KEGG ORTHOLOGY: K02186

ORTHOLOGY: K02186

Entry

K02186                      KO

Symbol

CASP2

Name

caspase 2 [EC:3.4.22.55]

Pathway

map04210

Apoptosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K02186  CASP2; caspase 2
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K02186  CASP2; caspase 2
   01002 Peptidases and inhibitors
    K02186  CASP2; caspase 2
Enzymes [BR:ko01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.55  caspase-2
     K02186  CASP2; caspase 2
Protein phosphatases and associated proteins [BR:ko01009]
Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K02186  CASP2; caspase 2
Peptidases and inhibitors [BR:ko01002]
Cysteine peptidases
  Family C14: caspase family
   K02186  CASP2; caspase 2

Genes

HSA:	835(CASP2)

PTR:	463804(CASP2)

PPS:	100984572(CASP2)

GGO:	101128958(CASP2)

PON:	100454928(CASP2)

NLE:	100599260(CASP2)

MCC:	704339(CASP2)

MCF:	102128712(CASP2)

CSAB:

103227412(CASP2)

CATY:

105584645(CASP2)

PANU:

101006276(CASP2)

TGE:	112620420(CASP2)

RRO:	104674919(CASP2)

RBB:	108544234(CASP2)

TFN:	117072364(CASP2)

PTEH:

111521444(CASP2)

CJC:	100402493(CASP2)

SBQ:	101040888(CASP2)

CSYR:

103271043(CASP2)

MMUR:

105873292(CASP2)

LCAT:

123647584(CASP2)

OGA:	100963099(CASP2)

MMU:	12366(Casp2)

MCAL:

110296109(Casp2)

MPAH:

110316173(Casp2)

RNO:	64314(Casp2)

MCOC:

116098811(Casp2)

MUN:	110558418(Casp2)

CGE:	100689445(Casp2)

MAUA:

101832827(Casp2)

PLEU:

114698017(Casp2)

MORG:

121435560(Casp2)

AAMP:

119806861(Casp2)

NGI:	103730398(Casp2)

HGL:	101712106(Casp2)

CPOC:

100735399(Casp2)

CCAN:

109697479(Casp2)

DORD:

105989490(Casp2)

DSP:	122105905(Casp2)

NCAR:

124991564

OCU:	100101590(CASP2)

OPI:	101521745(CASP2)

TUP:	102498970(CASP2)

CFA:	482737(CASP2)

VVP:	112934814(CASP2)

VLG:	121488914(CASP2)

AML:	100474060(CASP2)

UMR:	103668980(CASP2)

UAH:	113265500(CASP2)

UAR:	123788834(CASP2)

ELK:

111152078

LLV:

125080608

MPUF:

101674782(CASP2)

ORO:	101384305(CASP2)

EJU:	114211737(CASP2)

ZCA:	113911860(CASP2)

MLX:	118021190(CASP2)

FCA:	101088318(CASP2)

PYU:	121028175(CASP2)

PBG:	122488449(CASP2)

PTG:	102948856(CASP2)

PPAD:

109269169(CASP2)

AJU:	106980767(CASP2)

HHV:	120239002(CASP2)

BTA:	531419(CASP2)

BOM:	102272786(CASP2)

BIU:	109557747(CASP2)

BBUB:

102407716(CASP2)

CHX:	102183569(CASP2)

OAS:	101115025(CASP2)

ODA:	120877702(CASP2)

CCAD:

122438770(CASP2)

SSC:	100521118(CASP2)

CFR:	102508934(CASP2)

CBAI:

105069548(CASP2)

CDK:	105105559(CASP2)

VPC:	102534115(CASP2)

BACU:

103017857(CASP2)

LVE:	103085195(CASP2)

OOR:	101271768(CASP2)

DLE:	111177325(CASP2)

PCAD:

102982974(CASP2)

PSIU:

116759648(CASP2)

ECB:	100050611(CASP2)

EPZ:	103562808(CASP2)

EAI:	106833854(CASP2)

MYB:	102264102(CASP2)

MYD:	102774985(CASP2)

MMYO:

118666310(CASP2)

MLF:	102430756(CASP2)

MNA:	107523761(CASP2)

PKL:	118714167(CASP2)

HAI:	109376369(CASP2)

DRO:	112316166(CASP2)

SHON:

118997005(CASP2)

AJM:	119060599(CASP2)

PDIC:

114507769(CASP2)

PHAS:

123831001(CASP2)

MMF:	118620397(CASP2)

RFQ:	117018233(CASP2)

PALE:

102895485(CASP2)

PGIG:

120600953(CASP2)

PVP:	105304116(CASP2)

RAY:	107516993(CASP2)

MJV:	108404389(CASP2)

TOD:	119248048(CASP2)

SARA:

101557433(CASP2)

LAV:	100661506(CASP2)

TMU:

101361957

DNM:	101434852(CASP2)

MDO:	100011923(CASP2)

GAS:	123249181(CASP2)

SHR:	100919881(CASP2)

PCW:	110216131(CASP2)

OAA:	100074924(CASP2)

GGA:	395857(CASP2)

PCOC:

116239978(CASP2)

MGP:	100544010(CASP2)

CJO:	107319105(CASP2)

NMEL:

110398088(CASP2)

APLA:

101794734(CASP2)

ACYG:

106048728(CASP2)

AFUL:

116502385(CASP2)

TGU:	100221143(CASP2)

LSR:	110480764(CASP2)

SCAN:

103827175(CASP2)

PMOA:

120506440(CASP2)

OTC:	121335940(CASP2)

PRUF:

121354699(CASP2)

GFR:	102043378(CASP2)

FAB:	101805629(CASP2)

PHI:	102108085(CASP2)

PMAJ:

107210261(CASP2)

CCAE:

111938007(CASP2)

CCW:	104687148(CASP2)

ETL:	114065685(CASP2)

ZAB:	102066161(CASP2)

FPG:	101915905(CASP2)

FCH:	102048179(CASP2)

CLV:	102095337(CASP2)

EGZ:	104126551(CASP2)

NNI:	104009575(CASP2)

PLET:

104617509(CASP2)

ACUN:

113482177(CASP2)

TALA:

104355497(CASP2)

PADL:

103920778(CASP2)

ACHC:

115343994(CASP2)

AAM:	106497280(CASP2)

AROW:

112973008(CASP2)

NPD:	112951710(CASP2)

DNE:	112990867(CASP2)

ASN:	102377638(CASP2)

AMJ:	102558644(CASP2)

CPOO:

109318987(CASP2)

GGN:	109304524(CASP2)

PSS:	102463164(CASP2)

CMY:	102929343(CASP2)

CPIC:

101938497(CASP2)

TST:	117885444(CASP2)

CABI:

116815538(CASP2)

MRV:	120375179(CASP2)

ACS:	100567806(casp2)

PVT:	110091477(CASP2)

SUND:

121920580(CASP2)

PBI:	103051794(CASP2)

PMUR:

107289968(CASP2)

TSR:	106546743(CASP2)

PGUT:

117661785(CASP2)

VKO:	123028058(CASP2)

PMUA:

114587363(CASP2)

ZVI:	118075180(CASP2)

GJA:	107115535(CASP2)

STOW:

125437119(CASP2)

XLA:	108697326 397817(casp2.L)

XTR:	100486813(casp2)

NPR:	108784894(CASP2)

RTEM:

120946867(CASP2)

BBUF:

121004327(CASP2)

BGAR:

122940296(CASP2)

DRE:	373118(casp2)

SRX:	107744674 107748817

SANH:

107685580 107699940(casp2)

SGH:	107569996(casp2) 107596737

CCAR:

109085235 109105725 109105733

CAUA:

113060139 113116229

PPRM:

120495040(casp2)

MAMB:

125244106(casp2)

IPU:	108268399(casp2)

PHYP:

113533689(casp2)

SMEO:

124385013(casp2)

TFD:	113644153(casp2)

AMEX:

103030250(casp2)

EEE:	113575293(casp2)

TRU:	101072588(casp2)

TNG:	GSTEN00015350G001

LCO:	104929017(casp2)

NCC:

104954509

CGOB:

115021650(casp2)

ELY:	117266305(casp2)

PLEP:

121945259(casp2)

SLUC:

116049656(casp2)

ECRA:

117946229(casp2)

PFLV:

114557483(casp2)

GAT:	120810840(casp2)

PPUG:

119197234(casp2)

MSAM:

119897458(casp2)

CUD:	121513407(casp2)

ALAT:

119006337(casp2)

MZE:	101470507(casp2)

ONL:	100703280(casp2)

OAU:	116323771(casp2)

OLA:	101171774(casp2)

OML:	112143669(casp2)

XMA:	102216745(casp2)

XCO:	114142068(casp2)

XHE:	116715507(casp2)

PRET:

103478021(casp2)

PFOR:

103136717(casp2)

PLAI:

106952586(casp2)

PMEI:

106916578(casp2)

GAF:	122831031(casp2)

CVG:	107082265(casp2)

CTUL:

119783113(casp2)

GMU:	124866040(casp2)

NFU:	107379433(casp2)

KMR:	108235415(casp2)

ALIM:

106520479(casp2)

NWH:	119409340(casp2)

AOCE:

111586367(casp2)

CSEM:

103387931(casp2)

POV:	109633282(casp2)

SSEN:

122774915(casp2)

HHIP:

117776801(casp2)

HSP:	118113201(casp2)

LCF:	108887338(casp2)

SDU:	111230073(casp2)

SLAL:

111669846(casp2)

XGL:	120783990(casp2)

HCQ:	109515309(casp2)

BPEC:

110163095(casp2)

MALB:

109966150(casp2)

BSPL:

114842940(casp2)

SASA:

106576719 106591706 106605831

OTW:	112225903(casp2) 112253770

OMY:	110509281 110537322(casp2)

OGO:	123998118 124006155

ONE:	115140808(casp2)

SALP:

111964847(casp2)

SNH:	120031202 120047724

ELS:	105019056(casp2)

SFM:	108924035(casp2)

PKI:	111833972(casp2)

AANG:

118213118(casp2)

LOC:

102696227

PSPA:

121325365(casp2)

ARUT:

117425205(casp2)

LCM:	102349624(CASP2)

BFO:	118409150 118424979 118425349 118430265 118430471 118432211

BBEL:

109463126 109464943 109469527 109472931 109484124 109486134 109486423 109487213

CIN:	100177955 100185724 100186877

SCLV:

120328281 120328394 120328429 120328437 120328561 120330725 120330783 120331055 120331321 120331427 120332053 120332057 120333296 120335043 120341081 120347096

BCOO:

119079878 119080014 119083223

FAS:

DAM:

SOY:

CSET:

AGB:

LDC:

HHAL:

106679793 106679794 106692455 106692462

TPAL:

117645803

DMK:

116919288

PVM:

113815986

PJA:	122243890 122243891 122244216 122244446 122245056 122245057 122256802 122257482 122257483 122257485 122260554 122263094 122266355

PCHN:

125028142 125029737 125032519 125038516 125038661 125041106 125041107 125041314

HAME:

121855528 121862919 121867711 121873881 121879450

PCLA:

123745763 123754306 123756154 123763565

PTRU:

123501256 123510132 123516621

HAZT:

108665303 108666522 108670568

LSM:

121114714

PPOI:

119092901

DSV:

119445431

RSAN:

119390615 119390616 119398843

RMP:

119163741

VDE:

111249789

VJA:

111263318

LOA:	LOAG_03664

HRO:	HELRODRAFT_177179

LGI:	LOTGIDRAFT_236948

PCAN:

112556116 112556538 112556707 112557443

BGT:	106055445 106061941 106067681

GAE:	121372701 121373401 121390165 121390245 121390246 121390247 121390352 121390424 121390558 121390663

HRF:	124110783 124112468 124117145 124117732 124123912 124131199 124137147

HRJ:	124254802 124257484 124261785 124265586 124269445 124278193 124279710 124281642 124286221

MYI:	110449061 110461055

PMAX:

117314630 117314633 117314695 117314821 117315454 117323289 117327753 117327805 117345248

MMER:

123527379 123527584 123543142 123561121

OBI:	106869844 106878642

OSN:	115209565 115221437

LAK:	106156302 106157002 106162784 106178017 106178332

SMM:	Smp_032000

OVI:	T265_00765

EGL:	EGR_04133 EGR_04138

NVE:

ADF:

AMIL:

SPIS:

XEN:

TAES:

Reference

PMID:22531785

Authors

Imre G, Heering J, Takeda AN, Husmann M, Thiede B, zu Heringdorf DM, Green DR, van der Goot FG, Sinha B, Dotsch V, Rajalingam K

Title

Caspase-2 is an initiator caspase responsible for pore-forming toxin-mediated apoptosis.

Journal

EMBO J 31:2615-28 (2012)
DOI:10.1038/emboj.2012.93

Sequence

[hsa:835]

Reference

PMID:20735596

Authors

Sakamaki K, Satou Y

Title

Caspases: evolutionary aspects of their functions in vertebrates.

Journal

J Fish Biol 74:727-53 (2009)
DOI:10.1111/j.1095-8649.2009.02184.x

Reference

PMID:18602321

Authors

Chowdhury I, Tharakan B, Bhat GK

Title

Caspases - an update.

Journal

Comp Biochem Physiol B Biochem Mol Biol 151:10-27 (2008)
DOI:10.1016/j.cbpb.2008.05.010

LinkDB

DBGET integrated database retrieval system