KEGG   ORTHOLOGY: K01313
Entry
K01313                      KO                                     

Name
F2
Definition
coagulation factor II (thrombin) [EC:3.4.21.5]
Pathway
ko04072  Phospholipase D signaling pathway
ko04080  Neuroactive ligand-receptor interaction
ko04610  Complement and coagulation cascades
ko04611  Platelet activation
ko04810  Regulation of actin cytoskeleton
ko05130  Pathogenic Escherichia coli infection
ko05171  Coronavirus disease - COVID-19
ko05200  Pathways in cancer
Disease
H00223  Inherited thrombophilia
H01254  Congenital prothrombin deficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04072 Phospholipase D signaling pathway
    K01313  F2; coagulation factor II (thrombin)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K01313  F2; coagulation factor II (thrombin)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K01313  F2; coagulation factor II (thrombin)
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    K01313  F2; coagulation factor II (thrombin)
   04611 Platelet activation
    K01313  F2; coagulation factor II (thrombin)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K01313  F2; coagulation factor II (thrombin)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K01313  F2; coagulation factor II (thrombin)
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K01313  F2; coagulation factor II (thrombin)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K01313  F2; coagulation factor II (thrombin)
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K01313  F2; coagulation factor II (thrombin)
   00536 Glycosaminoglycan binding proteins
    K01313  F2; coagulation factor II (thrombin)
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.5  thrombin
     K01313  F2; coagulation factor II (thrombin)
Peptidases and inhibitors [BR:ko01002]
 Serine peptidases
  Family S1: chymotrypsin family
   K01313  F2; coagulation factor II (thrombin)
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of hepatic cells
   K01313  F2; coagulation factor II (thrombin)
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Heparin
  Coagulation and fibrinolysis
   K01313  F2; coagulation factor II (thrombin)
Genes
HSA: 2147(F2)
PTR: 451158(F2)
PPS: 100975534(F2)
GGO: 101149905(F2)
PON: 100173859(F2)
NLE: 100595467(F2)
MCC: 712729(F2)
MCF: 102131020(F2)
CSAB: 103236354
RRO: 104668398(F2)
RBB: 108521952(F2)
CJC: 100386446(F2)
SBQ: 101049318(F2)
MMU: 14061(F2)
MCAL: 110311945(F2)
MPAH: 110319115(F2)
RNO: 29251(F2)
MUN: 110549882(F2)
CGE: 100754947(F2)
NGI: 103742495(F2)
HGL: 101720561(F2)
CCAN: 109681600(F2)
OCU: 100009146(F2)
TUP: 102468231(F2)
CFA: 100856539(F2)
VVP: 112924085(F2)
AML: 100472871(F2)
UMR: 103672390(F2)
UAH: 113264978(F2)
ORO: 101381460(F2)
ELK: 111149799
FCA: 101090463(F2)
PTG: 102950768(F2)
PPAD: 109245108(F2)
AJU: 106978029(F2)
BTA: 280685(F2)
BOM: 102271164(F2)
BIU: 109569554(F2)
BBUB: 102415273(F2)
CHX: 102185018(F2)
OAS: 100307041(F2)
SSC: 100144442(F2)
CFR: 102515763(F2)
CDK: 105106867(F2)
BACU: 103013731(F2)
LVE: 103082406(F2)
OOR: 101289120(F2)
DLE: 111183976(F2)
PCAD: 102991552(F2)
ECB: 100057521(F2)
EPZ: 103566907(F2)
EAI: 106844001(F2)
MYB: 102252492(F2)
MYD: 102752205(F2)
MNA: 107530315(F2)
HAI: 109390173(F2)
DRO: 112303389(F2)
PALE: 102877724(F2)
RAY: 107511857(F2)
MJV: 108403296(F2)
LAV: 100666651(F2)
TMU: 101347713
MDO: 100015821(F2)
SHR: 100915186(F2)
PCW: 110223959(F2)
OAA: 100081028(F2)
GGA: 395306(F2)
MGP: 100549057(F2)
CJO: 107314808(F2)
NMEL: 110400969(F2)
APLA: 101792756(F2)
ACYG: 106043598(F2)
TGU: 100220988(F2)
LSR: 110472069(F2)
SCAN: 103826687(F2)
GFR: 102034334(F2)
FAB: 101811384(F2)
PHI: 102114657(F2)
PMAJ: 107205921(F2)
CCAE: 111930178(F2)
CCW: 104697991(F2)
ETL: 114058944(F2)
FPG: 101912106(F2)
FCH: 102047000(F2)
CLV: 102087936(F2)
EGZ: 104134075(F2)
NNI: 104020379(F2)
ACUN: 113480877(F2)
PADL: 103921711(F2)
AAM: 106498225(F2)
ASN: 102370968(F2)
AMJ: 102568064(F2)
PSS: 102449827(F2)
CMY: 102937607(F2)
CPIC: 101938037(F2)
ACS: 100566916(f2)
PVT: 110081895(F2)
PBI: 103065535(F2)
PMUR: 107294859(F2)
TSR: 106554431
PMUA: 114595904(F2)
GJA: 107106779(F2)
XLA: 443652(f2.L) 446352(f2.S)
XTR: 548514(f2)
NPR: 108791599(F2)
DRE: 325881(f2)
SRX: 107742559
IPU: 108259272(f2)
PHYP: 113546761(f2)
AMEX: 103039180(f2)
EEE: 113592322(f2)
TRU: 446073(f2)
LCO: 104936791(f2)
NCC: 104959957(f2)
ONL: 100702313
OLA: 101170246
XMA: 102217884(f2)
XCO: 114140554(f2)
PRET: 103480906(f2)
CVG: 107099194(f2)
NFU: 107384579(f2)
KMR: 108228250(f2)
ALIM: 106531261(f2)
AOCE: 111587274(f2)
CSEM: 103389837(f2)
POV: 109648054(f2)
SDU: 111235568(f2)
SLAL: 111646879(f2)
HCQ: 109510409(f2)
BPEC: 110172075(f2)
MALB: 109971101(f2)
ELS: 105017464(f2)
SFM: 108940837(f2)
PKI: 111858234(f2)
LCM: 102347036(F2)
CMK: 103186030(f2)
RTP: 109918716(f2)
APLC: 110974931
PTEP: 107437472
CRG: 105327809
OBI: 106884382
NVE: 5515513
SPIS: 111328185
HMG: 100204772
 » show all
Reference
PMID:6326805
  Authors
MacGillivray RT, Davie EW
  Title
Characterization of bovine prothrombin mRNA and its translation product.
  Journal
Biochemistry 23:1626-34 (1984)
DOI:10.1021/bi00303a007
  Sequence
[bta:280685]
Reference
PMID:2856554
  Authors
Glenn KC, Frost GH, Bergmann JS, Carney DH
  Title
Synthetic peptides bind to high-affinity thrombin receptors and modulate thrombin mitogenesis.
  Journal
Pept Res 1:65-73 (1988)
LinkDB

DBGET integrated database retrieval system