KEGG   PATHWAY: ko00640
Entry
ko00640                     Pathway                                

Name
Propanoate metabolism
Class
Metabolism; Carbohydrate metabolism
Pathway map
ko00640  Propanoate metabolism
ko00640

Module
M00013  Malonate semialdehyde pathway, propanoyl-CoA => acetyl-CoA [PATH:ko00640]
M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:ko00640]
Disease
H00175  Propionic acidemia
H01283  Malonyl-CoA decarboxylase deficiency
H02285  Methylmalonate semialdehyde dehydrogenase deficiency
Other DBs
GO: 0019541
Orthology
K01895  acetyl-CoA synthetase [EC:6.2.1.1]
K01908  propionyl-CoA synthetase [EC:6.2.1.17]
K01026  propionate CoA-transferase [EC:2.8.3.1]
K01905  acetate---CoA ligase (ADP-forming) subunit alpha [EC:6.2.1.13]
K22224  acetate---CoA ligase (ADP-forming) subunit beta [EC:6.2.1.13]
K24012  acetate---CoA ligase (ADP-forming) [EC:6.2.1.13]
K00925  acetate kinase [EC:2.7.2.1]
K00932  propionate kinase [EC:2.7.2.15]
K19697  propionate kinase [EC:2.7.2.15]
K00625  phosphate acetyltransferase [EC:2.3.1.8]
K13788  phosphate acetyltransferase [EC:2.3.1.8]
K15024  putative phosphotransacetylase [EC:2.3.1.8]
K13923  phosphate propanoyltransferase [EC:2.3.1.222]
K00166  2-oxoisovalerate dehydrogenase E1 component alpha subunit [EC:1.2.4.4]
K00167  2-oxoisovalerate dehydrogenase E1 component beta subunit [EC:1.2.4.4]
K11381  2-oxoisovalerate dehydrogenase E1 component [EC:1.2.4.4]
K09699  2-oxoisovalerate dehydrogenase E2 component (dihydrolipoyl transacylase) [EC:2.3.1.168]
K00382  dihydrolipoamide dehydrogenase [EC:1.8.1.4]
K00169  pyruvate ferredoxin oxidoreductase alpha subunit [EC:1.2.7.1]
K00170  pyruvate ferredoxin oxidoreductase beta subunit [EC:1.2.7.1]
K00172  pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.1]
K00189  2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.7 1.2.7.1]
K00171  pyruvate ferredoxin oxidoreductase delta subunit [EC:1.2.7.1]
K00656  formate C-acetyltransferase [EC:2.3.1.54]
K00248  butyryl-CoA dehydrogenase [EC:1.3.8.1]
K00232  acyl-CoA oxidase [EC:1.3.3.6]
K19745  acrylyl-CoA reductase (NADPH) [EC:1.3.1.-]
K20143  acrylyl-CoA reductase (NADH) [EC:1.3.1.95]
K20626  lactoyl-CoA dehydratase subunit alpha [EC:4.2.1.54]
K20627  lactoyl-CoA dehydratase subunit beta [EC:4.2.1.54]
K01692  enoyl-CoA hydratase [EC:4.2.1.17]
K01825  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8]
K01782  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3]
K07515  enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211]
K07514  enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8]
K07511  enoyl-CoA hydratase [EC:4.2.1.17]
K14729  multifunctional beta-oxidation protein [EC:4.2.1.- 1.1.1.-]
K05605  3-hydroxyisobutyryl-CoA hydrolase [EC:3.1.2.4]
K23146  3-hydroxyisobutyrate/3-hydroxypropionate dehydrogenase [EC:1.1.1.31 1.1.1.59]
K11262  acetyl-CoA carboxylase / biotin carboxylase 1 [EC:6.4.1.2 6.3.4.14 2.1.3.15]
K01946  acetyl-CoA carboxylase / biotin carboxylase 2 [EC:6.4.1.2 6.3.4.14 2.1.3.15]
K01962  acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15]
K02160  acetyl-CoA carboxylase biotin carboxyl carrier protein
K01961  acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]
K01963  acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2 2.1.3.15]
K11263  acetyl-CoA/propionyl-CoA carboxylase, biotin carboxylase, biotin carboxyl carrier protein [EC:6.4.1.2 6.4.1.3 6.3.4.14]
K18472  acetyl-CoA/propionyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.2 6.4.1.3 2.1.3.15]
K19312  acetyl-CoA/propionyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.2 6.4.1.3 2.1.3.15]
K22568  acetyl-CoA/propionyl-CoA carboxylase, PccX subunit [EC:6.4.1.2 6.4.1.3]
K01964  acetyl-CoA/propionyl-CoA carboxylase [EC:6.4.1.2 6.4.1.3]
K15036  acetyl-CoA/propionyl-CoA carboxylase [EC:6.4.1.2 6.4.1.3 2.1.3.15]
K15037  biotin carboxyl carrier protein
K01578  malonyl-CoA decarboxylase [EC:4.1.1.9]
K03416  methylmalonyl-CoA carboxyltransferase 5S subunit [EC:2.1.3.1]
K17489  methylmalonyl-CoA carboxyltransferase 12S subunit [EC:2.1.3.1]
K17490  methylmalonyl-CoA carboxyltransferase 1.3S subunit [EC:2.1.3.1]
K14468  malonyl-CoA reductase / 3-hydroxypropionate dehydrogenase (NADP+) [EC:1.2.1.75 1.1.1.298]
K00823  4-aminobutyrate aminotransferase [EC:2.6.1.19]
K07250  4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase / 5-aminovalerate transaminase [EC:2.6.1.19 2.6.1.22 2.6.1.48]
K13524  4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase [EC:2.6.1.19 2.6.1.22]
K00822  beta-alanine--pyruvate transaminase [EC:2.6.1.18]
K01965  propionyl-CoA carboxylase alpha chain [EC:6.4.1.3]
K01966  propionyl-CoA carboxylase beta chain [EC:6.4.1.3 2.1.3.15]
K18426  ethylmalonyl-CoA/methylmalonyl-CoA decarboxylase [EC:4.1.1.94 4.1.1.-]
K11264  methylmalonyl-CoA decarboxylase [EC:4.1.1.-]
K05606  methylmalonyl-CoA/ethylmalonyl-CoA epimerase [EC:5.1.99.1]
K01847  methylmalonyl-CoA mutase [EC:5.4.99.2]
K01849  methylmalonyl-CoA mutase, C-terminal domain [EC:5.4.99.2]
K01848  methylmalonyl-CoA mutase, N-terminal domain [EC:5.4.99.2]
K22214  propionyl-CoA:succinyl-CoA transferase [EC:2.8.3.-]
K01899  succinyl-CoA synthetase alpha subunit [EC:6.2.1.4 6.2.1.5]
K01900  succinyl-CoA synthetase beta subunit [EC:6.2.1.4 6.2.1.5]
K01903  succinyl-CoA synthetase beta subunit [EC:6.2.1.5]
K01902  succinyl-CoA synthetase alpha subunit [EC:6.2.1.5]
K00140  malonate-semialdehyde dehydrogenase (acetylating) / methylmalonate-semialdehyde dehydrogenase [EC:1.2.1.18 1.2.1.27]
K01659  2-methylcitrate synthase [EC:2.3.3.5]
K01720  2-methylcitrate dehydratase [EC:4.2.1.79]
K20455  2-methylcitrate dehydratase (2-methyl-trans-aconitate forming) [EC:4.2.1.117]
K09788  2-methylaconitate isomerase [EC:5.3.3.-]
K01682  aconitate hydratase 2 / 2-methylisocitrate dehydratase [EC:4.2.1.3 4.2.1.99]
K03417  methylisocitrate lyase [EC:4.1.3.30]
K00016  L-lactate dehydrogenase [EC:1.1.1.27]
K00626  acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
K01034  acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9]
K01035  acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9]
K19709  acetate CoA-transferase [EC:2.8.3.8]
K01574  acetoacetate decarboxylase [EC:4.1.1.4]
K18223  propane 2-monooxygenase large subunit [EC:1.14.13.227]
K18224  propane 2-monooxygenase small subunit [EC:1.14.13.227]
K18226  propane monooxygenase coupling protein
K18225  propane monooxygenase reductase component [EC:1.18.1.-]
K23259  isopropanol dehydrogenase (NADP+) [EC:1.1.1.80]
K18382  NAD+-dependent secondary alcohol dehydrogenase Adh1 [EC:1.1.1.-]
K18369  alcohol dehydrogenase [EC:1.1.1.-]
K18370  alcohol dehydrogenase [EC:1.1.1.-]
K18371  acetone monooxygenase (methyl acetate-forming) [EC:1.14.13.226]
K18372  methyl acetate hydrolase [EC:3.1.1.114]
K01734  methylglyoxal synthase [EC:4.2.3.3]
K08325  NADP-dependent alcohol dehydrogenase [EC:1.1.-.-]
K18471  methylglyoxal reductase [EC:1.1.1.-]
K00005  glycerol dehydrogenase [EC:1.1.1.6]
K17741  NADPH-dependent methylglyoxal reductase [EC:1.1.1.283]
K23257  methylglyoxal/glyoxal reductase [EC:1.1.1.283 1.1.1.-]
K00048  lactaldehyde reductase [EC:1.1.1.77]
K01699  propanediol dehydratase large subunit [EC:4.2.1.28]
K13919  propanediol dehydratase medium subunit [EC:4.2.1.28]
K13920  propanediol dehydratase small subunit [EC:4.2.1.28]
K00086  1,3-propanediol dehydrogenase [EC:1.1.1.202]
K13921  1-propanol dehydrogenase
K13922  propionaldehyde dehydrogenase [EC:1.2.1.87]
Compound
C00024  Acetyl-CoA
C00033  Acetate
C00042  Succinate
C00068  Thiamin diphosphate
C00083  Malonyl-CoA
C00091  Succinyl-CoA
C00099  beta-Alanine
C00100  Propanoyl-CoA
C00109  2-Oxobutanoate
C00111  Glycerone phosphate
C00132  Methanol
C00163  Propanoate
C00164  Acetoacetate
C00186  (S)-Lactate
C00207  Acetone
C00222  3-Oxopropanoate
C00332  Acetoacetyl-CoA
C00424  (S)-Lactaldehyde
C00479  Propanal
C00546  Methylglyoxal
C00583  Propane-1,2-diol
C00683  (S)-Methylmalonyl-CoA
C00804  Propynoate
C00827  Lactoyl-CoA
C00894  Propenoyl-CoA
C01013  3-Hydroxypropanoate
C01213  (R)-Methylmalonyl-CoA
C01845  Propan-2-ol
C02170  Methylmalonate
C02225  2-Methylcitrate
C02335  beta-Alanyl-CoA
C02876  Propanoyl phosphate
C04225  (Z)-But-2-ene-1,2,3-tricarboxylate
C04593  (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate
C05235  Hydroxyacetone
C05668  3-Hydroxypropionyl-CoA
C05979  Propane-1-ol
C05983  Propionyladenylate
C05984  2-Hydroxybutanoic acid
C05989  3-Oxopropionyl-CoA
C06002  (S)-Methylmalonate semialdehyde
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C17530  Methyl acetate
C20783  Propane
C21017  2-(alpha-Hydroxypropyl)thiamine diphosphate
C21018  Enzyme N6-(S-propyldihydrolipoyl)lysine
C21250  2-Methyl-trans-aconitate
Related
pathway
ko00010  Glycolysis / Gluconeogenesis
ko00020  Citrate cycle (TCA cycle)
ko00260  Glycine, serine and threonine metabolism
ko00270  Cysteine and methionine metabolism
ko00280  Valine, leucine and isoleucine degradation
ko00410  beta-Alanine metabolism
ko00620  Pyruvate metabolism
ko00660  C5-Branched dibasic acid metabolism
ko00770  Pantothenate and CoA biosynthesis
LinkDB

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