KEGG ORTHOLOGY: K00497

ORTHOLOGY: K00497

Entry

K00497 KO

Name

CYP11B1

Definition

steroid 11beta-monooxygenase [EC:1.14.15.4]

Pathway

ko00140

Steroid hormone biosynthesis

ko01100

Metabolic pathways

ko04927

Cortisol synthesis and secretion

ko04934

Cushing syndrome

Module

M00108

C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone

M00109

C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone

Disease

H00216

Congenital adrenal hyperplasia

H00602

Glucocorticoid-remediable aldosteronism (GRA)

H01603

Primary aldosteronism

H01633

High blood pressure

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K00497  CYP11B1; steroid 11beta-monooxygenase
09150 Organismal Systems
  09152 Endocrine system
   04927 Cortisol synthesis and secretion
    K00497  CYP11B1; steroid 11beta-monooxygenase
09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K00497  CYP11B1; steroid 11beta-monooxygenase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K00497  CYP11B1; steroid 11beta-monooxygenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.4  steroid 11beta-monooxygenase
     K00497  CYP11B1; steroid 11beta-monooxygenase
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP11 family
   K00497  CYP11B1; steroid 11beta-monooxygenase

Other DBs

RN:	R02218 R02725 R02843 R03329 R03851 R04850 R08949

GO:

0004507

Genes

HSA:	1584(CYP11B1)

PTR:	464437(CYP11B1)

PPS:

GGO:

PON:

NLE:

MCC:	695793(CYP11B1)

MCF:

102136659

CSAB:

103237546(CYP11B1)

RRO:

104679773

RBB:

108536535

CJC:	100415667(CYP11B1)

SBQ:

101048076

MMU:	110115(Cyp11b1) 13072(Cyp11b2)

MCAL:

110310257 110310258

MPAH:

110334511 110335023

RNO:	24294(Cyp11b2) 353498(Cyp11b3) 500892(Cyp11b1)

MUN:	110544545 110562757

CGE:	100771648 107977023

NGI:	103748431 103748432

HGL:	101700701 101701311

CCAN:

109681807 109681816

OCU:	100328543(CYP11B2) 100342863

TUP:	102471986 102492986

CFA:	111095088 482071(CYP11B2)

VVP:

AML:

UMR:

ORO:

ELK:

FCA:

PTG:

PPAD:

AJU:

BTA:	112449566 282422(CYP11B1) 787628

BOM:	102272939 102280195

BIU:	109568177 109568372 109568377

BBUB:

102394705 112577757 112579063

CHX:	102188238 102188517

OAS:	101102377 767576(CYP11B1)

SSC:

CFR:

CDK:

BACU:

LVE:

OOR:

DLE:

PCAD:

ECB:	100063612 100063645

EPZ:

EAI:

MYD:

MNA:

HAI:

DRO:

PALE:

RAY:

MJV:

LAV:

TMU:

MDO:

SHR:

PCW:

OAA:

TGU:

LSR:

PHI:

FPG:

FCH:

ASN:

AMJ:	102575737(CYP11B1)

CMY:

CPIC:

ACS:

PVT:

PBI:

PMUR:

TSR:

PMUA:

GJA:

XLA:	108718624(CYP11B1)

XTR:

101731070

DRE:	791124(cyp11c1)

SRX:

SANH:

SGH:

CCAR:

IPU:

PHYP:

AMEX:

EEE:

TRU:

TNG:	GSTEN00015374G001

LCO:

104920541

NCC:

104944920

MZE:

101463871

ONL:	100533461(cyp11b)

OLA:	100125822(cyp11b)

XMA:

XCO:

PRET:

CVG:

NFU:

KMR:

ALIM:

AOCE:

CSEM:

POV:

LCF:

SDU:

SLAL:

HCQ:

BPEC:

MALB:

SASA:

SALP:

ELS:

SFM:

PKI:

LCM:

Reference

PMID:2592361

Authors

Mornet E, Dupont J, Vitek A, White PC

Title

Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta).

Journal

J Biol Chem 264:20961-7 (1989)

Sequence

[hsa:1584]

Reference

PMID:3485096

Authors

Yanagibashi K, Haniu M, Shively JE, Shen WH, Hall P

Title

The synthesis of aldosterone by the adrenal cortex. Two zones (fasciculata and glomerulosa) possess one enzyme for 11 beta-, 18-hydroxylation, and aldehyde synthesis.

Journal

J Biol Chem 261:3556-62 (1986)

LinkDB

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