KEGG   PATHWAY: ko00630
Entry
ko00630                     Pathway                                

Name
Glyoxylate and dicarboxylate metabolism
Class
Metabolism; Carbohydrate metabolism
Pathway map
ko00630  Glyoxylate and dicarboxylate metabolism
ko00630

Module
M00012  Glyoxylate cycle [PATH:ko00630]
M00373  Ethylmalonyl pathway [PATH:ko00630]
M00532  Photorespiration [PATH:ko00630]
M00740  Methylaspartate cycle [PATH:ko00630]
M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:ko00630]
Disease
H00117  Primary hyperoxaluria
H02113  Infantile cerebellar-retinal degeneration
H02380  D-glyceric aciduria
Orthology
K01637  isocitrate lyase [EC:4.1.3.1]
K01895  acetyl-CoA synthetase [EC:6.2.1.1]
K01913  acetate/butyrate---CoA ligase [EC:6.2.1.1 6.2.1.2]
K01638  malate synthase [EC:2.3.3.9]
K00025  malate dehydrogenase [EC:1.1.1.37]
K00026  malate dehydrogenase [EC:1.1.1.37]
K00024  malate dehydrogenase [EC:1.1.1.37]
K01647  citrate synthase [EC:2.3.3.1]
K01681  aconitate hydratase [EC:4.2.1.3]
K01682  aconitate hydratase 2 / 2-methylisocitrate dehydratase [EC:4.2.1.3 4.2.1.99]
K08692  malate-CoA ligase subunit alpha [EC:6.2.1.9]
K14067  malate-CoA ligase subunit beta [EC:6.2.1.9]
K00626  acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
K00023  acetoacetyl-CoA reductase [EC:1.1.1.36]
K17865  3-hydroxybutyryl-CoA dehydratase [EC:4.2.1.55]
K14446  crotonyl-CoA carboxylase/reductase [EC:1.3.1.85]
K05606  methylmalonyl-CoA/ethylmalonyl-CoA epimerase [EC:5.1.99.1]
K14447  ethylmalonyl-CoA mutase [EC:5.4.99.63]
K14448  (2S)-methylsuccinyl-CoA dehydrogenase [EC:1.3.8.12]
K14449  2-methylfumaryl-CoA hydratase [EC:4.2.1.148]
K08691  malyl-CoA/(S)-citramalyl-CoA lyase [EC:4.1.3.24 4.1.3.25]
K14451  (3S)-malyl-CoA thioesterase [EC:3.1.2.30]
K01965  propionyl-CoA carboxylase alpha chain [EC:6.4.1.3]
K01966  propionyl-CoA carboxylase beta chain [EC:6.4.1.3 2.1.3.15]
K11263  acetyl-CoA/propionyl-CoA carboxylase, biotin carboxylase, biotin carboxyl carrier protein [EC:6.4.1.2 6.4.1.3 6.3.4.14]
K18472  acetyl-CoA/propionyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.2 6.4.1.3 2.1.3.15]
K19312  acetyl-CoA/propionyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.2 6.4.1.3 2.1.3.15]
K22568  acetyl-CoA/propionyl-CoA carboxylase, PccX subunit [EC:6.4.1.2 6.4.1.3]
K01964  acetyl-CoA/propionyl-CoA carboxylase [EC:6.4.1.2 6.4.1.3]
K15036  acetyl-CoA/propionyl-CoA carboxylase [EC:6.4.1.2 6.4.1.3 2.1.3.15]
K15037  biotin carboxyl carrier protein
K01847  methylmalonyl-CoA mutase [EC:5.4.99.2]
K01849  methylmalonyl-CoA mutase, C-terminal domain [EC:5.4.99.2]
K01848  methylmalonyl-CoA mutase, N-terminal domain [EC:5.4.99.2]
K19268  methylaspartate mutase epsilon subunit [EC:5.4.99.1]
K01846  methylaspartate mutase sigma subunit [EC:5.4.99.1]
K04835  methylaspartate ammonia-lyase [EC:4.3.1.2]
K19280  succinyl-CoA:mesaconate CoA transferase [EC:2.8.3.26]
K19281  beta-methylmalyl-CoA/(S)-malyl-CoA lyase [EC:4.1.3.24]
K19282  bifunctional (S)-malyl-CoA lyase/thioesterase [EC:4.1.3.24 3.1.2.30]
K11517  (S)-2-hydroxy-acid oxidase [EC:1.1.3.15]
K00104  glycolate oxidase [EC:1.1.3.15]
K11472  glycolate oxidase FAD binding subunit
K11473  glycolate oxidase iron-sulfur subunit
K03781  catalase [EC:1.11.1.6]
K00015  glyoxylate reductase [EC:1.1.1.26]
K00049  glyoxylate/hydroxypyruvate reductase [EC:1.1.1.79 1.1.1.81]
K15919  glyoxylate/hydroxypyruvate reductase [EC:1.1.1.79 1.1.1.81]
K18121  glyoxylate/succinic semialdehyde reductase [EC:1.1.1.79 1.1.1.-]
K12972  glyoxylate/hydroxypyruvate reductase [EC:1.1.1.79 1.1.1.81]
K00090  glyoxylate/hydroxypyruvate/2-ketogluconate reductase [EC:1.1.1.79 1.1.1.81 1.1.1.215]
K00018  glycerate dehydrogenase [EC:1.1.1.29]
K15893  glycerate dehydrogenase [EC:1.1.1.29]
K22982  hydroxypyruvate reductase [EC:1.1.1.81]
K19269  phosphoglycolate phosphatase [EC:3.1.3.18 3.1.3.48]
K01091  phosphoglycolate phosphatase [EC:3.1.3.18]
K22223  phosphoglycolate phosphatase [EC:3.1.3.18]
K01601  ribulose-bisphosphate carboxylase large chain [EC:4.1.1.39]
K01602  ribulose-bisphosphate carboxylase small chain [EC:4.1.1.39]
K00830  alanine-glyoxylate transaminase / serine-glyoxylate transaminase / serine-pyruvate transaminase [EC:2.6.1.44 2.6.1.45 2.6.1.51]
K14272  glutamate--glyoxylate aminotransferase [EC:2.6.1.4 2.6.1.2 2.6.1.44]
K00284  glutamate synthase (ferredoxin) [EC:1.4.7.1]
K01915  glutamine synthetase [EC:6.3.1.2]
K00600  glycine hydroxymethyltransferase [EC:2.1.2.1]
K00281  glycine dehydrogenase [EC:1.4.4.2]
K00282  glycine dehydrogenase subunit 1 [EC:1.4.4.2]
K00283  glycine dehydrogenase subunit 2 [EC:1.4.4.2]
K00605  aminomethyltransferase [EC:2.1.2.10]
K00382  dihydrolipoamide dehydrogenase [EC:1.8.1.4]
K02437  glycine cleavage system H protein
K01608  tartronate-semialdehyde synthase [EC:4.1.1.47]
K01816  hydroxypyruvate isomerase [EC:5.3.1.22]
K00042  2-hydroxy-3-oxopropionate reductase [EC:1.1.1.60]
K00865  glycerate 2-kinase [EC:2.7.1.165]
K11529  glycerate 2-kinase [EC:2.7.1.165]
K15918  D-glycerate 3-kinase [EC:2.7.1.31]
K00050  hydroxypyruvate reductase [EC:1.1.1.81]
K07248  lactaldehyde dehydrogenase / glycolaldehyde dehydrogenase [EC:1.2.1.22 1.2.1.21]
K00048  lactaldehyde reductase [EC:1.1.1.77]
K03779  L(+)-tartrate dehydratase alpha subunit [EC:4.2.1.32]
K03780  L(+)-tartrate dehydratase beta subunit [EC:4.2.1.32]
K07246  tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase [EC:1.1.1.93 4.1.1.73 1.1.1.83]
K01625  2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase [EC:4.1.2.14 4.1.3.42]
K18123  4-hydroxy-2-oxoglutarate aldolase [EC:4.1.3.16]
K01569  oxalate decarboxylase [EC:4.1.1.2]
K00122  formate dehydrogenase [EC:1.17.1.9]
K00126  formate dehydrogenase subunit delta [EC:1.17.1.9]
K00123  formate dehydrogenase major subunit [EC:1.17.1.9]
K22515  formate dehydrogenase beta subunit [EC:1.17.1.9]
K00124  formate dehydrogenase iron-sulfur subunit
K00127  formate dehydrogenase subunit gamma
K01432  arylformamidase [EC:3.5.1.9]
K14263  kynurenine formamidase [EC:3.5.1.9]
K07130  arylformamidase [EC:3.5.1.9]
K01433  formyltetrahydrofolate deformylase [EC:3.5.1.10]
K01455  formamidase [EC:3.5.1.49]
K03418  N,N-dimethylformamidase [EC:3.5.1.56]
K01458  N-formylglutamate deformylase [EC:3.5.1.68]
K22133  oxalate---CoA ligase [EC:6.2.1.8]
K01577  oxalyl-CoA decarboxylase [EC:4.1.1.8]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C20238  (2R)-Ethylmalonyl-CoA
Reference
PMID:10978349 (EC5.3.1.22)
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta -hydroxyacid dehydrogenases in Escherichia coli and Haemophilusinfluenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
ko00010  Glycolysis / Gluconeogenesis
ko00020  Citrate cycle (TCA cycle)
ko00053  Ascorbate and aldarate metabolism
ko00071  Fatty acid degradation
ko00230  Purine metabolism
ko00250  Alanine, aspartate and glutamate metabolism
ko00260  Glycine, serine and threonine metabolism
ko00620  Pyruvate metabolism
ko00710  Carbon fixation in photosynthetic organisms
ko00750  Vitamin B6 metabolism
ko00910  Nitrogen metabolism
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