KEGG   PATHWAY: ko00190
Entry
ko00190                     Pathway                                
Name
Oxidative phosphorylation
Class
Metabolism; Energy metabolism
Pathway map
ko00190  Oxidative phosphorylation
ko00190

Module
M00142  NADH:ubiquinone oxidoreductase, mitochondria [PATH:ko00190]
M00143  NADH dehydrogenase (ubiquinone) Fe-S protein/flavoprotein complex, mitochondria [PATH:ko00190]
M00144  NADH:quinone oxidoreductase, prokaryotes [PATH:ko00190]
M00145  NAD(P)H:quinone oxidoreductase, chloroplasts and cyanobacteria [PATH:ko00190]
M00146  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex [PATH:ko00190]
M00147  NADH dehydrogenase (ubiquinone) 1 beta subcomplex [PATH:ko00190]
M00148  Succinate dehydrogenase (ubiquinone) [PATH:ko00190]
M00149  Succinate dehydrogenase, prokaryotes [PATH:ko00190]
M00150  Fumarate reductase, prokaryotes [PATH:ko00190]
M00151  Cytochrome bc1 complex respiratory unit [PATH:ko00190]
M00152  Cytochrome bc1 complex [PATH:ko00190]
M00153  Cytochrome bd ubiquinol oxidase [PATH:ko00190]
M00154  Cytochrome c oxidase [PATH:ko00190]
M00155  Cytochrome c oxidase, prokaryotes [PATH:ko00190]
M00156  Cytochrome c oxidase, cbb3-type [PATH:ko00190]
M00157  F-type ATPase, prokaryotes and chloroplasts [PATH:ko00190]
M00158  F-type ATPase, eukaryotes [PATH:ko00190]
M00159  V/A-type ATPase, prokaryotes [PATH:ko00190]
M00160  V-type ATPase, eukaryotes [PATH:ko00190]
M00416  Cytochrome aa3-600 menaquinol oxidase [PATH:ko00190]
M00417  Cytochrome o ubiquinol oxidase [PATH:ko00190]
Drug
D02140  Thonzonium bromide (USAN)
D09872  Bedaquiline (USAN/INN)
D09873  Bedaquiline fumarate (JAN/USAN)
Orthology
K00330  NADH-quinone oxidoreductase subunit A [EC:7.1.1.2]
K00331  NADH-quinone oxidoreductase subunit B [EC:7.1.1.2]
K00332  NADH-quinone oxidoreductase subunit C [EC:7.1.1.2]
K00333  NADH-quinone oxidoreductase subunit D [EC:7.1.1.2]
K13378  NADH-quinone oxidoreductase subunit C/D [EC:7.1.1.2]
K13380  NADH-quinone oxidoreductase subunit B/C/D [EC:7.1.1.2]
K00334  NADH-quinone oxidoreductase subunit E [EC:7.1.1.2]
K00335  NADH-quinone oxidoreductase subunit F [EC:7.1.1.2]
K00336  NADH-quinone oxidoreductase subunit G [EC:7.1.1.2]
K00337  NADH-quinone oxidoreductase subunit H [EC:7.1.1.2]
K00338  NADH-quinone oxidoreductase subunit I [EC:7.1.1.2]
K00339  NADH-quinone oxidoreductase subunit J [EC:7.1.1.2]
K00340  NADH-quinone oxidoreductase subunit K [EC:7.1.1.2]
K00341  NADH-quinone oxidoreductase subunit L [EC:7.1.1.2]
K00342  NADH-quinone oxidoreductase subunit M [EC:7.1.1.2]
K15863  NADH-quinone oxidoreductase subunit L/M [EC:7.1.1.2]
K00343  NADH-quinone oxidoreductase subunit N [EC:7.1.1.2]
K05572  NAD(P)H-quinone oxidoreductase subunit 1 [EC:7.1.1.2]
K05573  NAD(P)H-quinone oxidoreductase subunit 2 [EC:7.1.1.2]
K05574  NAD(P)H-quinone oxidoreductase subunit 3 [EC:7.1.1.2]
K05575  NAD(P)H-quinone oxidoreductase subunit 4 [EC:7.1.1.2]
K05576  NAD(P)H-quinone oxidoreductase subunit 4L [EC:7.1.1.2]
K05577  NAD(P)H-quinone oxidoreductase subunit 5 [EC:7.1.1.2]
K05578  NAD(P)H-quinone oxidoreductase subunit 6 [EC:7.1.1.2]
K05579  NAD(P)H-quinone oxidoreductase subunit H [EC:7.1.1.2]
K05580  NAD(P)H-quinone oxidoreductase subunit I [EC:7.1.1.2]
K05581  NAD(P)H-quinone oxidoreductase subunit J [EC:7.1.1.2]
K05582  NAD(P)H-quinone oxidoreductase subunit K [EC:7.1.1.2]
K05583  NAD(P)H-quinone oxidoreductase subunit L [EC:7.1.1.2]
K05584  NAD(P)H-quinone oxidoreductase subunit M [EC:7.1.1.2]
K05585  NAD(P)H-quinone oxidoreductase subunit N [EC:7.1.1.2]
K05586  bidirectional [NiFe] hydrogenase diaphorase subunit [EC:7.1.1.2]
K05587  bidirectional [NiFe] hydrogenase diaphorase subunit [EC:7.1.1.2]
K05588  bidirectional [NiFe] hydrogenase diaphorase subunit [EC:7.1.1.2]
K03878  NADH-ubiquinone oxidoreductase chain 1 [EC:7.1.1.2]
K03879  NADH-ubiquinone oxidoreductase chain 2 [EC:7.1.1.2]
K03880  NADH-ubiquinone oxidoreductase chain 3 [EC:7.1.1.2]
K03881  NADH-ubiquinone oxidoreductase chain 4 [EC:7.1.1.2]
K03882  NADH-ubiquinone oxidoreductase chain 4L [EC:7.1.1.2]
K03883  NADH-ubiquinone oxidoreductase chain 5 [EC:7.1.1.2]
K03884  NADH-ubiquinone oxidoreductase chain 6 [EC:7.1.1.2]
K03934  NADH dehydrogenase (ubiquinone) Fe-S protein 1 [EC:7.1.1.2]
K03935  NADH dehydrogenase (ubiquinone) Fe-S protein 2 [EC:7.1.1.2]
K03936  NADH dehydrogenase (ubiquinone) Fe-S protein 3 [EC:7.1.1.2]
K03937  NADH dehydrogenase (ubiquinone) Fe-S protein 4
K03938  NADH dehydrogenase (ubiquinone) Fe-S protein 5
K03939  NADH dehydrogenase (ubiquinone) Fe-S protein 6
K03940  NADH dehydrogenase (ubiquinone) Fe-S protein 7 [EC:7.1.1.2]
K03941  NADH dehydrogenase (ubiquinone) Fe-S protein 8 [EC:7.1.1.2]
K03942  NADH dehydrogenase (ubiquinone) flavoprotein 1 [EC:7.1.1.2]
K03943  NADH dehydrogenase (ubiquinone) flavoprotein 2 [EC:7.1.1.2]
K03944  NADH dehydrogenase (ubiquinone) flavoprotein 3
K03945  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 1
K03946  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 2
K03947  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 3
K03948  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 4
K03949  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 5
K03950  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 6
K03951  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 7
K03952  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 8
K03953  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 9
K03954  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 10
K03955  NADH dehydrogenase (ubiquinone) 1 alpha/beta subcomplex 1, acyl-carrier protein
K03956  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 11
K11352  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 12
K11353  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 13
K03957  NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 1
K03958  NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 2
K03959  NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 3
K03960  NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 4
K03961  NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 5
K03962  NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 6
K03963  NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 7
K03964  NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 8
K03965  NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 9
K03966  NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 10
K11351  NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 11
K03967  NADH dehydrogenase (ubiquinone) 1 subunit C1
K03968  NADH dehydrogenase (ubiquinone) 1 subunit C2
K03885  NADH:quinone reductase (non-electrogenic) [EC:1.6.5.9]
K00234  succinate dehydrogenase (ubiquinone) flavoprotein subunit [EC:1.3.5.1]
K00235  succinate dehydrogenase (ubiquinone) iron-sulfur subunit [EC:1.3.5.1]
K00236  succinate dehydrogenase (ubiquinone) cytochrome b560 subunit
K00237  succinate dehydrogenase (ubiquinone) membrane anchor subunit
K25801  succinate dehydrogenase (ubiquinone) subunit 4
K00239  succinate dehydrogenase flavoprotein subunit [EC:1.3.5.1]
K00240  succinate dehydrogenase iron-sulfur subunit [EC:1.3.5.1]
K00241  succinate dehydrogenase cytochrome b subunit
K00242  succinate dehydrogenase membrane anchor subunit
K18859  succinate dehydrogenase subunit D
K18860  succinate dehydrogenase subunit D
K00244  succinate dehydrogenase flavoprotein subunit [EC:1.3.5.1]
K00233  succinate dehydrogenase flavoprotein subunit [EC:1.3.5.1 7.1.1.12]
K00245  succinate dehydrogenase iron-sulfur subunit [EC:1.3.5.1]
K25995  succinate dehydrogenase iron-sulfur subunit [EC:1.3.5.1 7.1.1.12]
K00246  succinate dehydrogenase subunit C
K25996  succinate dehydrogenase subunit C
K00247  succinate dehydrogenase subunit D
K00411  ubiquinol-cytochrome c reductase iron-sulfur subunit [EC:7.1.1.8]
K00412  ubiquinol-cytochrome c reductase cytochrome b subunit
K00413  ubiquinol-cytochrome c reductase cytochrome c1 subunit
K00410  ubiquinol-cytochrome c reductase cytochrome b/c1 subunit
K00414  ubiquinol-cytochrome c reductase core subunit 1
K00415  ubiquinol-cytochrome c reductase core subunit 2
K00416  ubiquinol-cytochrome c reductase subunit 6
K00417  ubiquinol-cytochrome c reductase subunit 7
K00418  ubiquinol-cytochrome c reductase subunit 8
K00419  ubiquinol-cytochrome c reductase subunit 9
K00420  ubiquinol-cytochrome c reductase subunit 10
K03886  quinol---cytochrome c reductase iron-sulfur subunit, bacillus type [EC:7.1.1.8]
K03887  quinol---cytochrome c reductase cytochrome b subunit, bacillus type [EC:7.1.1.8]
K03888  quinol---cytochrome c reductase cytochrome c subunit, bacillus type [EC:7.1.1.8]
K03890  quinol---cytochrome c reductase iron-sulfur subunit [EC:7.1.1.8]
K03891  quinol---cytochrome-c reductase cytochrome b subunit [EC:7.1.1.8]
K03889  quinol---cytochrome-c reductase cytochrome c subunit [EC:7.1.1.8]
K02257  heme o synthase [EC:2.5.1.141]
K02300  cytochrome o ubiquinol oxidase subunit IV
K02277  cytochrome c oxidase subunit IV [EC:7.1.1.9]
K27109  cytochrome c oxidase subunit IV [EC:7.1.1.9]
K02276  cytochrome c oxidase subunit III [EC:7.1.1.9]
K02274  cytochrome c oxidase subunit I [EC:7.1.1.9]
K15408  cytochrome c oxidase subunit I+III [EC:7.1.1.9]
K02275  cytochrome c oxidase subunit II [EC:7.1.1.9]
K02262  cytochrome c oxidase subunit 3
K02256  cytochrome c oxidase subunit 1 [EC:7.1.1.9]
K02261  cytochrome c oxidase subunit 2
K02263  cytochrome c oxidase subunit 4
K02264  cytochrome c oxidase subunit 5a
K02265  cytochrome c oxidase subunit 5b
K02266  cytochrome c oxidase subunit 6a
K02267  cytochrome c oxidase subunit 6b
K02268  cytochrome c oxidase subunit 6c
K02269  cytochrome c oxidase subunit 7
K02270  cytochrome c oxidase subunit 7a
K02271  cytochrome c oxidase subunit 7b
K02272  cytochrome c oxidase subunit 7c
K02273  cytochrome c oxidase subunit 8
K02258  cytochrome c oxidase assembly protein subunit 11
K02259  heme a synthase [EC:1.17.99.9]
K02260  cytochrome c oxidase assembly protein subunit 17
K00404  cytochrome c oxidase cbb3-type subunit I [EC:7.1.1.9]
K00405  cytochrome c oxidase cbb3-type subunit II
K15862  cytochrome c oxidase cbb3-type subunit I/II [EC:7.1.1.9]
K00407  cytochrome c oxidase cbb3-type subunit IV
K00406  cytochrome c oxidase cbb3-type subunit III
K02829  cytochrome aa3-600 menaquinol oxidase subunit IV [EC:7.1.1.5]
K02828  cytochrome aa3-600 menaquinol oxidase subunit III [EC:7.1.1.5]
K02827  cytochrome aa3-600 menaquinol oxidase subunit I [EC:7.1.1.5]
K02826  cytochrome aa3-600 menaquinol oxidase subunit II [EC:7.1.1.5]
K24007  cytochrome aa3-type oxidase subunit SoxD
K24008  cytochrome aa3-type oxidase subunit III
K24009  cytochrome aa3-type oxidase subunit I [EC:7.1.1.4]
K24010  cytochrome aa3-type oxidase subunit II [EC:7.1.1.4]
K24011  cytochrome aa3-type oxidase subunit I/III [EC:7.1.1.4]
K02299  cytochrome o ubiquinol oxidase subunit III
K02298  cytochrome o ubiquinol oxidase subunit I [EC:7.1.1.3]
K02297  cytochrome o ubiquinol oxidase subunit II [EC:7.1.1.3]
K00425  cytochrome bd ubiquinol oxidase subunit I [EC:7.1.1.7]
K00426  cytochrome bd ubiquinol oxidase subunit II [EC:7.1.1.7]
K00424  cytochrome bd-I ubiquinol oxidase subunit X [EC:7.1.1.7]
K22501  cytochrome bd-II ubiquinol oxidase subunit AppX [EC:7.1.1.7]
K08738  cytochrome c
K02111  F-type H+/Na+-transporting ATPase subunit alpha [EC:7.1.2.2 7.2.2.1]
K02112  F-type H+/Na+-transporting ATPase subunit beta [EC:7.1.2.2 7.2.2.1]
K02115  F-type H+-transporting ATPase subunit gamma
K02113  F-type H+-transporting ATPase subunit delta
K02114  F-type H+-transporting ATPase subunit epsilon
K02108  F-type H+-transporting ATPase subunit a
K02109  F-type H+-transporting ATPase subunit b
K02110  F-type H+-transporting ATPase subunit c
K02132  F-type H+-transporting ATPase subunit alpha
K02133  F-type H+-transporting ATPase subunit beta [EC:7.1.2.2]
K02136  F-type H+-transporting ATPase subunit gamma
K02134  F-type H+-transporting ATPase subunit delta
K02135  F-type H+-transporting ATPase subunit epsilon
K02137  F-type H+-transporting ATPase subunit O
K02126  F-type H+-transporting ATPase subunit a
K02127  F-type H+-transporting ATPase subunit b
K02128  F-type H+-transporting ATPase subunit c
K02138  F-type H+-transporting ATPase subunit d
K02129  F-type H+-transporting ATPase subunit e
K01549  F-type H+-transporting ATP synthase subunit e
K02130  F-type H+-transporting ATPase subunit f
K02139  F-type H+-transporting ATPase subunit f
K02140  F-type H+-transporting ATPase subunit g
K02131  F-type H+-transporting ATPase subunit 6
K02141  F-type H+-transporting ATPase subunit h
K02142  F-type H+-transporting ATPase subunit j
K02143  F-type H+-transporting ATPase subunit k
K02125  F-type H+-transporting ATPase subunit 8
K02117  V/A-type H+/Na+-transporting ATPase subunit A [EC:7.1.2.2 7.2.2.1]
K02118  V/A-type H+/Na+-transporting ATPase subunit B
K02119  V/A-type H+/Na+-transporting ATPase subunit C
K02120  V/A-type H+/Na+-transporting ATPase subunit D
K02121  V/A-type H+/Na+-transporting ATPase subunit E
K02122  V/A-type H+/Na+-transporting ATPase subunit F
K02107  V/A-type H+/Na+-transporting ATPase subunit G/H
K02123  V/A-type H+/Na+-transporting ATPase subunit I
K02124  V/A-type H+/Na+-transporting ATPase subunit K
K02145  V-type H+-transporting ATPase subunit A [EC:7.1.2.2]
K02147  V-type H+-transporting ATPase subunit B
K02148  V-type H+-transporting ATPase subunit C
K02149  V-type H+-transporting ATPase subunit D
K02150  V-type H+-transporting ATPase subunit E
K02151  V-type H+-transporting ATPase subunit F
K02152  V-type H+-transporting ATPase subunit G
K02144  V-type H+-transporting ATPase subunit H
K02154  V-type H+-transporting ATPase subunit a
K02155  V-type H+-transporting ATPase 16kDa proteolipid subunit
K03661  V-type H+-transporting ATPase 21kDa proteolipid subunit
K02146  V-type H+-transporting ATPase subunit d
K02153  V-type H+-transporting ATPase subunit e
K03662  V-type H+-transporting ATPase S1 subunit
K01535  H+-transporting ATPase [EC:7.1.2.1]
K01542  H+/K+-exchanging ATPase subunit alpha [EC:7.2.2.19]
K01543  H+/K+-exchanging ATPase subunit beta [EC:7.2.2.19]
K01544  non-gastric H+/K+-exchanging ATPase [EC:7.2.2.19]
K01507  inorganic pyrophosphatase [EC:3.6.1.1]
K15986  manganese-dependent inorganic pyrophosphatase [EC:3.6.1.1]
K06019  pyrophosphatase PpaX [EC:3.6.1.1]
K11725  phospholysine phosphohistidine inorganic pyrophosphate phosphatase [EC:3.6.1.1 3.1.3.-]
K11726  nucleosome-remodeling factor 38 kDa subunit [EC:3.6.1.1]
K00937  polyphosphate kinase [EC:2.7.4.1]
K22468  polyphosphate kinase [EC:2.7.4.34]
Compound
C00001  H2O
C00002  ATP
C00003  NAD+
C00004  NADH
C00007  Oxygen
C00008  ADP
C00009  Orthophosphate
C00013  Diphosphate
C00042  Succinate
C00080  H+
C00122  Fumarate
C00536  Triphosphate
Reference
PMID:16469879
  Authors
Sazanov LA, Hinchliffe P.
  Title
Structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus.
  Journal
Science 311:1430-6 (2006)
DOI:10.1126/science.1123809
Reference
PMID:16584177
  Authors
Hinchliffe P, Carroll J, Sazanov LA.
  Title
Identification of a novel subunit of respiratory complex I from Thermus thermophilus.
  Journal
Biochemistry 45:4413-20 (2006)
DOI:10.1021/bi0600998
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