KEGG   PATHWAY: ko00300
Entry
ko00300                     Pathway                                

Name
Lysine biosynthesis
Class
Metabolism; Amino acid metabolism
Pathway map
ko00300  Lysine biosynthesis
ko00300

Module
M00016  Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine [PATH:ko00300]
M00030  Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine [PATH:ko00300]
M00031  Lysine biosynthesis, mediated by LysW, 2-aminoadipate => lysine [PATH:ko00300]
M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate [PATH:ko00300]
M00525  Lysine biosynthesis, acetyl-DAP pathway, aspartate => lysine [PATH:ko00300]
M00526  Lysine biosynthesis, DAP dehydrogenase pathway, aspartate => lysine [PATH:ko00300]
M00527  Lysine biosynthesis, DAP aminotransferase pathway, aspartate => lysine [PATH:ko00300]
M00608  2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate [PATH:ko00300]
Disease
H00188  Hyperlysinemia
Other DBs
GO: 0009085
Orthology
K00003  homoserine dehydrogenase [EC:1.1.1.3]
K00928  aspartate kinase [EC:2.7.2.4]
K12524  bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:2.7.2.4 1.1.1.3]
K12525  bifunctional aspartokinase / homoserine dehydrogenase 2 [EC:2.7.2.4 1.1.1.3]
K12526  bifunctional diaminopimelate decarboxylase / aspartate kinase [EC:4.1.1.20 2.7.2.4]
K00133  aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]
K01714  4-hydroxy-tetrahydrodipicolinate synthase [EC:4.3.3.7]
K00215  4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]
K00674  2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase [EC:2.3.1.117]
K00821  acetylornithine/N-succinyldiaminopimelate aminotransferase [EC:2.6.1.11 2.6.1.17]
K14267  N-succinyldiaminopimelate aminotransferase [EC:2.6.1.17]
K01439  succinyl-diaminopimelate desuccinylase [EC:3.5.1.18]
K01778  diaminopimelate epimerase [EC:5.1.1.7]
K10206  LL-diaminopimelate aminotransferase [EC:2.6.1.83]
K01586  diaminopimelate decarboxylase [EC:4.1.1.20]
K05822  tetrahydrodipicolinate N-acetyltransferase [EC:2.3.1.89]
K00841  aminotransferase [EC:2.6.1.-]
K05823  N-acetyldiaminopimelate deacetylase [EC:3.5.1.47]
K03340  diaminopimelate dehydrogenase [EC:1.4.1.16]
K01655  homocitrate synthase [EC:2.3.3.14]
K10977  methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-]
K17450  homoaconitase [EC:4.2.1.-]
K01705  homoaconitate hydratase [EC:4.2.1.36]
K16792  methanogen homoaconitase large subunit [EC:4.2.1.114]
K16793  methanogen homoaconitase small subunit [EC:4.2.1.114]
K05824  homoisocitrate dehydrogenase [EC:1.1.1.87]
K10978  methanogen homoisocitrate dehydrogenase [EC:1.1.1.87 1.1.1.-]
K17753  isocitrate--homoisocitrate dehydrogenase [EC:1.1.1.286]
K00825  kynurenine/2-aminoadipate aminotransferase [EC:2.6.1.7 2.6.1.39]
K00838  aromatic amino acid aminotransferase I / 2-aminoadipate transaminase [EC:2.6.1.57 2.6.1.39 2.6.1.27 2.6.1.5]
K05825  2-aminoadipate transaminase [EC:2.6.1.-]
K00143  L-2-aminoadipate reductase [EC:1.2.1.95]
K00293  saccharopine dehydrogenase (NADP+, L-glutamate forming) [EC:1.5.1.10]
K24034  spermidine synthase / saccharopine dehydrogenase (NADP+, L-glutamate-forming) [EC:2.5.1.16 1.5.1.10]
K00290  saccharopine dehydrogenase (NAD+, L-lysine forming) [EC:1.5.1.7]
K05827  [lysine-biosynthesis-protein LysW]---L-2-aminoadipate ligase [EC:6.3.2.43]
K05828  [amino group carrier protein]-L-2-aminoadipate 6-kinase [EC:2.7.2.17]
K05829  LysW-gamma-L-alpha-aminoadipyl-6-phosphate/LysW-L-glutamyl-5-phosphate reductase [EC:1.2.1.103 1.2.1.-]
K05830  LysW-gamma-L-lysine/LysW-L-ornithine aminotransferase [EC:2.6.1.118 2.6.1.-]
K05831  [amino group carrier protein]-lysine/ornithine hydrolase [EC:3.5.1.130 3.5.1.132]
K01928  UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase [EC:6.3.2.13]
K01929  UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10]
K15792  MurE/MurF fusion protein [EC:6.3.2.13 6.3.2.10]
K01798  Alr-MurF fusion protein [EC:5.1.1.1 6.3.2.10]
K16180  methylornithine synthase [EC:5.4.99.58]
K16181  3-methylornithine--L-lysine ligase [EC:6.3.2.-]
K16182  3-methylornithyl-N6-L-lysine dehydrogenase [EC:1.4.1.-]
Compound
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00047  L-Lysine
C00049  L-Aspartate
C00263  L-Homoserine
C00322  2-Oxoadipate
C00441  L-Aspartate 4-semialdehyde
C00449  N6-(L-1,3-Dicarboxypropyl)-L-lysine
C00666  LL-2,6-Diaminoheptanedioate
C00680  meso-2,6-Diaminoheptanedioate
C00956  L-2-Aminoadipate
C01251  (R)-2-Hydroxybutane-1,2,4-tricarboxylate
C03082  4-Phospho-L-aspartate
C03871  L-2-Amino-6-oxoheptanedioate
C03972  2,3,4,5-Tetrahydrodipicolinate
C04002  (Z)-But-1-ene-1,2,4-tricarboxylate
C04076  L-2-Aminoadipate 6-semialdehyde
C04390  N6-Acetyl-LL-2,6-diaminoheptanedioate
C04421  N-Succinyl-LL-2,6-diaminoheptanedioate
C04462  N-Succinyl-2-L-amino-6-oxoheptanedioate
C04877  UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimelate
C04882  UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine
C05535  alpha-Aminoadipoyl-S-acyl enzyme
C05539  N-Acetyl-L-2-amino-6-oxopimelate
C05560  L-2-Aminoadipate adenylate
C05662  Homoisocitrate
C16138  L-Pyrrolysine
C19886  LysW-gamma-L-alpha-aminoadipate
C19887  LysW-gamma-L-alpha-aminoadipyl 6-phosphate
C19888  LysW-gamma-L-alpha-aminoadipate 6-semialdehyde
C19889  LysW-gamma-L-lysine
C20258  (2S,4S)-4-Hydroxy-2,3,4,5-tetrahydrodipicolinate
C20277  (2R,3R)-3-Methylornithine
C20278  (2R,3R)-3-Methylornithinyl-N6-lysine
C20279  (2R,3R)-3-Methylglutamyl-5-semialdehyde-N6-lysine
Reference
  Authors
Ledwidge R, Blanchard JS.
  Title
The dual biosynthetic capability of N-acetylornithine aminotransferase in arginine and lysine biosynthesis.
  Journal
Biochemistry 38:3019-3024 (1999)
DOI:10.1021/bi982574a
Reference
  Authors
Fuchs TM, Schneider B, Krumbach K, Eggeling L, Gross R.
  Title
Characterization of a bordetella pertussis diaminopimelate (DAP) biosynthesis locus identifies dapC, a novel gene coding for an N-succinyl-L,L-DAP aminotransferase.
  Journal
J Bacteriol 182:3626-3631 (2000)
DOI:10.1128/JB.182.13.3626-3631.2000
Reference
  Authors
Zabriskie TM, Jackson MD.
  Title
Lysine biosynthesis and metabolism in fungi.
  Journal
Nat Prod Rep 17:85-97 (2000)
DOI:10.1039/A801345D
Reference
  Authors
Rodionov DA, Vitreschak AG, Mironov AA, Gelfand MS.
  Title
Regulation of lysine biosynthesis and transport genes in bacteria: yet another RNA riboswitch?
  Journal
Nucleic Acids Res 31:6748-57 (2003)
DOI:10.1093/nar/gkg900
Reference
  Authors
Velasco AM, Leguina JI, Lazcano A.
  Title
Molecular evolution of the lysine biosynthetic pathways.
  Journal
J Mol Evol 55:445-59 (2002)
DOI:10.1007/s00239-002-2340-2
Reference
  Authors
Miyazaki T, Miyazaki J, Yamane H, Nishiyama M.
  Title
alpha-Aminoadipate aminotransferase from an extremely thermophilic bacterium, Thermus thermophilus.
  Journal
Microbiology 150:2327-34 (2004)
DOI:10.1099/mic.0.27037-0
Reference
  Authors
Goh DL, Patel A, Thomas GH, Salomons GS, Schor DS, Jakobs C, Geraghty MT.
  Title
Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT).
  Journal
Mol Genet Metab 76:172-80 (2002)
DOI:10.1016/S1096-7192(02)00037-9
Reference
  Authors
Nishiyama M.
  Title
[Novel lysine biosynthesis: a key to elucidate evolution of metabolic and biosynthetic pathways]
  Journal
Tanpakushitsu Kakusan Koso 49:758-63 (2004)
Reference
  Authors
Nishida H, Nishiyama M, Kobashi N, Kosuge T, Hoshino T, Yamane H.
  Title
A prokaryotic gene cluster involved in synthesis of lysine through the amino adipate pathway: a key to the evolution of amino acid biosynthesis.
  Journal
Genome Res 9:1175-83 (1999)
DOI:10.1101/gr.9.12.1175
Reference
  Authors
Sakai H, Vassylyeva MN, Matsuura T, Sekine S, Gotoh K, Nishiyama M, Terada T, Shirouzu M, Kuramitsu S, Vassylyev DG, Yokoyama S.
  Title
Crystal structure of a lysine biosynthesis enzyme, LysX, from Thermus thermophilus HB8.
  Journal
J Mol Biol 332:729-40 (2003)
DOI:10.1016/S0022-2836(03)00946-X
Reference
  Authors
Hudson AO, Singh BK, Leustek T, Gilvarg C.
  Title
An LL-diaminopimelate aminotransferase defines a novel variant of the lysine biosynthesis pathway in plants.
  Journal
Plant Physiol 140:292-301 (2006)
DOI:10.1104/pp.105.072629
Reference
  Authors
Horie A, Tomita T, Saiki A, Kono H, Taka H, Mineki R, Fujimura T, Nishiyama C, Kuzuyama T, Nishiyama M
  Title
Discovery of proteinaceous N-modification in lysine biosynthesis of Thermus thermophilus.
  Journal
Nat Chem Biol 5:673-9 (2009)
DOI:10.1038/nchembio.198
Reference
  Authors
Dairi T, Kuzuyama T, Nishiyama M, Fujii I
  Title
Convergent strategies in biosynthesis.
  Journal
Nat Prod Rep 28:1054-86 (2011)
DOI:10.1039/c0np00047g
Reference
  Authors
Gaston MA, Jiang R, Krzycki JA
  Title
Functional context, biosynthesis, and genetic encoding of pyrrolysine.
  Journal
Curr Opin Microbiol 14:342-9 (2011)
DOI:10.1016/j.mib.2011.04.001
Related
pathway
ko00010  Glycolysis / Gluconeogenesis
ko00020  Citrate cycle (TCA cycle)
ko00250  Alanine, aspartate and glutamate metabolism
ko00260  Glycine, serine and threonine metabolism
ko00310  Lysine degradation
ko00550  Peptidoglycan biosynthesis
ko00620  Pyruvate metabolism
ko00960  Tropane, piperidine and pyridine alkaloid biosynthesis
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