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ko04640                     Pathway                                

Hematopoietic cell lineage
Blood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid progenitor (CLP) or a common myeloid progenitor (CMP). A CLP gives rise to the lymphoid lineage of white blood cells or leukocytes-the natural killer (NK) cells and the T and B lymphocytes. A CMP gives rise to the myeloid lineage, which comprises the rest of the leukocytes, the erythrocytes (red blood cells), and the megakaryocytes that produce platelets important in blood clotting. Cells undergoing these differentiation process express a stage- and lineage-specific set of surface markers. Therefore cellular stages are identified by the specific expression patterns of these genes.
Organismal Systems; Immune system
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Pathway map
ko04640  Hematopoietic cell lineage

Ortholog table
H00219  Hemophilia
H00224  Bernard-Soulier syndrome
H01479  Castleman disease
K05461  KIT ligand
K05431  interleukin 7
K05430  interleukin 4
K05427  granulocyte-macrophage colony-stimulating factor
K05454  fms-related tyrosine kinase 3 ligand
K05428  interleukin 5
K05423  granulocyte colony-stimulating factor
K04736  interleukin 3
K05405  interleukin 6
K05417  interleukin 11
K04383  interleukin 1 alpha
K04519  interleukin 1 beta
K03156  tumor necrosis factor superfamily, member 2
K05453  macrophage colony-stimulating factor 1
K05437  erythropoietin
K06854  thrombopoietin
K06474  CD34 antigen
K05092  fms-related tyrosine kinase 3 [EC:]
K00977  DNA nucleotidylexotransferase [EC:]
K06752  major histocompatibility complex, class II
K06256  CD44 antigen
K05091  proto-oncogene tyrosine-protein kinase Kit [EC:]
K05068  interleukin 2 receptor alpha
K05072  interleukin 7 receptor
K06503  transferrin receptor
K01242  ADP-ribosyl cyclase 1 [EC:]
K06457  T-cell surface glycoprotein CD7
K06449  T-cell surface glycoprotein CD2
K06455  T-cell surface glycoprotein CD5
K06448  T-cell surface glycoprotein CD1
K06454  T-cell surface glycoprotein CD4
K06458  T-cell surface glycoprotein CD8 alpha chain
K06459  T-cell surface glycoprotein CD8 beta chain
K06450  T-cell surface glycoprotein CD3 delta chain
K06451  T-cell surface glycoprotein CD3 epsilon chain
K06452  T-cell surface glycoprotein CD3 gamma chain
K01389  neprilysin [EC:]
K06460  CD9 antigen
K06465  B-lymphocyte antigen CD19
K06467  CD22 antigen
K06469  CD24 antigen
K06466  B-lymphocyte antigen CD20
K04012  complement receptor type 2
K06475  CD37 antigen
K06856  immunoglobulin heavy chain
K06468  low affinity immunoglobulin epsilon Fc receptor
K04011  complement component (3b/4b) receptor 1
K05066  granulocyte-macrophage colony-stimulating factor receptor alpha
K04737  interleukin 3 receptor alpha
K06473  CD33 antigen
K05071  interleukin 4 receptor
K05055  interleukin 6 receptor
K06498  high affinity immunoglobulin gamma Fc receptor I
K05090  macrophage colony-stimulating factor 1 receptor [EC:]
K11140  aminopeptidase N [EC:]
K06461  integrin alpha M
K04391  monocyte differentiation antigen CD14
K05073  interleukin 9 receptor
K04386  interleukin 1 receptor type I
K04387  interleukin 1 receptor type II
K05061  granulocyte colony-stimulating factor receptor
K05067  interleukin 5 receptor alpha
K05079  erythropoietin receptor
K06259  CD36 antigen
K06575  glycophorin A
K04006  decay accelerating factor
K04008  CD59 antigen
K05056  interleukin 11 receptor alpha
K06493  integrin beta 3
K06476  integrin alpha 2B
K06263  platelet glycoprotein IX
K06261  platelet glycoprotein Ib alpha chain
K06262  platelet glycoprotein Ib beta chain
K06260  platelet glycoprotein V
K06480  integrin alpha 1
K06481  integrin alpha 2
K06482  integrin alpha 3
K06483  integrin alpha 4
K06484  integrin alpha 5
K06485  integrin alpha 6
Janeway CA Jr, Travers P, Walport M, Shlomchik MJ
Immunobiology - International editon: The immune system in health and disease
Harcourt Publishers Ltd, a subsidiary of Harcourt International Ltd (2001)
Abe T
[Atlas of malignancies in hematopoietic organ - Morphology, immunology, chromosome and gene] (Japanese)
Nihonijishinhousya (2000)
Rothenberg EV, Taghon T.
Molecular genetics of T cell development.
Annu Rev Immunol 23:601-49 (2005)
Ceredig R, Rolink T.
A positive look at double-negative thymocytes.
Nat Rev Immunol 2:888-97 (2002)
de Bruijn MF, Speck NA.
Core-binding factors in hematopoiesis and immune function.
Oncogene 23:4238-48 (2004)
Radtke F, Wilson A, Mancini SJ, MacDonald HR.
Notch regulation of lymphocyte development and function.
Nat Immunol 5:247-53 (2004)
Spits H.
Development of alphabeta T cells in the human thymus.
Nat Rev Immunol 2:760-72 (2002)
Di Santo JP, Aifantis I, Rosmaraki E, Garcia C, Feinberg J, Fehling HJ, Fischer A, von Boehmer H, Rocha B.
The common cytokine receptor gamma chain and the pre-T cell receptor provide independent but critically overlapping signals in early alpha/beta T cell development.
J Exp Med 189:563-74 (1999)
Mak TW, Penninger JM, Ohashi PS.
Knockout mice: a paradigm shift in modern immunology.
Nat Rev Immunol 1:11-9 (2001)
Shapiro-Shelef M, Calame K.
Regulation of plasma-cell development.
Nat Rev Immunol 5:230-42 (2005)
Maillard I, Adler SH, Pear WS.
Notch and the immune system.
Immunity 19:781-91 (2003)
Alpdogan O, van den Brink MR.
IL-7 and IL-15: therapeutic cytokines for immunodeficiency.
Trends Immunol 26:56-64 (2005)
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