KEGG   PATHWAY: ko02030
Entry
ko02030                     Pathway                                
Name
Bacterial chemotaxis
Description
Chemotaxis is the process by which cells sense chemical gradients in their environment and then move towards more favorable conditions. In chemotaxis, events at the receptors control autophosphorylation of the CheA histidine kinase, and the phosphohistidine is the substrate for the response regulator CheY, which catalyzes the transfer of the phosphoryl group to a conserved aspartate. The resulting CheY-P can interact with the switch mechanism in the motor. This interaction causes a change in behavior, such as in direction or speed of rotation of flagella.
Class
Cellular Processes; Cell motility
Pathway map
ko02030  Bacterial chemotaxis
ko02030

Other DBs
GO: 0006935
Orthology
K03406  methyl-accepting chemotaxis protein
K05874  methyl-accepting chemotaxis protein I, serine sensor receptor
K05875  methyl-accepting chemotaxis protein II, aspartate sensor receptor
K05876  methyl-accepting chemotaxis protein III, ribose and galactose sensor receptor
K05877  methyl-accepting chemotaxis protein IV, peptide sensor receptor
K03776  aerotaxis receptor
K10108  maltose/maltodextrin transport system substrate-binding protein
K10439  ribose transport system substrate-binding protein
K10540  methyl-galactoside transport system substrate-binding protein
K12368  dipeptide transport system substrate-binding protein
K03407  two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
K03408  purine-binding chemotaxis protein CheW
K03413  two-component system, chemotaxis family, chemotaxis protein CheY
K03410  chemotaxis protein CheC
K03414  chemotaxis protein CheZ
K03409  chemotaxis protein CheX
K03412  two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
K13924  two-component system, chemotaxis family, CheB/CheR fusion protein [EC:2.1.1.80 3.1.1.61]
K03415  two-component system, chemotaxis family, chemotaxis protein CheV
K03411  chemotaxis protein CheD [EC:3.5.1.44]
K00575  chemotaxis protein methyltransferase CheR [EC:2.1.1.80]
K02410  flagellar motor switch protein FliG
K02416  flagellar motor switch protein FliM
K02417  flagellar motor switch protein FliN
K02556  chemotaxis protein MotA
K02557  chemotaxis protein MotB
Compound
C00049  L-Aspartate
C00107  Dipeptide
C00121  D-Ribose
C00124  D-Galactose
C00208  Maltose
C00716  Serine
Reference
  Authors
Kristich CJ, Ordal GW.
  Title
Bacillus subtilis CheD is a chemoreceptor modification enzyme required for chemotaxis.
  Journal
J Biol Chem 277:25356-62 (2002)
DOI:10.1074/jbc.M201334200
Reference
  Authors
Kirby JR, Kristich CJ, Saulmon MM, Zimmer MA, Garrity LF, Zhulin IB, Ordal GW.
  Title
CheC is related to the family of flagellar switch proteins and acts independently from CheD to control chemotaxis in Bacillus subtilis.
  Journal
Mol Microbiol 42:573-85 (2001)
DOI:10.1046/j.1365-2958.2001.02581.x
Reference
  Authors
Szurmant H, Bunn MW, Cannistraro VJ, Ordal GW.
  Title
Bacillus subtilis hydrolyzes CheY-P at the location of its action, the flagellar switch.
  Journal
J Biol Chem 278:48611-6 (2003)
DOI:10.1074/jbc.M306180200
Reference
  Authors
Szurmant H, Muff TJ, Ordal GW.
  Title
Bacillus subtilis CheC and FliY are members of a novel class of CheY-P-hydrolyzing proteins in the chemotactic signal transduction cascade.
  Journal
J Biol Chem 279:21787-92 (2004)
DOI:10.1074/jbc.M311497200
Reference
  Authors
Yoshihara S, Geng X, Okamoto S, Yura K, Murata T, Go M, Ohmori M, Ikeuchi M.
  Title
Mutational analysis of genes involved in pilus structure, motility and transformation competency in the unicellular motile cyanobacterium Synechocystis sp. PCC 6803.
  Journal
Plant Cell Physiol 42:63-73 (2001)
DOI:10.1093/pcp/pce007
Reference
PMID:8104179
  Authors
Darzins A.
  Title
The pilG gene product, required for Pseudomonas aeruginosa pilus production and twitching motility, is homologous to the enteric, single-domain response regulator CheY.
  Journal
J Bacteriol 175:5934-44 (1993)
DOI:10.1128/JB.175.18.5934-5944.1993
Reference
  Authors
Szurmant H, Ordal GW
  Title
Diversity in chemotaxis mechanisms among the bacteria and archaea.
  Journal
Microbiol Mol Biol Rev 68:301-19 (2004)
DOI:10.1128/MMBR.68.2.301-319.2004
Reference
  Authors
Rao CV, Glekas GD, Ordal GW
  Title
The three adaptation systems of Bacillus subtilis chemotaxis.
  Journal
Trends Microbiol 16:480-7 (2008)
DOI:10.1016/j.tim.2008.07.003
Reference
  Authors
Muff TJ, Ordal GW
  Title
The diverse CheC-type phosphatases: chemotaxis and beyond.
  Journal
Mol Microbiol 70:1054-61 (2008)
DOI:10.1111/j.1365-2958.2008.06482.x
Reference
  Authors
Miller LD, Russell MH, Alexandre G
  Title
Diversity in bacterial chemotactic responses and niche adaptation.
  Journal
Adv Appl Microbiol 66:53-75 (2009)
DOI:10.1016/S0065-2164(08)00803-4
Related
pathway
ko02040  Flagellar assembly
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