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Metabolism of xenobiotics by cytochrome P450
Metabolism; Xenobiotics biodegradation and metabolism
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ko00980  Metabolism of xenobiotics by cytochrome P450

Ortholog table
H01111  Cortisone reductase deficiency
H01203  Primary congenital glaucoma
K07408  cytochrome P450 family 1 subfamily A polypeptide 1 [EC:]
K17719  cytochrome P450 family 2 subfamily C polypeptide 9 [EC: 1.14.14.-]
K17689  cytochrome P450 family 3 subfamily A polypeptide 4 [EC: 1.14.13.-]
K07410  cytochrome P450 family 1 subfamily B polypeptide 1 [EC:]
K00799  glutathione S-transferase [EC:]
K23790  glutathione S-transferase P [EC:]
K13299  glutathione S-transferase kappa 1 [EC:]
K04097  prostaglandin-H2 D-isomerase / glutathione transferase [EC:]
K01253  microsomal epoxide hydrolase [EC:]
K17709  cytochrome P450 family 2 subfamily B polypeptide 6 [EC:1.14.13.-]
K11822  bile-salt sulfotransferase [EC:]
K07409  cytochrome P450 family 1 subfamily A polypeptide 2 [EC:]
K17683  cytochrome P450 family 2 subfamily A polypeptide 6 [EC:1.14.13.-]
K07415  cytochrome P450 family 2 subfamily E polypeptide 1 [EC:1.14.13.-]
K07416  cytochrome P450 family 2 subfamily F [EC:]
K07420  cytochrome P450 family 2 subfamily S polypeptide 1 [EC:]
K00212  20alpha/3alpha-hydroxysteroid dehydrogenase / dihydrodiol dehydrogenase [EC:]
K00078  dihydrodiol dehydrogenase / D-xylose 1-dehydrogenase (NADP) [EC:]
K17685  cytochrome P450 family 2 subfamily A polypeptide 13 [EC:]
K17712  cytochrome P450 family 2 subfamily D polypeptide 6 [EC:]
K15680  corticosteroid 11-beta-dehydrogenase isozyme 1 [EC:]
K00079  carbonyl reductase 1 [EC:]
K00081  carbonyl reductase 2 [EC:]
K00084  carbonyl reductase 3 [EC:]
K00699  glucuronosyltransferase [EC:]
K17690  cytochrome P450 family 3 subfamily A polypeptide 5 [EC:]
K15303  aflatoxin B1 aldehyde reductase
K00129  aldehyde dehydrogenase (NAD(P)+) [EC:]
K13951  alcohol dehydrogenase 1/7 [EC:]
K13980  alcohol dehydrogenase 4 [EC:]
K00121  S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase [EC:]
K13952  alcohol dehydrogenase 6 [EC:]
K13953  alcohol dehydrogenase, propanol-preferring [EC:]
K00001  alcohol dehydrogenase [EC:]
C00745  Nicotine
C00829  Naphthalene
C02617  1,4-Naphthoquinone
C03012  Naphthalene-1,2-diol
C06205  1,2-Dihydronaphthalene-1,2-diol
C06755  Chloroacetic acid
C06790  Trichloroethene
C06800  Aflatoxin B1
C06899  Chloral hydrate
C07490  Trichloroethanol
C07535  Benzo[a]pyrene
C11036  Bromobenzene
C11088  1,2-Dibromoethane
C11148  TCE epoxide
C11149  Dichloroacetate
C11150  Trichloroacetate
C11278  Aflatoxin B1exo-8,9-epoxide-GSH
C11713  2-Naphthol
C11714  1-Naphthol
C14039  1,1-Dichloroethylene
C14040  1-Nitronaphthalene
C14453  4-Bromophenol
C14556  9-Hydroxybenzo[a]pyrene
C14783  1,2-Naphthoquinone
C14784  1,2-Dihydroxy-3,4-epoxy-1,2,3,4-tetrahydronaphthalene
C14785  1,4-Dihydroxynaphthalene
C14786  (1R,2S)-Naphthalene 1,2-oxide
C14787  (1S,2R)-Naphthalene 1,2-oxide
C14788  1-Nitrosonaphthalene
C14789  N-Hydroxy-1-aminonaphthalene
C14790  1-Naphthylamine
C14791  (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
C14792  (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
C14793  (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
C14796  (1R)-Hydroxy-(2R)-N-acetyl-L-cysteinyl-1,2-dihydronaphthalene
C14797  (1R)-N-Acetyl-L-cysteinyl-(2R)-hydroxy-1,2-dihydronaphthalene
C14798  (1S)-Hydroxy-(2S)-N-acetyl-L-cysteinyl-1,2-dihydronaphthalene
C14799  (1R,2R)-3-[(1,2-Dihydro-2-hydroxy-1-naphthalenyl)thio]-2-oxopropanoic acid
C14800  1-Nitronaphthalene-5,6-oxide
C14801  1-Nitro-5,6-dihydroxy-dihydronaphthalene
C14802  1-Nitronaphthalene-7,8-oxide
C14803  1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene
C14804  1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene
C14805  1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene
C14806  1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene
C14839  Bromobenzene-3,4-oxide
C14840  Bromobenzene-2,3-oxide
C14841  2-Bromophenol
C14842  Bromobenzene-2,3-dihydrodiol
C14843  4-Bromocatechol
C14844  Bromobenzene-3,4-dihydrodiol
C14845  4-Bromophenol-2,3-epoxide
C14846  4-Bromo-3,5-cyclohexadiene-1,2-dione
C14847  3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene
C14848  2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene
C14849  Benzo[a]pyrene-9,10-oxide
C14850  Benzo[a]pyrene-7,8-oxide
C14851  Benzo[a]pyrene-4,5-oxide
C14852  Benzo[a]pyrene-7,8-diol
C14853  Benzo[a]pyrene-7,8-dihydrodiol-9,10-oxide
C14854  9-Hydroxybenzo[a]pyrene-4,5-oxide
C14855  4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene
C14856  7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene
C14857  1,1-Dichloroethylene epoxide
C14858  2,2-Dichloroacetaldehyde
C14859  Chloroacetyl chloride
C14860  2,2-Dichloro-1,1-ethanediol
C14861  S-(2,2-Dichloro-1-hydroxy)ethyl glutathione
C14862  2-S-Glutathionyl acetate
C14863  2-(S-Glutathionyl)acetyl glutathione
C14864  S-(2-Chloroacetyl)glutathione
C14865  2-(S-Glutathionyl)acetyl chloride
C14866  Chloral
C14867  Dichloroacetyl chloride
C14868  S-(1,2-Dichlorovinyl)glutathione
C14869  Trichloroethanol glucuronide
C14870  2-Bromoacetaldehyde
C14871  S-(Formylmethyl)glutathione
C14872  Thiodiacetic acid
C14873  Thiodiacetic acid sulfoxide
C14874  Glutathione episulfonium ion
C14875  S-(2-Hydroxyethyl)glutathione
C14876  S-(2-Hydroxyethyl)-N-acetyl-L-cysteine
C14877  S-[2-(N7-Guanyl)ethyl]-N-acetyl-L-cysteine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16756  Aflatoxin M1
C19488  7,12-Dimethylbenz[a]anthracene
C19489  1a,11b-Dihydro-4,9-dimethylbenz[a]anthra[3,4-b]oxirene
C19490  trans-3,4-Dihydro-3,4-dihydroxy-7,12-dimethylbenz[a]anthracene
C19559  (1aalpha,2beta,3alpha,11calpha)-1a,2,3,11c-Tetrahydro-6,11-dimethylbenzo[6,7]phenanthro[3,4-b]oxirene-2,3-diol
C19561  7-Hydroxymethyl-12-methylbenz[a]anthracene
C19562  7-Hydroxymethyl-12-methylbenz[a]anthracene sulfate
C19563  4-[(Hydroxymethyl)nitrosoamino]-1-(3-pyridinyl)-1-butanone
C19564  4-(Nitrosoamino)-1-(3-pyridinyl)-1-butanone
C19565  4-Hydroxy-1-(3-pyridinyl)-1-butanone
C19566  4-Hydroxy-4-(methylnitrosoamino)-1-(3-pyridinyl)-1-butanone
C19567  4-Oxo-1-(3-pyridyl)-1-butanone
C19568  N-Nitrosomethanamine
C19569  3-Succinoylpyridine
C19574  4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol
C19577  1-(Methylnitrosoamino)-4-(3-pyridinyl)-1,4-butanediol
C19578  5-(3-Pyridyl)-2-hydroxytetrahydrofuran
C19579  gamma-Hydroxy-3-pyridinebutanoate
C19580  alpha-[3-[(Hydroxymethyl)nitrosoamino]propyl]-3-pyridinemethanol
C19581  alpha-[3-(Nitrosoamino)propyl]-3-pyridinemethanol
C19582  1-(3-Pyridinyl)-1,4-butanediol
C19585  Aflatoxin Q1
C19586  Aflatoxin B1-exo-8,9-epoxide
C19588  Aflatoxin B1 diol
C19589  Aflatoxin B1 dialdehyde
C19590  6-[2,3-Dihydroxy-1-(hydroxymethyl)propyl]-1,2-dihydro-7-hydroxy-9-methoxy-cyclopenta[c][1]benzopyran-3,4-dione
C19591  1,2,3,4-Tetrahydro-alpha,7-dihydroxy-beta-(hydroxymethyl)-9-methoxy-3,4-dioxocyclopenta[c][1]benzopyran-6-propanal
C19592  alpha-(1,2-Dihydroxyethyl)-1,2,3,4-tetrahydro-7-hydroxy-9-methoxy-3,4-dioxocyclopenta[c][1]benzopyran-6-acetaldehyde
C19594  Aflatoxin-M1-8,9-epoxide
C19595  Aflatoxin B1-endo-8,9-epoxide
C19602  4-(Methylnitrosamino)-1-(1-oxido-3-pyridinyl)-1-butanone
C19603  4-(Methylnitrosamino)-1-(3-pyridyl-N-oxide)-1-butanol
C19604  7,12-Dimethylbenz[a]anthracene 5,6-oxide
C19605  4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronide
C19606  NNAL-N-glucuronide
C19607  trans-5,6-Dihydro-5,6-dihydroxy-7,12-dimethylbenz[a]anthracene
Buckpitt A, Boland B, Isbell M, Morin D, Shultz M, Baldwin R, Chan K, Karlsson A, Lin C, Taff A, West J, Fanucchi M, Van Winkle L, Plopper C.
Naphthalene-induced respiratory tract toxicity: metabolic mechanisms of toxicity.
Drug Metab Rev 34:791-820 (2002)
Bolton JL, Trush MA, Penning TM, Dryhurst G, Monks TJ.
Role of quinones in toxicology.
Chem Res Toxicol 13:135-60 (2000)
Halladay JS, Sauer JM, Sipes IG.
Metabolism and disposition of [(14)C]1-nitronaphthalene in male Sprague-Dawley rats.
Drug Metab Dispos 27:1456-65 (1999)
Watt KC, Morin DM, Kurth MJ, Mercer RS, Plopper CG, Buckpitt AR.
Glutathione conjugation of electrophilic metabolites of 1-nitronaphthalene in rat tracheobronchial airways and liver: identification by mass spectrometry and proton nuclear magnetic resonance spectroscopy.
Chem Res Toxicol 12:831-9 (1999)
Simmonds AC, Reilly CA, Baldwin RM, Ghanayem BI, Lanza DL, Yost GS, Collins KS, Forkert PG.
Bioactivation of 1,1-dichloroethylene to its epoxide by CYP2E1 and CYP2F enzymes.
Drug Metab Dispos 32:1032-9 (2004)
Forkert PG, Baldwin RM, Millen B, Lash LH, Putt DA, Shultz MA, Collins KS.
Pulmonary bioactivation of trichloroethylene to chloral hydrate: relative contributions of CYP2E1, CYP2F, and CYP2B1.
Drug Metab Dispos 33:1429-37 (2005)
Wormhoudt LW, Commandeur JN, Ploemen JH, Abdoelgafoer RS, Makansi A, Van Bladeren PJ, Vermeulen NP.
Urinary thiodiacetic acid. A selective biomarker for the cytochrome P450-catalyzed oxidation of 1,2-dibromoethane in the rat.
Drug Metab Dispos 25:508-15 (1997)
Brodie BB, Reid WD, Cho AK, Sipes G, Krishna G, Gillette JR.
Possible mechanism of liver necrosis caused by aromatic organic compounds.
Proc Natl Acad Sci U S A 68:160-4 (1971)
Lodovici M, Luceri C, Guglielmi F, Bacci C, Akpan V, Fonnesu ML, Boddi V, Dolara P.
Benzo(a)pyrene diolepoxide (BPDE)-DNA adduct levels in leukocytes of smokers in relation to polymorphism of CYP1A1, GSTM1, GSTP1, GSTT1, and mEH.
Cancer Epidemiol Biomarkers Prev 13:1342-8 (2004)
Omura T, Ishimura Y, Fujii Y (eds).
[Molecular Biology of P450] (In Japanese)
Kodansya (2003)
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