KEGG   ORTHOLOGY: K01648
Entry
K01648                      KO                                     
Symbol
ACLY
Name
ATP citrate (pro-S)-lyase [EC:2.3.3.8]
Pathway
map00020  Citrate cycle (TCA cycle)
map00720  Carbon fixation pathways in prokaryotes
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    K01648  ACLY; ATP citrate (pro-S)-lyase
  09102 Energy metabolism
   00720 Carbon fixation pathways in prokaryotes
    K01648  ACLY; ATP citrate (pro-S)-lyase
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K01648  ACLY; ATP citrate (pro-S)-lyase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.3  Acyl groups converted into alkyl groups on transfer
    2.3.3.8  ATP citrate synthase
     K01648  ACLY; ATP citrate (pro-S)-lyase
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K01648  ACLY; ATP citrate (pro-S)-lyase
  Exosomal proteins of bladder cancer cells
   K01648  ACLY; ATP citrate (pro-S)-lyase
  Exosomal proteins of melanoma cells
   K01648  ACLY; ATP citrate (pro-S)-lyase
Other DBs
RN: R00352
GO: 0003878
Genes
HSA: 47(ACLY)
PTR: 454672(ACLY)
PPS: 100981849(ACLY)
GGO: 101132535(ACLY)
PON: 100439535(ACLY)
NLE: 100601132(ACLY)
MCC: 708501(ACLY)
MCF: 102139439(ACLY)
CSAB: 103243859(ACLY)
CATY: 105579653(ACLY)
PANU: 101024186(ACLY)
TGE: 112608921(ACLY)
RBB: 108518356 108534726(ACLY)
TFN: 117066983(ACLY)
PTEH: 111537388(ACLY)
CJC: 100405725(ACLY)
SBQ: 101051906(ACLY)
CSYR: 103274483(ACLY)
MMUR: 105872020(ACLY)
LCAT: 123620941(ACLY)
OGA: 100956684(ACLY)
MMU: 104112(Acly)
MCAL: 110304306(Acly)
MPAH: 110332696(Acly)
RNO: 24159(Acly)
MCOC: 116076949(Acly)
MUN: 110540730(Acly)
CGE: 100773325(Acly)
MAUA: 101830495(Acly)
PLEU: 114687692(Acly)
MORG: 121442402(Acly)
AAMP: 119811232(Acly)
NGI: 103735876(Acly)
HGL: 101700349(Acly)
CPOC: 100714933(Acly)
CCAN: 109695762(Acly)
DORD: 106003104(Acly)
DSP: 122103208(Acly)
NCAR: 124979100
OCU: 100346747(ACLY)
OPI: 101524926(ACLY)
TUP: 102487454(ACLY)
CFA: 607852(ACLY)
VVP: 112910827(ACLY)
VLG: 121472941(ACLY)
AML: 100467494(ACLY)
UMR: 103672560(ACLY)
UAH: 113265439(ACLY)
UAR: 123781807(ACLY)
ELK: 111151216
LLV: 125087875
MPUF: 101674988(ACLY)
ORO: 101368080(ACLY)
EJU: 114201339(ACLY)
ZCA: 113939688(ACLY)
MLX: 118024894(ACLY)
FCA: 100422779(ACLY)
PYU: 121045002(ACLY)
PBG: 122485581(ACLY)
PTG: 102954566(ACLY)
PPAD: 109258552(ACLY)
AJU: 106972598(ACLY)
HHV: 120248391(ACLY)
BTA: 511135(ACLY)
BOM: 102287054(ACLY)
BIU: 109573634(ACLY)
BBUB: 102393057(ACLY)
CHX: 102181894(ACLY)
OAS: 654404(ACLY)
ODA: 120867066(ACLY)
CCAD: 122441777(ACLY)
SSC: 100125957(ACLY)
CFR: 102508520(ACLY)
CBAI: 105080129(ACLY)
CDK: 105090445(ACLY)
VPC: 102545612(ACLY)
LVE: 103077497(ACLY)
OOR: 101277148(ACLY)
DLE: 111166237(ACLY)
PSIU: 116745727(ACLY)
ECB: 100053195(ACLY)
EPZ: 103550376(ACLY)
EAI: 106826361(ACLY)
MYB: 102246873(ACLY)
MYD: 102759921(ACLY)
MMYO: 118671528(ACLY)
MLF: 102431689(ACLY)
MNA: 107538758(ACLY)
PKL: 118726558(ACLY)
HAI: 109395729(ACLY)
DRO: 112298553(ACLY)
SHON: 118978158(ACLY)
AJM: 119037478(ACLY) 119058959
PDIC: 114504011(ACLY)
PHAS: 123817050(ACLY)
MMF: 118633865(ACLY)
RFQ: 117013319(ACLY)
PALE: 102888049(ACLY)
PGIG: 120611110(ACLY)
PVP: 105306309(ACLY)
RAY: 107513807(ACLY)
MJV: 108397138(ACLY)
TOD: 119232995(ACLY)
SARA: 101557062(ACLY)
LAV: 100667233(ACLY)
TMU: 101346806
DNM: 101433265(ACLY)
MDO: 100011977(ACLY)
GAS: 123247978(ACLY)
SHR: 100924578(ACLY)
PCW: 110198389(ACLY)
OAA: 100089333(ACLY)
GGA: 395373(ACLY)
PCOC: 116233620(ACLY)
MGP: 100544111(ACLY)
CJO: 107325118(ACLY)
NMEL: 110388478(ACLY)
APLA: 101793308(ACLY)
ACYG: 106048017(ACLY)
AFUL: 116498362(ACLY)
TGU: 100221719(ACLY)
LSR: 110471854(ACLY)
SCAN: 103821599(ACLY)
PMOA: 120496574(ACLY)
OTC: 121347625(ACLY)
PRUF: 121351094(ACLY)
GFR: 102034815(ACLY)
FAB: 101805819(ACLY)
PHI: 102099293(ACLY)
PMAJ: 107215114(ACLY)
CCAE: 111939941(ACLY)
CCW: 104697755(ACLY)
ETL: 114063634(ACLY)
ZAB: 102067752(ACLY)
FPG: 101918381(ACLY)
FCH: 102047351(ACLY)
CLV: 102097494(ACLY)
EGZ: 104131387(ACLY)
NNI: 104009868(ACLY)
PLET: 104614235(ACLY)
ACUN: 113489156(ACLY)
TALA: 104365621(ACLY)
PADL: 103919491(ACLY)
ACHC: 115344409(ACLY)
AAM: 106487628(ACLY)
AROW: 112968734(ACLY)
NPD: 112951798(ACLY)
DNE: 112992593(ACLY)
ASN: 102386616(ACLY)
AMJ: 102572777(ACLY)
CPOO: 109320349(ACLY)
GGN: 109289957(ACLY)
PSS: 102444696(ACLY)
CMY: 102930695(ACLY)
CPIC: 101941763(ACLY)
TST: 117869177(ACLY)
CABI: 116829910(ACLY)
MRV: 120392131(ACLY)
ACS: 100557175(acly)
PVT: 110088988(ACLY)
SUND: 121934891(ACLY)
PBI: 103067911(ACLY)
PMUR: 107303043(ACLY)
TSR: 106538254(ACLY)
PGUT: 117664713(ACLY)
VKO: 123031763(ACLY)
PMUA: 114581513(ACLY)
ZVI: 118094376(ACLY)
GJA: 107116244(ACLY)
STOW: 125444737(ACLY)
XLA: 495086(acly.S) 495316(acly.L)
XTR: 493390(acly)
NPR: 108788936(ACLY)
RTEM: 120919493(ACLY)
BBUF: 121003463(ACLY)
BGAR: 122940355(ACLY)
DRE: 436922(aclya) 794259(aclyb)
PPRM: 120488705(aclyb) 120489691(aclya)
MAMB: 125265715(aclyb) 125279648(aclya)
IPU: 108258521(aclya) 108273769(aclyb)
PHYP: 113528283(acly) 113535056
SMEO: 124388718(aclyb) 124396749(aclya)
TFD: 113652150(aclya) 113662180
AMEX: 103023371 103042216(acly)
EEE: 113581553 113592331(acly)
TRU: 101069651 101072240(acly)
NCC: 104949162(acly) 104967624
CGOB: 115012143(acly) 115024735
ELY: 117259920 117268634(aclya)
PLEP: 121956466(aclya) 121958597(aclyb)
SLUC: 116059528(aclya) 116060998(aclyb)
ECRA: 117937471(aclyb) 117958405(aclya)
PFLV: 114547671 114569737(acly)
GAT: 120819475(aclyb) 120828434(aclya)
PPUG: 119212752(aclyb) 119219987(aclya)
MSAM: 119892455(aclya) 119915765(aclyb)
CUD: 121503598(aclya) 121528317
ALAT: 119009675(aclyb) 119014446(aclya)
MZE: 101483257 101485070(acly)
ONL: 100690537(acly) 100706997
OAU: 116329806(aclyb) 116330962(aclya)
OML: 112146149(aclya) 112153948
XMA: 102224554(acly) 102228484
XCO: 114152045 114159617(acly)
XHE: 116726715 116735355(acly)
PRET: 103469414(acly) 103481260
PFOR: 103142184(acly) 103155717
PLAI: 106949824 106950771(acly)
PMEI: 106921562(acly) 106926202
GAF: 122821438(aclya) 122822929(aclyb)
CVG: 107099611(acly) 107099763
CTUL: 119778894(aclya) 119792203
NFU: 107387857 107395298(acly)
KMR: 108243751(aclya) 108249058(aclyb)
ALIM: 106516978 106527937(acly)
NWH: 119421901(aclya) 119424004(aclyb)
AOCE: 111566731 111584364(acly)
CSEM: 103381466 103393105(acly)
SSEN: 122759229 122784904(aclya)
HHIP: 117752512(aclyb) 117766451(aclya)
HSP: 118100585(aclyb) 118123023(aclya)
LCF: 108901343(acly) 108901721
SDU: 111217495(acly) 111220212
SLAL: 111652814(acly) 111657113
XGL: 120787218(aclya) 120794225(aclyb)
BPEC: 110154214 110161819(acly)
MALB: 109963029 109964230(acly)
BSPL: 114846003(aclyb) 114860054(aclya)
ELS: 105013338(acly)
SFM: 108919709 108941823(acly)
PKI: 111842517 111855971(acly)
LOC: 102685883(acly)
LCM: 102364563(ACLY)
CMK: 103185738(aclya)
RTP: 109918067(acly)
BFO: 118424959
BBEL: 109478072
CIN: 445783(acl)
SCLV: 120340506
SKO: 100377487
DME: Dmel_CG8322(ATPCL)
DER: 6548754
DSE: 6609355
DSI: Dsimw501_GD25577(Dsim_GD25577)
DAN: 6496171
DSR: 110178519
DPE: 6601350
DWI: 6637856
DGR: 6559431
DAZ: 108615968
DNV: 108654447
DHE: 111594006
DVI: 6627274
CCAT: 101454151
BOD: 106624638
MDE: 101891858
SCAC: 106080979
LCQ: 111680485
LSQ: 119602967
HIS: 119648075
ACOZ: 120954680
AARA: 120904258
ASTE: 118511080
AAG: 5564509
AALB: 109425132
CNS: 116352200
BCOO: 119073824
AME: 550686
ACER: 108000656
ALAB: 122711357
BIM: 100745478
BBIF: 117206207
BVK: 117243094
BVAN: 117155419
BTER: 100650219
BPYO: 122574930
CCAL: 108627768
OBB: 114876334
MGEN: 117226026
NMEA: 116434004
CGIG: 122400811
MPHA: 105839063
AEC: 105143187
ACEP: 105622935
PBAR: 105429784
VEM: 105560699
HST: 105188186
DQU: 106743343
CFO: 105250699
FEX: 115240037
LHU: 105675266
PGC: 109855528
OBO: 105285413
PCF: 106788484
PFUC: 122515481
VPS: 122637096
NVI: 100119651
CSOL: 105361316
TPRE: 106653511
MDL: 103568760
CGLO: 123269135
FAS: 105265654
DAM: 107037520
CCIN: 107269339
TCA: 656728
DPA: 109541269
SOY: 115883184
CSET: 123319914
AGB: 108903861
NVL: 108569619
APLN: 108732322
PPYR: 116167655
OTU: 111417043
BMOR: 101741993
BMAN: 114247106
MSEX: 115449308
BANY: 112054577
PMAC: 106711742
PPOT: 106100023
PXU: 106115279
PRAP: 111001964
ZCE: 119838899
HAW: 110382034
TNL: 113505697
SLIU: 111351504
OFU: 114353856
PXY: 105380677
API: 100165099(Atpcl)
DNX: 107173542
AGS: 114119839
RMD: 113557292
BTAB: 109033027
DCI: 103505301
CLEC: 106665077
HHAL: 106689183
NLU: 111048221
FOC: 113209811
TPAL: 117641689
ZNE: 110839946
CSEC: 111861706
FCD: 110847723
DMK: 116918736
PVM: 113820574
PJA: 122254350
PCHN: 125037371
HAME: 121853184
PCLA: 123767574
PTRU: 123515388
HAZT: 108664892
LSM: 121121478
PPOI: 119096431
DSV: 119441599
RSAN: 119386505
RMP: 119178791
VDE: 111251065
VJA: 111273700
TUT: 107362563
DPTE: 113791137
DFR: 124498178
CSCU: 111628825
PTEP: 107443062
SDM: 118183502
CEL: CELE_B0365.1(acly-2) CELE_D1005.1(acly-1)
BMY: BM_BM1778(Bm1778)
TSP: Tsp_01728
PCAN: 112564404
BGT: 106058278
HRF: 124141569
HRJ: 124285067
CRG: 105335901
MYI: 110465532
PMAX: 117344311
MMER: 123532481
OBI: 106879485
OSN: 115216353
NVE: 5509100
EPA: 110250736
ATEN: 116302957
AMIL: 114957318
PDAM: 113678655
SPIS: 111328982
DGT: 114530732
XEN: 124439725
HMG: 100201862
AQU: 100640666
ATH: AT1G09430(ACLA-3) AT1G10670(ACLA-1) AT1G60810(ACLA-2) AT3G06650(ACLB-1) AT5G49460(ACLB-2)
LJA: Lj0g3v0068209.1(Lj0g3v0068209.1) Lj1g3v4804050.1(Lj1g3v4804050.1) Lj1g3v4804050.2(Lj1g3v4804050.2) Lj2g3v1415070.1(Lj2g3v1415070.1) Lj3g3v0937850.1(Lj3g3v0937850.1) Lj4g3v2265020.1(Lj4g3v2265020.1) Lj4g3v2266260.1(Lj4g3v2266260.1) Lj6g3v1915820.1(Lj6g3v1915820.1) Lj6g3v1915820.2(Lj6g3v1915820.2)
DOSA: Os01t0300200-01(Os01g0300200) Os11t0693800-01(Os11g0693800) Os11t0696200-01(Os11g0696200) Os12t0566300-01(Os12g0566300)
SLB: AWJ20_2117(LSC1)
NTE: NEUTE1DRAFT117451(NEUTE1DRAFT_117451) NEUTE1DRAFT123184(NEUTE1DRAFT_123184)
SMP: SMAC_06774(acl2) SMAC_06775(acl1)
BFU: BCIN_13g02430(CND16) BCIN_13g02440(CND6)
ANG: ANI_1_76094(An11g00510) ANI_1_78094(An11g00530)
ALUC: AKAW2_80054A(ACL1) AKAW2_80055S(ACL2)
ACHE: ACHE_60186A(ACL1) ACHE_60187S(ACL2)
APUU: APUU_20841A(ACL2) APUU_20842S(ACL1)
CNE: CNJ00800
CNB: CNBJ2710
TASA: A1Q1_06527
ABP: AGABI1DRAFT115583(AGABI1DRAFT_115583)
ABV: AGABI2DRAFT194501(AGABI2DRAFT_194501)
DFA: DFA_04229 DFA_09735(acly)
SMIN: v1.2.003200.t1(symbB.v1.2.003200.t1) v1.2.026551.t1(symbB.v1.2.026551.t1) v1.2.028198.t1(symbB.v1.2.028198.t1) v1.2.030373.t1(symbB.v1.2.030373.t1)
PTI: PHATRDRAFT_54477(ACL)
SPAR: SPRG_01813
BANA: BARAN1_0736(aclA)
PSYT: DSAG12_02466(sucD_2)
 » show all
Reference
PMID:1371749
  Authors
Elshourbagy NA, Near JC, Kmetz PJ, Wells TN, Groot PH, Saxty BA, Hughes SA, Franklin M, Gloger IS
  Title
Cloning and expression of a human ATP-citrate lyase cDNA.
  Journal
Eur J Biochem 204:491-9 (1992)
DOI:10.1111/j.1432-1033.1992.tb16659.x
  Sequence
[hsa:47]
Reference
  Authors
Beckner ME, Fellows-Mayle W, Zhang Z, Agostino NR, Kant JA, Day BW, Pollack IF
  Title
Identification of ATP citrate lyase as a positive regulator of glycolytic function in glioblastomas.
  Journal
Int J Cancer 126:2282-95 (2010)
DOI:10.1002/ijc.24918
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