KEGG   ORTHOLOGY: K01044
Entry
K01044                      KO                                     

Name
CES1
Definition
carboxylesterase 1 [EC:3.1.1.1]
Pathway
ko00983  Drug metabolism - other enzymes
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00983 Drug metabolism - other enzymes
    K01044  CES1; carboxylesterase 1
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.1  Carboxylic-ester hydrolases
    3.1.1.1  carboxylesterase
     K01044  CES1; carboxylesterase 1
Other DBs
RN: R06728 R08220 R08249 R08251 R08255 R08258
GO: 0004091
CAZy: CE10
Genes
HSA: 1066(CES1)
PTR: 747009 750059
PPS: 100980372
GGO: 101149966 109023710 115931015 115931059
PON: 100174711(CES1) 100450658 100451021
NLE: 100590392(CES1) 100599005
MCC: 699486 707292 707412
MCF: 102127617 102128556 102129184(CES1)
CSAB: 103233018(CES1) 103233020 103233528
RRO: 104660506 104665604 104671477
CJC: 100390116 100390472(CES1)
SBQ: 101052402
MMU: 104158(Ces1d) 13884(Ces1c) 13897(Ces1e) 234564(Ces1f)
RNO: 100125372(Ces1f) 113902(Ces1d) 24346(Ces1c) 291863 29225(Ces1e)
HGL: 101725528
CCAN: 109694656
OCU: 100009551
TUP: 102481101(CES1)
CFA: 403643(CES1)
VVP: 112929624(CES1)
AML: 100465627(CES1)
UMR: 103673786(CES1)
UAH: 113252254(CES1)
ORO: 101377267(CES1)
ELK: 111157342
FCA: 493774(CES1)
PTG: 102957516(CES1)
PPAD: 109270897(CES1)
AJU: 106973293(CES1)
BTA: 508916 512098(CES1)
BOM: 102267380
BIU: 109572788
SSC: 100736962 397478(CES1)
CDK: 105096170(CES1) 116147134
BACU: 103015234
DLE: 111171077
PCAD: 102990478
MYB: 102241821(CES1)
MNA: 107543469(CES1)
HAI: 109395626(CES1)
DRO: 112296767(CES1)
PALE: 102884390(CES1)
RAY: 107499667(CES1)
MJV: 108387933(CES1)
MDO: 100144615(CES1)
SHR: 100922782
PCW: 110207506
OAA: 100079382
GGA: 415786(CES1L1) 769339(CES1L2) 769704
MGP: 104912916
APLA: 101790670
ACYG: 106033238
TGU: 100225286
SCAN: 103821143
FAB: 101818796
CCAE: 111934718
CCW: 104687533
FPG: 101920451
FCH: 102058343
EGZ: 104123642
NNI: 104013262
PADL: 103913725
AAM: 106483246
ASN: 102383127
AMJ: 102563772(CES1)
PSS: 102459884
PVT: 110081268
PBI: 103049679
PMUR: 107284175
TSR: 106547493(CES1)
PMUA: 114601889
GJA: 107110324(CES1)
DME: Dmel_CG17148(Est-P) Dmel_CG34139(Nlg4) Dmel_CG6917(Est-6)
DSI: Dsimw501_GD14366(Dsim_Est-6) Dsimw501_GD14367(Dsim_Est-P)
DYA: Dyak_GE21892 Dyak_GE21893(Dyak_Est-7)
DPO: Dpse_GA14349(Dpse_Est-5B)
DPE: 6596069
DMN: 108151116
DWI: 6645211
DNV: 108660307
DVI: 6632969
MDE: 101889364
LCQ: 111684753
AGA: AgaP_AGAP005372(COEBE3D)
CEL: CELE_C52A10.2(cest-35.2) CELE_R12A1.4(ges-1)
 » show all
Reference
  Authors
Furihata T, Hosokawa M, Koyano N, Nakamura T, Satoh T, Chiba K
  Title
Identification of di-(2-ethylhexyl) phthalate-induced carboxylesterase 1 in C57BL/6 mouse liver microsomes: purification, cDNA cloning, and baculovirus-mediated expression.
  Journal
Drug Metab Dispos 32:1170-7 (2004)
DOI:10.1124/dmd.104.000620
  Sequence
[mmu:104158]
Reference
PMID:9169443
  Authors
Pindel EV, Kedishvili NY, Abraham TL, Brzezinski MR, Zhang J, Dean RA, Bosron WF
  Title
Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin.
  Journal
J Biol Chem 272:14769-75 (1997)
DOI:10.1074/jbc.272.23.14769
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