KEGG   PATHWAY: ko04114
Entry
ko04114                     Pathway                                

Name
Oocyte meiosis
Description
During meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segregate to opposite poles, while the sister chromatids segregate from each other at meoisis II. In vertebrates, immature oocytes are arrested at the PI (prophase of meiosis I). The resumption of meiosis is stimulated by progesterone, which carries the oocyte through two consecutive M-phases (MI and MII) to a second arrest at MII. The key activity driving meiotic progression is the MPF (maturation-promoting factor), a heterodimer of CDC2 (cell division cycle 2 kinase) and cyclin B. In PI-arrested oocytes, MPF is initially inactive and is activated by the dual-specificity CDC25C phosphatase as the result of new synthesis of Mos induced by progesterone. MPF activation mediates the transition from the PI arrest to MI. The subsequent decrease in MPF levels, required to exit from MI into interkinesis, is induced by a negative feedback loop, where CDC2 brings about the activation of the APC (anaphase-promoting complex), which mediates destruction of cyclin B. Re-activation of MPF for MII requires re-accumulation of high levels of cyclin B as well as the inactivation of the APC by newly synthesized Emi2 and other components of the CSF (cytostatic factor), such as cyclin E or high levels of Mos. CSF antagonizes the ubiquitin ligase activity of the APC, preventing cyclin B destruction and meiotic exit until fertilization occurs. Fertilization triggers a transient increase in cytosolic free Ca2+, which leads to CSF inactivation and cyclin B destruction through the APC. Then eggs are released from MII into the first embryonic cell cycle.
Class
Cellular Processes; Cell growth and death
Pathway map
ko04114  Oocyte meiosis
ko04114

Disease
H00574  Coffin-Lowry syndrome
H00631  Cornelia de Lange syndrome
H01274  Growth delay due to insulin-like growth factor I resistance
H02122  Chronic atrial and intestinal dysrhythmia
Drug
D02840  Altrenogest (USAN/INN)
Other DBs
GO: 0051321
Orthology
K04526  insulin
K05459  insulin-like growth factor 1
K05087  insulin-like growth factor 1 receptor [EC:2.7.10.1]
K08556  progesterone receptor
K08557  androgen receptor
K08041  adenylate cyclase 1 [EC:4.6.1.1]
K08042  adenylate cyclase 2 [EC:4.6.1.1]
K08043  adenylate cyclase 3 [EC:4.6.1.1]
K08044  adenylate cyclase 4 [EC:4.6.1.1]
K08045  adenylate cyclase 5 [EC:4.6.1.1]
K08046  adenylate cyclase 6 [EC:4.6.1.1]
K08047  adenylate cyclase 7 [EC:4.6.1.1]
K08048  adenylate cyclase 8 [EC:4.6.1.1]
K08049  adenylate cyclase 9 [EC:4.6.1.1]
K04345  protein kinase A [EC:2.7.11.11]
K11481  aurora kinase A [EC:2.7.11.1]
K02602  cytoplasmic polyadenylation element-binding protein
K04367  proto-oncogene serine/threonine-protein kinase mos [EC:2.7.11.1]
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04371  mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04373  ribosomal protein S6 kinase alpha-1/2/3/6 [EC:2.7.11.1]
K06633  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [EC:2.7.11.1]
K16197  14-3-3 protein beta/theta/zeta
K06630  14-3-3 protein epsilon
K16198  14-3-3 protein gamma/eta
K08694  speedy
K02087  cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
K02206  cyclin-dependent kinase 2 [EC:2.7.11.22]
K04441  p38 MAP kinase [EC:2.7.11.24]
K06269  serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
K08836  STE20-like kinase [EC:2.7.11.1]
K06631  polo-like kinase 1 [EC:2.7.11.21]
K05867  M-phase inducer phosphatase 3 [EC:3.1.3.48]
K21770  G2/mitotic-specific cyclin-B2
K13056  CCCH zinc finger protein C3H-4
K03868  RING-box protein 1 [EC:2.3.2.32]
K03347  cullin 1
K03094  S-phase kinase-associated protein 1
K03362  F-box and WD-40 domain protein 1/11
K10292  F-box protein 5
K03348  anaphase-promoting complex subunit 1
K03349  anaphase-promoting complex subunit 2
K03350  anaphase-promoting complex subunit 3
K03351  anaphase-promoting complex subunit 4
K03352  anaphase-promoting complex subunit 5
K03353  anaphase-promoting complex subunit 6
K03354  anaphase-promoting complex subunit 7
K03355  anaphase-promoting complex subunit 8
K03356  anaphase-promoting complex subunit 9
K03357  anaphase-promoting complex subunit 10
K03358  anaphase-promoting complex subunit 11
K03359  anaphase-promoting complex subunit 12
K12456  anaphase-promoting complex subunit 13
K03363  cell division cycle 20, cofactor of APC complex
K10318  F-box protein 43
K06635  securin
K02365  separase [EC:3.4.22.49]
K13054  meiotic recombination protein REC8, animal type
K13055  cohesin complex subunit SA-3
K06636  structural maintenance of chromosome 1
K06669  structural maintenance of chromosome 3 (chondroitin sulfate proteoglycan 6)
K05868  G2/mitotic-specific cyclin-B1
K02178  checkpoint serine/threonine-protein kinase [EC:2.7.11.1]
K02537  mitotic spindle assembly checkpoint protein MAD2
K13728  mitotic spindle assembly checkpoint protein MAD2B
K06679  mitotic spindle assembly checkpoint protein MAD1
K06626  G1/S-specific cyclin-E1
K11580  shugoshin-like 1
K11584  serine/threonine-protein phosphatase 2A regulatory subunit B'
K03456  serine/threonine-protein phosphatase 2A regulatory subunit A
K04382  serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
K05861  phosphatidylinositol phospholipase C, zeta [EC:3.1.4.11]
K04958  inositol 1,4,5-triphosphate receptor type 1
K04959  inositol 1,4,5-triphosphate receptor type 2
K04960  inositol 1,4,5-triphosphate receptor type 3
K02183  calmodulin
K04348  serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]
K06268  serine/threonine-protein phosphatase 2B regulatory subunit
K04515  calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
Compound
C00076  Calcium cation
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
  Authors
Haccard O, Jessus C
  Title
Oocyte maturation, Mos and cyclins--a matter of synthesis: two functionally redundant ways to induce meiotic maturation.
  Journal
Cell Cycle 5:1152-9 (2006)
DOI:10.4161/cc.5.11.2800
Reference
  Authors
Crane R, Gadea B, Littlepage L, Wu H, Ruderman JV
  Title
Aurora A, meiosis and mitosis.
  Journal
Biol Cell 96:215-29 (2004)
DOI:10.1016/j.biolcel.2003.09.008
Reference
  Authors
Perdiguero E, Nebreda AR
  Title
Regulation of Cdc25C activity during the meiotic G2/M transition.
  Journal
Cell Cycle 3:733-7 (2004)
DOI:10.4161/cc.3.6.906
Reference
  Authors
Perry JA, Kornbluth S
  Title
Cdc25 and Wee1: analogous opposites?
  Journal
Cell Div 2:12 (2007)
DOI:10.1186/1747-1028-2-12
Reference
  Authors
Jessus C, Ozon R
  Title
How does Xenopus oocyte acquire its competence to undergo meiotic maturation?
  Journal
Biol Cell 96:187-92 (2004)
DOI:10.1016/j.biolcel.2003.12.007
Reference
  Authors
Revenkova E, Jessberger R
  Title
Shaping meiotic prophase chromosomes: cohesins and synaptonemal complex proteins.
  Journal
Chromosoma 115:235-40 (2006)
DOI:10.1007/s00412-006-0060-x
Reference
  Authors
Belloc E, Pique M, Mendez R
  Title
Sequential waves of polyadenylation and deadenylation define a translation circuit that drives meiotic progression.
  Journal
Biochem Soc Trans 36:665-70 (2008)
DOI:10.1042/BST0360665
Reference
  Authors
Pesin JA, Orr-Weaver TL
  Title
Regulation of APC/C activators in mitosis and meiosis.
  Journal
Annu Rev Cell Dev Biol 24:475-99 (2008)
DOI:10.1146/annurev.cellbio.041408.115949
Reference
  Authors
Tang W, Wu JQ, Guo Y, Hansen DV, Perry JA, Freel CD, Nutt L, Jackson PK, Kornbluth S
  Title
Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition.
  Journal
Mol Biol Cell 19:3536-43 (2008)
DOI:10.1091/mbc.E08-04-0417
Reference
  Authors
Wu JQ, Kornbluth S
  Title
Across the meiotic divide - CSF activity in the post-Emi2/XErp1 era.
  Journal
J Cell Sci 121:3509-14 (2008)
DOI:10.1242/jcs.036855
Reference
  Authors
Schmidt A, Rauh NR, Nigg EA, Mayer TU
  Title
Cytostatic factor: an activity that puts the cell cycle on hold.
  Journal
J Cell Sci 119:1213-8 (2006)
DOI:10.1242/jcs.02919
Reference
  Authors
Vogt E, Kirsch-Volders M, Parry J, Eichenlaub-Ritter U
  Title
Spindle formation, chromosome segregation and the spindle checkpoint in mammalian oocytes and susceptibility to meiotic error.
  Journal
Mutat Res 651:14-29 (2008)
DOI:10.1016/j.mrgentox.2007.10.015
Reference
  Authors
Perry AC, Verlhac MH
  Title
Second meiotic arrest and exit in frogs and mice.
  Journal
EMBO Rep 9:246-51 (2008)
DOI:10.1038/embor.2008.22
Reference
  Authors
Tunquist BJ, Eyers PA, Chen LG, Lewellyn AL, Maller JL
  Title
Spindle checkpoint proteins Mad1 and Mad2 are required for cytostatic factor-mediated metaphase arrest.
  Journal
J Cell Biol 163:1231-42 (2003)
DOI:10.1083/jcb.200306153
Reference
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Related
pathway
ko04010  MAPK signaling pathway
ko04120  Ubiquitin mediated proteolysis
ko04914  Progesterone-mediated oocyte maturation
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