PATHWAY: ko00650 Entry ko00650                     Pathway                                 Name Butanoate metabolism Class Metabolism; Carbohydrate metabolism Pathway map ko00650   Butanoate metabolism Module M00027   GABA (gamma-Aminobutyrate) shunt [PATH:ko00650] Disease H00179   3-Hydroxy-3-methylglutaryl-CoA lyase deficiency H00835   Succinic semialdehyde dehydrogenase deficiency H01121   Succinyl CoA:3-oxoacid CoA transferase (SCOT) deficiency H01123   HMG-CoA synthase deficiency H01280   L-2-hydroxyglutaric aciduria H01364   3-Hydroxyacyl-CoA dehydrogenase deficiency Orthology K00626   acetyl-CoA C-acetyltransferase [EC:2.3.1.9] K00074   3-hydroxybutyryl-CoA dehydrogenase [EC:1.1.1.157] K00022   3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35] K07516   3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35] K01825   3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8] K01782   3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3] K01692   enoyl-CoA hydratase [EC:4.2.1.17] K01715   enoyl-CoA hydratase [EC:4.2.1.17] K07515   enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211] K07514   enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8] K07511   enoyl-CoA hydratase [EC:4.2.1.17] K00248   butyryl-CoA dehydrogenase [EC:1.3.8.1] K00209   enoyl-[acyl-carrier protein] reductase / trans-2-enoyl-CoA reductase (NAD+) [EC:1.3.1.9 1.3.1.44] K17829   crotonyl-CoA reductase [EC:1.3.1.86] K01034   acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9] K01035   acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9] K19709   acetate CoA-transferase [EC:2.8.3.8] K23756   medium-chain acyl-CoA ligase / lipoate-activating enzyme [EC:6.2.1.2] K01896   medium-chain acyl-CoA synthetase [EC:6.2.1.2] K01913   acetate/butyrate---CoA ligase [EC:6.2.1.1 6.2.1.2] K00929   butyrate kinase [EC:2.7.2.7] K00634   phosphate butyryltransferase [EC:2.3.1.19] K00132   acetaldehyde dehydrogenase (acetylating) [EC:1.2.1.10] K04072   acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1] K04073   acetaldehyde dehydrogenase [EC:1.2.1.10] K18366   acetaldehyde/propanal dehydrogenase [EC:1.2.1.10 1.2.1.87] K00100   butanol dehydrogenase [EC:1.1.1.-] K21317   butane monooxygenase alpha subunit [EC:1.14.13.230] K21318   butane monooxygenase beta subunit [EC:1.14.13.230] K21319   butane monooxygenase gamma subunit [EC:1.14.13.230] K21320   butane monooxygenase reductase K21321   butane monooxygenase regulatory protein K21322   butane monooxygenase hypothetical assembly protein K17865   3-hydroxybutyryl-CoA dehydratase [EC:4.2.1.55] K03821   polyhydroxyalkanoate synthase subunit PhaC [EC:2.3.1.-] K22881   polyhydroxyalkanoate synthase subunit PhaE K05973   poly(3-hydroxybutyrate) depolymerase [EC:3.1.1.75] K00023   acetoacetyl-CoA reductase [EC:1.1.1.36] K01615   glutaconyl-CoA decarboxylase subunit alpha [EC:7.2.4.5] K20509   carboxybiotin decarboxylase [EC:7.2.4.1] K23351   glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit gamma K23352   glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit delta K01039   glutaconate CoA-transferase, subunit A [EC:2.8.3.12] K01040   glutaconate CoA-transferase, subunit B [EC:2.8.3.12] K00109   2-hydroxyglutarate dehydrogenase [EC:1.1.99.2] K07246   tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase [EC:1.1.1.93 4.1.1.73 1.1.1.83] K01799   maleate isomerase [EC:5.2.1.1] K00239   succinate dehydrogenase / fumarate reductase, flavoprotein subunit [EC:1.3.5.1 1.3.5.4] K00240   succinate dehydrogenase / fumarate reductase, iron-sulfur subunit [EC:1.3.5.1 1.3.5.4] K00241   succinate dehydrogenase / fumarate reductase, cytochrome b subunit K00242   succinate dehydrogenase / fumarate reductase, membrane anchor subunit K18859   succinate dehydrogenase / fumarate reductase, subunit D K18860   putative succinate dehydrogenase / fumarate reductase, subunit D K00244   fumarate reductase flavoprotein subunit [EC:1.3.5.4] K00245   fumarate reductase iron-sulfur subunit [EC:1.3.5.4] K00246   fumarate reductase subunit C K00247   fumarate reductase subunit D K01580   glutamate decarboxylase [EC:4.1.1.15] K00823   4-aminobutyrate aminotransferase [EC:2.6.1.19] K14268   5-aminovalerate/4-aminobutyrate aminotransferase [EC:2.6.1.48 2.6.1.19] K07250   4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase / 5-aminovalerate transaminase [EC:2.6.1.19 2.6.1.22 2.6.1.48] K13524   4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase [EC:2.6.1.19 2.6.1.22] K16871   4-aminobutyrate---pyruvate transaminase [EC:2.6.1.96] K00135   succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20] K00139   succinate-semialdehyde dehydrogenase [EC:1.2.1.24] K17761   succinate-semialdehyde dehydrogenase, mitochondrial [EC:1.2.1.24] K08324   succinate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.24] K18118   succinyl-CoA:acetate CoA-transferase [EC:2.8.3.18] K18119   succinate-semialdehyde dehydrogenase [EC:1.2.1.76] K18120   4-hydroxybutyrate dehydrogenase [EC:1.1.1.61] K00043   4-hydroxybutyrate dehydrogenase [EC:1.1.1.61] K08318   4-hydroxybutyrate dehydrogenase / sulfolactaldehyde 3-reductase [EC:1.1.1.61 1.1.1.373] K18121   glyoxylate/succinic semialdehyde reductase [EC:1.1.1.79 1.1.1.-] K18122   4-hydroxybutyrate CoA-transferase [EC:2.8.3.-] K14534   4-hydroxybutyryl-CoA dehydratase / vinylacetyl-CoA-Delta-isomerase [EC:4.2.1.120 5.3.3.3] K00656   formate C-acetyltransferase [EC:2.3.1.54] K00169   pyruvate ferredoxin oxidoreductase alpha subunit [EC:1.2.7.1] K00170   pyruvate ferredoxin oxidoreductase beta subunit [EC:1.2.7.1] K00172   pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.1] K00189   2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.7 1.2.7.1] K00171   pyruvate ferredoxin oxidoreductase delta subunit [EC:1.2.7.1] K03737   pyruvate-ferredoxin/flavodoxin oxidoreductase [EC:1.2.7.1 1.2.7.-] K00174   2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit alpha [EC:1.2.7.3 1.2.7.11] K00175   2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit beta [EC:1.2.7.3 1.2.7.11] K01641   hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10] K01640   hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4] K01027   3-oxoacid CoA-transferase [EC:2.8.3.5] K01028   3-oxoacid CoA-transferase subunit A [EC:2.8.3.5] K01029   3-oxoacid CoA-transferase subunit B [EC:2.8.3.5] K01907   acetoacetyl-CoA synthetase [EC:6.2.1.16] K00019   3-hydroxybutyrate dehydrogenase [EC:1.1.1.30] K07518   hydroxybutyrate-dimer hydrolase [EC:3.1.1.22] K01652   acetolactate synthase I/II/III large subunit [EC:2.2.1.6] K01653   acetolactate synthase I/III small subunit [EC:2.2.1.6] K11258   acetolactate synthase II small subunit [EC:2.2.1.6] K01575   acetolactate decarboxylase [EC:4.1.1.5] K00004   (R,R)-butanediol dehydrogenase / meso-butanediol dehydrogenase / diacetyl reductase [EC:1.1.1.4 1.1.1.- 1.1.1.303] K03366   meso-butanediol dehydrogenase / (S,S)-butanediol dehydrogenase / diacetyl reductase [EC:1.1.1.- 1.1.1.76 1.1.1.304] K18009   meso-butanediol dehydrogenase / (S,S)-butanediol dehydrogenase / diacetyl reductase [EC:1.1.1.- 1.1.1.76 1.1.1.304] Compound C00022   Pyruvate C00024   Acetyl-CoA C00025   L-Glutamate C00026   2-Oxoglutarate C00042   Succinate C00091   Succinyl-CoA C00122   Fumarate C00136   Butanoyl-CoA C00164   Acetoacetate C00232   Succinate semialdehyde C00246   Butanoic acid C00332   Acetoacetyl-CoA C00334   4-Aminobutanoate C00356   (S)-3-Hydroxy-3-methylglutaryl-CoA C00497   (R)-Malate C00741   Diacetyl C00810   (R)-Acetoin C00877   Crotonoyl-CoA C00989   4-Hydroxybutanoic acid C01089   (R)-3-Hydroxybutanoate C01144   (S)-3-Hydroxybutanoyl-CoA C01384   Maleic acid C01412   Butanal C01769   (S)-Acetoin C02331   Vinylacetyl-CoA C02411   Glutaconyl-1-CoA C02527   Butanoylphosphate C02630   2-Hydroxyglutarate C03044   (R,R)-Butane-2,3-diol C03046   (S,S)-Butane-2,3-diol C03058   2-Hydroxyglutaryl-CoA C03561   (R)-3-Hydroxybutanoyl-CoA C04546   (R)-3-((R)-3-Hydroxybutanoyloxy)butanoate C06010   (S)-2-Acetolactate C06142   1-Butanol C06143   Poly-beta-hydroxybutyrate C06144   3-Butynoate C06145   3-Butyn-1-al C06146   3-Butyn-1-ol C11062   4-Hydroxybutyryl-CoA C20657   meso-2,3-Butanediol C21390   Butane Related pathway ko00010   Glycolysis / Gluconeogenesis ko00020   Citrate cycle (TCA cycle) ko00072   Synthesis and degradation of ketone bodies ko00250   Alanine, aspartate and glutamate metabolism ko00330   Arginine and proline metabolism ko00620   Pyruvate metabolism ko00750   Vitamin B6 metabolism ko01056   Biosynthesis of type II polyketide backbone LinkDB

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