KEGG   ORTHOLOGY: K00234
Entry
K00234                      KO                                     

Name
SDHA, SDH1
Definition
succinate dehydrogenase (ubiquinone) flavoprotein subunit [EC:1.3.5.1]
Pathway
ko00020  Citrate cycle (TCA cycle)
ko00190  Oxidative phosphorylation
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
ko04714  Thermogenesis
ko04932  Non-alcoholic fatty liver disease
ko05010  Alzheimer disease
ko05012  Parkinson disease
ko05014  Amyotrophic lateral sclerosis
ko05016  Huntington disease
ko05020  Prion disease
ko05022  Pathways of neurodegeneration - multiple diseases
ko05415  Diabetic cardiomyopathy
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
M00148  Succinate dehydrogenase (ubiquinone)
Disease
H00294  Dilated cardiomyopathy
H01022  Diseases of the tricarboxylic acid cycle
H01354  Leigh syndrome
H02005  Mitochondrial complex II deficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    K00234  SDHA, SDH1; succinate dehydrogenase (ubiquinone) flavoprotein subunit
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    K00234  SDHA, SDH1; succinate dehydrogenase (ubiquinone) flavoprotein subunit
 09150 Organismal Systems
  09159 Environmental adaptation
   04714 Thermogenesis
    K00234  SDHA, SDH1; succinate dehydrogenase (ubiquinone) flavoprotein subunit
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K00234  SDHA, SDH1; succinate dehydrogenase (ubiquinone) flavoprotein subunit
   05012 Parkinson disease
    K00234  SDHA, SDH1; succinate dehydrogenase (ubiquinone) flavoprotein subunit
   05014 Amyotrophic lateral sclerosis
    K00234  SDHA, SDH1; succinate dehydrogenase (ubiquinone) flavoprotein subunit
   05016 Huntington disease
    K00234  SDHA, SDH1; succinate dehydrogenase (ubiquinone) flavoprotein subunit
   05020 Prion disease
    K00234  SDHA, SDH1; succinate dehydrogenase (ubiquinone) flavoprotein subunit
   05022 Pathways of neurodegeneration - multiple diseases
    K00234  SDHA, SDH1; succinate dehydrogenase (ubiquinone) flavoprotein subunit
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    K00234  SDHA, SDH1; succinate dehydrogenase (ubiquinone) flavoprotein subunit
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K00234  SDHA, SDH1; succinate dehydrogenase (ubiquinone) flavoprotein subunit
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.5  With a quinone or related compound as acceptor
    1.3.5.1  succinate dehydrogenase
     K00234  SDHA, SDH1; succinate dehydrogenase (ubiquinone) flavoprotein subunit
Other DBs
RN: R02164
COG: COG1053
GO: 0008177
Genes
HSA: 6389(SDHA)
PTR: 107970891 107974583(SDHA)
PPS: 100987473(SDHA)
GGO: 101124208 101141874(SDHA)
PON: 100173631(SDHA) 100446843
NLE: 100593202(SDHA) 100600690 101177207 115833880 115834056
MCC: 708018(SDHA) 723069
MCF: 102126003
CSAB: 103215231(SDHA) 103215235
RRO: 104662045 104668708(SDHA)
CJC: 100400483(SDHA)
SBQ: 101049489(SDHA)
MMU: 66945(Sdha)
MCAL: 110307604(Sdha)
MPAH: 110328746(Sdha)
RNO: 157074(Sdha)
MUN: 110545371(Sdha)
CGE: 100750732(Sdha)
NGI: 103749659(Sdha)
HGL: 101697591(Sdha)
CCAN: 109693457(Sdha)
OCU: 100328584(SDHA)
TUP: 102502720(SDHA)
CFA: 478634(SDHA)
VVP: 112935451(SDHA)
AML: 100483034(SDHA)
UMR: 103679246(SDHA)
UAH: 113260769(SDHA)
ORO: 101382073(SDHA)
ELK: 111153400
FCA: 751619(SDHA)
PTG: 102949810(SDHA)
PPAD: 109260209(SDHA)
AJU: 106988566(SDHA)
BTA: 281480(SDHA)
BOM: 102278228(SDHA)
BBUB: 102416641(SDHA)
CHX: 102183107(SDHA)
OAS: 100036762(SDHA)
SSC: 780433(SDHA)
CFR: 102523856(SDHA)
CDK: 105102189(SDHA)
BACU: 103005047(SDHA)
LVE: 103090475(SDHA)
OOR: 101271279(SDHA)
DLE: 111178524(SDHA)
PCAD: 102987120(SDHA)
ECB: 100034244(SDHA)
EPZ: 103560327(SDHA)
EAI: 106835869(SDHA)
MYB: 102240483(SDHA)
MYD: 102766070(SDHA)
MNA: 107536555(SDHA)
HAI: 109371695(SDHA)
DRO: 112321014(SDHA)
PALE: 102897292(SDHA)
RAY: 107499960(SDHA)
MJV: 108399099(SDHA)
LAV: 100141371(SDHA)
TMU: 101357812
MDO: 751085(SDHA)
SHR: 100931806(SDHA)
PCW: 110207921(SDHA)
OAA: 100083131(SDHA)
GGA: 395758(SDHA)
MGP: 100546340(SDHA)
CJO: 107309446(SDHA)
NMEL: 110393340(SDHA)
APLA: 101792265(SDHA)
ACYG: 106045013(SDHA)
TGU: 100230079(SDHA)
LSR: 110469718(SDHA)
SCAN: 103825927(SDHA)
GFR: 102036351(SDHA)
FAB: 101819469(SDHA)
PHI: 102108670(SDHA)
PMAJ: 107200805(SDHA)
CCAE: 111925336(SDHA)
CCW: 104685847(SDHA)
ETL: 114060981(SDHA)
FPG: 101916111(SDHA)
FCH: 102047706(SDHA)
CLV: 102093871(SDHA)
EGZ: 104128506(SDHA)
NNI: 104013410(SDHA)
ACUN: 113476078(SDHA)
PADL: 103922329(SDHA)
AAM: 106492875(SDHA)
ASN: 102372796(SDHA)
AMJ: 102561508(SDHA)
CMY: 102943548(SDHA)
CPIC: 101930831(SDHA)
ACS: 100551545(sdha)
PVT: 110090570(SDHA)
PBI: 103055336
PMUR: 107289374(SDHA)
TSR: 106548328(SDHA)
PMUA: 114581481(SDHA)
GJA: 107118404(SDHA)
XLA: 380463(sdha.S) 398946(sdha.L)
XTR: 548743(sdha)
NPR: 108803812(SDHA)
DRE: 393884(sdha)
CCAR: 109111237
IPU: 108272761(sdha)
PHYP: 113535102(sdha)
AMEX: 103022581(sdha)
EEE: 113591252(sdha)
TRU: 101076572(sdha)
LCO: 104928090(sdha)
NCC: 104952821(sdha)
MZE: 101470960(sdha)
ONL: 100692881(sdha)
OLA: 101169635
XMA: 102235474(sdha)
XCO: 114141583(sdha)
PRET: 103478296(sdha)
CVG: 107100341(sdha)
NFU: 107378888(sdha)
KMR: 108232300(sdha)
ALIM: 106528892(sdha)
AOCE: 111572960(sdha)
CSEM: 103388781(sdha)
POV: 109632148(sdha)
LCF: 108888123(sdha)
SDU: 111227789(sdha)
SLAL: 111658076(sdha)
HCQ: 109529672(sdha)
BPEC: 110171397(sdha)
MALB: 109958516(sdha)
SASA: 100194530(sdha) 106570380 106573122(DHSA)
SFM: 108931739(sdha)
PKI: 111852695(sdha)
LCM: 102348838(SDHA)
CMK: 103181549(sdha)
RTP: 109932563
BFO: 118404242
CIN: 100183000
SPU: 580610
APLC: 110986692
SKO: 100371134
DME: Dmel_CG17246(SdhA) Dmel_CG5718(SdhAL)
DSE: 6609931
DSI: Dsimw501_GD12763(Dsim_GD12763) Dsimw501_GD25325(Dsim_GD25325)
DAN: 6495460
DSR: 110176253
DAZ: 108616144
DNV: 108653573
DHE: 111595070
DVI: 6625273
MDE: 101898176
AAG: 5575223
AALB: 115253577
OBB: 114874996
VEM: 105568431
NVI: 100119074(Sdha) 100119112
CSOL: 105366575
NVL: 108560967
API: 100166540
DNX: 107161701
AGS: 114131668
RMD: 113550287
BTAB: 109044150
ZNE: 110840631
FCD: 110845478
TUT: 107362728
DPTE: 113791554
CSCU: 111614390
PTEP: 107445648
CEL: CELE_C03G5.1(sdha-1) CELE_C34B2.7(sdha-2)
CBR: CBG12805(Cbr-sdha-2) CBG22795(Cbr-sdha-1)
TSP: Tsp_06974
PCAN: 112562911
CRG: 105337089
MYI: 110450908
OBI: 106882182
SHX: MS3_00508
EGL: EGR_02366
NVE: 5510196
EPA: 110233821
AMIL: 114950074
PDAM: 113674379
SPIS: 111342152
DGT: 114526967
HMG: 100210215
AQU: 100632409
ATH: AT2G18450(SDH1-2) AT5G66760(SDH1-1)
CPAP: 110822288
CIT: 102623970
TCC: 18610944
EGR: 104419754
LJA: Lj4g3v0948900.1(Lj4g3v0948900.1)
ADU: 107487854
AIP: 107642871
FVE: 101303935
RCN: 112187731
PPER: 18769030
PMUM: 103340079
PAVI: 110773605
ZJU: 107424596
CSV: 101211616
CMO: 103494381
MCHA: 111008239
CMAX: 111483154
CMOS: 111435915
CPEP: 111810124
RCU: 8283123
JCU: 105641357
VVI: 100254718
SLY: 101256641
SPEN: 107011073
SOT: 102604123
CANN: 107859955
NSY: 104241425
NTO: 104115838
NAU: 109244493
LSV: 111901866
BVG: 104895015
SOE: 110803652
OSA: 4342350
DOSA: Os07t0134800-01(Os07g0134800)
OBR: 102704350
ATS: 109753010(LOC109753010) 109757946(LOC109757946)
ZMA: 100279930(TIDP3457) 100280324
DCT: 110098030
PEQ: 110027552
ATR: 18445831
CRE: CHLREDRAFT_195972(SDH1)
VCN: VOLCADRAFT_74298(sdh1)
APRO: F751_1347
MIS: MICPUN_106467(SDH2)
SCE: YJL045W YKL148C(SDH1)
ERC: Ecym_8248
KMX: KLMA_20466(SDH1)
NCS: NCAS_0F02320(NCAS0F02320)
NDI: NDAI_0C03810(NDAI0C03810)
TPF: TPHA_0E02930(TPHA0E02930)
TBL: TBLA_0A10080(TBLA0A10080)
TDL: TDEL_0E03730(TDEL0E03730)
KAF: KAFR_0H03590(KAFR0H03590)
PIC: PICST_66251(SDH1)
SLB: AWJ20_4699(SDH1)
BNN: FOA43_004408(SDH1)
NCR: NCU08336(tca-12)
NTE: NEUTE1DRAFT71896(NEUTE1DRAFT_71896)
MGR: MGG_00168
SSCK: SPSK_08603
MAW: MAC_01061
MAJ: MAA_05673
CMT: CCM_02366
MBE: MBM_01461
ANI: AN2916.2
ANG: ANI_1_1750024(An02g12770) ANI_1_2706024(An02g07600)
ABE: ARB_06591
TVE: TRV_04812
PNO: SNOG_07395(SNOG_07394) SNOG_16547(SNOG_16546)
SPO: SPAC1556.02c(sdh1)
CNE: CNI03270
CNB: CNBH3130
TASA: A1Q1_08198
ABP: AGABI1DRAFT111304(SDH1)
ABV: AGABI2DRAFT190526(SDH1)
SLA: SERLADRAFT_475471(SDH1)
MGL: MGL_3463
MRT: MRET_2097
DDI: DDB_G0280535(sdhA)
DFA: DFA_01593(sdhA)
PCB: PCHAS_051830(PC001322.02.0)
TAN: TA03455
TPV: TP03_0230
BBO: BBOV_IV007210(23.m06369)
SMIN: v1.2.013871.t1(symbB.v1.2.013871.t1)
PTI: PHATR_41812(SDH1)
FCY: FRACYDRAFT_173934(SDH5)
SPAR: SPRG_13201
 » show all
Reference
PMID:8142412
  Authors
Morris AA, Farnsworth L, Ackrell BA, Turnbull DM, Birch-Machin MA
  Title
The cDNA sequence of the flavoprotein subunit of human heart succinate dehydrogenase.
  Journal
Biochim Biophys Acta 1185:125-8 (1994)
DOI:10.1016/0005-2728(94)90203-8
  Sequence
[hsa:6389]
Reference
  Authors
Renkema GH, Wortmann SB, Smeets RJ, Venselaar H, Antoine M, Visser G, Ben-Omran T, van den Heuvel LP, Timmers HJ, Smeitink JA, Rodenburg RJ
  Title
SDHA mutations causing a multisystem mitochondrial disease: novel mutations and genetic overlap with hereditary tumors.
  Journal
Eur J Hum Genet 23:202-9 (2015)
DOI:10.1038/ejhg.2014.80
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