KEGG   PATHWAY: ko00561
Entry
ko00561                     Pathway                                

Name
Glycerolipid metabolism
Class
Metabolism; Lipid metabolism
Pathway map
ko00561  Glycerolipid metabolism
ko00561

Module
M00089  Triacylglycerol biosynthesis [PATH:ko00561]
M00098  Acylglycerol degradation [PATH:ko00561]
Disease
H00154  Hyperlipoproteinemia, type I
H01117  Chronic recurrent multifocal osteomyelitis
H01290  Acute recurrent myoglobinuria
H01333  Nonalcoholic fatty liver disease
H02013  Glycerol kinase deficiency
H02329  Hepatic lipase deficiency
H02330  Pancreatic lipase deficiency
H02380  D-glyceric aciduria
Other DBs
GO: 0045017 0046486 0046503
Orthology
K00865  glycerate 2-kinase [EC:2.7.1.165]
K11529  glycerate 2-kinase [EC:2.7.1.165]
K15918  D-glycerate 3-kinase [EC:2.7.1.31]
K00128  aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]
K14085  aldehyde dehydrogenase family 7 member A1 [EC:1.2.1.31 1.2.1.8 1.2.1.3]
K00149  aldehyde dehydrogenase family 9 member A1 [EC:1.2.1.47 1.2.1.3]
K00011  aldehyde reductase [EC:1.1.1.21]
K00002  alcohol dehydrogenase (NADP+) [EC:1.1.1.2]
K13979  alcohol dehydrogenase (NADP+) [EC:1.1.1.2]
K00863  triose/dihydroxyacetone kinase / FAD-AMP lyase (cyclizing) [EC:2.7.1.28 2.7.1.29 4.6.1.15]
K05878  phosphoenolpyruvate---glycerone phosphotransferase subunit DhaK [EC:2.7.1.121]
K05879  phosphoenolpyruvate---glycerone phosphotransferase subunit DhaL [EC:2.7.1.121]
K05881  phosphoenolpyruvate---glycerone phosphotransferase subunit DhaM [EC:2.7.1.121]
K00005  glycerol dehydrogenase [EC:1.1.1.6]
K22251  glycerol dehydrogenase [EC:1.1.1.6]
K18097  glycerol 2-dehydrogenase (NADP+) [EC:1.1.1.156]
K00864  glycerol kinase [EC:2.7.1.30]
K24189  (DL)-glycerol-3-phosphatase [EC:3.1.3.21]
K06116  glycerol-1-phosphatase [EC:3.1.3.21]
K06117  glycerol-1-phosphatase [EC:3.1.3.21]
K00629  glycerol-3-phosphate O-acyltransferase 1/2 [EC:2.3.1.15]
K13506  glycerol-3-phosphate O-acyltransferase 3/4 [EC:2.3.1.15]
K13507  glycerol-3-phosphate O-acyltransferase / dihydroxyacetone phosphate acyltransferase [EC:2.3.1.15 2.3.1.42]
K00630  glycerol-3-phosphate O-acyltransferase [EC:2.3.1.15]
K13508  glycerol-3-phosphate acyltransferase [EC:2.3.1.15 2.3.1.198]
K00631  glycerol-3-phosphate O-acyltransferase [EC:2.3.1.15]
K03621  phosphate acyltransferase [EC:2.3.1.274]
K08591  acyl phosphate:glycerol-3-phosphate acyltransferase [EC:2.3.1.275]
K00655  1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51]
K13509  lysophosphatidate acyltransferase [EC:2.3.1.51]
K13523  lysophosphatidic acid acyltransferase / lysophosphatidylinositol acyltransferase [EC:2.3.1.51 2.3.1.-]
K19007  lysophosphatidiate acyltransferase [EC:2.3.1.51]
K13513  lysocardiolipin and lysophospholipid acyltransferase [EC:2.3.1.- 2.3.1.51]
K13517  lysophospholipid acyltransferase 1/2 [EC:2.3.1.51 2.3.1.-]
K13519  lysophospholipid acyltransferase [EC:2.3.1.51 2.3.1.23 2.3.1.-]
K22831  1-acylglycerol-3-phosphate O-acyltransferase [EC:2.3.1.51]
K01080  phosphatidate phosphatase [EC:3.1.3.4]
K15728  phosphatidate phosphatase LPIN [EC:3.1.3.4]
K18693  diacylglycerol diphosphate phosphatase / phosphatidate phosphatase [EC:3.1.3.81 3.1.3.4]
K00901  diacylglycerol kinase (ATP) [EC:2.7.1.107]
K07029  diacylglycerol kinase (ATP) [EC:2.7.1.107]
K11155  diacylglycerol O-acyltransferase 1 [EC:2.3.1.20 2.3.1.75 2.3.1.76]
K11160  diacylglycerol O-acyltransferase 2 [EC:2.3.1.20 2.3.1.75]
K14456  2-acylglycerol O-acyltransferase 3 [EC:2.3.1.20 2.3.1.22]
K22848  diacylglycerol O-acyltransferase 2, plant [EC:2.3.1.20]
K22849  diacylglycerol O-acyltransferase 3, plant [EC:2.3.1.20]
K00635  diacylglycerol O-acyltransferase / wax synthase [EC:2.3.1.20 2.3.1.75]
K18851  diacylglycerol O-acyltransferase / trehalose O-mycolyltransferase [EC:2.3.1.20 2.3.1.122]
K00679  phospholipid:diacylglycerol acyltransferase [EC:2.3.1.158]
K01046  triacylglycerol lipase [EC:3.1.1.3]
K12298  bile salt-stimulated lipase [EC:3.1.1.13 3.1.1.3]
K16816  patatin-like phospholipase domain-containing protein 2 [EC:3.1.1.3]
K13534  patatin-like phospholipase domain-containing protein 3 [EC:3.1.1.3 2.3.1.-]
K14073  pancreatic triacylglycerol lipase [EC:3.1.1.3]
K14074  pancreatic lipase-related protein 1 [EC:3.1.1.3]
K14075  pancreatic lipase-related protein 2 [EC:3.1.1.3]
K14076  pancreatic lipase-related protein 3 [EC:3.1.1.3]
K22283  hepatic triacylglycerol lipase [EC:3.1.1.3]
K14452  gastric triacylglycerol lipase [EC:3.1.1.3]
K22284  endothelial lipase [EC:3.1.1.3]
K14675  TAG lipase / lysophosphatidylethanolamine acyltransferase [EC:3.1.1.3 2.3.1.-]
K14674  TAG lipase / steryl ester hydrolase / phospholipase A2 / LPA acyltransferase [EC:3.1.1.3 3.1.1.13 3.1.1.4 2.3.1.51]
K17900  lipase ATG15 [EC:3.1.1.3]
K01059  lipoprotein lipase [EC:3.1.1.34]
K09881  acylglycerol kinase [EC:2.7.1.94]
K23736  2-lysophosphatidate phosphatase [EC:3.1.3.106]
K23737  2-lysophosphatidate phosphatase [EC:3.1.3.106]
K01054  acylglycerol lipase [EC:3.1.1.23]
K14458  2-acylglycerol O-acyltransferase 1 [EC:2.3.1.22]
K14457  2-acylglycerol O-acyltransferase 2 [EC:2.3.1.22]
K19002  1,2-diacylglycerol 3-alpha-glucosyltransferase [EC:2.4.1.337]
K03429  processive 1,2-diacylglycerol beta-glucosyltransferase [EC:2.4.1.315]
K19004  processive 1,2-diacylglycerol beta-glycosyltransferase [EC:2.4.1.315 2.4.1.-]
K19003  1,2-diacylglycerol 3-beta-glucosyltransferase [EC:2.4.1.336]
K20024  monoglucosyldiacylglycerol epimerase [EC:5.1.3.34]
K13677  1,2-diacylglycerol-3-alpha-glucose alpha-1,2-glucosyltransferase [EC:2.4.1.208]
K19005  lipoteichoic acid synthase [EC:2.7.8.20]
K22920  UTP---glucose-1-phosphate uridylyltransferase [EC:2.7.7.9]
K06118  UDP-sulfoquinovose synthase [EC:3.13.1.1]
K06119  sulfoquinovosyltransferase [EC:2.4.1.-]
K03715  1,2-diacylglycerol 3-beta-galactosyltransferase [EC:2.4.1.46]
K09480  digalactosyldiacylglycerol synthase [EC:2.4.1.241]
K01189  alpha-galactosidase [EC:3.2.1.22]
K07406  alpha-galactosidase [EC:3.2.1.22]
K07407  alpha-galactosidase [EC:3.2.1.22]
K21362  galactolipid galactosyltransferase [EC:2.4.1.184]
K06120  glycerol dehydratase large subunit [EC:4.2.1.30]
K06121  glycerol dehydratase medium subunit [EC:4.2.1.30]
K06122  glycerol dehydratase small subunit [EC:4.2.1.30]
K00086  1,3-propanediol dehydrogenase [EC:1.1.1.202]
Compound
C00029  UDP-glucose
C00040  Acyl-CoA
C00093  sn-Glycerol 3-phosphate
C00103  D-Glucose 1-phosphate
C00111  Glycerone phosphate
C00116  Glycerol
C00162  Fatty acid
C00173  Acyl-[acyl-carrier protein]
C00184  Glycerone
C00197  3-Phospho-D-glycerate
C00258  D-Glycerate
C00416  Phosphatidate
C00422  Triacylglycerol
C00577  D-Glyceraldehyde
C00631  2-Phospho-D-glycerate
C00641  1,2-Diacyl-sn-glycerol
C00681  1-Acyl-sn-glycerol 3-phosphate
C00969  3-Hydroxypropanal
C01885  1-Acylglycerol
C02133  Acyl phosphate
C02457  Propane-1,3-diol
C03692  1,2-Diacyl-3-beta-D-galactosyl-sn-glycerol
C04046  3-D-Glucosyl-1,2-diacylglycerol
C04315  2-Acyl-3-O-(beta-D-galactosyl)-sn-glycerol
C04872  1,2-Diacyl-3-[3-(alpha-D-N-acetylneuraminyl)-beta-D-galactosyl]-sn-glycerol
C05401  3-beta-D-Galactosyl-sn-glycerol
C06037  Digalactosyl-diacylglycerol
C06038  Acyl1-monogalactosyl-diacylglycerol
C06040  Diglucosyldiacylglycerol
C06041  Glycerophosphoglycoglycerolipid
C06042  Lipoteichoic acid
C06364  1,2-Diacyl-3-alpha-D-glucosyl-sn-glycerol
C06365  alpha-Kojibiosyldiacylglycerol
C11521  UDP-6-sulfoquinovose
C13508  Sulfoquinovosyldiacylglycerol
C20897  Glycerophosphoglycoglycerolipid
C20898  Lipoteichoic acid
C20991  1,2-Diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol
Reference
PMID:8662716
  Authors
Norbeck J, Pahlman AK, Akhtar N, Blomberg A, Adler L.
  Title
Purification and characterization of two isoenzymes of DL-glycerol-3-phosphatase from Saccharomyces cerevisiae. Identification of the corresponding GPP1 and GPP2 genes and evidence for osmotic regulation of Gpp2p expression by the osmosensing mitogen-activated protein kinase signal transduction pathway.
  Journal
J Biol Chem 271:13875-81 (1996)
DOI:10.1074/jbc.271.23.13875
Reference
PMID:8995384
  Authors
Karlsson OP, Dahlqvist A, Vikstrom S, Wieslander A.
  Title
Lipid dependence and basic kinetics of the purified 1,2-diacylglycerol 3-glucosyltransferase from membranes of Acholeplasma laidlawii.
  Journal
J Biol Chem 272:929-36 (1997)
DOI:10.1074/jbc.272.2.929
Reference
  Authors
Berg S, Edman M, Li L, Wikstrom M, Wieslander A.
  Title
Sequence properties of the 1,2-diacylglycerol 3-glucosyltransferase from Acholeplasma laidlawii membranes. Recognition of a large group of lipid glycosyltransferases in eubacteria and archaea.
  Journal
J Biol Chem 276:22056-63 (2001)
DOI:10.1074/jbc.M102576200
Related
pathway
ko00010  Glycolysis / Gluconeogenesis
ko00071  Fatty acid degradation
ko00564  Glycerophospholipid metabolism
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