KEGG   PATHWAY: ko04341
Entry
ko04341                     Pathway                                

Name
Hedgehog signaling pathway - fly
Description
Hedgehog (Hh) signaling plays essential roles in embryonic development and adult tissue homeostasis. It is first elucidated by genetic studies in Drosophila and the core of the Hh signaling pathway is conserved in evolution. The Hh signaling components include an important complex composed of Cos2, Fu, SuFu and Ci. In the absence of Hh, Ptc inhibits Smo and the complex promotes the formation of the Ci's repressor form CiR. In the presentation of Hh, binding Hh to Ptc relieves Smo repression, which results in Ci's activation and then the increased transcription of Hh target genes in the nucleus.
Class
Environmental Information Processing; Signal transduction
Pathway map
ko04341  Hedgehog signaling pathway - fly
ko04341

Orthology
K06225  patched 1
K06226  smoothened
K06227  costal 2
K06228  fused [EC:2.7.11.1]
K04345  protein kinase A [EC:2.7.11.11]
K08957  casein kinase 1, alpha [EC:2.7.11.1]
K08958  casein kinase 1, gamma [EC:2.7.11.1]
K08960  casein kinase 1, epsilon [EC:2.7.11.1]
K03083  glycogen synthase kinase 3 beta [EC:2.7.11.26]
K16799  transcriptional activator cubitus interruptus
K06229  suppressor of fused
K03362  F-box and WD-40 domain protein 1/11
K03347  cullin 1
K03094  S-phase kinase-associated protein 1
K03868  E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
K10523  speckle-type POZ protein
K04662  bone morphogenetic protein 4
K09319  homeobox protein engrailed
K06224  hedgehog
K20244  interference hedgohog
K20245  brother of ihog
K04678  E3 ubiquitin ligase SMURF1/2 [EC:2.3.2.26]
K08291  G protein-coupled receptor kinase [EC:2.7.11.16]
K03869  cullin 3
Reference
  Authors
Wilson CW, Chuang PT
  Title
Mechanism and evolution of cytosolic Hedgehog signal transduction.
  Journal
Development 137:2079-94 (2010)
DOI:10.1242/dev.045021
Reference
  Authors
Briscoe J, Therond PP
  Title
The mechanisms of Hedgehog signalling and its roles in development and disease.
  Journal
Nat Rev Mol Cell Biol 14:416-29 (2013)
DOI:10.1038/nrm3598
Reference
  Authors
Aikin RA, Ayers KL, Therond PP
  Title
The role of kinases in the Hedgehog signalling pathway.
  Journal
EMBO Rep 9:330-6 (2008)
DOI:10.1038/embor.2008.38
Reference
  Authors
Ingham PW, Nakano Y, Seger C
  Title
Mechanisms and functions of Hedgehog signalling across the metazoa.
  Journal
Nat Rev Genet 12:393-406 (2011)
DOI:10.1038/nrg2984
Reference
  Authors
Jiang J
  Title
Regulation of Hh/Gli signaling by dual ubiquitin pathways.
  Journal
Cell Cycle 5:2457-63 (2006)
DOI:10.4161/cc.5.21.3406
Reference
  Authors
Hsia EY, Gui Y, Zheng X
  Title
Regulation of Hedgehog signaling by ubiquitination.
  Journal
Front Biol (Beijing) 10:203-220 (2015)
DOI:10.1007/s11515-015-1343-5
Reference
  Authors
Zhang Q, Zhang L, Wang B, Ou CY, Chien CT, Jiang J
  Title
A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor.
  Journal
Dev Cell 10:719-29 (2006)
DOI:10.1016/j.devcel.2006.05.004
Reference
  Authors
Zhou Z, Xu C, Chen P, Liu C, Pang S, Yao X, Zhang Q
  Title
Stability of HIB-Cul3 E3 ligase adaptor HIB Is Regulated by Self-degradation and Availability of Its Substrates.
  Journal
Sci Rep 5:12709 (2015)
DOI:10.1038/srep12709
Related
pathway
ko04120  Ubiquitin mediated proteolysis
ko04340  Hedgehog signaling pathway
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