KEGG ORTHOLOGY: K02157

ORTHOLOGY: K02157

Entry

K02157 KO

Name

AXIN1

Definition

axin 1

Pathway

ko04310

Wnt signaling pathway

ko04390

Hippo signaling pathway

ko04550

Signaling pathways regulating pluripotency of stem cells

ko04934

Cushing syndrome

ko05010

Alzheimer disease

ko05022

Pathways of neurodegeneration - multiple diseases

ko05165

Human papillomavirus infection

ko05200

Pathways in cancer

ko05210

Colorectal cancer

ko05213

Endometrial cancer

ko05217

Basal cell carcinoma

ko05224

Breast cancer

ko05225

Hepatocellular carcinoma

ko05226

Gastric cancer

Disease

H00048

Hepatocellular carcinoma

H00934

Caudal duplication anomaly

H01667

Medulloblastoma

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K02157  AXIN1; axin 1
   04390 Hippo signaling pathway
    K02157  AXIN1; axin 1
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K02157  AXIN1; axin 1
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K02157  AXIN1; axin 1
  09162 Cancer: specific types
   05210 Colorectal cancer
    K02157  AXIN1; axin 1
   05225 Hepatocellular carcinoma
    K02157  AXIN1; axin 1
   05226 Gastric cancer
    K02157  AXIN1; axin 1
   05217 Basal cell carcinoma
    K02157  AXIN1; axin 1
   05213 Endometrial cancer
    K02157  AXIN1; axin 1
   05224 Breast cancer
    K02157  AXIN1; axin 1
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    K02157  AXIN1; axin 1
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K02157  AXIN1; axin 1
   05022 Pathways of neurodegeneration - multiple diseases
    K02157  AXIN1; axin 1
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K02157  AXIN1; axin 1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K02157  AXIN1; axin 1
Protein phosphatases and associated proteins [BR:ko01009]
Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K02157  AXIN1; axin 1

Genes

HSA:	8312(AXIN1)

PTR:	453789(AXIN1)

PPS:	100986279(AXIN1)

GGO:	101150555(AXIN1)

PON:	100434225(AXIN1)

NLE:	101179424(AXIN1)

MCC:	100424087(AXIN1)

MCF:	102142970(AXIN1)

CSAB:

103225216(AXIN1)

RRO:	104676962(AXIN1)

RBB:	108521119(AXIN1)

CJC:	100392475(AXIN1)

SBQ:	101035780(AXIN1)

MMU:	12005(Axin1)

MCAL:

110284040(Axin1)

MPAH:

110338127(Axin1)

RNO:	79257(Axin1)

MUN:	110548696(Axin1)

CGE:	100758169(Axin1)

NGI:	103748223(Axin1)

HGL:	101700795(Axin1)

CCAN:

109694685(Axin1)

OCU:	100348127(AXIN1)

TUP:	102469399(AXIN1)

CFA:	490099(AXIN1)

VVP:	112909128(AXIN1)

AML:	100473018(AXIN1)

UMR:	103668450(AXIN1)

UAH:	113245367(AXIN1)

ORO:	101375084(AXIN1)

ELK:

111156118

FCA:	101088804(AXIN1)

PTG:	102951323(AXIN1)

PPAD:

109259643(AXIN1)

AJU:	106977359(AXIN1)

BTA:	504357(AXIN1)

BOM:	102267637(AXIN1)

BIU:	109578518(AXIN1)

BBUB:

102394098(AXIN1)

CHX:	102170375(AXIN1)

OAS:	101122656(AXIN1)

SSC:	100523725(AXIN1)

CFR:	102508916(AXIN1)

CDK:	105098424(AXIN1)

BACU:

103006014(AXIN1)

LVE:	103085333(AXIN1)

OOR:	101272348(AXIN1)

DLE:	111185093(AXIN1)

PCAD:

102986270(AXIN1)

ECB:	100065116(AXIN1)

EPZ:	103564115(AXIN1)

EAI:	106836161(AXIN1)

MYB:	102248340(AXIN1)

MYD:	102759594(AXIN1)

MNA:	107539654(AXIN1)

HAI:	109385980(AXIN1)

DRO:	112298256(AXIN1)

PALE:

102878657(AXIN1)

RAY:	107506131(AXIN1)

MJV:	108408106(AXIN1)

LAV:	100655765(AXIN1)

TMU:

101346985

MDO:	100016298(AXIN1)

SHR:	100923576(AXIN1)

PCW:	110221974(AXIN1)

OAA:	100093450(AXIN1)

GGA:	395786(AXIN1)

MGP:	100539162(AXIN1)

CJO:	107320950(AXIN1)

NMEL:

110405669(AXIN1)

APLA:

101800899(AXIN1)

ACYG:

106033419(AXIN1)

TGU:	100226467(AXIN1)

LSR:	110480560(AXIN1)

SCAN:

103817752(AXIN1)

GFR:	102034015(AXIN1)

FAB:	101812314(AXIN1)

PHI:	102108019(AXIN1)

PMAJ:

107211202(AXIN1)

CCAE:

111935875(AXIN1)

CCW:	104684681(AXIN1)

ETL:	114057037(AXIN1)

FPG:	101924311(AXIN1)

FCH:	102054847(AXIN1)

CLV:	102091034(AXIN1)

EGZ:	104135741(AXIN1)

NNI:	104023427(AXIN1)

ACUN:

113485942(AXIN1)

PADL:

103917539(AXIN1)

AAM:	106482339(AXIN1)

ASN:	102383198(AXIN1)

AMJ:	102566966(AXIN1)

PSS:	102453080(AXIN1)

CMY:	102945350(AXIN1)

CPIC:

101932057(AXIN1)

ACS:	100561864(axin1)

PVT:

110089118

PBI:	103053070(AXIN1)

PMUR:

107283957

TSR:	106551582(AXIN1)

PMUA:

114583932(AXIN1)

GJA:	107109315(AXIN1)

XLA:	398097(axin1.L) 734298(axin1.S)

XTR:	100498631(axin1)

NPR:	108796271(AXIN1)

DRE:	57931(axin1)

SRX:	107727128 107745589 107758382

SANH:

107662718 107674664 107703383

SGH:	107564695 107568923 107575039

CCAR:

109047174 109096359 109110185

IPU:	108257243(axin1)

PHYP:

113536021(axin1)

AMEX:

103030717 103045152(axin1)

EEE:	113570287(axin1) 113591421

TRU:	101065196(axin1) 101075840

TNG:	GSTEN00015703G001 GSTEN00034436G001

LCO:	104918719(axin1) 104921153

NCC:

104952093

MZE:	101472703 101487168(axin1)

ONL:	100695880 100697931

OLA:	101155494 101155852(axin1)

XMA:	102228925 102232266(axin1)

XCO:	114144827 114160292(axin1)

PRET:

103456513 103468679(axin1)

CVG:	107092806(axin1) 107097051

NFU:	107378411(axin1) 107395828

KMR:	108241749 108243734(axin1)

ALIM:

106522717 106528550(axin1)

AOCE:

111576703(axin1) 111587652

CSEM:

103383461 103392632(axin1)

POV:	109634337(axin1) 109639592

LCF:	108901170 108903015(axin1)

SDU:	111216635 111217642(axin1)

SLAL:

111651284 111660637(axin1)

HCQ:	109511398 109513801(axin1)

BPEC:

110157754 110168848

MALB:

109965916(axin1) 109973291

SASA:

106593205 106595544 106601114 106607340

OTW:	112226036 112246035

SALP:

111980490 111980587

ELS:	105013228(axin1) 105030252

SFM:	108927488 108929577

PKI:	111836909 111845554

LCM:	102351869(AXIN1)

CMK:	103188268(axin1)

RTP:

109935789

BFO:

118429299

CIN:	778548(axin)

SPU:

576611

APLC:

110976115

SKO:	100303567(axin1)

DME:	Dmel_CG7926(Axn)

DER:

6554369

DSE:

6612800

DSI:	Dsimw501_GD21494(Dsim_Axn)

DYA:	Dyak_GE10849

DAN:

6505639

DSR:

110186964

DPO:	Dpse_GA20694

DPE:

6594969

DMN:

108156381

DWI:

6651128

DGR:	Dgri_GH19169

DMO:	Dmoj_GI24204

DAZ:

DNV:

DHE:

DVI:

MDE:

LCQ:

AGA:	AgaP_AGAP002123

AAG:

5577995

AALB:

109402027 109413707

CQU:	CpipJ_CPIJ001221

AME:

BIM:

BTER:

CCAL:

OBB:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:	105557855 105563303 105567083

HST:

DQU:

CFO:

LHU:

PGC:

OBO:

PCF:

NVI:

CSOL:

MDL:

TCA:	655873(Axn)

DPA:

ATD:

NVL:

BMOR:

BMAN:

DPL:	KGM_210820

PMAC:

PRAP:

HAW:

TNL:

API:

DNX:

AGS:

RMD:

BTAB:

CLEC:

PHU:	Phum_PHUM327400

ZNE:

110835724

FCD:

110848502

DPX:	DAPPUDRAFT_301655

PVM:	113802786 113809792

ISC:	IscW_ISCW013850

DPTE:

113794778

CSCU:

111630953

PTEP:

107454244

CEL:	CELE_C37A5.9(pry-1)

CBR:	CBG18802(Cbr-pry-1)

BMY:	Bm1_30340 Bm1_56035

LOA:	LOAG_02197 LOAG_09731

NAI:	NECAME_03426

TSP:

PCAN:

CRG:

MYI:

OBI:

LAK:

SMM:	Smp_166200 Smp_171750

OVI:	T265_07915 T265_14407

EGL:	EGR_02768 EGR_07621

NVE:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

HMG:

TAD:	TRIADDRAFT_53011

» show all

Reference

PMID:9230313

Authors

Zeng L, Fagotto F, Zhang T, Hsu W, Vasicek TJ, Perry WL 3rd, Lee JJ, Tilghman SM, Gumbiner BM, Costantini F

Title

The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation.

Journal

Cell 90:181-92 (1997)
DOI:10.1016/S0092-8674(00)80324-4

Sequence

[hsa:8312]

Reference

PMID:15067197

Authors

Luo W, Lin SC

Title

Axin: a master scaffold for multiple signaling pathways.

Journal

Neurosignals 13:99-113 (2004)
DOI:10.1159/000076563

Reference

PMID:10457025

Authors

Willert K, Logan CY, Arora A, Fish M, Nusse R

Title

A Drosophila Axin homolog, Daxin, inhibits Wnt signaling.

Journal

Development 126:4165-73 (1999)

Sequence

[dme:Dmel_CG7926]

LinkDB

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