KEGG   PATHWAY: ko04672Help
Entry
ko04672                     Pathway                                

Name
Intestinal immune network for IgA production
Description
The intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies that serve as the first line of defense against microorganisms. The basic map of IgA production includes induction of mucosal B cells in the Peyer's patches, circulation through the bloodstream and homing to intestinal mucosa of IgA-commited plasma cells, and local antibody production for export across the intestinal membranes. Multiple cytokines, including TGF-{beta}, IL-10, IL-4, IL-5, and IL-6, are required to promote IgA class switching and terminal differentiation process of the B cells. Secreted IgA promotes immune exclusion by entrapping dietary antigens and microorganisms in the mucus and functions for neutralization of toxins and pathogenic microbes.
Class
Organismal Systems; Immune system
BRITE hierarchy
Pathway map
ko04672  Intestinal immune network for IgA production
ko04672

Ortholog table
Other DBs
BSID: 128670
GO: 0002387
Orthology
K05412  CD80 antigen
K05413  CD86 antigen
K06752  major histocompatibility complex, class II
K06470  CD28 antigen
K10784  T cell receptor alpha chain V region
K10785  T-cell receptor beta chain V region
K05429  interleukin 2
K05430  interleukin 4
K05428  interleukin 5
K05405  interleukin 6
K05443  interleukin 10
K13375  transforming growth factor beta-1
K05475  tumor necrosis factor ligand superfamily member 13
K05476  tumor necrosis factor ligand superfamily member 13B
K05150  tumor necrosis factor receptor superfamily member 13B
K05153  tumor necrosis factor receptor superfamily member 17
K05151  tumor necrosis factor receptor superfamily member 13C
K06856  immunoglobulin heavy chain
K10989  activation-induced cytidine deaminase [EC:3.5.4.38]
K03160  tumor necrosis factor receptor superfamily member 5
K03161  tumor necrosis factor ligand superfamily member 5
K06713  inducible T-cell co-stimulator
K06710  inducible T-cell co-stimulator ligand
K04184  C-C chemokine receptor type 9
K06483  integrin alpha 4
K06590  integrin beta 7
K10031  C-X-C motif chemokine 12
K04189  C-X-C chemokine receptor type 4
K05513  C-C motif chemokine 28
K04185  C-C chemokine receptor type 10
K13072  C-C motif chemokine 25
K06779  mucosal vascular addressin cell adhesion molecule 1
K03159  lymphotoxin beta receptor TNFR superfamily member 3
K04466  mitogen-activated protein kinase kinase kinase 14 [EC:2.7.11.25]
K05433  interleukin 15
K05074  interleukin 15 receptor alpha
K13073  polymeric immunoglobulin receptor
Compound
C00777  Retinoate
C15493  9-cis-Retinoic acid
Reference
  Authors
Fagarasan S, Honjo T
  Title
Intestinal IgA synthesis: regulation of front-line body defences.
  Journal
Nat Rev Immunol 3:63-72 (2003)
DOI:10.1038/nri982
Reference
  Authors
Macpherson AJ, McCoy KD, Johansen FE, Brandtzaeg P
  Title
The immune geography of IgA induction and function.
  Journal
Mucosal Immunol 1:11-22 (2008)
DOI:10.1038/mi.2007.6
Reference
  Authors
Kunisawa J, Kiyono H
  Title
A marvel of mucosal T cells and secretory antibodies for the creation of first lines of defense.
  Journal
Cell Mol Life Sci 62:1308-21 (2005)
DOI:10.1007/s00018-005-5035-1
Reference
  Authors
Cerutti A, Rescigno M
  Title
The biology of intestinal immunoglobulin A responses.
  Journal
Immunity 28:740-50 (2008)
DOI:10.1016/j.immuni.2008.05.001
Reference
  Authors
Tsuji M, Suzuki K, Kinoshita K, Fagarasan S
  Title
Dynamic interactions between bacteria and immune cells leading to intestinal IgA synthesis.
  Journal
Semin Immunol 20:59-66 (2008)
DOI:10.1016/j.smim.2007.12.003
Reference
  Authors
Corthesy B
  Title
Roundtrip ticket for secretory IgA: role in mucosal homeostasis?
  Journal
J Immunol 178:27-32 (2007)
DOI:10.4049/jimmunol.178.1.27
Reference
  Authors
Suzuki K, Fagarasan S
  Title
How host-bacterial interactions lead to IgA synthesis in the gut.
  Journal
Trends Immunol 29:523-31 (2008)
DOI:10.1016/j.it.2008.08.001
Reference
  Authors
Mora JR, von Andrian UH
  Title
Differentiation and homing of IgA-secreting cells.
  Journal
Mucosal Immunol 1:96-109 (2008)
DOI:10.1038/mi.2007.14
Reference
  Authors
Suzuki K, Ha SA, Tsuji M, Fagarasan S
  Title
Intestinal IgA synthesis: a primitive form of adaptive immunity that regulates microbial communities in the gut.
  Journal
Semin Immunol 19:127-35 (2007)
DOI:10.1016/j.smim.2006.10.001
Reference
  Authors
Cerutti A
  Title
The regulation of IgA class switching.
  Journal
Nat Rev Immunol 8:421-34 (2008)
DOI:10.1038/nri2322
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