KEGG   PATHWAY: ko00620
Entry
ko00620                     Pathway                                

Name
Pyruvate metabolism
Class
Metabolism; Carbohydrate metabolism
Pathway map
ko00620  Pyruvate metabolism
ko00620

Module
M00168  CAM (Crassulacean acid metabolism), dark [PATH:ko00620]
M00169  CAM (Crassulacean acid metabolism), light [PATH:ko00620]
M00172  C4-dicarboxylic acid cycle, NADP - malic enzyme type [PATH:ko00620]
M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:ko00620]
M00579  Phosphate acetyltransferase-acetate kinase pathway, acetyl-CoA => acetate [PATH:ko00620]
Disease
H00072  Pyruvate dehydrogenase complex deficiency
H00073  Pyruvate carboxylase deficiency
H01096  Pyruvate kinase deficiency
H01946  Glycogen storage disease type XI
H01997  Pyruvate dehydrogenase E1-alpha deficiency
H01998  Pyruvate dehydrogenase E1-beta deficiency
H01999  Pyruvate dehydrogenase E2 deficiency
H02000  Dihydrolipoamide dehydrogenase deficiency
Other DBs
GO: 0006090
Orthology
K01895  acetyl-CoA synthetase [EC:6.2.1.1]
K01913  acetate/butyrate---CoA ligase [EC:6.2.1.1 6.2.1.2]
K00169  pyruvate ferredoxin oxidoreductase alpha subunit [EC:1.2.7.1]
K00170  pyruvate ferredoxin oxidoreductase beta subunit [EC:1.2.7.1]
K00172  pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.1]
K00189  2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.7 1.2.7.1]
K00171  pyruvate ferredoxin oxidoreductase delta subunit [EC:1.2.7.1]
K03737  pyruvate-ferredoxin/flavodoxin oxidoreductase [EC:1.2.7.1 1.2.7.-]
K00174  2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit alpha [EC:1.2.7.3 1.2.7.11]
K00175  2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit beta [EC:1.2.7.3 1.2.7.11]
K00163  pyruvate dehydrogenase E1 component [EC:1.2.4.1]
K00161  pyruvate dehydrogenase E1 component alpha subunit [EC:1.2.4.1]
K00162  pyruvate dehydrogenase E1 component beta subunit [EC:1.2.4.1]
K00627  pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase) [EC:2.3.1.12]
K00382  dihydrolipoamide dehydrogenase [EC:1.8.1.4]
K00656  formate C-acetyltransferase [EC:2.3.1.54]
K00132  acetaldehyde dehydrogenase (acetylating) [EC:1.2.1.10]
K04072  acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1]
K04073  acetaldehyde dehydrogenase [EC:1.2.1.10]
K18366  acetaldehyde/propanal dehydrogenase [EC:1.2.1.10 1.2.1.87]
K04021  aldehyde dehydrogenase
K00925  acetate kinase [EC:2.7.2.1]
K00625  phosphate acetyltransferase [EC:2.3.1.8]
K13788  phosphate acetyltransferase [EC:2.3.1.8]
K15024  putative phosphotransacetylase [EC:2.3.1.8]
K04020  phosphotransacetylase
K00873  pyruvate kinase [EC:2.7.1.40]
K12406  pyruvate kinase isozymes R/L [EC:2.7.1.40]
K11262  acetyl-CoA carboxylase / biotin carboxylase 1 [EC:6.4.1.2 6.3.4.14 2.1.3.15]
K01946  acetyl-CoA carboxylase / biotin carboxylase 2 [EC:6.4.1.2 6.3.4.14 2.1.3.15]
K01962  acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15]
K02160  acetyl-CoA carboxylase biotin carboxyl carrier protein
K01961  acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]
K01963  acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2 2.1.3.15]
K11263  acetyl-CoA/propionyl-CoA carboxylase, biotin carboxylase, biotin carboxyl carrier protein [EC:6.4.1.2 6.4.1.3 6.3.4.14]
K18472  acetyl-CoA/propionyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.2 6.4.1.3 2.1.3.15]
K01512  acylphosphatase [EC:3.6.1.7]
K00128  aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]
K14085  aldehyde dehydrogenase family 7 member A1 [EC:1.2.1.31 1.2.1.8 1.2.1.3]
K00149  aldehyde dehydrogenase family 9 member A1 [EC:1.2.1.47 1.2.1.3]
K00138  aldehyde dehydrogenase [EC:1.2.1.-]
K01067  acetyl-CoA hydrolase [EC:3.1.2.1]
K18118  succinyl-CoA:acetate CoA-transferase [EC:2.8.3.18]
K01026  propionate CoA-transferase [EC:2.8.3.1]
K01905  acetate---CoA ligase (ADP-forming) subunit alpha [EC:6.2.1.13]
K22224  acetate---CoA ligase (ADP-forming) subunit beta [EC:6.2.1.13]
K24012  acetate---CoA ligase (ADP-forming) [EC:6.2.1.13]
K00158  pyruvate oxidase [EC:1.2.3.3]
K00101  L-lactate dehydrogenase (cytochrome) [EC:1.1.2.3]
K00016  L-lactate dehydrogenase [EC:1.1.1.27]
K00156  pyruvate dehydrogenase (quinone) [EC:1.2.5.1]
K00467  lactate 2-monooxygenase [EC:1.13.12.4]
K03778  D-lactate dehydrogenase [EC:1.1.1.28]
K03777  D-lactate dehydrogenase (quinone) [EC:1.1.5.12]
K21836  D-lactate dehydrogenase (acceptor) [EC:1.1.99.6]
K00102  D-lactate dehydrogenase (cytochrome) [EC:1.1.2.4]
K18930  D-lactate dehydrogenase
K21618  (R)-2-hydroxyglutarate---pyruvate transhydrogenase [EC:1.1.99.40]
K17741  NADPH-dependent methylglyoxal reductase [EC:1.1.1.283]
K23257  methylglyoxal/glyoxal reductase [EC:1.1.1.283 1.1.1.-]
K07248  lactaldehyde dehydrogenase / glycolaldehyde dehydrogenase [EC:1.2.1.22 1.2.1.21]
K19266  lactaldehyde dehydrogenase [EC:1.2.1.22]
K01759  lactoylglutathione lyase [EC:4.4.1.5]
K01069  hydroxyacylglutathione hydrolase [EC:3.1.2.6]
K05523  D-lactate dehydratase / protein deglycase [EC:4.2.1.130 3.5.1.124]
K18881  D-lactate dehydratase [EC:4.2.1.130]
K22211  D-lactate dehydratase [EC:4.2.1.130]
K22373  lactate racemase [EC:5.1.2.1]
K00049  glyoxylate/hydroxypyruvate reductase [EC:1.1.1.79 1.1.1.81]
K12972  glyoxylate/hydroxypyruvate reductase [EC:1.1.1.79 1.1.1.81]
K00090  glyoxylate/hydroxypyruvate/2-ketogluconate reductase [EC:1.1.1.79 1.1.1.81 1.1.1.215]
K00027  malate dehydrogenase (oxaloacetate-decarboxylating) [EC:1.1.1.38]
K00028  malate dehydrogenase (decarboxylating) [EC:1.1.1.39]
K00029  malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) [EC:1.1.1.40]
K01571  oxaloacetate decarboxylase (Na+ extruding) subunit alpha [EC:7.2.4.2]
K20509  carboxybiotin decarboxylase [EC:7.2.4.1]
K01573  oxaloacetate decarboxylase (Na+ extruding) subunit gamma
K01003  oxaloacetate decarboxylase [EC:4.1.1.112]
K01958  pyruvate carboxylase [EC:6.4.1.1]
K01959  pyruvate carboxylase subunit A [EC:6.4.1.1]
K01960  pyruvate carboxylase subunit B [EC:6.4.1.1]
K00025  malate dehydrogenase [EC:1.1.1.37]
K00026  malate dehydrogenase [EC:1.1.1.37]
K00024  malate dehydrogenase [EC:1.1.1.37]
K00051  malate dehydrogenase (NADP+) [EC:1.1.1.82]
K00116  malate dehydrogenase (quinone) [EC:1.1.5.4]
K01676  fumarate hydratase, class I [EC:4.2.1.2]
K01677  fumarate hydratase subunit alpha [EC:4.2.1.2]
K01678  fumarate hydratase subunit beta [EC:4.2.1.2]
K01679  fumarate hydratase, class II [EC:4.2.1.2]
K01675  fumarate hydratase D [EC:4.2.1.2]
K01774  fumarate hydratase E [EC:4.2.1.2]
K00244  fumarate reductase flavoprotein subunit [EC:1.3.5.4]
K00245  fumarate reductase iron-sulfur subunit [EC:1.3.5.4]
K00246  fumarate reductase subunit C
K00247  fumarate reductase subunit D
K22212  malolactic enzyme [EC:4.1.1.101]
K01595  phosphoenolpyruvate carboxylase [EC:4.1.1.31]
K01596  phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32]
K20370  phosphoenolpyruvate carboxykinase (diphosphate) [EC:4.1.1.38]
K01610  phosphoenolpyruvate carboxykinase (ATP) [EC:4.1.1.49]
K01006  pyruvate, orthophosphate dikinase [EC:2.7.9.1]
K01007  pyruvate, water dikinase [EC:2.7.9.2]
K01638  malate synthase [EC:2.3.3.9]
K00626  acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
K01649  2-isopropylmalate synthase [EC:2.3.3.13]
K01655  homocitrate synthase [EC:2.3.3.14]
K02594  homocitrate synthase NifV [EC:2.3.3.14]
K10977  methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00033  Acetate
C00036  Oxaloacetate
C00042  Succinate
C00058  Formate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00083  Malonyl-CoA
C00084  Acetaldehyde
C00122  Fumarate
C00149  (S)-Malate
C00186  (S)-Lactate
C00227  Acetyl phosphate
C00256  (R)-Lactate
C00332  Acetoacetyl-CoA
C00424  (S)-Lactaldehyde
C00546  Methylglyoxal
C00937  (R)-Lactaldehyde
C01251  (R)-2-Hydroxybutane-1,2,4-tricarboxylate
C02488  (R)-2-Ethylmalate
C02504  alpha-Isopropylmalate
C03248  Acetylenedicarboxylate
C03451  (R)-S-Lactoylglutathione
C03981  2-Hydroxyethylenedicarboxylate
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05993  Acetyl adenylate
C05994  2-Propylmalate
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Related
pathway
ko00010  Glycolysis / Gluconeogenesis
ko00020  Citrate cycle (TCA cycle)
ko00061  Fatty acid biosynthesis
ko00072  Synthesis and degradation of ketone bodies
ko00260  Glycine, serine and threonine metabolism
ko00290  Valine, leucine and isoleucine biosynthesis
ko00300  Lysine biosynthesis
ko00522  Biosynthesis of 12-, 14- and 16-membered macrolides
ko00630  Glyoxylate and dicarboxylate metabolism
ko00640  Propanoate metabolism
ko00650  Butanoate metabolism
ko00760  Nicotinate and nicotinamide metabolism
ko01056  Biosynthesis of type II polyketide backbone
ko01059  Biosynthesis of enediyne antibiotics
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