KEGG   PATHWAY: ko05202Help
Entry
ko05202                     Pathway                                

Name
Transcriptional misregulation in cancer
Description
In tumor cells, genes encoding transcription factors (TFs) are often amplified, deleted, rearranged via chromosomal translocation and inversion, or subjected to point mutations that result in a gain- or loss-of- function. In hematopoietic cancers and solid tumors, the translocations and inversions increase or deregulate transcription of the oncogene. Recurrent chromosome translocations generate novel fusion oncoproteins, which are common in myeloid cancers and soft-tissue sarcomas. The fusion proteins have aberrant transcriptional function compared to their wild-type counterparts. These fusion transcription factors alter expression of target genes, and thereby result in a variety of altered cellular properties that contribute to the tumourigenic process.
Class
09160 Human Diseases; 09161 Cancers
BRITE hierarchy
Pathway map
ko05202  Transcriptional misregulation in cancer
ko05202

Ortholog table
Disease
H00001  B lymphoblastic leukemia/lymphoma
H00002  T lymphoblastic leukemia/lymphoma
H00003  Acute myeloid leukemia (AML)
H00006  Hairy-cell leukemia
H00007  Hodgkin lymphoma
H00010  Multiple myeloma
H00011  Lymphoplasmacytic lymphoma
H00021  Renal cell carcinoma
H00024  Prostate cancer
H00032  Thyroid cancer
H00034  Carcinoid
H00035  Ewing's sarcoma
H00037  Alveolar rhabdomyosarcoma
H00043  Neuroblastoma
H00049  Myxoid liposarcoma
H00050  Synovial sarcoma
H00051  Alveolar soft part sarcoma
H00052  Clear cell sarcoma of soft tissue
H00053  Extraskeletal myxoid chondrosarcoma
H01102  Pituitary adenomas
H01985  Desmoplastic small round cell tumor
Orthology
K08367  runt-related transcription factor 1
K05090  macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
K10789  myeloperoxidase [EC:1.11.2.2]
K05427  granulocyte-macrophage colony-stimulating factor
K04736  interleukin 3
K10053  CBFA2/RNUX1 translocation partner 1
K06067  histone deacetylase 1/2 [EC:3.5.1.98]
K11644  paired amphipathic helix protein Sin3a
K04650  nuclear receptor co-repressor 1
K09055  CCAAT/enhancer binding protein (C/EBP), alpha
K02633  period circadian protein 2
K09438  transcription factor PU.1
K04391  monocyte differentiation antigen CD14
K06461  integrin alpha M
K06498  high affinity immunoglobulin gamma Fc receptor I
K10056  junction plakoglobin
K10054  probable transcription factor PML
K08527  retinoic acid receptor alpha
K10051  CCAAT/enhancer binding protein (C/EBP), epsilon
K02162  hematopoietic Bcl-2-related protein A1
K10055  zinc finger and BTB domain-containing protein 16
K04377  Myc proto-oncogene protein
K21946  dual specificity phosphatase 6 [EC:3.1.3.48 3.1.3.16]
K09063  transcription factor E2-alpha
K09355  pre-B-cell leukemia transcription factor 1
K01558  wingless-type MMTV integration site family, member 16
K03211  ETS translocation variant 6/7
K10784  T cell receptor alpha chain V region
K10785  T-cell receptor beta chain V region
K01327  leukocyte elastase [EC:3.4.21.37]
K01353  granzyme B [EC:3.4.21.79]
K09186  histone-lysine N-methyltransferase MLL1 [EC:2.1.1.43]
K15184  AF4/FMR2 family member 1
K02211  cyclin-dependent kinase 9 [EC:2.7.11.23 2.7.11.22]
K15188  cyclin T
K15187  YEATS domain-containing protein 1/3
K11427  histone-lysine N-methyltransferase, H3 lysine-79 specific [EC:2.1.1.43]
K15612  rhombotin-2
K15610  pre-B-cell leukemia transcription factor 3
K09278  runt-related transcription factor 2
K04676  mothers against decapentaplegic homolog 1
K15605  krueppel-like factor 3
K04454  MADS-box transcription enhancer factor 2C
K21950  homeobox protein Hox-A9
K17443  homrobox protein Hox-A10
K11449  jumonji domain-containing protein 1C [EC:1.14.11.-]
K09283  high mobility group AT-hook protein 2
K11447  histone demethylase [EC:1.14.11.-]
K11313  transcription initiation protein SPT3
K06532  prominin 1
K05092  fms-related tyrosine kinase 3 [EC:2.7.10.1]
K08854  BMP2 inducible kinase [EC:2.7.11.1]
K05087  insulin-like growth factor 1 receptor [EC:2.7.10.1]
K06624  cyclin-dependent kinase inhibitor 1B
K08821  cyclin-dependent kinase 14 [EC:2.7.11.22]
K15613  homeobox protein Meis1
K21951  homeobox protein Hox-A11
K15614  homeobox protein SIX1
K15615  homeobox protein SIX4
K15616  eyes absent homolog 1 [EC:3.1.3.48]
K06622  cyclin-dependent kinase inhibitor 2C
K00069  15-hydroxyprostaglandin dehydrogenase (NAD) [EC:1.1.1.141]
K05199  glutamate receptor 3
K00717  glycoprotein 6-alpha-L-fucosyltransferase [EC:2.4.1.68]
K15607  T-cell leukemia homeobox protein 3
K09340  T-cell leukemia homeobox protein 1
K22046  B-cell lymphoma/leukemia 11B
K15617  LIM domain-binding protein 1
K15604  protein lyl-1
K08024  homeobox protein HEX
K06056  pre T-cell antigen receptor alpha
K09254  c-Rel proto-oncogene protein
K10151  G1/S-specific cyclin-D2
K03172  TNF receptor-associated factor 1
K04570  Bcl-2-like 1 (apoptosis regulator Bcl-X)
K05413  CD86 antigen
K03160  tumor necrosis factor receptor superfamily member 5
K15618  B-cell lymphoma 6 protein
K06856  immunoglobulin heavy chain
K09035  transcription factor Maf
K06590  integrin beta 7
K11424  histone-lysine N-methyltransferase NSD2 [EC:2.1.1.43]
K11253  histone H3
K09383  paired box protein 5
K09293  paired box protein 8
K08530  peroxisome proliferator-activated receptor gamma
K08524  retinoid X receptor alpha
K08525  retinoid X receptor beta
K08526  retinoid X receptor gamma
K13105  proline-rich protein PRCC
K09105  transcription factor E3
K06625  cyclin-dependent kinase inhibitor 1A
K09633  transmembrane protease serine 2 [EC:3.4.21.-]
K09435  transcriptional regulator ERG
K01348  urokinase plasminogen activator [EC:3.4.21.73]
K01343  tissue plasminogen activator [EC:3.4.21.68]
K01394  matrix metalloproteinase-3 (stromelysin 1, progelatinase) [EC:3.4.24.17]
K01403  matrix metalloproteinase-9 (gelatinase B) [EC:3.4.24.35]
K04387  interleukin 1 receptor type II
K15619  Kunitz-type protease inhibitor 1
K09431  ets translocation variant 1
K15592  ets translocation variant 4
K15593  ets translocation variant 5
K15379  solute carrier family 45, member 3
K04376  ETS domain-containing protein Elk-4
K12823  ATP-dependent RNA helicase DDX5/DBP2 [EC:3.6.4.13]
K09109  N-myc proto-oncogene protein
K04453  Max protein
K06643  E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]
K05725  focal adhesion kinase 1 [EC:2.7.10.2]
K04451  tumor protein p53
K11459  polycomb group RING finger protein 4
K04684  transcription factor Sp1
K10500  zinc finger and BTB domain-containing protein 17
K03176  neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]
K02583  tumor necrosis factor receptor superfamily member 16
K14970  menin
K13209  RNA-binding protein EWS
K09436  friend leukemia integration 1 transcription factor
K05459  insulin-like growth factor 1
K17693  DNA-binding protein inhibitor ID2
K04388  TGF-beta receptor type-2 [EC:2.7.11.30]
K10138  insulin-like growth factor-binding protein 3
K09437  ETS oncogene family protein FEV
K09053  activating transcription factor 1
K15589  aryl hydrocarbon receptor nuclear translocator 2
K04728  ataxia telangiectasia mutated family protein [EC:2.7.11.1]
K09455  microphthalmia-associated transcription factor
K09234  Wilms tumor protein 1
K04359  platelet-derived growth factor subunit A
K05069  interleukin 2 receptor beta
K15621  BAI1-associated protein 3
K06571  tetraspanin-7
K15622  myeloid leukemia factor 1
K08559  nuclear receptor subfamily 4 group A member 3
K14651  transcription initiation factor TFIID subunit 15
K13098  RNA-binding protein FUS
K04452  DNA damage-inducible transcript 3
K10048  CCAAT/enhancer binding protein (C/EBP), beta
K05405  interleukin 6
K14242  NF-kappa-B inhibitor zeta
K02580  nuclear factor NF-kappa-B p105 subunit
K04735  transcription factor p65
K10030  interleukin 8
K07201  forkhead box protein O1
K05096  FMS-like tyrosine kinase 1 [EC:2.7.10.1]
K15623  protein SSXT
K15624  protein SSX1
K15625  protein SSX2
K15626  nuclear protein, 1
K15627  tether containing UBX domain for GLUT4
K05099  proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
K04402  growth arrest and DNA-damage-inducible protein
K02159  apoptosis regulator BAX
K14021  Bcl-2 homologous antagonist/killer
K10140  DNA damage-binding protein 2
K03511  DNA polymerase kappa [EC:2.7.7.7]
Reference
  Authors
Alcalay M, Orleth A, Sebastiani C, Meani N, Chiaradonna F, Casciari C, Sciurpi MT, Gelmetti V, Riganelli D, Minucci S, Fagioli M, Pelicci PG
  Title
Common themes in the pathogenesis of acute myeloid leukemia.
  Journal
Oncogene 20:5680-94 (2001)
DOI:10.1038/sj.onc.1204642
Reference
  Authors
Scandura JM, Boccuni P, Cammenga J, Nimer SD
  Title
Transcription factor fusions in acute leukemia: variations on a theme.
  Journal
Oncogene 21:3422-44 (2002)
DOI:10.1038/sj.onc.1205315
Reference
  Authors
Roumier C, Fenaux P, Lafage M, Imbert M, Eclache V, Preudhomme C
  Title
New mechanisms of AML1 gene alteration in hematological malignancies.
  Journal
Leukemia 17:9-16 (2003)
DOI:10.1038/sj.leu.2402766
Reference
  Authors
Lutterbach B, Hiebert SW
  Title
Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation.
  Journal
Gene 245:223-35 (2000)
DOI:10.1016/S0378-1119(00)00014-7
Reference
  Authors
Koschmieder S, Halmos B, Levantini E, Tenen DG
  Title
Dysregulation of the C/EBPalpha differentiation pathway in human cancer.
  Journal
J Clin Oncol 27:619-28 (2009)
DOI:10.1200/JCO.2008.17.9812
Reference
  Authors
Johansen LM, Iwama A, Lodie TA, Sasaki K, Felsher DW, Golub TR, Tenen DG
  Title
c-Myc is a critical target for c/EBPalpha in granulopoiesis.
  Journal
Mol Cell Biol 21:3789-806 (2001)
DOI:10.1128/MCB.21.11.3789-3806.2001
Reference
  Authors
Gery S, Gombart AF, Yi WS, Koeffler C, Hofmann WK, Koeffler HP
  Title
Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemia.
  Journal
Blood 106:2827-36 (2005)
DOI:10.1182/blood-2005-01-0358
Reference
  Authors
Vangala RK, Heiss-Neumann MS, Rangatia JS, Singh SM, Schoch C, Tenen DG, Hiddemann W, Behre G
  Title
The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia.
  Journal
Blood 101:270-7 (2003)
DOI:10.1182/blood-2002-04-1288
Reference
  Authors
Mueller BU, Pabst T, Osato M, Asou N, Johansen LM, Minden MD, Behre G, Hiddemann W, Ito Y, Tenen DG
  Title
Heterozygous PU.1 mutations are associated with acute myeloid leukemia.
  Journal
Blood 100:998-1007 (2002)
DOI:10.1182/blood.V100.3.998
Reference
  Authors
Jing Y
  Title
The PML-RARalpha fusion protein and targeted therapy for acute promyelocytic leukemia.
  Journal
Leuk Lymphoma 45:639-48 (2004)
DOI:10.1080/10428190310001609933
Reference
  Authors
Muller-Tidow C, Steffen B, Cauvet T, Tickenbrock L, Ji P, Diederichs S, Sargin B, Kohler G, Stelljes M, Puccetti E, Ruthardt M, deVos S, Hiebert SW, Koeffler HP, Berdel WE, Serve H
  Title
Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.
  Journal
Mol Cell Biol 24:2890-904 (2004)
DOI:10.1128/MCB.24.7.2890-2904.2004
Reference
  Authors
Rice KL, Hormaeche I, Doulatov S, Flatow JM, Grimwade D, Mills KI, Leiva M, Ablain J, Ambardekar C, McConnell MJ, Dick JE, Licht JD
  Title
Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC.
  Journal
Blood 114:5499-511 (2009)
DOI:10.1182/blood-2009-03-206524
Reference
  Authors
McWhirter JR, Neuteboom ST, Wancewicz EV, Monia BP, Downing JR, Murre C
  Title
Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia.
  Journal
Proc Natl Acad Sci U S A 96:11464-9 (1999)
DOI:10.1073/pnas.96.20.11464
Reference
  Authors
Zelent A, Greaves M, Enver T
  Title
Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia.
  Journal
Oncogene 23:4275-83 (2004)
DOI:10.1038/sj.onc.1207672
Reference
  Authors
Sawinska M, Ladon D
  Title
Mechanism, detection and clinical significance of the reciprocal translocation t(12;21)(p12;q22) in the children suffering from acute lymphoblastic leukaemia.
  Journal
Leuk Res 28:35-42 (2004)
DOI:10.1016/S0145-2126(03)00160-7
Reference
  Authors
Guenther MG, Lawton LN, Rozovskaia T, Frampton GM, Levine SS, Volkert TL, Croce CM, Nakamura T, Canaani E, Young RA
  Title
Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia.
  Journal
Genes Dev 22:3403-8 (2008)
DOI:10.1101/gad.1741408
Reference
  Authors
Xia ZB, Popovic R, Chen J, Theisler C, Stuart T, Santillan DA, Erfurth F, Diaz MO, Zeleznik-Le NJ
  Title
The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression.
  Journal
Proc Natl Acad Sci U S A 102:14028-33 (2005)
DOI:10.1073/pnas.0506464102
Reference
  Authors
Wang QF, Wu G, Mi S, He F, Wu J, Dong J, Luo RT, Mattison R, Kaberlein JJ, Prabhakar S, Ji H, Thirman MJ
  Title
MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome.
  Journal
Blood 117:6895-905 (2011)
DOI:10.1182/blood-2010-12-324699
Reference
  Authors
Zeisig BB, Milne T, Garcia-Cuellar MP, Schreiner S, Martin ME, Fuchs U, Borkhardt A, Chanda SK, Walker J, Soden R, Hess JL, Slany RK
  Title
Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization.
  Journal
Mol Cell Biol 24:617-28 (2004)
DOI:10.1128/MCB.24.2.617-628.2004
Reference
  Authors
Riz I, Hawley TS, Johnston H, Hawley RG
  Title
Role of TLX1 in T-cell acute lymphoblastic leukaemia pathogenesis.
  Journal
Br J Haematol 145:140-3 (2009)
DOI:10.1111/j.1365-2141.2008.07556.x
Reference
  Authors
Barth TF, Martin-Subero JI, Joos S, Menz CK, Hasel C, Mechtersheimer G, Parwaresch RM, Lichter P, Siebert R, Mooller P
  Title
Gains of 2p involving the REL locus correlate with nuclear c-Rel protein accumulation in neoplastic cells of classical Hodgkin lymphoma.
  Journal
Blood 101:3681-6 (2003)
DOI:10.1182/blood-2002-08-2577
Reference
  Authors
Hinz M, Loser P, Mathas S, Krappmann D, Dorken B, Scheidereit C
  Title
Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells.
  Journal
Blood 97:2798-807 (2001)
DOI:10.1182/blood.V97.9.2798
Reference
  Authors
Zuzel M, Cawley JC.
  Title
The biology of hairy cells.
  Journal
Best Pract Res Clin Haematol 16:1-13 (2003)
DOI:10.1016/S1521-6926(02)00082-8
Reference
  Authors
Hurt EM, Wiestner A, Rosenwald A, Shaffer AL, Campo E, Grogan T, Bergsagel PL, Kuehl WM, Staudt LM
  Title
Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma.
  Journal
Cancer Cell 5:191-9 (2004)
DOI:10.1016/S1535-6108(04)00019-4
Reference
  Authors
Martinez-Garcia E, Popovic R, Min DJ, Sweet SM, Thomas PM, Zamdborg L, Heffner A, Will C, Lamy L, Staudt LM, Levens DL, Kelleher NL, Licht JD
  Title
The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells.
  Journal
Blood 117:211-20 (2011)
DOI:10.1182/blood-2010-07-298349
Reference
  Authors
Brito JL, Walker B, Jenner M, Dickens NJ, Brown NJ, Ross FM, Avramidou A, Irving JA, Gonzalez D, Davies FE, Morgan GJ
  Title
MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cells.
  Journal
Haematologica 94:78-86 (2009)
DOI:10.3324/haematol.13426
Reference
  Authors
Iida S, Rao PH, Ueda R, Chaganti RS, Dalla-Favera R
  Title
Chromosomal rearrangement of the PAX-5 locus in lymphoplasmacytic lymphoma with t(9;14)(p13;q32).
  Journal
Leuk Lymphoma 34:25-33 (1999)
DOI:10.3109/10428199909083377
Reference
  Authors
Ohno H, Ueda C, Akasaka T
  Title
The t(9;14)(p13;q32) translocation in B-cell non-Hodgkin's lymphoma.
  Journal
Leuk Lymphoma 36:435-45 (2000)
DOI:10.3109/10428190009148390
Reference
  Authors
Prensner JR, Chinnaiyan AM
  Title
Oncogenic gene fusions in epithelial carcinomas.
  Journal
Curr Opin Genet Dev 19:82-91 (2009)
DOI:10.1016/j.gde.2008.11.008
Reference
  Authors
Brenner JC, Chinnaiyan AM
  Title
Translocations in epithelial cancers.
  Journal
Biochim Biophys Acta 1796:201-15 (2009)
DOI:10.1016/j.bbcan.2009.04.005
Reference
  Authors
Reddi HV, McIver B, Grebe SK, Eberhardt NL
  Title
The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis.
  Journal
Endocrinology 148:932-5 (2007)
DOI:10.1210/en.2006-0926
Reference
  Authors
Medendorp K, van Groningen JJ, Vreede L, Hetterschijt L, Brugmans L, van den Hurk WH, van Kessel AG
  Title
The renal cell carcinoma-associated oncogenic fusion protein PRCCTFE3 provokes p21 WAF1/CIP1-mediated cell cycle delay.
  Journal
Exp Cell Res 315:2399-409 (2009)
DOI:10.1016/j.yexcr.2009.04.022
Reference
  Authors
Kumar-Sinha C, Tomlins SA, Chinnaiyan AM
  Title
Recurrent gene fusions in prostate cancer.
  Journal
Nat Rev Cancer 8:497-511 (2008)
DOI:10.1038/nrc2402
Reference
  Authors
Yu J, Yu J, Mani RS, Cao Q, Brenner CJ, Cao X, Wang X, Wu L, Li J, Hu M, Gong Y, Cheng H, Laxman B, Vellaichamy A, Shankar S, Li Y, Dhanasekaran SM, Morey R, Barrette T, Lonigro RJ, Tomlins SA, Varambally S, Qin ZS, Chinnaiyan AM
  Title
An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression.
  Journal
Cancer Cell 17:443-54 (2010)
DOI:10.1016/j.ccr.2010.03.018
Reference
  Authors
Leshem O, Madar S, Kogan-Sakin I, Kamer I, Goldstein I, Brosh R, Cohen Y, Jacob-Hirsch J, Ehrlich M, Ben-Sasson S, Goldfinger N, Loewenthal R, Gazit E, Rotter V, Berger R
  Title
TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model.
  Journal
PLoS One 6:e21650 (2011)
DOI:10.1371/journal.pone.0021650
Reference
  Authors
Cai C, Hsieh CL, Omwancha J, Zheng Z, Chen SY, Baert JL, Shemshedini L
  Title
ETV1 is a novel androgen receptor-regulated gene that mediates prostate cancer cell invasion.
  Journal
Mol Endocrinol 21:1835-46 (2007)
DOI:10.1210/me.2006-0480
Reference
  Authors
Helgeson BE, Tomlins SA, Shah N, Laxman B, Cao Q, Prensner JR, Cao X, Singla N, Montie JE, Varambally S, Mehra R, Chinnaiyan AM
  Title
Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer.
  Journal
Cancer Res 68:73-80 (2008)
DOI:10.1158/0008-5472.CAN-07-5352
Reference
  Authors
Westermark UK, Wilhelm M, Frenzel A, Henriksson MA
  Title
The MYCN oncogene and differentiation in neuroblastoma.
  Journal
Semin Cancer Biol 21:256-66 (2011)
DOI:10.1016/j.semcancer.2011.08.001
Reference
  Authors
Bell E, Chen L, Liu T, Marshall GM, Lunec J, Tweddle DA
  Title
MYCN oncoprotein targets and their therapeutic potential.
  Journal
Cancer Lett 293:144-57 (2010)
DOI:10.1016/j.canlet.2010.01.015
Reference
  Authors
Slack A, Chen Z, Tonelli R, Pule M, Hunt L, Pession A, Shohet JM
  Title
The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.
  Journal
Proc Natl Acad Sci U S A 102:731-6 (2005)
DOI:10.1073/pnas.0405495102
Reference
  Authors
Ochiai H, Takenobu H, Nakagawa A, Yamaguchi Y, Kimura M, Ohira M, Okimoto Y, Fujimura Y, Koseki H, Kohno Y, Nakagawara A, Kamijo T
  Title
Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1Bbeta and TSLC1 in neuroblastoma.
  Journal
Oncogene 29:2681-90 (2010)
DOI:10.1038/onc.2010.22
Reference
  Authors
Chen L, Iraci N, Gherardi S, Gamble LD, Wood KM, Perini G, Lunec J, Tweddle DA
  Title
p53 is a direct transcriptional target of MYCN in neuroblastoma.
  Journal
Cancer Res 70:1377-88 (2010)
DOI:10.1158/0008-5472.CAN-09-2598
Reference
  Authors
Beierle EA, Trujillo A, Nagaram A, Kurenova EV, Finch R, Ma X, Vella J, Cance WG, Golubovskaya VM
  Title
N-MYC regulates focal adhesion kinase expression in human neuroblastoma.
  Journal
J Biol Chem 282:12503-16 (2007)
DOI:10.1074/jbc.M701450200
Reference
  Authors
Iraci N, Diolaiti D, Papa A, Porro A, Valli E, Gherardi S, Herold S, Eilers M, Bernardoni R, Della Valle G, Perini G
  Title
A SP1/MIZ1/MYCN repression complex recruits HDAC1 at the TRKA and p75NTR promoters and affects neuroblastoma malignancy by inhibiting the cell response to NGF.
  Journal
Cancer Res 71:404-12 (2011)
DOI:10.1158/0008-5472.CAN-10-2627
Reference
  Authors
Dreijerink KM, Hoppener JW, Timmers HM, Lips CJ
  Title
Mechanisms of disease: multiple endocrine neoplasia type 1-relation to chromatin modifications and transcription regulation.
  Journal
Nat Clin Pract Endocrinol Metab 2:562-70 (2006)
DOI:10.1038/ncpendmet0292
Reference
  Authors
Wu X, Hua X
  Title
Menin, histone h3 methyltransferases, and regulation of cell proliferation: current knowledge and perspective.
  Journal
Curr Mol Med 8:805-15 (2008)
DOI:10.2174/156652408786733702
Reference
  Authors
Sakurai A, Murakami A, Sano K, Uchino S, Fukushima Y
  Title
Unusual clinical and pathological presentation of a neuroendocrine tumor in a patient with multiple endocrine neoplasia type 1.
  Journal
Endocr J 56:887-95 (2009)
DOI:10.1507/endocrj.K09E-126
Reference
  Authors
Yang Y, Hua X
  Title
In search of tumor suppressing functions of menin.
  Journal
Mol Cell Endocrinol 265-266:34-41 (2007)
DOI:10.1016/j.mce.2006.12.032
Reference
  Authors
Aman P
  Title
Fusion oncogenes in tumor development.
  Journal
Semin Cancer Biol 15:236-43 (2005)
DOI:10.1016/j.semcancer.2005.01.009
Reference
  Authors
Fukuma M, Okita H, Hata J, Umezawa A
  Title
Upregulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWS/ets protein in Ewing sarcoma.
  Journal
Oncogene 22:1-9 (2003)
DOI:10.1038/sj.onc.1206055
Reference
  Authors
Cironi L, Riggi N, Provero P, Wolf N, Suva ML, Suva D, Kindler V, Stamenkovic I
  Title
IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells.
  Journal
PLoS One 3:e2634 (2008)
DOI:10.1371/journal.pone.0002634
Reference
  Authors
Riggi N, Stamenkovic I.
  Title
The Biology of Ewing sarcoma.
  Journal
Cancer Lett 254:1-10 (2007)
DOI:10.1016/j.canlet.2006.12.009
Reference
  Authors
Jedlicka P
  Title
Ewing Sarcoma, an enigmatic malignancy of likely progenitor cell origin, driven by transcription factor oncogenic fusions.
  Journal
Int J Clin Exp Pathol 3:338-47 (2010)
Reference
  Authors
Ordonez JL, Osuna D, Herrero D, de Alava E, Madoz-Gurpide J
  Title
Advances in Ewing's sarcoma research: where are we now and what lies ahead?
  Journal
Cancer Res 69:7140-50 (2009)
DOI:10.1158/0008-5472.CAN-08-4041
Reference
  Authors
Jishage M, Fujino T, Yamazaki Y, Kuroda H, Nakamura T
  Title
Identification of target genes for EWS/ATF-1 chimeric transcription factor.
  Journal
Oncogene 22:41-9 (2003)
DOI:10.1038/sj.onc.1206074
Reference
  Authors
Gerald WL, Haber DA
  Title
The EWS-WT1 gene fusion in desmoplastic small round cell tumor.
  Journal
Semin Cancer Biol 15:197-205 (2005)
DOI:10.1016/j.semcancer.2005.01.005
Reference
  Authors
Filion C, Motoi T, Olshen AB, Lae M, Emnett RJ, Gutmann DH, Perry A, Ladanyi M, Labelle Y
  Title
The EWSR1/NR4A3 fusion protein of extraskeletal myxoid chondrosarcoma activates the PPARG nuclear receptor gene.
  Journal
J Pathol 217:83-93 (2009)
DOI:10.1002/path.2445
Reference
  Authors
Kim S, Lee HJ, Jun HJ, Kim J
  Title
The hTAF II 68-TEC fusion protein functions as a strong transcriptional activator.
  Journal
Int J Cancer 122:2446-53 (2008)
DOI:10.1002/ijc.23379
Reference
  Authors
Sjogren H, Meis-Kindblom J, Kindblom LG, Aman P, Stenman G
  Title
Fusion of the EWS-related gene TAF2N to TEC in extraskeletal myxoid chondrosarcoma.
  Journal
Cancer Res 59:5064-7 (1999)
Reference
  Authors
Goransson M, Elias E, Stahlberg A, Olofsson A, Andersson C, Aman P
  Title
Myxoid liposarcoma FUS-DDIT3 fusion oncogene induces C/EBP beta-mediated interleukin 6 expression.
  Journal
Int J Cancer 115:556-60 (2005)
DOI:10.1002/ijc.20893
Reference
  Authors
Goransson M, Andersson MK, Forni C, Stahlberg A, Andersson C, Olofsson A, Mantovani R, Aman P
  Title
The myxoid liposarcoma FUS-DDIT3 fusion oncoprotein deregulates NF-kappaB target genes by interaction with NFKBIZ.
  Journal
Oncogene 28:270-8 (2009)
DOI:10.1038/onc.2008.378
Reference
  Authors
Willems SM, Schrage YM, Bruijn IH, Szuhai K, Hogendoorn PC, Bovee JV
  Title
Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and casein kinase II inhibition as a potential treatment option.
  Journal
Mol Cancer 9:257 (2010)
DOI:10.1186/1476-4598-9-257
Reference
  Authors
Linardic CM
  Title
PAX3-FOXO1 fusion gene in rhabdomyosarcoma.
  Journal
Cancer Lett 270:10-8 (2008)
DOI:10.1016/j.canlet.2008.03.035
Reference
  Authors
Barber TD, Barber MC, Tomescu O, Barr FG, Ruben S, Friedman TB
  Title
Identification of target genes regulated by PAX3 and PAX3-FKHR in embryogenesis and alveolar rhabdomyosarcoma.
  Journal
Genomics 79:278-84 (2002)
DOI:10.1006/geno.2002.6703
Reference
  Authors
Ishida M, Miyamoto M, Naitoh S, Tatsuda D, Hasegawa T, Nemoto T, Yokozeki H, Nishioka K, Matsukage A, Ohki M, Ohta T
  Title
The SYT-SSX fusion protein down-regulates the cell proliferation regulator COM1 in t(x;18) synovial sarcoma.
  Journal
Mol Cell Biol 27:1348-55 (2007)
DOI:10.1128/MCB.00658-06
Reference
  Authors
Jun HJ, Lee J, Lim do H, Park JO, Ahn G, Seo SW, Sung KS, Lim do H, Yoo KH, Choi YL
  Title
Expression of MET in alveolar soft part sarcoma.
  Journal
Med Oncol 27:459-65 (2010)
DOI:10.1007/s12032-009-9234-8
Reference
  Authors
Rivlin N, Brosh R, Oren M, Rotter V
  Title
Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis.
  Journal
Genes Cancer 2:466-74 (2011)
DOI:10.1177/1947601911408889
Reference
  Authors
Suzuki K, Matsubara H
  Title
Recent advances in p53 research and cancer treatment.
  Journal
J Biomed Biotechnol 2011:978312 (2011)
DOI:10.1155/2011/978312
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