KEGG   PATHWAY: ko00053
Entry
ko00053                     Pathway                                

Name
Ascorbate and aldarate metabolism
Class
Metabolism; Carbohydrate metabolism
Pathway map
ko00053  Ascorbate and aldarate metabolism
ko00053

Module
M00114  Ascorbate biosynthesis, plants, fructose-6P => ascorbate [PATH:ko00053]
M00129  Ascorbate biosynthesis, animals, glucose-1P => ascorbate [PATH:ko00053]
M00550  Ascorbate degradation, ascorbate => D-xylulose-5P [PATH:ko00053]
Other DBs
GO: 0019852 0019572
Orthology
K00012  UDPglucose 6-dehydrogenase [EC:1.1.1.22]
K12447  UDP-sugar pyrophosphorylase [EC:2.7.7.64]
K16190  glucuronokinase [EC:2.7.1.43]
K00699  glucuronosyltransferase [EC:2.4.1.17]
K01195  beta-glucuronidase [EC:3.2.1.31]
K14756  klotho [EC:3.2.1.31]
K00469  inositol oxygenase [EC:1.13.99.1]
K00002  alcohol dehydrogenase (NADP+) [EC:1.1.1.2]
K01053  gluconolactonase [EC:3.1.1.17]
K00103  L-gulonolactone oxidase [EC:1.1.3.8]
K10046  GDP-D-mannose 3', 5'-epimerase [EC:5.1.3.18 5.1.3.-]
K14190  GDP-L-galactose phosphorylase [EC:2.7.7.69]
K10047  inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase [EC:3.1.3.25 3.1.3.93]
K18649  inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase / histidinol-phosphatase [EC:3.1.3.25 3.1.3.93 3.1.3.15]
K00064  D-threo-aldose 1-dehydrogenase [EC:1.1.1.122]
K17744  L-galactose dehydrogenase [EC:1.1.1.316]
K00225  L-galactono-1,4-lactone dehydrogenase [EC:1.3.2.3]
K08679  UDP-glucuronate 4-epimerase [EC:5.1.3.6]
K19642  D-galacturonate reductase [EC:1.1.1.365]
K23003  L-galactose dehydrogenase [EC:1.1.1.-]
K23004  L-galactono-1,5-lactonase [EC:3.1.1.-]
K23005  L-galactonate 5-dehydrogenase [EC:1.1.1.414]
K23007  L-galactonate 5-dehydrogenase [EC:1.1.1.414]
K02821  ascorbate PTS system EIIA or EIIAB component [EC:2.7.1.194]
K02822  ascorbate PTS system EIIB component [EC:2.7.1.194]
K03475  ascorbate PTS system EIIC component
K03476  L-ascorbate 6-phosphate lactonase [EC:3.1.1.-]
K03078  3-dehydro-L-gulonate-6-phosphate decarboxylase [EC:4.1.1.85]
K03079  L-ribulose-5-phosphate 3-epimerase [EC:5.1.3.22]
K03077  L-ribulose-5-phosphate 4-epimerase [EC:5.1.3.4]
K08232  monodehydroascorbate reductase (NADH) [EC:1.6.5.4]
K00434  L-ascorbate peroxidase [EC:1.11.1.11]
K21888  glutathione dehydrogenase/transferase [EC:1.8.5.1 2.5.1.18]
K00423  L-ascorbate oxidase [EC:1.10.3.3]
K08092  3-dehydro-L-gulonate 2-dehydrogenase [EC:1.1.1.130]
K00880  L-xylulokinase [EC:2.7.1.53]
K00128  aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]
K14085  aldehyde dehydrogenase family 7 member A1 [EC:1.2.1.31 1.2.1.8 1.2.1.3]
K00149  aldehyde dehydrogenase family 9 member A1 [EC:1.2.1.47 1.2.1.3]
K01706  glucarate dehydratase [EC:4.2.1.40]
K01630  2-dehydro-3-deoxyglucarate aldolase [EC:4.1.2.20]
K13873  L-arabinose 1-dehydrogenase [EC:1.1.1.376]
K19660  L-arabinose 1-dehydrogenase [NAD(P)+] [EC:1.1.1.376]
K13874  L-arabinonolactonase [EC:3.1.1.15]
K24443  D-xylono/L-arabinono-1,4-lactonase [EC:3.1.1.68 3.1.1.15]
K13875  L-arabonate dehydrase [EC:4.2.1.25]
K13876  2-keto-3-deoxy-L-arabinonate dehydratase [EC:4.2.1.43]
K13877  2,5-dioxopentanoate dehydrogenase [EC:1.2.1.26]
K19588  2,5-dioxopentanoate dehydrogenase [EC:1.2.1.26]
K01707  5-dehydro-4-deoxyglucarate dehydratase [EC:4.2.1.41]
K01708  galactarate dehydratase [EC:4.2.1.42]
K20023  L-talarate/galactarate dehydratase [EC:4.2.1.156 4.2.1.42]
K18981  uronate dehydrogenase [EC:1.1.1.203]
K18982  D-galactarolactone isomerase [EC:5.4.1.4]
K18983  D-galactarolactone cycloisomerase [EC:5.5.1.27]
Compound
C00022  Pyruvate
C00026  2-Oxoglutarate
C00029  UDP-glucose
C00072  Ascorbate
C00096  GDP-mannose
C00137  myo-Inositol
C00167  UDP-glucuronate
C00191  D-Glucuronate
C00231  D-Xylulose 5-phosphate
C00259  L-Arabinose
C00333  D-Galacturonate
C00433  2,5-Dioxopentanoate
C00545  L-Arabinonate
C00558  D-Tagaturonate
C00617  UDP-D-galacturonate
C00618  3-Dehydro-L-gulonate
C00679  5-Dehydro-4-deoxy-D-glucarate
C00684  2-Dehydro-3-deoxy-L-arabinonate
C00800  L-Gulonate
C00818  D-Glucarate
C00879  D-Galactarate
C01040  L-Gulono-1,4-lactone
C01041  Monodehydroascorbate
C01101  L-Ribulose 5-phosphate
C01114  L-Arabinono-1,4-lactone
C01115  L-Galactono-1,4-lactone
C01146  2-Hydroxy-3-oxopropanoate
C01620  Threonate
C01825  L-Galactose
C02280  GDP-L-galactose
C02670  D-Glucuronolactone
C03033  beta-D-Glucuronoside
C03064  3-Dehydro-L-threonate
C03289  L-xylo-Hexulonolactone
C03291  L-Xylulose 5-phosphate
C03921  2-Dehydro-3-deoxy-D-glucarate
C04037  1-Phospho-alpha-D-galacturonate
C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  D-Glucuronate 1-phosphate
C05411  L-Xylonate
C05412  L-Lyxonate
C05422  Dehydroascorbate
C14899  3-Dehydro-L-gulonate 6-phosphate
C15923  L-Gulose
C15924  L-Gulose 1-phosphate
C15925  GDP-L-gulose
C15926  beta-L-Galactose 1-phosphate
C15930  L-Galactonate
C16186  L-Ascorbate 6-phosphate
C20889  D-Galactaro-1,5-lactone
C20896  D-Galactaro-1,4-lactone
C21955  L-Galactono-1,5-lactone
Reference
  Authors
Linster CL, Van Schaftingen E
  Title
Vitamin C. Biosynthesis, recycling and degradation in mammals.
  Journal
FEBS J 274:1-22 (2007)
DOI:10.1111/j.1742-4658.2006.05607.x
Reference
  Authors
Valpuesta V, Botella MA.
  Title
Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  Journal
Trends Plant Sci 9:573-7 (2004)
DOI:10.1016/j.tplants.2004.10.002
Reference
  Authors
Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  Title
Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  Journal
Plant Physiol 121:535-43 (1999)
DOI:10.1104/pp.121.2.535
Reference
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
DOI:10.1074/jbc.M601409200
Reference
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
DOI:10.1074/jbc.M702094200
Reference
  Authors
Campos E, Baldoma L, Aguilar J, Badia J.
  Title
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  Journal
J Bacteriol 186:1720-8 (2004)
DOI:10.1128/JB.186.6.1720-1728.2004
Reference
  Authors
Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  Title
The ascorbate transporter of Escherichia coli.
  Journal
J Bacteriol 185:2243-50 (2003)
DOI:10.1128/JB.185.7.2243-2250.2003
Related
pathway
ko00020  Citrate cycle (TCA cycle)
ko00040  Pentose and glucuronate interconversions
ko00051  Fructose and mannose metabolism
ko00520  Amino sugar and nucleotide sugar metabolism
ko00630  Glyoxylate and dicarboxylate metabolism
LinkDB

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