KEGG   PATHWAY: ko00290
Entry
ko00290                     Pathway                                

Name
Valine, leucine and isoleucine biosynthesis
Class
Metabolism; Amino acid metabolism
Pathway map
ko00290  Valine, leucine and isoleucine biosynthesis
ko00290

Module
M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:ko00290]
M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:ko00290]
M00535  Isoleucine biosynthesis, pyruvate => 2-oxobutanoate [PATH:ko00290]
M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:ko00290]
Other DBs
GO: 0009097 0009098 0009099
Orthology
K01754  threonine dehydratase [EC:4.3.1.19]
K17989  L-serine/L-threonine ammonia-lyase [EC:4.3.1.17 4.3.1.19]
K09011  (R)-citramalate synthase [EC:2.3.1.182]
K01702  3-isopropylmalate dehydratase [EC:4.2.1.33]
K01703  3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit [EC:4.2.1.33 4.2.1.35]
K01704  3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit [EC:4.2.1.33 4.2.1.35]
K00052  3-isopropylmalate dehydrogenase [EC:1.1.1.85]
K01652  acetolactate synthase I/II/III large subunit [EC:2.2.1.6]
K01653  acetolactate synthase I/III small subunit [EC:2.2.1.6]
K11258  acetolactate synthase II small subunit [EC:2.2.1.6]
K00053  ketol-acid reductoisomerase [EC:1.1.1.86]
K01687  dihydroxy-acid dehydratase [EC:4.2.1.9]
K00826  branched-chain amino acid aminotransferase [EC:2.6.1.42]
K00263  leucine dehydrogenase [EC:1.4.1.9]
K00835  valine--pyruvate aminotransferase [EC:2.6.1.66]
K14260  alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2]
K01649  2-isopropylmalate synthase [EC:2.3.3.13]
K21359  3-isopropylmalate/methylthioalkylmalate dehydratase small subunit [EC:4.2.1.33 4.2.1.170]
K21360  3-isopropylmalate/methylthioalkylmalate dehydrogenase [EC:1.1.1.85 1.1.1.-]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00109  2-Oxobutanoate
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00183  L-Valine
C00188  L-Threonine
C00233  4-Methyl-2-oxopentanoate
C00407  L-Isoleucine
C00671  (S)-3-Methyl-2-oxopentanoic acid
C02226  2-Methylmaleate
C02504  alpha-Isopropylmalate
C02612  (R)-2-Methylmalate
C02631  2-Isopropylmaleate
C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  (2S)-2-Isopropyl-3-oxosuccinate
C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
C04411  (2R,3S)-3-Isopropylmalate
C06006  (S)-2-Aceto-2-hydroxybutanoate
C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
C06010  (S)-2-Acetolactate
C06032  D-erythro-3-Methylmalate
C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
DOI:10.1128/JB.186.16.5400-5409.2004
Related
pathway
ko00260  Glycine, serine and threonine metabolism
ko00280  Valine, leucine and isoleucine degradation
ko00620  Pyruvate metabolism
LinkDB

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