KEGG   PATHWAY: ko00750
Entry
ko00750                     Pathway                                

Name
Vitamin B6 metabolism
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
ko00750  Vitamin B6 metabolism
ko00750

Module
M00124  Pyridoxal-P biosynthesis, erythrose-4P => pyridoxal-P [PATH:ko00750]
M00916  Pyridoxal-P biosynthesis, R5P + glyceraldehyde-3P + glutamine => pyridoxal-P [PATH:ko00750]
Disease
H01082  Phosphoserine aminotransferase deficiency
H01124  Pyridoxamine-5'-phosphate oxidase (PNPO) deficiency
H02117  Neu-Laxova syndrome
Other DBs
GO: 0042816
Orthology
K00275  pyridoxamine 5'-phosphate oxidase [EC:1.4.3.5]
K23998  pyridoxal 5'-phosphate synthase / NAD(P)H-hydrate epimerase [EC:1.4.3.5 5.1.99.6]
K00868  pyridoxine kinase [EC:2.7.1.35]
K07758  pyridoxal phosphatase [EC:3.1.3.74]
K13248  pyridoxal phosphate phosphatase PHOSPHO2 [EC:3.1.3.74]
K05275  pyridoxine 4-dehydrogenase [EC:1.1.1.65]
K00157  aldehyde oxidase [EC:1.2.3.1]
K03472  D-erythrose 4-phosphate dehydrogenase [EC:1.2.1.72]
K03473  erythronate-4-phosphate dehydrogenase [EC:1.1.1.290]
K00831  phosphoserine aminotransferase [EC:2.6.1.52]
K00097  4-hydroxythreonine-4-phosphate dehydrogenase [EC:1.1.1.262]
K03474  pyridoxine 5-phosphate synthase [EC:2.6.99.2]
K01733  threonine synthase [EC:4.2.3.1]
K06215  pyridoxal 5'-phosphate synthase pdxS subunit [EC:4.3.3.6]
K08681  pyridoxal 5'-phosphate synthase pdxT subunit [EC:4.3.3.6]
K18607  pyridoxine 4-oxidase [EC:1.1.3.12]
K18608  pyridoxamine---pyruvate transaminase [EC:2.6.1.30]
K18609  pyridoxal 4-dehydrogenase [EC:1.1.1.107]
K18610  4-pyridoxolactonase [EC:3.1.1.27]
K18611  4-pyridoxate dehydrogenase [EC:1.1.99.42]
K18612  5-formyl-3-hydroxy-2-methylpyridine 4-carboxylic acid 5-dehydrogenase [EC:1.2.1.100]
K18613  3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase [EC:4.1.1.51]
K18071  2-methyl-3-hydroxypyridine 5-carboxylic acid dioxygenase [EC:1.14.13.242]
K18614  2-(acetamidomethylene)succinate hydrolase [EC:3.5.1.29]
Compound
C00018  Pyridoxal phosphate
C00064  L-Glutamine
C00117  D-Ribose 5-phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00232  Succinate semialdehyde
C00250  Pyridoxal
C00266  Glycolaldehyde
C00279  D-Erythrose 4-phosphate
C00314  Pyridoxine
C00534  Pyridoxamine
C00627  Pyridoxine phosphate
C00647  Pyridoxamine phosphate
C00847  4-Pyridoxate
C00971  4-Pyridoxolactone
C01215  2-(Acetamidomethylene)succinate
C01270  3-Hydroxy-2-methylpyridine-5-carboxylate
C03393  4-Phospho-D-erythronate
C04106  2-(Hydroxymethyl)-4-oxobutanoate
C04604  3-Hydroxy-2-methylpyridine-4,5-dicarboxylate
C04690  2-(Hydroxymethyl)-3-(acetamidomethylene)succinate
C04773  3-Hydroxy-4-hydroxymethyl-2-methylpyridine-5-carboxylate
C06050  2-Methyl-3-hydroxy-5-formylpyridine-4-carboxylate
C06051  Isopyridoxal
C06052  5-Pyridoxolactone
C06054  2-Oxo-3-hydroxy-4-phosphobutanoate
C06055  O-Phospho-4-hydroxy-L-threonine
C06056  4-Hydroxy-L-threonine
C07335  2-Amino-3-oxo-4-phosphonooxybutyrate
C11638  3-Amino-2-oxopropyl phosphate
Reference
  Authors
Tazoe M, Ichikawa K, Hoshino T.
  Title
Biosynthesis of vitamin B(6) in rhizobium.
  Journal
J Biol Chem 275:11300-5 (2000)
DOI:10.1074/jbc.275.15.11300
Reference
PMID:9696782
  Authors
Yang Y, Zhao G, Man TK, Winkler ME.
  Title
Involvement of the gapA- and epd (gapB)-encoded dehydrogenases in pyridoxal 5'-phosphate coenzyme biosynthesis in Escherichia coli K-12.
  Journal
J Bacteriol 180:4294-9 (1998)
DOI:10.1128/JB.180.16.4294-4299.1998
Reference
  Authors
Yeh JI, Du S, Pohl E, Cane DE.
  Title
Multistate binding in pyridoxine 5'-phosphate synthase: 1.96 A crystal structure in complex with 1-deoxy-D-xylulose phosphate.
  Journal
Biochemistry 41:11649-57 (2002)
DOI:10.1021/bi026292t
Reference
  Authors
Laber B, Maurer W, Scharf S, Stepusin K, Schmidt FS.
  Title
Vitamin B6 biosynthesis: formation of pyridoxine 5'-phosphate from 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose-5-phosphate by PdxA and PdxJ protein.
  Journal
FEBS Lett 449:45-8 (1999)
DOI:10.1016/S0014-5793(99)00393-2
Reference
  Authors
Tambasco-Studart M, Titiz O, Raschle T, Forster G, Amrhein N, Fitzpatrick TB.
  Title
Vitamin B6 biosynthesis in higher plants.
  Journal
Proc Natl Acad Sci U S A 102:13687-92 (2005)
DOI:10.1073/pnas.0506228102
Reference
  Authors
Nagase T, Mugo AN, Chu HN, Yoshikane Y, Ohnishi K, Yagi T
  Title
The mll6786 gene encodes a repressor protein controlling the degradation pathway for vitamin B6 in Mesorhizobium loti.
  Journal
FEMS Microbiol Lett 329:116-22 (2012)
DOI:10.1111/j.1574-6968.2012.02510.x
Related
pathway
ko00010  Glycolysis / Gluconeogenesis
ko00030  Pentose phosphate pathway
ko00630  Glyoxylate and dicarboxylate metabolism
ko00650  Butanoate metabolism
ko00730  Thiamine metabolism
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