KEGG   PATHWAY: ko04150Help
ko04150                     Pathway                                

mTOR signaling pathway
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Environmental Information Processing; Signal transduction
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Pathway map
ko04150  mTOR signaling pathway

Ortholog table
H00666  Peutz-Jeghers syndrome
H00896  Lymphangioleiomyomatosis
H00915  Tuberous sclerosis complex
H01112  Polyhydramnios, megalencephaly, and symptomatic epilepsy
H01251  Focal cortical dysplasia of Taylor
H01691  Renal angiomyolipoma
H01692  Subependymal giant cell astrocytoma
H01885  Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome
H01909  Hypoinsulinemic hypoglycemia with hemihypertrophy
H01912  Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi
H01928  Smith-Kingsmore syndrome
H02111  Autism
H02119  Proteus syndrome
H02153  Megalencephaly-capillary malformation syndrome
H02214  Familial focal epilepsy with variable foci
H02219  DDOD syndrome
K13780  solute carrier family 7 (L-type amino acid transporter), member 5
K06519  solute carrier family 3, member 2
K14995  solute carrier family 38 (sodium-coupled neutral amino acid transporter), member 9
K02145  V-type H+-transporting ATPase subunit A [EC:]
K02147  V-type H+-transporting ATPase subunit B
K02148  V-type H+-transporting ATPase subunit C
K02149  V-type H+-transporting ATPase subunit D
K02150  V-type H+-transporting ATPase subunit E
K02151  V-type H+-transporting ATPase subunit F
K02152  V-type H+-transporting ATPase subunit G
K02144  V-type H+-transporting ATPase subunit H
K20397  ragulator complex protein LAMTOR1
K20398  ragulator complex protein LAMTOR2
K04370  ragulator complex protein LAMTOR3
K20399  ragulator complex protein LAMTOR4
K16344  ragulator complex protein LAMTOR5
K09594  folliculin
K20400  folliculin-interacting protein 1
K20401  folliculin-interacting protein 2
K16185  Ras-related GTP-binding protein A/B
K16186  Ras-related GTP-binding protein C/D
K07204  regulatory associated protein of mTOR
K16184  proline-rich AKT1 substrate 1
K07203  serine/threonine-protein kinase mTOR [EC:]
K20402  DEP domain-containing mTOR-interacting protein
K08266  target of rapamycin complex subunit LST8
K11137  telomere length regulation protein
K20403  TELO2-interacting protein 1
K10421  CAP-Gly domain-containing linker protein 1
K20064  growth factor receptor-bound protein 10
K21357  serine/threonine-protein kinase ULK1 [EC:]
K08269  serine/threonine-protein kinase ULK2 [EC:]
K07205  eukaryotic translation initiation factor 4E binding protein 1
K03259  translation initiation factor 4E
K04688  ribosomal protein S6 kinase beta [EC:]
K03258  translation initiation factor 4B
K02991  small subunit ribosomal protein S6e
K15705  E3 ubiquitin-protein ligase RNF152 [EC:]
K03875  F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
K20404  DEP domain-containing protein 5
K20405  nitrogen permease regulator 2-like protein
K20406  nitrogen permease regulator 3-like protein
K20407  WD repeat-containing protein mio
K14299  nucleoporin SEH1
K20408  WD repeat-containing protein 24
K20409  WD repeat-containing protein 59
K14004  protein transport protein SEC13
K20394  sestrin 2
K08271  STE20-related kinase adapter protein alpha
K17532  STE20-related kinase adapter protein beta
K07298  serine/threonine-protein kinase 11 [EC:]
K08272  calcium binding protein 39
K07198  5'-AMP-activated protein kinase, catalytic alpha subunit [EC:]
K07206  tuberous sclerosis 1
K07207  tuberous sclerosis 2
K20396  TBC1 domain family member 7
K07208  Ras homolog enriched in brain
K08270  DNA-damage-inducible transcript 4
K03209  wingless-type MMTV integration site family, member 1
K00182  wingless-type MMTV integration site family, member 2
K00312  wingless-type MMTV integration site family, member 3
K00408  wingless-type MMTV integration site family, member 4
K00444  wingless-type MMTV integration site family, member 5
K00445  wingless-type MMTV integration site family, member 6
K00572  wingless-type MMTV integration site family, member 7
K00714  wingless-type MMTV integration site family, member 8
K01064  wingless-type MMTV integration site family, member 9
K01357  wingless-type MMTV integration site family, member 10
K01384  wingless-type MMTV integration site family, member 11
K01558  wingless-type MMTV integration site family, member 16
K02432  frizzled 1/7
K02235  frizzled 2
K02329  frizzled 3
K02354  frizzled 4
K02375  frizzled 5/8
K02376  frizzled 6
K02842  frizzled 9/10
K04690  frizzled
K03068  low density lipoprotein receptor-related protein 5/6
K02353  segment polarity protein dishevelled
K03083  glycogen synthase kinase 3 beta [EC:]
K03156  tumor necrosis factor superfamily, member 2
K03158  tumor necrosis factor receptor superfamily member 1A
K07209  inhibitor of nuclear factor kappa-B kinase subunit beta [EC:]
K04526  insulin
K05459  insulin-like growth factor 1
K04527  insulin receptor [EC:]
K05087  insulin-like growth factor 1 receptor [EC:]
K04364  growth factor receptor-binding protein 2
K03099  son of sevenless
K02833  GTPase HRas
K07827  GTPase KRas
K07828  GTPase NRas
K04365  B-Raf proto-oncogene serine/threonine-protein kinase [EC:]
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:]
K04368  mitogen-activated protein kinase kinase 1 [EC:]
K04369  mitogen-activated protein kinase kinase 2 [EC:]
K04371  mitogen-activated protein kinase 1/3 [EC:]
K04373  ribosomal protein S6 kinase alpha-1/2/3/6 [EC:]
K16172  insulin receptor substrate 1
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:]
K01110  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:]
K06276  3-phosphoinositide dependent protein kinase-1 [EC:]
K04456  RAC serine/threonine-protein kinase [EC:]
K04467  inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:]
K20410  target of rapamycin complex 2 subunit MAPKAP1
K08267  rapamycin-insensitive companion of mTOR
K20411  proline-rich protein 5
K04513  Ras homolog gene family, member A
K02677  classical protein kinase C alpha type [EC:]
K19662  classical protein kinase C beta type [EC:]
K19663  classical protein kinase C gamma type [EC:]
K13302  serum/glucocorticoid-regulated kinase 1 [EC:]
C00020  AMP
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Kennedy BK, Lamming DW
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
Cell Metab 23:990-1003 (2016)
Shimobayashi M, Hall MN
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
Nat Rev Mol Cell Biol 15:155-62 (2014)
Huang K, Fingar DC
Growing knowledge of the mTOR signaling network.
Semin Cell Dev Biol 36:79-90 (2014)
Bockaert J, Marin P
mTOR in Brain Physiology and Pathologies.
Physiol Rev 95:1157-87 (2015)
Caron A, Richard D, Laplante M
The Roles of mTOR Complexes in Lipid Metabolism.
Annu Rev Nutr 35:321-48 (2015)
Shimobayashi M, Hall MN
Multiple amino acid sensing inputs to mTORC1.
Cell Res 26:7-20 (2016)
Bar-Peled L, Sabatini DM
Regulation of mTORC1 by amino acids.
Trends Cell Biol 24:400-6 (2014)
Fingar DC
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
Mol Cell 58:713-5 (2015)
Cai H, Dong LQ, Liu F
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
Trends Pharmacol Sci 37:303-17 (2016)
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
Br J Haematol 166:336-51 (2014)
Jewell JL, Guan KL
Nutrient signaling to mTOR and cell growth.
Trends Biochem Sci 38:233-42 (2013)
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
ASN Neuro 5:e00108 (2013)
Kim SG, Buel GR, Blenis J
Nutrient regulation of the mTOR complex 1 signaling pathway.
Mol Cells 35:463-73 (2013)
Laplante M, Sabatini DM
mTOR signaling at a glance.
J Cell Sci 122:3589-94 (2009)
Alessi DR, Sakamoto K, Bayascas JR
LKB1-dependent signaling pathways.
Annu Rev Biochem 75:137-63 (2006)
Dan HC, Antonia RJ, Baldwin AS
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
Oncotarget 7:21064-75 (2016)
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