KEGG   ORTHOLOGY: K01648
Entry
K01648                      KO                                     

Name
ACLY
Definition
ATP citrate (pro-S)-lyase [EC:2.3.3.8]
Pathway
ko00020  Citrate cycle (TCA cycle)
ko00720  Carbon fixation pathways in prokaryotes
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    K01648  ACLY; ATP citrate (pro-S)-lyase
  09102 Energy metabolism
   00720 Carbon fixation pathways in prokaryotes
    K01648  ACLY; ATP citrate (pro-S)-lyase
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K01648  ACLY; ATP citrate (pro-S)-lyase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.3  Acyl groups converted into alkyl groups on transfer
    2.3.3.8  ATP citrate synthase
     K01648  ACLY; ATP citrate (pro-S)-lyase
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K01648  ACLY; ATP citrate (pro-S)-lyase
  Exosomal proteins of bladder cancer cells
   K01648  ACLY; ATP citrate (pro-S)-lyase
  Exosomal proteins of melanoma cells
   K01648  ACLY; ATP citrate (pro-S)-lyase
Other DBs
RN: R00352
GO: 0003878
Genes
HSA: 47(ACLY)
PTR: 454672(ACLY)
PPS: 100981849(ACLY)
GGO: 101132535(ACLY)
PON: 100439535(ACLY)
NLE: 100601132(ACLY)
MCC: 708501(ACLY)
MCF: 102139439(ACLY)
CSAB: 103243859(ACLY)
RRO: 104680455(ACLY) 115894939 115894954
RBB: 108518356 108534726(ACLY)
CJC: 100405725(ACLY)
SBQ: 101051906(ACLY)
MMU: 104112(Acly)
MCAL: 110304306(Acly)
MPAH: 110332696(Acly)
RNO: 24159(Acly)
MUN: 110540730(Acly)
CGE: 100773325(Acly)
NGI: 103735876(Acly)
HGL: 101700349(Acly)
CCAN: 109695762(Acly)
OCU: 100346747(ACLY)
TUP: 102487454(ACLY)
CFA: 607852(ACLY)
VVP: 112910827(ACLY)
AML: 100467494(ACLY)
UMR: 103672560(ACLY)
UAH: 113265439(ACLY)
ORO: 101368080(ACLY)
ELK: 111151216
FCA: 100422779(ACLY)
PTG: 102954566(ACLY)
PPAD: 109258552(ACLY)
AJU: 106972598(ACLY)
BTA: 511135(ACLY)
BOM: 102287054(ACLY)
BIU: 109573634(ACLY)
BBUB: 102393057(ACLY)
CHX: 102181894(ACLY)
OAS: 654404(ACLY)
SSC: 100125957(ACLY)
CFR: 102508520(ACLY)
CDK: 105090445(ACLY)
LVE: 103077497(ACLY)
OOR: 101277148(ACLY)
DLE: 111166237(ACLY)
ECB: 100053195(ACLY)
EPZ: 103550376(ACLY)
EAI: 106826361(ACLY)
MYB: 102246873(ACLY)
MYD: 102759921(ACLY)
MNA: 107538758(ACLY)
HAI: 109395729(ACLY)
DRO: 112298553(ACLY)
PALE: 102888049(ACLY)
RAY: 107513807(ACLY)
MJV: 108397138(ACLY)
LAV: 100667233(ACLY)
TMU: 101346806
MDO: 100011977(ACLY)
SHR: 100924578(ACLY)
PCW: 110198389(ACLY)
OAA: 100089333(ACLY)
GGA: 395373(ACLY)
MGP: 100544111(ACLY)
CJO: 107325118(ACLY)
NMEL: 110388478(ACLY)
APLA: 101793308(ACLY)
ACYG: 106048017(ACLY)
TGU: 100221719(ACLY)
LSR: 110471854(ACLY)
SCAN: 103821599(ACLY)
GFR: 102034815(ACLY)
FAB: 101805819(ACLY)
PHI: 102099293(ACLY)
PMAJ: 107215114(ACLY)
CCAE: 111939941(ACLY)
CCW: 104697755(ACLY)
ETL: 114063634(ACLY)
FPG: 101918381(ACLY)
FCH: 102047351(ACLY)
CLV: 102097494(ACLY)
EGZ: 104131387(ACLY)
NNI: 104009868(ACLY)
ACUN: 113489156(ACLY)
PADL: 103919491(ACLY)
AAM: 106487628(ACLY)
ASN: 102386616(ACLY)
AMJ: 102572777(ACLY)
PSS: 102444696(ACLY)
CMY: 102930695(ACLY)
CPIC: 101941763(ACLY)
ACS: 100557175(acly)
PVT: 110088988(ACLY)
PBI: 103067911(ACLY)
PMUR: 107303043(ACLY)
TSR: 106538254(ACLY)
PMUA: 114581513(ACLY)
GJA: 107116244(ACLY)
XLA: 495086(acly.S) 495316
XTR: 493390(acly)
NPR: 108788936(ACLY)
DRE: 436922(aclya) 794259(aclyb)
IPU: 108258521(acly) 108273769
PHYP: 113528283(acly) 113535056
AMEX: 103023371 103042216(acly)
EEE: 113581553 113592331(acly)
TRU: 101069651 101072240(acly)
NCC: 104949162(acly) 104967624
MZE: 101483257 101485070(acly)
ONL: 100690537(acly) 100706997
XMA: 102224554(acly) 102228484
XCO: 114152045 114159617(acly)
PRET: 103469414(acly) 103481260
CVG: 107099611(acly) 107099763
NFU: 107387857 107395298(acly)
KMR: 108243751(acly) 108249058
ALIM: 106516978 106527937(acly)
AOCE: 111566731 111584364(acly)
CSEM: 103381466 103393105(acly)
LCF: 108901343(acly) 108901721
SDU: 111217495(acly) 111220212
SLAL: 111652814(acly) 111657113
BPEC: 110154214 110161819(acly)
MALB: 109963029 109964230(acly)
ELS: 105013338(acly)
SFM: 108919709 108941823(acly)
PKI: 111842517 111855971(acly)
LCM: 102364563(ACLY)
CMK: 103185738(acly)
RTP: 109918067(acly)
BFO: 118424959
CIN: 445783(acl)
SKO: 100377487
DME: Dmel_CG8322(ATPCL)
DER: 6548754
DSE: 6609355
DSI: Dsimw501_GD25577(Dsim_GD25577)
DAN: 6496171
DSR: 110178519
DPE: 6601350
DWI: 6637856
DAZ: 108615968
DNV: 108654447
DHE: 111594006
DVI: 6627274
MDE: 101891858
LCQ: 111680485
AAG: 5564509
AALB: 109425132
AME: 550686
BIM: 100745478
BTER: 100650219
CCAL: 108627768
OBB: 114876334
MPHA: 105839063
AEC: 105143187
ACEP: 105622935
PBAR: 105429784
VEM: 105560699
HST: 105188186
DQU: 106743343
CFO: 105250699
LHU: 105675266
PGC: 109855528
OBO: 105285413
PCF: 106788484
NVI: 100119651
CSOL: 105361316
MDL: 103568760
TCA: 656728
DPA: 109541269
NVL: 108569619
BMAN: 114247106
PMAC: 106711742
PRAP: 111001964
HAW: 110382034
TNL: 113505697
PXY: 105380677
API: 100165099(Atpcl)
DNX: 107173542
AGS: 114119839
RMD: 113557292
BTAB: 109033027
CLEC: 106665077
ZNE: 110839946
FCD: 110847723
PVM: 113820574
TUT: 107362563
DPTE: 113791137
CSCU: 111628825
PTEP: 107443062
CEL: CELE_B0365.1(acly-2) CELE_D1005.1(acly-1)
BMY: Bm1_26245
TSP: Tsp_01728
PCAN: 112564404
CRG: 105335901
MYI: 110465532
OBI: 106879485
SHX: MS3_06938
NVE: 5509100
EPA: 110250736
AMIL: 114957318
PDAM: 113678655
SPIS: 111328982
DGT: 114530732
HMG: 100201862
AQU: 100640666
ATH: AT1G09430(ACLA-3) AT1G10670(ACLA-1) AT1G60810(ACLA-2) AT3G06650(ACLB-1) AT5G49460(ACLB-2)
LJA: Lj0g3v0068209.1(Lj0g3v0068209.1) Lj1g3v4804050.1(Lj1g3v4804050.1) Lj1g3v4804050.2(Lj1g3v4804050.2) Lj2g3v1415070.1(Lj2g3v1415070.1) Lj3g3v0937850.1(Lj3g3v0937850.1) Lj4g3v2265020.1(Lj4g3v2265020.1) Lj4g3v2266260.1(Lj4g3v2266260.1) Lj6g3v1915820.1(Lj6g3v1915820.1) Lj6g3v1915820.2(Lj6g3v1915820.2)
DOSA: Os01t0300200-01(Os01g0300200) Os11t0693800-01(Os11g0693800) Os11t0696200-01(Os11g0696200) Os12t0566300-01(Os12g0566300)
ATS: 109750159(LOC109750159) 109752526(LOC109752526) 109778001(LOC109778001) 109782165(LOC109782165)
ZMA: 100273868(cl718_1(752)) 100282948(pco080711) 100381760(pco065117) 103635086
SLB: AWJ20_2117(LSC1)
NTE: NEUTE1DRAFT117451(NEUTE1DRAFT_117451) NEUTE1DRAFT123184(NEUTE1DRAFT_123184)
SMP: SMAC_06774(acl2) SMAC_06775(acl1)
BFU: BCIN_13g02430(CND16) BCIN_13g02440(CND6)
ANG: ANI_1_76094(An11g00510) ANI_1_78094(An11g00530)
CNE: CNJ00800
CNB: CNBJ2710
TASA: A1Q1_06527
ABP: AGABI1DRAFT115583(AGABI1DRAFT_115583)
ABV: AGABI2DRAFT194501(AGABI2DRAFT_194501)
DFA: DFA_04229 DFA_09735(acly)
SMIN: v1.2.003200.t1(symbB.v1.2.003200.t1) v1.2.026551.t1(symbB.v1.2.026551.t1) v1.2.028198.t1(symbB.v1.2.028198.t1) v1.2.030373.t1(symbB.v1.2.030373.t1)
PTI: PHATRDRAFT_54477(ACL)
SPAR: SPRG_01813
BANA: BARAN1_0736(aclA)
PSYT: DSAG12_02466(sucD_2)
 » show all
Reference
PMID:1371749
  Authors
Elshourbagy NA, Near JC, Kmetz PJ, Wells TN, Groot PH, Saxty BA, Hughes SA, Franklin M, Gloger IS
  Title
Cloning and expression of a human ATP-citrate lyase cDNA.
  Journal
Eur J Biochem 204:491-9 (1992)
DOI:10.1111/j.1432-1033.1992.tb16659.x
  Sequence
[hsa:47]
Reference
  Authors
Beckner ME, Fellows-Mayle W, Zhang Z, Agostino NR, Kant JA, Day BW, Pollack IF
  Title
Identification of ATP citrate lyase as a positive regulator of glycolytic function in glioblastomas.
  Journal
Int J Cancer 126:2282-95 (2010)
DOI:10.1002/ijc.24918
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