KEGG   PATHWAY: ko04060Help
Entry
ko04060                     Pathway                                

Name
Cytokine-cytokine receptor interaction
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
09130 Environmental Information Processing; 09133 Signaling molecules and interaction
BRITE hierarchy
Pathway map
ko04060  Cytokine-cytokine receptor interaction
ko04060

Ortholog table
Disease
H00097  Chemokine receptor defect
H00227  Congenital amegakaryocytic thrombocytopenia (CAMT)
H00286  Crohn disease
H00344  Leprosy
H00408  Type I diabetes mellitus
H00609  46,XY disorders of sex development (Other)
H00632  Heterotaxy
H00651  Ectodermal dysplasia
H00800  Loeys-Dietz syndrome (LDS)
H00801  Familial thoracic aortic aneurysm and dissection (TAAD)
H00912  Tumor necrosis factor receptor-associated periodic syndrome (TRAPS)
H00935  Cold-induced sweating syndrome (CISS) and Crisponi syndrome (CRISPS)
H01023  Juvenile polyposis syndrome
H01024  Hereditary mixed polyposis syndrome
H01109  Chronic mucocutaneous candidiasis (CMC)
H01122  Congenital pulmonary alveolar proteinosis
H01217  Primary localized cutaneous amyloidosis (PLCA)
H01227  Inflammatory bowel disease (IBD)
H01466  Ulcerative colitis (UC)
H01479  Castleman disease
H01672  Juvenile idiopathic arthritis (JIA)
H02037  Laron syndrome
H02039  Kowarski syndrome
H02059  Leptin deficiency
H02060  Leptin receptor deficiency
Orthology
K05514  C-C motif chemokine 1
K13072  C-C motif chemokine 25
K05512  C-C motif chemokine 19
K16062  C-C motif chemokine 21
K05408  C-C motif chemokine 3
K12964  C-C motif chemokine 4
K21083  C-C motif chemokine 17
K21095  C-C motif chemokine 22
K12499  C-C motif chemokine 5
K16596  C-C motif chemokine 8
K22671  C-C motif chemokine 9
K21092  C-C motif chemokine 14
K21093  C-C motif chemokine 16
K05511  C-C motif chemokine 15/23
K16595  C-C motif chemokine 13
K05510  C-C motif chemokine 6
K05509  C-C motif chemokine 7
K14624  C-C motif chemokine 2
K16597  C-C motif chemokine 11
K21097  C-C motif chemokine 24
K21096  C-C motif chemokine 26
K16598  C-C motif chemokine 27
K05513  C-C motif chemokine 28
K21094  C-C motif chemokine 18
K14625  C-C motif chemokine 20
K05505  C-X-C motif chemokine 1/2/3
K05506  C-X-C motif chemokine 5/6
K10030  interleukin 8
K10029  platelet basic protein
K05407  platelet factor 4
K05416  C-X-C motif chemokine 9
K12671  C-X-C motif chemokine 10
K12672  C-X-C motif chemokine 11
K10032  C-X-C motif chemokine 13
K10031  C-X-C motif chemokine 12
K10035  C-X-C motif chemokine 16
K10033  C-X-C motif chemokine 14
K10034  C-X-C motif chemokine 15
K22627  C-X-C motif chemokine 17
K05507  C motif chemokine 1
K22675  C motif chemokine 2
K05508  C-X3-C motif chemokine 1
K05429  interleukin 2
K05430  interleukin 4
K05431  interleukin 7
K05432  interleukin 9
K05433  interleukin 15
K05434  interleukin 21
K05436  thymic stromal lymphopoietin
K04736  interleukin 3
K05428  interleukin 5
K05427  granulocyte-macrophage colony-stimulating factor
K05435  interleukin 13
K05437  erythropoietin
K05438  growth hormone
K05439  prolactin
K06854  thrombopoietin
K05423  granulocyte colony-stimulating factor
K05424  leptin
K05405  interleukin 6
K05417  interleukin 11
K05406  interleukin 12A
K05425  interleukin 12B
K05426  interleukin 23 subunit alpha
K22629  interleukin 27
K22631  interleukin 31
K05421  B-cell stimulating factor 3
K05420  ciliary neurotrophic factor
K05422  cardiotrophin 1
K05419  leukemia inhibitory factor
K05418  oncostatin M
K05443  interleukin 10
K05444  interleukin 19
K22667  interleukin 20
K22668  interleukin 24
K05445  interleukin 22
K05446  interleukin 26
K22669  interferon lambda 2/3
K05447  interferon lambda 1
K05414  interferon alpha
K05415  interferon beta
K05440  interferon omega
K05441  interferon kappa
K05442  interferon epsilon
K04687  interferon gamma
K04383  interleukin 1 alpha
K04519  interleukin 1 beta
K05481  interleukin 1 receptor antagonist
K05483  interleukin 36 receptor antagonist protein
K05484  interleukin 36 alpha
K05486  interleukin 36 beta
K05487  interleukin 36 gamma
K05488  interleukin 1 family member 10
K05485  interleukin 37
K05482  interleukin 18
K12967  interleukin 33
K05489  interleukin 17A
K05494  interleukin 17F
K05490  interleukin 17B
K05491  interleukin 17C
K05492  interleukin 17D
K05493  interleukin 17E
K22628  interleukin 16
K22632  interleukin 32
K22633  interleukin 34
K05453  macrophage colony-stimulating factor 1
K03156  tumor necrosis factor superfamily, member 2
K05468  lymphotoxin alpha (TNF superfamily, member 1)
K03157  lymphotoxin beta (TNF superfamily, member 3)
K05477  tumor necrosis factor ligand superfamily member 14
K04389  tumor necrosis factor ligand superfamily member 6
K05478  tumor necrosis factor ligand superfamily member 15
K04721  tumor necrosis factor ligand superfamily member 10
K05480  ectodysplasin-A
K05451  nerve growth factor, alpha
K02582  nerve growth factor, beta
K05473  tumor necrosis factor ligand superfamily member 11
K05474  tumor necrosis factor ligand superfamily member 12
K05470  tumor necrosis factor ligand superfamily member 7
K05471  tumor necrosis factor ligand superfamily member 8
K03161  tumor necrosis factor ligand superfamily member 5
K05472  tumor necrosis factor ligand superfamily member 9
K05469  tumor necrosis factor ligand superfamily member 4
K05479  tumor necrosis factor ligand superfamily member 18
K05475  tumor necrosis factor ligand superfamily member 13
K05476  tumor necrosis factor ligand superfamily member 13B
K13375  transforming growth factor beta-1
K13376  transforming growth factor beta-2
K13377  transforming growth factor beta-3
K05504  growth differentiation factor 15
K05503  growth differentiation factor 2
K22670  bone morphogenetic protein 10
K05500  inhibin, alpha
K05496  bone morphogenetic protein 3
K22674  growth differentiation factor 10
K22679  growth differentiation factor 11
K05497  growth differentiation factor 8
K04667  inhibin beta A chain
K22687  inhibin beta B chain
K05495  growth differentiation factor 1
K22672  growth differentiation factor 3
K04666  nodal
K22673  growth differentiation factor 9
K22688  inhibin beta C chain
K22689  inhibin beta E chain
K04665  anti-mullerian hormone
K21283  bone morphogenetic protein 2
K04662  bone morphogenetic protein 4
K04664  growth differentiation factor 5
K20012  growth differentiation factor 6
K20013  growth differentiation factor 7
K05498  bone morphogenetic protein 15
K04663  bone morphogenetic protein 5
K16620  bone morphogenetic protein 6
K16621  bone morphogenetic protein 7
K16622  bone morphogenetic protein 8
K04183  C-C chemokine receptor type 8
K04184  C-C chemokine receptor type 9
K04186  C-C chemokine receptor-like 1
K04182  C-C chemokine receptor type 7
K04179  C-C chemokine receptor type 4
K04180  C-C chemokine receptor type 5
K04178  C-C chemokine receptor type 3
K04177  C-C chemokine receptor type 2
K04176  C-C chemokine receptor type 1
K04185  C-C chemokine receptor type 10
K04181  C-C chemokine receptor type 6
K04175  C-X-C chemokine receptor type 1
K05050  C-X-C chemokine receptor type 2
K04188  C-X-C chemokine receptor type 3
K04190  C-X-C chemokine receptor type 5
K04189  C-X-C chemokine receptor type 4
K04304  C-X-C chemokine receptor type 7
K04191  C-X-C chemokine receptor type 6
K04193  XC chemokine receptor 1
K04192  CX3C chemokine receptor 1
K05068  interleukin 2 receptor alpha
K05069  interleukin 2 receptor beta
K05070  interleukin 2 receptor gamma
K05071  interleukin 4 receptor
K05072  interleukin 7 receptor
K05073  interleukin 9 receptor
K05074  interleukin 15 receptor alpha
K05075  interleukin 21 receptor
K05078  thymic stromal-derived lymphopoietin receptor
K04737  interleukin 3 receptor alpha
K04738  cytokine receptor common subunit beta
K05067  interleukin 5 receptor alpha
K05066  granulocyte-macrophage colony-stimulating factor receptor alpha
K05076  interleukin 13 receptor alpha-1
K05077  interleukin 13 receptor alpha-2
K05079  erythropoietin receptor
K05080  growth hormone receptor
K05081  prolactin receptor
K05082  thrombopoietin receptor
K05061  granulocyte colony-stimulating factor receptor
K05062  leptin receptor
K05055  interleukin 6 receptor
K05060  interleukin 6 signal transducer
K05056  interleukin 11 receptor alpha
K05063  interleukin 12 receptor beta-1
K05064  interleukin 12 receptor beta-2
K05065  interleukin 23 receptor
K19598  interleukin 27 receptor alpha
K22630  interleukin 31 receptor subunit alpha
K05059  ciliary neurotrophic factor receptor
K05058  leukemia inhibitory factor receptor
K05057  oncostatin M receptor
K05134  interleukin 10 receptor alpha
K05135  interleukin 10 receptor beta
K05136  interleukin 20 receptor alpha
K05137  interleukin 20 receptor beta
K05138  interleukin 22 receptor alpha 1
K05140  interferon lambda receptor 1
K05130  interferon receptor 1
K05131  interferon receptor 2
K05132  interferon gamma receptor 1
K05133  interferon gamma receptor 2
K04386  interleukin 1 receptor type I
K04723  interleukin 1 receptor accessory protein
K04387  interleukin 1 receptor type II
K05172  interleukin 1 receptor-like 2
K05173  interleukin 18 receptor 1
K05174  interleukin 18 receptor accessory protein
K05171  interleukin 1 receptor-like 1
K05164  interleukin 17 receptor A
K05166  interleukin 17 receptor C
K05165  interleukin 17 receptor B
K05168  interleukin 17 receptor E
K06454  T-cell surface glycoprotein CD4
K05090  macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
K03158  tumor necrosis factor receptor superfamily member 1A
K05141  tumor necrosis factor receptor superfamily member 1B
K03159  lymphotoxin beta receptor TNFR superfamily member 3
K05152  tumor necrosis factor receptor superfamily member 14
K05143  tumor necrosis factor receptor superfamily member 6B
K04390  tumor necrosis factor receptor superfamily member 6
K05160  tumor necrosis factor receptor superfamily member 25
K04722  tumor necrosis factor receptor superfamily member 10A/B
K22701  tumor necrosis factor receptor superfamily member 10C
K22702  tumor necrosis factor receptor superfamily member 10D
K05157  tumor necrosis factor receptor superfamily member 21
K05162  tumor necrosis factor receptor superfamily member EDAR
K05163  tumor necrosis factor receptor superfamily member 27
K02583  tumor necrosis factor receptor superfamily member 16
K05148  tumor necrosis factor receptor superfamily member 11B
K05147  tumor necrosis factor receptor superfamily member 11A
K05149  tumor necrosis factor receptor superfamily member 12A
K05144  tumor necrosis factor receptor superfamily member 7
K05145  tumor necrosis factor receptor superfamily member 8
K03160  tumor necrosis factor receptor superfamily member 5
K05146  tumor necrosis factor receptor superfamily member 9
K05142  tumor necrosis factor receptor superfamily member 4
K05154  tumor necrosis factor receptor superfamily member 18
K05153  tumor necrosis factor receptor superfamily member 17
K05150  tumor necrosis factor receptor superfamily member 13B
K05151  tumor necrosis factor receptor superfamily member 13C
K05155  tumor necrosis factor receptor superfamily member 19
K05156  tumor necrosis factor receptor superfamily member 19-like
K04674  TGF-beta receptor type-1 [EC:2.7.11.30]
K04388  TGF-beta receptor type-2 [EC:2.7.11.30]
K13594  activin receptor-like kinase 1 [EC:2.7.11.30]
K04670  activin receptor type-2A [EC:2.7.11.30]
K04671  bone morphogenetic protein receptor type-2 [EC:2.7.11.30]
K13596  activin receptor type-2B [EC:2.7.11.30]
K13567  activin receptor type-1B [EC:2.7.11.30]
K13568  activin receptor type-1C [EC:2.7.11.30]
K04675  activin receptor type-1 [EC:2.7.11.30]
K04672  anti-mullerian hormone receptor type-2 [EC:2.7.11.30]
K04673  bone morphogenetic protein receptor type-1A [EC:2.7.11.30]
K13578  bone morphogenetic protein receptor type-1B [EC:2.7.11.30]
Reference
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
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