KEGG   PATHWAY: ko04664
Entry
ko04664                     Pathway                                

Name
Fc epsilon RI signaling pathway
Description
Fc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation pathways are regulated both positively and negatively by the interactions of numerous signaling molecules. Mast cells that are thus activated release preformed granules which contain biogenic amines (especially histamines) and proteoglycans (especially heparin). The activation of phospholipase A2 causes the release of membrane lipids followed by development of lipid mediators such as leukotrienes (LTC4, LTD4 and LTE4) and prostaglandins (especially PDG2). There is also secretion of cytokines, the most important of which are TNF-alpha, IL-4 and IL-5. These mediators and cytokines contribute to inflammatory responses.
Class
Organismal Systems; Immune system
Pathway map
ko04664  Fc epsilon RI signaling pathway
ko04664

Disease
H01387  Activated PI3K-delta syndrome
Other DBs
GO: 0045576
Orthology
K06856  immunoglobulin heavy chain
K08089  high affinity immunoglobulin epsilon receptor subunit alpha
K08090  high affinity immunoglobulin epsilon receptor subunit beta
K07983  high affinity immunoglobulin epsilon receptor subunit gamma
K05855  spleen tyrosine kinase [EC:2.7.10.2]
K05854  tyrosine-protein kinase Lyn [EC:2.7.10.2]
K07370  Bruton agammaglobulinemia tyrosine kinase [EC:2.7.10.2]
K03084  phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 [EC:3.1.3.86]
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
K05859  phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
K02677  classical protein kinase C alpha type [EC:2.7.11.13]
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K06276  3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04392  Ras-related C3 botulinum toxin substrate 1
K07860  Ras-related C3 botulinum toxin substrate 2
K07861  Ras-related C3 botulinum toxin substrate 3
K04430  mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
K04431  mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]
K04432  mitogen-activated protein kinase kinase 3 [EC:2.7.12.2]
K04433  mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]
K04440  mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04441  p38 MAP kinase [EC:2.7.11.24]
K05430  interleukin 4
K05435  interleukin 13
K04736  interleukin 3
K05428  interleukin 5
K05427  granulocyte-macrophage colony-stimulating factor
K03156  tumor necrosis factor superfamily, member 2
K07361  lymphocyte cytosolic protein 2
K05730  guanine nucleotide exchange factor VAV
K05703  tyrosine-protein kinase Fyn [EC:2.7.10.2]
K08091  GRB2-associated-binding protein 2
K07362  linker for activation of T cells
K04364  growth factor receptor-bound protein 2
K03099  son of sevenless
K02833  GTPase HRas
K07827  GTPase KRas
K07828  GTPase NRas
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369  mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371  mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K16342  cytosolic phospholipase A2 [EC:3.1.1.4]
K00461  arachidonate 5-lipoxygenase [EC:1.13.11.34]
K20735  arachidonate 5-lipoxygenase-activating protein
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00374  Heparin
C00388  Histamine
C00696  Prostaglandin D2
C01245  D-myo-Inositol 1,4,5-trisphosphate
C02166  Leukotriene C4
C05951  Leukotriene D4
C05952  Leukotriene E4
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Kawakami T, Galli SJ.
  Title
Regulation of mast-cell and basophil function and survival by IgE.
  Journal
Nat Rev Immunol 2:773-86 (2002)
DOI:10.1038/nri914
Reference
  Authors
Siraganian RP.
  Title
Mast cell signal transduction from the high-affinity IgE receptor.
  Journal
Curr Opin Immunol 15:639-46 (2003)
DOI:10.1016/j.coi.2003.09.010
Reference
  Authors
Janeway CA, Travers P, Walport M, Shlomchik MJ.
  Title
Immunobiology 6th edition
  Journal
Garland Science Publishing (2005)
Reference
  Authors
Turner H, Kinet JP.
  Title
Signalling through the high-affinity IgE receptor Fc epsilonRI.
  Journal
Nature 402:B24-30 (1999)
DOI:10.1038/35037021
Reference
  Authors
Gilfillan AM, Tkaczyk C.
  Title
Integrated signalling pathways for mast-cell activation.
  Journal
Nat Rev Immunol 6:218-30 (2006)
DOI:10.1038/nri1782
Reference
  Authors
Nadler MJ, Matthews SA, Turner H, Kinet JP.
  Title
Signal transduction by the high-affinity immunoglobulin E receptor Fc epsilon RI: coupling form to function.
  Journal
Adv Immunol 76:325-55 (2000)
DOI:10.1016/S0065-2776(01)76022-1
Reference
  Authors
Gu H, Saito K, Klaman LD, Shen J, Fleming T, Wang Y, Pratt JC, Lin G, Lim B, Kinet JP, Neel BG.
  Title
Essential role for Gab2 in the allergic response.
  Journal
Nature 412:186-90 (2001)
DOI:10.1038/35084076
Reference
  Authors
Nadler MJ, Kinet JP.
  Title
Uncovering new complexities in mast cell signaling.
  Journal
Nat Immunol 3:707-8 (2002)
DOI:10.1038/ni0802-707
Related
pathway
ko00590  Arachidonic acid metabolism
ko04010  MAPK signaling pathway
ko04070  Phosphatidylinositol signaling system
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