KEGG   PATHWAY: ko00310
Entry
ko00310                     Pathway                                

Name
Lysine degradation
Class
Metabolism; Amino acid metabolism
Pathway map
ko00310  Lysine degradation
ko00310

Module
M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA [PATH:ko00310]
Disease
H00178  Glutaric acidemia
H00188  Hyperlysinemia
H00570  Kabuki syndrome
H00718  Sotos syndrome
H00907  Kleefstra syndrome
H00980  Nevo syndrome
H01192  Lysyl hydroxylase 3 deficiency
H01242  Saccharopinuria
H01247  Pyridoxine-dependent epilepsy
H01364  3-Hydroxyacyl-CoA dehydrogenase deficiency
H01751  Weaver syndrome
Orthology
K00290  saccharopine dehydrogenase (NAD+, L-lysine forming) [EC:1.5.1.7]
K14157  alpha-aminoadipic semialdehyde synthase [EC:1.5.1.8 1.5.1.9]
K00293  saccharopine dehydrogenase (NADP+, L-glutamate forming) [EC:1.5.1.10]
K24034  spermidine synthase / saccharopine dehydrogenase (NADP+, L-glutamate-forming) [EC:2.5.1.16 1.5.1.10]
K14085  aldehyde dehydrogenase family 7 member A1 [EC:1.2.1.31 1.2.1.8 1.2.1.3]
K00825  kynurenine/2-aminoadipate aminotransferase [EC:2.6.1.7 2.6.1.39]
K15791  probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 [EC:1.2.4.2]
K00658  2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC:2.3.1.61]
K00382  dihydrolipoamide dehydrogenase [EC:1.8.1.4]
K00252  glutaryl-CoA dehydrogenase [EC:1.3.8.6]
K01692  enoyl-CoA hydratase [EC:4.2.1.17]
K01825  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8]
K01782  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3]
K07515  enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211]
K07514  enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8]
K07511  enoyl-CoA hydratase [EC:4.2.1.17]
K00022  3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
K00626  acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
K18201  hydroxylysine kinase [EC:2.7.1.81]
K18202  5-phosphonooxy-L-lysine phospho-lyase [EC:4.2.3.134]
K00468  lysine 2-monooxygenase [EC:1.13.12.2]
K01506  5-aminopentanamidase [EC:3.5.1.30]
K01582  lysine decarboxylase [EC:4.1.1.18]
K23385  D-ornithine/D-lysine decarboxylase [EC:4.1.1.116]
K09251  putrescine aminotransferase [EC:2.6.1.82]
K00137  aminobutyraldehyde dehydrogenase [EC:1.2.1.19]
K14268  5-aminovalerate/4-aminobutyrate aminotransferase [EC:2.6.1.48 2.6.1.19]
K07250  4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase / 5-aminovalerate transaminase [EC:2.6.1.19 2.6.1.22 2.6.1.48]
K00135  succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20]
K15737  glutarate dioxygenase [EC:1.14.11.64]
K15736  (S)-2-hydroxyglutarate dehydrogenase [EC:1.1.5.13]
K01843  lysine 2,3-aminomutase [EC:5.4.3.2]
K01844  beta-lysine 5,6-aminomutase alpha subunit [EC:5.4.3.3]
K18011  beta-lysine 5,6-aminomutase beta subunit [EC:5.4.3.3]
K18012  L-erythro-3,5-diaminohexanoate dehydrogenase [EC:1.4.1.11]
K18013  3-keto-5-aminohexanoate cleavage enzyme [EC:2.3.1.247]
K18014  3-aminobutyryl-CoA ammonia-lyase [EC:4.3.1.14]
K01034  acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9]
K01035  acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9]
K21672  2,4-diaminopentanoate dehydrogenase [EC:1.4.1.12 1.4.1.26]
K00824  D-alanine transaminase [EC:2.6.1.21]
K13609  delta1-piperideine-2-carboxylate reductase [EC:1.5.1.21]
K19743  1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H] [EC:1.5.1.1]
K00306  sarcosine oxidase / L-pipecolate oxidase [EC:1.5.3.1 1.5.3.7]
K18854  lysine N-acetyltransferase [EC:2.3.1.32]
K18804  [cytochrome c]-lysine N-methyltransferase [EC:2.1.1.59]
K18826  calmodulin-lysine N-methyltransferase [EC:2.1.1.60]
K09186  [histone H3]-lysine4 N-trimethyltransferase MLL1 [EC:2.1.1.354]
K09187  [histone H3]-lysine4 N-trimethyltransferase MLL2 [EC:2.1.1.354]
K09188  [histone H3]-lysine4 N-trimethyltransferase MLL3 [EC:2.1.1.354]
K14959  [histone H3]-lysine4 N-trimethyltransferase MLL4 [EC:2.1.1.354]
K09189  [histone H3]-lysine4 N-trimethyltransferase MLL5 [EC:2.1.1.354]
K11422  [histone H3]-lysine4 N-trimethyltransferase SETD1 [EC:2.1.1.354]
K11431  [histone H3]-lysine4 N-methyltransferase [EC:2.1.1.364]
K20796  [histone H3]-lysine4 N-trimethyltransferase PRDM7/9 [EC:2.1.1.354]
K06101  [histone H3]-lysine4 N-trimethyltransferase ASH1L [EC:2.1.1.354]
K11426  [histone H3]-lysine4/36 N-trimethyltransferase SMYD [EC:2.1.1.354 2.1.1.357]
K22748  [histone H3]-lysine4 N-trimethyltransferase ATXR3 [EC:2.1.1.354]
K11419  [histone H3]-lysine9 N-trimethyltransferase SUV39H [EC:2.1.1.355]
K11420  [histone H3]-lysine9 N-trimethyltransferase EHMT [EC:2.1.1.355]
K11421  [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase [EC:2.1.1.366]
K18494  [histone H3]-lysine9 N-trimethyltransferase SETDB2 [EC:2.1.1.355]
K11432  [histone H3]-lysine9 N-trimethyltransferase PRDM2 [EC:2.1.1.355]
K17451  [histone H3]-lysine27 N-trimethyltransferase EZH1 [EC:2.1.1.356]
K11430  [histone H3]-lysine27 N-trimethyltransferase EZH2 [EC:2.1.1.356]
K11433  [histone H3]-lysine36 N-dimethyltransferase SETMAR [EC:2.1.1.357]
K15588  [histone H3]-lysine36 N-dimethyltransferase NSD1 [EC:2.1.1.357]
K11424  [histone H3]-lysine36 N-dimethyltransferase NSD2 [EC:2.1.1.357]
K11425  [histone H3]-lysine4 N-dimethyltransferase / [histone H3]-lysine27 N-dimethyltransferase [EC:2.1.1.370 2.1.1.371]
K11423  [histone H3]-lysine36 N-trimethyltransferase [EC:2.1.1.359]
K23700  [histone H3]-lysine36 N-trimethyltransferase [EC:2.1.1.359]
K11427  [histone H3]-lysine79 N-trimethyltransferase [EC:2.1.1.360]
K11428  [histone H4]-lysine20 N-methyltransferase SETD8 [EC:2.1.1.361]
K20795  [histone H4]-lysine20 N-methyltransferase PRDM6 [EC:2.1.1.361]
K11429  [histone H4]-N-methyl-L-lysine20 N-methyltransferase [EC:2.1.1.362]
K04462  [histone H3]-lysine9 N-methyltransferase (ecotropic virus integration site 1 protein) [EC:2.1.1.367]
K22410  [histone H3]-lysine9 N-methyltransferase [EC:2.1.1.367]
K24405  [histone H3]-lysine9 N-dimethyltransferase [EC:2.1.1.368]
K24406  [histone H3]-lysine27 N-methyltransferase [EC:2.1.1.369]
K24407  [histone H4]-lysine20 N-trimethyltransferase [EC:2.1.1.372]
K00474  trimethyllysine dioxygenase [EC:1.14.11.8]
K00128  aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]
K00149  aldehyde dehydrogenase family 9 member A1 [EC:1.2.1.47 1.2.1.3]
K00471  gamma-butyrobetaine dioxygenase [EC:1.14.11.1]
K00473  procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 [EC:1.14.11.4]
K13645  procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 [EC:1.14.11.4]
K13646  lysyl hydroxylase/galactosyltransferase/glucosyltransferase [EC:1.14.11.4 2.4.1.50 2.4.1.66]
K13647  procollagen-lysine,2-oxoglutarate 5-dioxygenase, invertebrate [EC:1.14.11.4]
K11703  collagen beta-1,O-galactosyltransferase [EC:2.4.1.50]
Compound
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00037  Glycine
C00042  Succinate
C00047  L-Lysine
C00136  Butanoyl-CoA
C00164  Acetoacetate
C00322  2-Oxoadipate
C00332  Acetoacetyl-CoA
C00408  L-Pipecolate
C00431  5-Aminopentanoate
C00449  N6-(L-1,3-Dicarboxypropyl)-L-lysine
C00450  (S)-2,3,4,5-Tetrahydropyridine-2-carboxylate
C00487  Carnitine
C00489  Glutarate
C00527  Glutaryl-CoA
C00739  D-Lysine
C00877  Crotonoyl-CoA
C00956  L-2-Aminoadipate
C00990  5-Aminopentanamide
C01142  (3S)-3,6-Diaminohexanoate
C01144  (S)-3-Hydroxybutanoyl-CoA
C01149  4-Trimethylammoniobutanal
C01181  4-Trimethylammoniobutanoate
C01186  (3S,5S)-3,5-Diaminohexanoate
C01211  Procollagen 5-hydroxy-L-lysine
C01259  (3S)-3-Hydroxy-N6,N6,N6-trimethyl-L-lysine
C01672  Cadaverine
C02188  Protein lysine
C02727  N6-Acetyl-L-lysine
C03087  5-Acetamidopentanoate
C03196  (S)-2-Hydroxyglutarate
C03239  6-Amino-2-oxohexanoate
C03273  5-Oxopentanoate
C03366  5-Phosphooxy-L-lysine
C03656  (S)-5-Amino-3-oxohexanoic acid
C03793  N6,N6,N6-Trimethyl-L-lysine
C04020  D-Lysopine
C04076  L-2-Aminoadipate 6-semialdehyde
C04092  Delta1-Piperideine-2-carboxylate
C04487  5-(D-Galactosyloxy)-L-lysine-procollagen
C05161  (2R,5S)-2,5-Diaminohexanoate
C05231  L-3-Aminobutyryl-CoA
C05544  Protein N6-methyl-L-lysine
C05545  Protein N6,N6-dimethyl-L-lysine
C05546  Protein N6,N6,N6-trimethyl-L-lysine
C05548  6-Acetamido-2-oxohexanoate
C05825  2-Amino-5-oxohexanoate
C12455  5-Aminopentanal
C16741  L-Hydroxylysine
Reference
  Authors
Vaz FM, Wanders RJ.
  Title
Carnitine biosynthesis in mammals.
  Journal
Biochem J 361:417-29 (2002)
DOI:10.1042/bj3610417
Reference
PMID:1682209
  Authors
Large PJ, Robertson A.
  Title
The route of lysine breakdown in Candida tropicalis.
  Journal
FEMS Microbiol Lett 66:209-13 (1991)
DOI:10.1111/j.1574-6968.1990.tb03998.x
Related
pathway
ko00020  Citrate cycle (TCA cycle)
ko00300  Lysine biosynthesis
ko00311  Penicillin and cephalosporin biosynthesis
ko00780  Biotin metabolism
LinkDB

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