KEGG   PATHWAY: ko05152Help
Entry
ko05152                     Pathway                                

Name
Tuberculosis
Description
Tuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent infections, and about 10% of latent infections develop active diseases when their immune system is impaired due to the age, other diseases such as AIDS or exposure to immunosuppressive drugs. TB is transmitted through the air and primarily attacks the lungs, then it can spread by the circulatory system to other parts of body. Once TB bacilli have entered the host by the respiratory route and infected macrophages in the lungs, they interfere with phagosomal maturation, antigen presentation, apoptosis and host immune system to establish persistent or latent infection.
Class
Human Diseases; Infectious diseases: Bacterial
BRITE hierarchy
Pathway map
ko05152  Tuberculosis
ko05152

Ortholog table
Disease
H00342  Tuberculosis
Orthology
K03156  tumor necrosis factor superfamily, member 2
K03158  tumor necrosis factor receptor superfamily member 1A
K03171  tumor necrosis factor receptor type 1-associated DEATH domain protein
K02373  FAS-associated death domain protein
K04398  caspase 8 [EC:3.4.22.61]
K04400  caspase 10 [EC:3.4.22.63]
K02187  caspase 3 [EC:3.4.22.56]
K04726  BH3 interacting domain death agonist
K02159  apoptosis regulator BAX
K08738  cytochrome c
K04399  caspase 9 [EC:3.4.22.62]
K02084  apoptotic protease-activating factor
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
K02158  Bcl-2-antagonist of cell death
K02161  apoptosis regulator Bcl-2
K04515  calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
K04687  interferon gamma
K05132  interferon gamma receptor 1
K05133  interferon gamma receptor 2
K11217  Janus kinase 1 [EC:2.7.10.2]
K04447  Janus kinase 2 [EC:2.7.10.2]
K11220  signal transducer and activator of transcription 1
K08060  class II, major histocompatibility complex, transactivator
K08061  regulatory factor X 5
K08062  regulatory factor X-associated ankyrin-containing protein
K08063  regulatory factor X-associated protein
K08064  nuclear transcription factor Y, alpha
K08065  nuclear transcription Y subunit beta
K08066  nuclear transcription factor Y, gamma
K05870  cyclic AMP-responsive element-binding protein 1
K06752  major histocompatibility complex, class II
K06505  CD74 antigen
K04498  E1A/CREB-binding protein [EC:2.3.1.48]
K05443  interleukin 10
K05134  interleukin 10 receptor alpha
K05135  interleukin 10 receptor beta
K01368  cathepsin S [EC:3.4.22.27]
K10059  C-type lectin domain family 4 member E
K07983  high affinity immunoglobulin epsilon receptor subunit gamma
K10074  C-type lectin domain family 7 member A
K05704  tyrosine-protein kinase Src [EC:2.7.10.2]
K05855  spleen tyrosine kinase [EC:2.7.10.2]
K12794  caspase recruitment domain-containing protein 9
K07369  mucosa-associated lymphoid tissue lymphoma translocation protein 1 [EC:3.4.22.-]
K07368  B-cell CLL/lymphoma 10
K14952  UDP-MurNAc hydroxylase
K10165  nucleotide-binding oligomerization domain-containing protein 2
K08846  receptor-interacting serine/threonine-protein kinase 2 [EC:2.7.11.1]
K14953  ipoprotein LpqH
K14954  lipoprotein LprG
K14955  lipoprotein LprA
K02040  phosphate transport system substrate-binding protein
K04043  molecular chaperone DnaK
K04077  chaperonin GroEL
K14956  6 kDa early secretory antigenic target
K05399  lipopolysaccharide-binding protein
K10159  toll-like receptor 2
K05398  toll-like receptor 1
K10169  toll-like receptor 6
K10160  toll-like receptor 4
K04391  monocyte differentiation antigen CD14
K05403  toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
K04729  myeloid differentiation primary response protein MyD88
K04733  interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]
K04730  interleukin-1 receptor-associated kinase 1 [EC:2.7.11.1]
K04731  interleukin-1 receptor-associated kinase 2 [EC:2.7.11.1]
K03175  TNF receptor-associated factor 6 [EC:2.3.2.27]
K02580  nuclear factor NF-kappa-B p105 subunit
K04735  transcription factor p65
K04441  p38 MAP kinase [EC:2.7.11.24]
K04371  mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04440  mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K13241  nitric-oxide synthase, inducible [EC:1.14.13.39]
K05405  interleukin 6
K05406  interleukin 12A
K05425  interleukin 12B
K05482  interleukin 18
K05426  interleukin 23 subunit alpha
K04383  interleukin 1 alpha
K04519  interleukin 1 beta
K10048  CCAAT/enhancer binding protein (C/EBP), beta
K10049  CCAAT/enhancer binding protein (C/EBP), gamma
K10161  toll-like receptor 9
K05414  interferon alpha
K05415  interferon beta
K06563  C-type lectin domain family 4 member M
K07532  Rho guanine nucleotide exchange factor 12
K04513  Ras homolog gene family, member A
K14957  lymphocyte-specific protein 1
K08862  polo-like kinase 3 [EC:2.7.11.21]
K14958  kinase suppressor of Ras 1
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K13375  transforming growth factor beta-1
K13376  transforming growth factor beta-2
K13377  transforming growth factor beta-3
K07438  calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase) [EC:1.14.15.18]
K08539  vitamin D3 receptor
K13916  cathelicidin antimicrobial peptide
K03990  complement component 3
K04011  complement component (3b/4b) receptor 1
K06462  integrin alpha X
K06464  integrin beta 2
K06461  integrin alpha M
K06560  mannose receptor, C type
K04718  sphingosine kinase [EC:2.7.1.91]
K02183  calmodulin
K00914  phosphatidylinositol 3-kinase [EC:2.7.1.137]
K07887  Ras-related protein Rab-5A
K07888  Ras-related protein Rab-5B
K07889  Ras-related protein Rab-5C
K12478  early endosome antigen 1
K07897  Ras-related protein Rab-7A
K01379  cathepsin D [EC:3.4.23.5]
K02154  V-type H+-transporting ATPase subunit a
K02146  V-type H+-transporting ATPase subunit d
K02144  V-type H+-transporting ATPase subunit H
K03662  V-type H+-transporting ATPase S1 subunit
K02155  V-type H+-transporting ATPase 16kDa proteolipid subunit
K03661  V-type H+-transporting ATPase 21kDa proteolipid subunit
K06528  lysosomal-associated membrane protein 1/2
K21302  phosphatidylinositol-3-phosphatase [EC:3.1.3.64]
K04348  serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]
K06268  serine/threonine-protein phosphatase 2B regulatory subunit
K13882  coronin-1A
K14949  serine/threonine-protein kinase PknG [EC:2.7.11.1]
K06856  immunoglobulin heavy chain
K06498  high affinity immunoglobulin gamma Fc receptor I
K06472  low affinity immunoglobulin gamma Fc receptor II-a
K12560  low affinity immunoglobulin gamma Fc receptor II-b
K16824  low affinity immunoglobulin gamma Fc receptor II-c
K06463  low affinity immunoglobulin gamma Fc receptor III
Compound
C00076  Calcium cation
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C01561  Calcidiol
C01673  Calcitriol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C06124  Sphingosine 1-phosphate
C19190  Trehalose-6,6'-dibehenate
C21790  Trehalose dimycolate
G13101  Lipomannan
G13105  Triacylated phosphatidyl-myo-inositol pentamannoside
G13106  Triacylated phosphatidyl-myo-inositol hexamannoside
G13108  Triacylated phosphatidyl-myo-inositol dimannoside
G13109  Tetraacylated phosphatidyl-myo-inositol dimannoside
G13112  Tetraacylated phosphatidyl-myo-inositol hexamannoside
G13113  Tetraacylated phosphatidyl-myo-inositol pentamannoside
G13114  Lipoarabinomannan
G13115  Mannose-capped lipoarabinomannan
Reference
  Authors
Saiga H, Shimada Y, Takeda K
  Title
Innate immune effectors in mycobacterial infection.
  Journal
Clin Dev Immunol 2011:347594 (2011)
DOI:10.1155/2011/347594
Reference
  Authors
Dheda K, Schwander SK, Zhu B, van Zyl-Smit RN, Zhang Y
  Title
The immunology of tuberculosis: from bench to bedside.
  Journal
Respirology 15:433-50 (2010)
DOI:10.1111/j.1440-1843.2010.01739.x
Reference
  Authors
van Crevel R, Ottenhoff TH, van der Meer JW
  Title
Innate immunity to Mycobacterium tuberculosis.
  Journal
Clin Microbiol Rev 15:294-309 (2002)
DOI:10.1128/CMR.15.2.294-309.2002
Reference
  Authors
Torrelles JB, Azad AK, Henning LN, Carlson TK, Schlesinger LS
  Title
Role of C-type lectins in mycobacterial infections.
  Journal
Curr Drug Targets 9:102-12 (2008)
DOI:10.2174/138945008783502467
Reference
  Authors
Jo EK, Yang CS, Choi CH, Harding CV
  Title
Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors.
  Journal
Cell Microbiol 9:1087-98 (2007)
DOI:10.1111/j.1462-5822.2007.00914.x
Reference
  Authors
Marakalala MJ, Graham LM, Brown GD
  Title
The role of Syk/CARD9-coupled C-type lectin receptors in immunity to Mycobacterium tuberculosis infections.
  Journal
Clin Dev Immunol 2010:567571 (2010)
DOI:10.1155/2010/567571
Reference
  Authors
Koul A, Herget T, Klebl B, Ullrich A
  Title
Interplay between mycobacteria and host signalling pathways.
  Journal
Nat Rev Microbiol 2:189-202 (2004)
DOI:10.1038/nrmicro840
Reference
  Authors
Torrelles JB, Schlesinger LS
  Title
Diversity in Mycobacterium tuberculosis mannosylated cell wall determinants impacts adaptation to the host.
  Journal
Tuberculosis (Edinb) 90:84-93 (2010)
DOI:10.1016/j.tube.2010.02.003
Reference
  Authors
Briken V, Porcelli SA, Besra GS, Kremer L
  Title
Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response.
  Journal
Mol Microbiol 53:391-403 (2004)
DOI:10.1111/j.1365-2958.2004.04183.x
Reference
  Authors
Baena A, Porcelli SA
  Title
Evasion and subversion of antigen presentation by Mycobacterium tuberculosis.
  Journal
Tissue Antigens 74:189-204 (2009)
DOI:10.1111/j.1399-0039.2009.01301.x
Reference
  Authors
Flannagan RS, Cosio G, Grinstein S
  Title
Antimicrobial mechanisms of phagocytes and bacterial evasion strategies.
  Journal
Nat Rev Microbiol 7:355-66 (2009)
DOI:10.1038/nrmicro2128
Reference
  Authors
Pieters J
  Title
Mycobacterium tuberculosis and the macrophage: maintaining a balance.
  Journal
Cell Host Microbe 3:399-407 (2008)
DOI:10.1016/j.chom.2008.05.006
Reference
  Authors
Scherr N, Jayachandran R, Mueller P, Pieters J
  Title
Interference of Mycobacterium tuberculosis with macrophage responses.
  Journal
Indian J Exp Biol 47:401-6 (2009)
Reference
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
  Authors
Rothfuchs AG, Bafica A, Feng CG, Egen JG, Williams DL, Brown GD, Sher A
  Title
Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells.
  Journal
J Immunol 179:3463-71 (2007)
DOI:10.4049/jimmunol.179.6.3463
Reference
  Authors
Master SS, Rampini SK, Davis AS, Keller C, Ehlers S, Springer B, Timmins GS, Sander P, Deretic V
  Title
Mycobacterium tuberculosis prevents inflammasome activation.
  Journal
Cell Host Microbe 3:224-32 (2008)
DOI:10.1016/j.chom.2008.03.003
Reference
  Authors
Shtrichman R, Samuel CE
  Title
The role of gamma interferon in antimicrobial immunity.
  Journal
Curr Opin Microbiol 4:251-9 (2001)
DOI:10.1016/S1369-5274(00)00199-5
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