KEGG ORTHOLOGY: K02158

ORTHOLOGY: K02158

Entry

K02158                      KO

Symbol

BAD

Name

Bcl-2-antagonist of cell death

Pathway

map01521

EGFR tyrosine kinase inhibitor resistance

map01522

Endocrine resistance

map01524

Platinum drug resistance

map04012

ErbB signaling pathway

map04014

Ras signaling pathway

map04022

cGMP-PKG signaling pathway

map04024

cAMP signaling pathway

map04062

Chemokine signaling pathway

map04140

Autophagy - animal

map04151

PI3K-Akt signaling pathway

map04210

Apoptosis

map04370

VEGF signaling pathway

map04510

Focal adhesion

map04722

Neurotrophin signaling pathway

map04910

Insulin signaling pathway

map04919

Thyroid hormone signaling pathway

map05010

Alzheimer disease

map05014

Amyotrophic lateral sclerosis

map05020

Prion disease

map05022

Pathways of neurodegeneration - multiple diseases

map05145

Toxoplasmosis

map05152

Tuberculosis

map05160

Hepatitis C

map05161

Hepatitis B

map05162

Measles

map05165

Human papillomavirus infection

map05168

Herpes simplex virus 1 infection

map05170

Human immunodeficiency virus 1 infection

map05200

Pathways in cancer

map05203

Viral carcinogenesis

map05207

Chemical carcinogenesis - receptor activation

map05208

Chemical carcinogenesis - reactive oxygen species

map05210

Colorectal cancer

map05211

Renal cell carcinoma

map05212

Pancreatic cancer

map05213

Endometrial cancer

map05215

Prostate cancer

map05218

Melanoma

map05220

Chronic myeloid leukemia

map05221

Acute myeloid leukemia

map05223

Non-small cell lung cancer

map05225

Hepatocellular carcinoma

map05417

Lipid and atherosclerosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K02158  BAD; Bcl-2-antagonist of cell death
   04014 Ras signaling pathway
    K02158  BAD; Bcl-2-antagonist of cell death
   04370 VEGF signaling pathway
    K02158  BAD; Bcl-2-antagonist of cell death
   04024 cAMP signaling pathway
    K02158  BAD; Bcl-2-antagonist of cell death
   04022 cGMP-PKG signaling pathway
    K02158  BAD; Bcl-2-antagonist of cell death
   04151 PI3K-Akt signaling pathway
    K02158  BAD; Bcl-2-antagonist of cell death
09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K02158  BAD; Bcl-2-antagonist of cell death
  09143 Cell growth and death
   04210 Apoptosis
    K02158  BAD; Bcl-2-antagonist of cell death
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K02158  BAD; Bcl-2-antagonist of cell death
09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    K02158  BAD; Bcl-2-antagonist of cell death
  09152 Endocrine system
   04910 Insulin signaling pathway
    K02158  BAD; Bcl-2-antagonist of cell death
   04919 Thyroid hormone signaling pathway
    K02158  BAD; Bcl-2-antagonist of cell death
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K02158  BAD; Bcl-2-antagonist of cell death
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K02158  BAD; Bcl-2-antagonist of cell death
   05207 Chemical carcinogenesis - receptor activation
    K02158  BAD; Bcl-2-antagonist of cell death
   05208 Chemical carcinogenesis - reactive oxygen species
    K02158  BAD; Bcl-2-antagonist of cell death
   05203 Viral carcinogenesis
    K02158  BAD; Bcl-2-antagonist of cell death
  09162 Cancer: specific types
   05210 Colorectal cancer
    K02158  BAD; Bcl-2-antagonist of cell death
   05212 Pancreatic cancer
    K02158  BAD; Bcl-2-antagonist of cell death
   05225 Hepatocellular carcinoma
    K02158  BAD; Bcl-2-antagonist of cell death
   05221 Acute myeloid leukemia
    K02158  BAD; Bcl-2-antagonist of cell death
   05220 Chronic myeloid leukemia
    K02158  BAD; Bcl-2-antagonist of cell death
   05218 Melanoma
    K02158  BAD; Bcl-2-antagonist of cell death
   05211 Renal cell carcinoma
    K02158  BAD; Bcl-2-antagonist of cell death
   05215 Prostate cancer
    K02158  BAD; Bcl-2-antagonist of cell death
   05213 Endometrial cancer
    K02158  BAD; Bcl-2-antagonist of cell death
   05223 Non-small cell lung cancer
    K02158  BAD; Bcl-2-antagonist of cell death
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K02158  BAD; Bcl-2-antagonist of cell death
   05161 Hepatitis B
    K02158  BAD; Bcl-2-antagonist of cell death
   05160 Hepatitis C
    K02158  BAD; Bcl-2-antagonist of cell death
   05162 Measles
    K02158  BAD; Bcl-2-antagonist of cell death
   05168 Herpes simplex virus 1 infection
    K02158  BAD; Bcl-2-antagonist of cell death
   05165 Human papillomavirus infection
    K02158  BAD; Bcl-2-antagonist of cell death
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    K02158  BAD; Bcl-2-antagonist of cell death
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K02158  BAD; Bcl-2-antagonist of cell death
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K02158  BAD; Bcl-2-antagonist of cell death
   05014 Amyotrophic lateral sclerosis
    K02158  BAD; Bcl-2-antagonist of cell death
   05020 Prion disease
    K02158  BAD; Bcl-2-antagonist of cell death
   05022 Pathways of neurodegeneration - multiple diseases
    K02158  BAD; Bcl-2-antagonist of cell death
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K02158  BAD; Bcl-2-antagonist of cell death
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K02158  BAD; Bcl-2-antagonist of cell death
   01524 Platinum drug resistance
    K02158  BAD; Bcl-2-antagonist of cell death
   01522 Endocrine resistance
    K02158  BAD; Bcl-2-antagonist of cell death

Genes

HSA:

572(BAD)

PTR:	100615623(BAD)

PPS:	100988665(BAD)

GGO:	101151128(BAD)

PON:	100454097(BAD)

PPYG:

129008804(BAD)

NLE:	101178725(BAD)

HMH:	116468949(BAD)

SSYN:

129460822(BAD)

MCC:	717740(BAD)

MCF:	102121921(BAD)

MTHB:

126935617

MNI:	105469512(BAD)

CSAB:

103233293(BAD)

CATY:

105577493(BAD)

PANU:

101012551(BAD)

TGE:	112606473(BAD)

MLEU:

105549098(BAD)

RRO:	104673141(BAD)

RBB:	108542734(BAD)

TFN:	117080612(BAD)

PTEH:

111522294(BAD)

CANG:

105512212(BAD)

CJC:	100412880(BAD)

SBQ:	101049631(BAD)

CIMI:

108310302(BAD)

ANAN:

105724476(BAD)

MMUR:

105878474(BAD)

LCAT:

123641429(BAD)

PCOQ:

105827296(BAD)

OGA:	100962306(BAD)

MMU:	12015(Bad)

MCAL:

110285481(Bad)

MPAH:

110326250(Bad)

RNO:	64639(Bad)

MCOC:

116103467(Bad)

ANU:	117706557(Bad)

ASYL:

127691417(Bad)

MUN:	110551603(Bad)

CGE:	100760426(Bad)

MAUA:

101836153(Bad)

PROB:

127228773(Bad)

PLEU:

114680676(Bad)

MORG:

121454562(Bad)

MFOT:

126498361

AAMP:

119820525(Bad)

NGI:	103738795(Bad)

HGL:	101726042(Bad)

CPOC:

100734151(Bad)

CCAN:

109683261(Bad)

DORD:

105989249(Bad)

DSP:	122105036(Bad)

PLOP:

125362685(Bad)

NCAR:

124958534

MMMA:

107135974(Bad)

ITI:	101960598(Bad)

OCU:

100358587

OPI:	101534340(BAD)

TUP:	102498069(BAD)

GVR:	103586204(BAD)

CFA:	483763(BAD)

CLUD:

112659359(BAD)

VVP:	112924315(BAD)

VLG:	121501608(BAD)

NPO:	129503119(BAD)

AML:	100473937(BAD)

UMR:	103679423(BAD)

UAH:	113244178(BAD)

UAR:	123778440(BAD)

ELK:

111149975

LLV:

125079150

MPUF:

101686427(BAD)

MNP:	132019536(BAD)

MLK:	131814653(BAD)

NVS:	122913061(BAD)

ORO:	101375422(BAD)

EJU:	114220328(BAD)

ZCA:	113914539(BAD)

MLX:	118016000(BAD)

NSU:	110575945(BAD)

LWW:	102728568(BAD)

FCA:	768269(BAD)

PYU:	121023947(BAD)

PCOO:

112852108(BAD)

PBG:	122483950(BAD)

PVIV:

125176067(BAD)

LRUF:

124505120

PTG:	102956027(BAD)

PPAD:

109246663(BAD)

PUC:

125931741

AJU:

106981699

HHV:	120240137(BAD)

BTA:	615013(BAD)

BOM:	102275975(BAD)

BIU:	109554386(BAD)

BBUB:

102414298(BAD)

BBIS:

104987190(BAD)

CHX:	102189930(BAD)

OAS:	780444(BAD)

BTAX:

128068977(BAD)

CSUM:

138082916(BAD)

ODA:	120874698(BAD)

CCAD:

122430652(BAD)

MREE:

136169687(BAD)

MBEZ:

129548816(BAD)

SSC:	100521065(BAD)

CFR:	102523295(BAD)

CBAI:

105070634(BAD)

CDK:	105101547(BAD)

VPC:	102538813(BAD)

BACU:

103005702(BAD)

BMUS:

118899830(BAD)

LVE:	103083608(BAD)

OOR:	101274967(BAD)

DLE:	111183810(BAD)

PCAD:

102974655(BAD)

PSIU:

116758242(BAD)

NASI:

112402326(BAD)

ECB:	100055447(BAD)

EPZ:	103542187(BAD)

EAI:	106833626(BAD)

MYB:	102239479(BAD)

MYD:	102771665(BAD)

MMYO:

118665363(BAD)

MLF:	102437980(BAD)

MDT:	132241476(BAD)

PKL:	118707283(BAD)

EFUS:

103302047(BAD)

MNA:	107539805(BAD)

DRO:	112317275(BAD)

SHON:

118991674(BAD)

AJM:	119045448(BAD)

PDIC:

114499526(BAD)

PHAS:

123829336(BAD)

MMF:	118627989(BAD)

PPAM:

129068612(BAD)

HAI:	109384256(BAD)

RFQ:	117030073(BAD)

PALE:

102877892(BAD)

PGIG:

120600645(BAD)

PVP:	105297848(BAD)

RAY:	107497091(BAD)

MJV:	108407571(BAD)

TOD:	119250022(BAD)

SARA:

101549930(BAD)

SFUM:

130039811(BAD)

SETR:

126017861(BAD)

LAV:	100668387(BAD)

TMU:

101352047

ETF:	101658729(BAD)

DNM:	101414407(BAD)

MDO:	100031246(BAD)

GAS:	123251373(BAD)

SHR:	100923199(BAD)

AFZ:

127540994

PCW:	110195467(BAD)

TVP:	118852834(BAD)

PBRV:

138144806(BAD)

OAA:	114810030(BAD)

SHAB:

115603521(BAD)

ASN:	112548233(BAD)

AMJ:	109282419(BAD)

PSS:	102450183(BAD)

CMY:	102931799(BAD)

CCAY:

125640640(BAD)

CPIC:

101939860(BAD)

TST:	117881047(BAD)

CABI:

116838846(BAD)

MRV:	120408932(BAD)

ASAO:

132764441(BAD)

PVT:	110083340(BAD)

PBI:	103066611(BAD)

PMUR:

107299065(BAD) 107301245

CTIG:

120317124(BAD)

TSR:	106540304(BAD)

PGUT:

117659359(BAD)

APRI:

131186774(BAD)

PTEX:

113446643(BAD)

NSS:	113429826(BAD)

VKO:	123032688(BAD)

PMUA:

114586309(BAD)

PRAF:

128403315(BAD)

ZVI:	118076378(BAD)

HCG:	128337066(BAD)

GJA:	107115197(BAD)

STOW:

125441612(BAD)

EMC:	129340405(BAD)

XLA:	108713905 108715151

XTR:	100487418(bad)

NPR:	108794161(BAD)

RTEM:

120917599(BAD)

BBUF:

120982316(BAD)

BGAR:

122920050(BAD) 122921928

MUO:	115479972(BAD)

GSH:	117364780(BAD)

DRE:	564921(bada) 58100(badb)

SRX:	107715303 107749804 107750664 107756098

SANH:

107669205 107669322 107691899 107699975

SGH:	107559611 107562077 107567912 107567916 107568298 107588192

CCAR:

109068019 109071367 109093067

CAUA:

113038511 113052085 113064149 113079035 113105840

CGIB:

127942231 127961164 127986440 128017102

PTET:

122326411(bada) 122326478 122348429(badb)

LROH:

127153080(bada) 127167836(badb)

OMC:	131528556(bada) 131543359(badb)

PPRM:

120470606(badb) 120494605(bada)

RKG:	130095274(bada) 130102719(badb)

MAMB:

125252459(bada) 125264027 125264575

CIDE:

127515266

CERY:

137012850(bada) 137030221

MASI:

127430503 127445216

TROS:

130556339(badb) 130569788(bada)

TDW:	130407982(bada) 130432938(badb)

MANU:

129423706(bada) 129440917(badb)

IPU:	108267538(badb) 108278747(bada)

IFU:	128610063(badb) 128622039(bada)

PHYP:

113539791

SMEO:

124386784(badb) 124397989(bada)

TFD:	113635157(badb) 113662083(bada)

TVC:	132848633(badb) 132860032(bada)

TRN:	134312327(badb) 134330510(bada)

AMEX:

103032659(badb) 103047163(bada)

CMAO:

118820664(bada) 118826580(badb)

EEE:	113579817 113586001

CHAR:

105895565(badb) 105911344(bada)

SPIL:

134060438(badb) 134079867(bada)

TRU:	105418743 115250644

TFS:	130522254(badb)

TNG:	GSTEN00025871G001

LCO:	104928899(bad)

NCC:	104948201(bad)

TBEN:

117487811(badb)

CGOB:

115023677(bad)

PGEO:

117463516(badb)

GACU:

117551507(badb)

EMAC:

134875663(badb)

ELY:	117246273(badb)

EFO:	125883566(badb)

PLEP:

121962343(badb)

SLUC:

116042254(badb)

ECRA:

117934567(badb)

ESP:	116707131(bad)

PFLV:

114545719(bad)

GAT:	120821354(badb)

PPUG:

119222301(badb)

AFB:	129093541(badb)

CLUM:

117747774(badb)

PSWI:

130211665(badb)

CANA:

137792668(badb)

CVE:	137874661(badb)

MSAM:

119911743(badb)

SCHU:

122869670(badb)

CUD:	121504452(badb)

SPUL:

138600780(badb)

LMIX:

132958989(badb)

ALAT:

119027095(badb)

ASTR:

137590804(badb)

MZE:	101483296(bad)

ONL:	100712130(bad)

OAU:	116317904(badb)

OLA:	101171945(bad)

OML:	112155974(badb)

CSAI:

133420158(badb)

XMA:	111611010(bad)

XCO:	114157548(bad)

XHE:	116732883(bad)

PRET:

103480747(bad)

PFOR:

103153616(bad)

PLAI:

106948309(bad)

PMEI:

106916906(bad)

GAF:	122820788(badb)

PPRL:

129373309(badb)

CVG:	107084153(bad)

CTUL:

119776392(badb)

GMU:	124880840(badb)

NFU:	107377126(bad)

KMR:	108242862(badb)

ALIM:

106524975(bad)

NWH:	119416821(badb)

AOCE:

111588385(bad)

EJA:	138204129(badb)

BFRE:

138631815(badb)

MCEP:

125012876(badB)

CSEM:

103384187(bad)

POV:	109634873(bad)

SSEN:

122767280(badb)

HHIP:

117752269(badb)

HSP:	118102525(badb)

PPLT:

128429764(badb)

LCF:	108888776(badb)

SDU:	111231315(bad)

SLAL:

111666425(bad)

XGL:	120797372(badb)

HCQ:	109516634(bad)

SSCV:

125993156(badb)

SBIA:

PEE:

PTAO:

BPEC:

MALB:

109965841(bad)

BSPL:

114865679(badb)

SJO:	128383316(badb)

SSCO:

134006058(badb)

SASA:

106563493(BAD) 106578087 106603152(BAD)

STRU:

115154667 115184996 115204267

OTW:	112228809(bada) 112237949(badb)

OMY:	110509964 110532989(badb) 110533975

OGO:	123993880 124007485 124029329(badb)

ONE:	115101321 115135649

OKI:	109873362 109874217 109883922

OKE:	118385125 118390355 127916301(badb)

SALP:

111950212 111964172 112076205

SNH:	120043352(badb) 120056594(bada)

CCLU:

121541833(bada) 121554365(badb) 121571247

ELS:	114839466(bad)

SFM:	108925227(bad)

PKI:	111834777(bad)

AANG:

118224014 118234823

CCOG:

133119537 133125223

PSPA:

121310102(badb)

ARUT:

117398525 117967845

PSEX:

120533795

LCM:	102363793(BAD)

HOC:	132836223(badb)

AHF:

112764321

» show all

Reference

PMID:9388232

Authors

Ottilie S, Diaz JL, Horne W, Chang J, Wang Y, Wilson G, Chang S, Weeks S, Fritz LC, Oltersdorf T

Title

Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins.

Journal

J Biol Chem 272:30866-72 (1997)
DOI:10.1074/jbc.272.49.30866

Sequence

[hsa:572]

Reference

PMID:9372935

Authors

Kelekar A, Chang BS, Harlan JE, Fesik SW, Thompson CB

Title

Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL.

Journal

Mol Cell Biol 17:7040-6 (1997)
DOI:10.1128/MCB.17.12.7040

Sequence

[mmu:12015]

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