER:

6552488

DSE:

6616842

DSI:	Dsimw501_GD26981(Dsim_GD26981)

DYA:	Dyak_GE26134

DAN:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI22636

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

DSM:

NPT:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_215947

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

PGW:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM414700

FOC:

TPAL:

ZNE:

CSEC:

BROR:

IEL:

DMK:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

HAZT:

EAF:

LSM:

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_C18A3.1(damt-1)

CBR:

CBG_02487

CRQ:	GCK72_006106

NAI:	NECAME_05759

LOA:	LOAG_03516

HRO:	HELRODRAFT_69400

LGI:	LOTGIDRAFT_121106

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

RPHI:

OBI:

OSN:

LAK:

NVE:

EPA:

ATEN:

ADF:	107355267 107358434

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

AQU:

Reference

PMID:30982744

Authors

Kweon SM, Chen Y, Moon E, Kvederaviciute K, Klimasauskas S, Feldman DE

Title

An Adversarial DNA N(6)-Methyladenine-Sensor Network Preserves Polycomb Silencing.

Journal

Mol Cell 74:1138-1147.e6 (2019)
DOI:10.1016/j.molcel.2019.03.018

Sequence

[mmu:76781]

LinkDB

DBGET integrated database retrieval system