KEGG   PATHWAY: ko05200Help
Entry
ko05200                     Pathway                                

Name
Pathways in cancer
Class
Human Diseases; Cancers: Overview
BRITE hierarchy
Pathway map
ko05200  Pathways in cancer
ko05200

Ortholog table
Disease
H00559  von Hippel-Lindau syndrome
H00646  Odontoonychodermal dysplasia
H00857  Oligodontia-colorectal cancer syndrome
H00881  Li-Fraumeni syndrome
H00895  Basal cell nevus syndrome
H00947  Pilomatricoma
H01007  Choroid plexus papilloma
H01023  Juvenile polyposis syndrome
H01025  Familial adenomatous polyposis
Orthology
K06765  deleted in colorectal carcinoma
K02187  caspase 3 [EC:3.4.22.56]
K04399  caspase 9 [EC:3.4.22.62]
K08733  DCC-interacting protein 13 alpha
K05689  cadherin 1, type 1, E-cadherin
K02105  catenin beta 1
K05691  catenin alpha
K02157  axin 1
K04385  axin 2
K02085  adenomatosis polyposis coli protein
K03083  glycogen synthase kinase 3 beta [EC:2.7.11.26]
K02620  transcription factor 7
K04490  transcription factor 7-like 1
K04491  transcription factor 7-like 2
K04492  lymphoid enhancer-binding factor 1
K08731  baculoviral IAP repeat-containing protein 5
K04377  Myc proto-oncogene protein
K04503  G1/S-specific cyclin-D1
K03209  wingless-type MMTV integration site family, member 1
K00182  wingless-type MMTV integration site family, member 2
K00312  wingless-type MMTV integration site family, member 3
K00408  wingless-type MMTV integration site family, member 4
K00444  wingless-type MMTV integration site family, member 5
K00445  wingless-type MMTV integration site family, member 6
K00572  wingless-type MMTV integration site family, member 7
K00714  wingless-type MMTV integration site family, member 8
K01064  wingless-type MMTV integration site family, member 9
K01357  wingless-type MMTV integration site family, member 10
K01384  wingless-type MMTV integration site family, member 11
K01558  wingless-type MMTV integration site family, member 16
K02432  frizzled 1/7
K02235  frizzled 2
K02329  frizzled 3
K02354  frizzled 4
K02375  frizzled 5/8
K02376  frizzled 6
K02842  frizzled 9/10
K03068  low density lipoprotein receptor-related protein 5/6
K02353  segment polarity protein dishevelled
K03069  frequently rearranged in advanced T-cell lymphomas 1
K03096  frequently rearranged in advanced T-cell lymphomas 2
K03914  coagulation factor II (thrombin) receptor
K04236  coagulation factor II (thrombin) receptor-like 3
K04289  lysophosphatidic acid receptor 1
K04291  lysophosphatidic acid receptor 2
K04294  lysophosphatidic acid receptor 3
K04275  lysophosphatidic acid receptor 4
K08390  lysophosphatidic acid receptor 5
K04273  lysophosphatidic acid receptor 6
K04166  angiotensin II receptor type 1
K04346  guanine nucleotide-binding protein subunit alpha-12
K04639  guanine nucleotide-binding protein subunit alpha-13
K07532  Rho guanine nucleotide exchange factor 12
K12331  Rho guanine nucleotide exchange factor 11
K12330  Rho guanine nucleotide exchange factor 1
K19464  pleckstrin homology domain-containing family G member 5
K04513  Ras homolog gene family, member A
K04514  Rho-associated protein kinase 1 [EC:2.7.11.1]
K17388  Rho-associated protein kinase 2 [EC:2.7.11.1]
K10031  C-X-C motif chemokine 12
K04189  C-X-C chemokine receptor type 4
K04630  guanine nucleotide-binding protein G(i) subunit alpha
K04258  prostaglandin E receptor 1
K04259  prostaglandin E receptor 2
K04260  prostaglandin E receptor 3
K04261  prostaglandin E receptor 4
K04632  guanine nucleotide-binding protein G(s) subunit alpha
K08041  adenylate cyclase 1 [EC:4.6.1.1]
K08042  adenylate cyclase 2 [EC:4.6.1.1]
K08043  adenylate cyclase 3 [EC:4.6.1.1]
K08044  adenylate cyclase 4 [EC:4.6.1.1]
K08045  adenylate cyclase 5 [EC:4.6.1.1]
K08046  adenylate cyclase 6 [EC:4.6.1.1]
K08047  adenylate cyclase 7 [EC:4.6.1.1]
K08048  adenylate cyclase 8 [EC:4.6.1.1]
K08049  adenylate cyclase 9 [EC:4.6.1.1]
K04345  protein kinase A [EC:2.7.11.11]
K04536  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
K04537  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
K07825  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
K04538  guanine nucleotide-binding protein subunit beta-4
K04539  guanine nucleotide-binding protein subunit beta-5
K07826  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
K04540  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
K04541  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
K04542  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
K04543  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
K04544  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
K04545  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
K04546  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
K04347  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
K04547  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
K04548  guanine nucleotide-binding protein G(T) subunit gamma-T1
K04549  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
K06237  collagen, type IV, alpha
K05637  laminin, alpha 1/2
K06240  laminin, alpha 3/5
K06241  laminin, alpha 4
K05636  laminin, beta 1
K06243  laminin, beta 2
K06244  laminin, beta 3
K06245  laminin, beta 4
K05635  laminin, gamma 1
K06246  laminin, gamma 2
K06247  laminin, gamma 3
K05717  fibronectin 1
K06481  integrin alpha 2
K06476  integrin alpha 2B
K06482  integrin alpha 3
K06485  integrin alpha 6
K06487  integrin alpha V
K05719  integrin beta 1
K05725  focal adhesion kinase 1 [EC:2.7.10.2]
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K01110  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.67 3.1.3.48 3.1.3.16]
K09348  homeobox protein Nkx-3.1
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04467  inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K07209  inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K07210  inhibitor of nuclear factor kappa-B kinase subunit gamma
K04734  NF-kappa-B inhibitor alpha
K02580  nuclear factor NF-kappa-B p105 subunit
K04469  nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
K04735  transcription factor p65
K11987  prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]
K13241  nitric-oxide synthase, inducible [EC:1.14.13.39]
K02161  apoptosis regulator Bcl-2
K16060  baculoviral IAP repeat-containing protein 2/3
K04725  E3 ubiquitin-protein ligase XIAP [EC:2.3.2.27]
K16061  baculoviral IAP repeat-containing protein 7/8
K04570  Bcl-2-like 1 (apoptosis regulator Bcl-X)
K03172  TNF receptor-associated factor 1
K03173  TNF receptor-associated factor 2 [EC:2.3.2.27]
K03174  TNF receptor-associated factor 3
K09848  TNF receptor-associated factor 4
K09849  TNF receptor-associated factor 5
K03175  TNF receptor-associated factor 6 [EC:2.3.2.27]
K07203  serine/threonine-protein kinase mTOR [EC:2.7.11.1]
K04688  ribosomal protein S6 kinase beta [EC:2.7.11.1]
K02158  Bcl-2-antagonist of cell death
K07201  forkhead box protein O1
K06643  E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]
K04451  tumor protein p53
K06624  cyclin-dependent kinase inhibitor 1B
K06625  cyclin-dependent kinase inhibitor 1A
K08878  breakpoint cluster region protein [EC:2.7.11.1]
K06619  abelson tyrosine-protein kinase 1 [EC:2.7.10.2]
K04438  proto-oncogene C-crk
K04707  E3 ubiquitin-protein ligase CBL [EC:2.3.2.27]
K11223  signal transducer and activator of transcription 5A
K11224  signal transducer and activator of transcription 5B
K04702  proto-oncogene serine/threonine-protein kinase Pim-1 [EC:2.7.11.1]
K08806  proto-oncogene serine/threonine-protein kinase Pim-2 [EC:2.7.11.1]
K03915  bradykinin receptor B1
K03916  bradykinin receptor B2
K04197  endothelin receptor type A
K04198  endothelin receptor type B
K04634  guanine nucleotide-binding protein G(q) subunit alpha
K04635  guanine nucleotide-binding protein subunit alpha-11
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
K02677  classical protein kinase C alpha type [EC:2.7.11.13]
K19662  classical protein kinase C beta type [EC:2.7.11.13]
K19663  classical protein kinase C gamma type [EC:2.7.11.13]
K05429  interleukin 2
K04736  interleukin 3
K05430  interleukin 4
K05428  interleukin 5
K05405  interleukin 6
K05431  interleukin 7
K05406  interleukin 12A
K05425  interleukin 12B
K05435  interleukin 13
K05433  interleukin 15
K05426  interleukin 23 subunit alpha
K05437  erythropoietin
K05414  interferon alpha
K04687  interferon gamma
K05068  interleukin 2 receptor alpha
K05069  interleukin 2 receptor beta
K05070  interleukin 2 receptor gamma
K04737  interleukin 3 receptor alpha
K05071  interleukin 4 receptor
K04738  cytokine receptor common subunit beta
K05067  interleukin 5 receptor alpha
K05055  interleukin 6 receptor
K05060  interleukin 6 signal transducer
K05072  interleukin 7 receptor
K05063  interleukin 12 receptor beta-1
K05064  interleukin 12 receptor beta-2
K05076  interleukin 13 receptor alpha-1
K05074  interleukin 15 receptor alpha
K05065  interleukin 23 receptor
K05079  erythropoietin receptor
K05130  interferon receptor 1
K05131  interferon receptor 2
K05132  interferon gamma receptor 1
K05133  interferon gamma receptor 2
K15420  echinoderm microtubule-associated protein-like 4
K05119  anaplastic lymphoma kinase [EC:2.7.10.1]
K04350  RAS guanyl-releasing protein 1
K12361  RAS guanyl-releasing protein 2
K12362  RAS guanyl-releasing protein 3
K12363  RAS guanyl-releasing protein 4
K11217  Janus kinase 1 [EC:2.7.10.2]
K04447  Janus kinase 2 [EC:2.7.10.2]
K11218  Janus kinase 3 [EC:2.7.10.2]
K04692  signal transducer and activator of transcription 3
K11220  signal transducer and activator of transcription 1
K11221  signal transducer and activator of transcription 2
K11222  signal transducer and activator of transcription 4
K11225  signal transducer and activator of transcription 6
K05448  vascular endothelial growth factor A
K16858  vascular endothelial growth factor B
K16859  placenta growth factor
K05449  vascular endothelial growth factor C/D
K08774  transforming growth factor, alpha
K04357  epidermal growth factor
K04361  epidermal growth factor receptor [EC:2.7.10.1]
K05083  receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
K04359  platelet-derived growth factor subunit A
K17386  platelet-derived growth factor subunit B
K04363  platelet-derived growth factor receptor alpha [EC:2.7.10.1]
K05089  platelet-derived growth factor receptor beta [EC:2.7.10.1]
K05459  insulin-like growth factor 1
K13769  insulin-like growth factor 2
K05087  insulin-like growth factor 1 receptor [EC:2.7.10.1]
K05461  KIT ligand
K05091  proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]
K05454  fms-related tyrosine kinase 3 ligand
K05092  fms-related tyrosine kinase 3 [EC:2.7.10.1]
K05460  hepatocyte growth factor
K05099  proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
K18496  fibroblast growth factor 1
K18497  fibroblast growth factor 2
K04358  fibroblast growth factor
K22603  fibroblast growth factor 19
K22429  fibroblast growth factor 21
K22428  fibroblast growth factor 23
K04362  fibroblast growth factor receptor 1 [EC:2.7.10.1]
K05093  fibroblast growth factor receptor 2 [EC:2.7.10.1]
K05094  fibroblast growth factor receptor 3 [EC:2.7.10.1]
K05095  fibroblast growth factor receptor 4 [EC:2.7.10.1]
K04364  growth factor receptor-binding protein 2
K03099  son of sevenless
K02833  GTPase HRas
K07827  GTPase KRas
K07828  GTPase NRas
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04365  B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369  mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371  mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04448  transcription factor AP-1
K04379  proto-oncogene protein c-fos
K02678  C-ets-1
K01388  matrix metalloproteinase-1 (interstitial collagenase) [EC:3.4.24.7]
K01398  matrix metalloproteinase-2 (gelatinase A) [EC:3.4.24.24]
K01403  matrix metalloproteinase-9 (gelatinase B) [EC:3.4.24.35]
K10030  interleukin 8
K02089  cyclin-dependent kinase 4 [EC:2.7.11.22]
K04445  ribosomal protein S6 kinase alpha-5 [EC:2.7.11.1]
K05126  proto-oncogene tyrosine-protein kinase Ret [EC:2.7.10.1]
K09288  coiled-coil domain-containing protein 6
K09289  nuclear receptor coactivator 4
K03176  neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]
K09290  tropomyosin 3
K09291  nucleoprotein TPR
K09292  protein TFG
K09850  Ras association domain-containing protein 1
K08015  Ras association domain-containing protein 5
K04411  serine/threonine kinase 4
K08803  death-associated protein kinase [EC:2.7.11.1]
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
K05859  phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
K04375  ETS domain-containing protein Elk-1
K02183  calmodulin
K04515  calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
K08732  ral guanine nucleotide dissociation stimulator
K07834  Ras-related protein Ral-A
K07835  Ras-related protein Ral-B
K08773  RalA-binding protein 1
K04393  cell division control protein 42
K04392  Ras-related C3 botulinum toxin substrate 1
K07860  Ras-related C3 botulinum toxin substrate 2
K07861  Ras-related C3 botulinum toxin substrate 3
K04440  mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K09293  paired box protein 8
K08530  peroxisome proliferator-activated receptor gamma
K08524  retinoid X receptor alpha
K08525  retinoid X receptor beta
K08526  retinoid X receptor gamma
K08528  retinoic acid receptor beta
K08550  estrogen receptor alpha
K08551  estrogen receptor beta
K09101  nuclear receptor coactivator 1 [EC:2.3.1.48]
K11256  nuclear receptor coactivator 3 [EC:2.3.1.48]
K04684  transcription factor Sp1
K04504  peroxisome proliferator-activated receptor delta
K10056  junction plakoglobin
K10055  zinc finger and BTB domain-containing protein 16
K10054  probable transcription factor PML
K08527  retinoic acid receptor alpha
K08367  runt-related transcription factor 1
K10053  CBFA2/RNUX1 translocation partner 1
K09438  transcription factor PU.1
K09055  CCAAT/enhancer binding protein (C/EBP), alpha
K05066  granulocyte-macrophage colony-stimulating factor receptor alpha
K05061  granulocyte colony-stimulating factor receptor
K05090  macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
K06621  cyclin-dependent kinase inhibitor 2A
K17454  transcription factor E2F1
K09389  transcription factor E2F2
K06620  transcription factor E2F3
K04453  Max protein
K10500  zinc finger and BTB domain-containing protein 17
K04685  cyclin-dependent kinase inhibitor 2B
K02091  cyclin-dependent kinase 6 [EC:2.7.11.22]
K10151  G1/S-specific cyclin-D2
K10152  G1/S-specific cyclin-D3
K02219  cyclin-dependent kinase regulatory subunit CKS1
K03094  S-phase kinase-associated protein 1
K03347  cullin 1
K03868  RING-box protein 1 [EC:2.3.2.32]
K03875  F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
K02206  cyclin-dependent kinase 2 [EC:2.7.11.22]
K06626  G1/S-specific cyclin-E1
K06618  retinoblastoma-associated protein
K04402  growth arrest and DNA-damage-inducible protein
K02159  apoptosis regulator BAX
K14021  Bcl-2 homologous antagonist/killer
K10140  DNA damage-binding protein 2
K03511  DNA polymerase kappa [EC:2.7.7.7]
K11126  telomerase reverse transcriptase [EC:2.7.7.49]
K22183  telomerase RNA component
K09455  microphthalmia-associated transcription factor
K13375  transforming growth factor beta-1
K13376  transforming growth factor beta-2
K13377  transforming growth factor beta-3
K04674  TGF-beta receptor type-1 [EC:2.7.11.30]
K04388  TGF-beta receptor type-2 [EC:2.7.11.30]
K04500  mothers against decapentaplegic homolog 2/3
K04501  mothers against decapentaplegic homolog 4
K04462  ecotropic virus integration site 1 protein
K04496  C-terminal binding protein
K06067  histone deacetylase 1/2 [EC:3.5.1.98]
K08734  DNA mismatch repair protein MLH1
K08735  DNA mismatch repair protein MSH2
K08736  DNA mismatch repair protein MSH3
K08737  DNA mismatch repair protein MSH6
K08775  breast cancer 2 susceptibility protein
K04482  DNA repair protein RAD51
K04389  tumor necrosis factor ligand superfamily member 6
K04390  tumor necrosis factor receptor superfamily member 6
K02373  FAS-associated death domain protein
K04398  caspase 8 [EC:3.4.22.61]
K04726  BH3 interacting domain death agonist
K10131  phorbol-12-myristate-13-acetate-induced protein 1
K10132  Bcl-2-binding component 3
K16341  Bcl-2-like protein 11
K08738  cytochrome c
K02084  apoptotic protease-activating factor
K04397  caspase 7 [EC:3.4.22.60]
K10456  kelch-like protein 19
K05638  nuclear factor erythroid 2-related factor 2
K00510  heme oxygenase 1 [EC:1.14.14.18]
K00355  NAD(P)H dehydrogenase (quinone) [EC:1.6.5.2]
K00799  glutathione S-transferase [EC:2.5.1.18]
K22182  thioredoxin reductase (NADPH) [EC:1.8.1.9]
K03871  von Hippel-Lindau disease tumor supressor
K03872  elongin-C
K03873  elongin-B
K03870  cullin 2
K09592  hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.29]
K01679  fumarate hydratase, class II [EC:4.2.1.2]
K08268  hypoxia-inducible factor 1 alpha
K09095  hypoxia-inducible factor 2 alpha
K09097  aryl hydrocarbon receptor nuclear translocator
K15589  aryl hydrocarbon receptor nuclear translocator 2
K04498  E1A/CREB-binding protein [EC:2.3.1.48]
K07299  MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1
K06052  jagged-1
K21635  jagged-2
K06051  delta
K02599  Notch 1
K20994  Notch 2
K20995  Notch 3
K20996  Notch 4
K06054  hairy and enhancer of split 1
K06055  hairy and enhancer of split 5
K09091  hairy and enhancer of split related with YRPW motif
K05097  FMS-like tyrosine kinase 4 [EC:2.7.10.1]
K11988  sonic hedgehog
K06225  patched 1
K06226  smoothened
K18806  kinesin family member 7
K06229  suppressor of fused
K16797  zinc finger protein GLI1
K16798  zinc finger protein GLI2
K06230  zinc finger protein GLI3
K21283  bone morphogenetic protein 2
K04662  bone morphogenetic protein 4
K06231  hedgehog interacting protein
K11101  patched 2
K08557  androgen receptor
K04079  molecular chaperone HtpG
K09487  heat shock protein 90kDa beta
K01351  semenogelase [EC:3.4.21.77]
Compound
C00027  Hydrogen peroxide
C00039  DNA
C00076  Calcium cation
C00122  Fumarate
C00149  (S)-Malate
C00165  Diacylglycerol
C00187  Cholesterol
C00280  Androstenedione
C00306  Bradykinin
C00410  Progesterone
C00416  Phosphatidate
C00533  Nitric oxide
C00535  Testosterone
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00681  1-Acyl-sn-glycerol 3-phosphate
C00704  O2.-
C00735  Cortisol
C00752  Thrombin
C00762  Cortisone
C00777  Retinoate
C00951  Estradiol-17beta
C01227  Dehydroepiandrosterone
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01471  Acrolein
C02135  Angiotensin II
C03917  Dihydrotestosterone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07653  Flutamide
C15493  9-cis-Retinoic acid
C16010  Endothelin-1
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16844  Hydroxyl radical
C21641  Hydroperoxyl radical
C21642  4-Hydroxynonenal
Reference
  Authors
Weinberg RA.
  Title
The biology of cancer
  Journal
Garland Science, Taylor & Francis Group, LLC (2007)
Reference
  Authors
Hanahan D, Weinberg RA
  Title
The hallmarks of cancer.
  Journal
Cell 100:57-70 (2000)
DOI:10.1016/S0092-8674(00)81683-9
Reference
  Authors
Grady WM.
  Title
Genomic instability and colon cancer.
  Journal
Cancer Metastasis Rev 23:11-27 (2004)
DOI:10.1023/A:1025861527711
Reference
  Authors
Soreide K, Janssen EA, Soiland H, Korner H, Baak JP.
  Title
Microsatellite instability in colorectal cancer.
  Journal
Br J Surg 93:395-406 (2006)
DOI:10.1002/bjs.5328
Reference
  Authors
Anwar S, Hall C, White J, Deakin M, Farrell W, Elder JB.
  Title
Hereditary non-polyposis colorectal cancer: an updated review.
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