KEGG ORTHOLOGY: K02740

ORTHOLOGY: K02740

Entry

K02740                      KO

Symbol

PSMB8, LMP7

Name

20S proteasome subunit beta 8 [EC:3.4.25.1]

Pathway

map03050

Proteasome

Disease

H01741

Autoinflammation lipodystrophy and dermatosis syndrome

H02532

Proteasome-associated autoinflammatory syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    K02740  PSMB8, LMP7; 20S proteasome subunit beta 8
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K02740  PSMB8, LMP7; 20S proteasome subunit beta 8
  09182 Protein families: genetic information processing
   03051 Proteasome
    K02740  PSMB8, LMP7; 20S proteasome subunit beta 8
Enzymes [BR:ko01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.25  Threonine endopeptidases
    3.4.25.1  proteasome endopeptidase complex
     K02740  PSMB8, LMP7; 20S proteasome subunit beta 8
Peptidases and inhibitors [BR:ko01002]
Threonine peptidases
  Family T1: proteasome family
   K02740  PSMB8, LMP7; 20S proteasome subunit beta 8
Proteasome [BR:ko03051]
Eukaryotic proteasome
  Core particles (20S proteasome)
   beta type subunits
    K02740  PSMB8, LMP7; 20S proteasome subunit beta 8

Genes

HSA:	5696(PSMB8)

PTR:	746418(PSMB8)

PPS:	100969919(PSMB8)

GGO:	101136133(PSMB8)

PON:	100445244(PSMB8)

PPYG:

129038175(PSMB8)

NLE:	100604916(PSMB8)

HMH:	116460422(PSMB8)

SSYN:

129472996(PSMB8)

MCC:	717766(PSMB8)

MCF:	102141301(PSMB8)

MTHB:

126952704

MNI:	105474424(PSMB8)

CSAB:

103221690(PSMB8)

PANU:

101015801(PSMB8)

TGE:	112623509(PSMB8)

MLEU:

105531117(PSMB8)

RRO:	104666627(PSMB8)

RBB:	108512978(PSMB8)

TFN:	117087013(PSMB8)

PTEH:

111528123(PSMB8)

CANG:

105513819(PSMB8)

CJC:	100406682(PSMB8)

SBQ:

101050853

CIMI:

108300078(PSMB8)

ANAN:

105704654(PSMB8)

CSYR:

103271933(PSMB8)

MMUR:

105886024(PSMB8)

LCAT:

123631803(PSMB8)

PCOQ:

105824380(PSMB8)

OGA:	100958703(PSMB8)

MMU:	16913(Psmb8)

MCAL:

110312690(Psmb8)

MPAH:

110335701(Psmb8)

RNO:	24968(Psmb8)

MCOC:

116074433(Psmb8)

ANU:	117724449(Psmb8)

MUN:	110543263(Psmb8)

CGE:	100751746(Psmb8)

MAUA:

101835386(Psmb8)

PROB:

127224280(Psmb8)

PLEU:

114686352(Psmb8)

MORG:

121435282(Psmb8)

MFOT:

126499448

AAMP:

119823267(Psmb8)

NGI:	103748237(Psmb8)

HGL:	101702300(Psmb8)

CPOC:

100717290(Psmb8)

CCAN:

109686708(Psmb8)

DORD:

105999857(Psmb8)

DSP:	122111483(Psmb8)

PLOP:

125352722(Psmb8)

NCAR:

124988937

MMMA:

107143778(Psmb8)

OCU:

100351918

OPI:	101535709(PSMB8)

TUP:	102484029(PSMB8)

GVR:	103608008(PSMB8)

CFA:	474865(PSMB8)

CLUD:

112641382(PSMB8)

VVP:	112913863(PSMB8)

VLG:	121494759(PSMB8)

NPO:	129512880(PSMB8)

AML:	100477784(PSMB8)

UMR:	103665514(PSMB8)

UAH:	113243782(PSMB8)

UAR:	123790944(PSMB8)

ELK:

111152369

LLV:

125103274

MPUF:

101691295(PSMB8)

MNP:	132017856(PSMB8)

MLK:	131834273(PSMB8)

NVS:	122899862(PSMB8)

ORO:	101371019(PSMB8)

EJU:	114222138(PSMB8)

ZCA:	113927770(PSMB8)

MLX:	118001397(PSMB8)

NSU:	110575562(PSMB8)

LWW:	102748767(PSMB8)

FCA:	111556170(PSMB8)

PYU:	121029259(PSMB8)

PCOO:

112862919(PSMB8)

PBG:	122489375(PSMB8)

PVIV:

125165408(PSMB8)

LRUF:

124528923

PTG:	102958580(PSMB8)

PPAD:

109271412(PSMB8)

PUC:

125938392

AJU:

106976129

HHV:	120238161(PSMB8)

BTA:	282013(PSMB8)

BOM:	102283566(PSMB8)

BIU:	109577141(PSMB8)

BBUB:

102391390(PSMB8)

BBIS:

104994882(PSMB8)

CHX:	102180902(PSMB8)

OAS:	100174905(PSMB8)

BTAX:

128056296(PSMB8)

ODA:	120869863(PSMB8)

CCAD:

122429561(PSMB8)

MBEZ:

129543430(PSMB8)

SSC:	396975(PSMB8)

CFR:	102519631(PSMB8)

CBAI:

105064242(PSMB8)

CDK:	105101405(PSMB8)

VPC:	102535478(PSMB8)

BACU:

103011762(PSMB8)

BMUS:

118903735(PSMB8)

LVE:	103084339(PSMB8)

OOR:	101290117(PSMB8)

DLE:	111178661(PSMB8)

PCAD:

102995453(PSMB8)

PSIU:

116762909(PSMB8)

NASI:

112414081(PSMB8)

ECB:	100052481(PSMB8)

EPZ:	103544695(PSMB8)

EAI:	106834614(PSMB8)

MYB:	102245229(PSMB8)

MYD:	102761800(PSMB8)

MMYO:

118679635(PSMB8)

MLF:	102422161(PSMB8)

MDT:	132237494(PSMB8)

PKL:	118705665(PSMB8)

EFUS:

103305025(PSMB8)

MNA:	107542675(PSMB8)

DRO:	112302285(PSMB8)

SHON:

118991467(PSMB8)

AJM:	119049934(PSMB8)

PDIC:

114494488(PSMB8)

PHAS:

123816531(PSMB8)

MMF:	118621115(PSMB8)

PPAM:

129067355(PSMB8)

HAI:	109378147(PSMB8)

RFQ:	117015676(PSMB8)

PALE:

102893806(PSMB8)

PGIG:

120597656(PSMB8)

PVP:

105300968

RAY:	107511997(PSMB8)

MJV:

108389188

TOD:	119253281(PSMB8)

SARA:

101558371(PSMB8)

SETR:

125995696(PSMB8)

LAV:	100664123(PSMB8)

TMU:

101342060

ETF:	101639342(PSMB8)

DNM:	101422881(PSMB8)

MDO:	100026706(PSMB8)

GAS:	123245213(PSMB8)

SHR:	116423204(PSMB8)

AFZ:

127561631

PCW:	110199437(PSMB8)

TVP:

118856804

OAA:	100529058(PSMB8)

ASN:

106722823

AMJ:	109286085(PSMB8)

CMY:	119567536(PSMB8)

CCAY:

125621143(PSMB8)

DCC:	119842597(PSMB8)

CPIC:

101952518(PSMB8)

CABI:

116826954

MRV:	120393309(PSMB8) 120394815

ACS:	100559169(psmb8)

ASAO:

132765337(PSMB8)

PVT:

110071035

SUND:

121923036(PSMB8) 121923190

PBI:	103057075(PSMB8)

PMUR:

107298997

CTIG:

120317822(PSMB8)

PGUT:

117670034(PSMB8)

APRI:

131190458

PTEX:

113451020(PSMB8)

NSS:	113425987(PSMB8)

VKO:	123023276(PSMB8)

PMUA:

114591070 114592358

PRAF:

128409469(PSMB8)

ZVI:	118081365(PSMB8)

HCG:	128347546(PSMB8)

STOW:

125428909(PSMB8)

EMC:	129326944(PSMB8)

XLA:	399439(psmb8.L)

XTR:	100485711 445258(psmb8)

NPR:	108788367(PSMB8)

RTEM:

120914286(PSMB8)

BBUF:

120977451(PSMB8)

BGAR:

122946484(PSMB8)

MUO:	115459446 115464931(PSMB8)

GSH:	117349881(PSMB8)

DRE:	30666(psmb8a) 550488(psmb8f)

SRX:	107705860 107712559 107722803(psmb8)

SANH:

107679352 107694197 107694758

SGH:	107549856 107554342 107574275

CCAR:

109102325 109111463

CAUA:

113062601 113102786 113119658

CGIB:

127935751 127979739

PTET:

122335238(psmb8a)

LROH:

127160980 127162473(psmb8a)

OMC:	131525171 131525721(psmb8a)

RKG:	130102314 130102352

MAMB:

125266074 125274606(psmb8a) 125275811

CIDE:

127500843 127501474

CERY:

137037731(psmb8a)

MASI:

127421102 127421103

TROS:

130566602

TDW:	130415195 130415878

MANU:

129455657(psmb8a)

IPU:	108258500 108258501

IFU:	128601941 128602069(psmb8a)

PHYP:

113537507 113537508

SMEO:

124378082(psmb8a)

TFD:	113648940(psmb8a)

TVC:	132839238(psmb8a)

TRN:	134305380(psmb8a)

AMEX:

103025308(psmb8a)

CMAO:

118805917(psmb8a)

EEE:

113581270

CHAR:

105888923(psmb8a)

TRU:	101077532(psmb8) 115251835

TNG:	GSTEN00033724G001

LCO:	104933383(psmb8)

NCC:

104959103

TBEN:

117478162(psmb8a)

CGOB:

115016197(psmb8)

PGEO:

117455352(psmb8a)

GACU:

117534679(psmb8a)

EMAC:

134875354(psmb8a)

ELY:	117263778(psmb8a)

EFO:	125904724(psmb8a)

PLEP:

121958140(psmb8a) 121966615

SLUC:

116047054(psmb8a)

ECRA:

117956859(psmb8a)

ESP:	116701195(psmb8)

PFLV:

114568377(psmb8)

GAT:	120825989 120825990 120825991 120825992 120825993 120825994 120826001 120826767(psmb8a) 120826772 120826884

PPUG:

119218713(psmb8a) 119218720 119218857

AFB:	129097329(psmb8a)

CLUM:

117738848(psmb8a)

MSAM:

119884281(psmb8a)

SCHU:

122864411(psmb8a)

CUD:	121523162(psmb8a)

ALAT:

119014628(psmb8a)

MZE:	101480087(psmb8)

ONL:	100697999(psmb8)

OAU:	116317727(psmb8a) 116324042 120435545

OLA:	100049532(psmb8)

OML:	112137399(psmb8a) 112140153

CSAI:

133460681(psmb8a)

XMA:

XCO:

XHE:

PRET:

PFOR:

103146407(psmb8)

PMEI:

106908351(psmb8)

GAF:	122843208 122844004

PPRL:

129375882(psmb8a)

CVG:	107104176 107104819(psmb8)

CTUL:

119794974(psmb8a)

GMU:	124879565(psmb8a)

NFU:	107394859(psmb8)

KMR:	108242638(psmb8a)

ALIM:

106519544(psmb8)

NWH:	119425619(psmb8a)

AOCE:

111584577(psmb8)

MCEP:

125019831(psmb8a)

CSEM:

103393841(psmb8)

POV:

109646446

SSEN:

122761152(psmb8a)

HHIP:

117770991(psmb8a)

HSP:	118124648(psmb8a)

PPLT:

128461393(psmb8a)

SMAU:

118292362(psmb8a)

LCF:	108881903 108888424

SDU:	111239427(psmb8)

SLAL:

111661206(psmb8)

XGL:	120786281(psmb8a)

BPEC:

110173314(psmb8)

BSPL:

114866161(psmb8a)

SJO:	128374436(psmb8a)

SASA:

100136367(psmb8b) 106588400(LMP7)

STRU:

115173547 115175922

OTW:	112229809(psmb8a) 112264790

OMY:	100305311(psb8) 110488347(psmb8a)

OGO:	124012337 124018411 124043536

ONE:	115128384 115131616

OKI:	109903607 109907528

OKE:	118398188 118398948

SALP:

111954717 111954718 111955583 112075852

SNH:	120022587 120026799 120026892 120026894

CCLU:

121571578 121585769 121586459 123482657 123486451

ELS:

105009104

SFM:	108930382(psmb8)

PKI:

111835645

AANG:

118232974(psmb8a)

LOC:

102683700

PSPA:

121304325(psmb8a)

ARUT:

117434213

LCM:	102358775(PSMB8)

CMK:

103171674

RTP:	109939102 125486905

CPLA:

122541277(psmb8a)

HOC:	132832858(psmb8a)

LERI:

129694456(psmb8a)

PMRN:

LRJ:

LJP:

LLON:

HSY:

Reference

PMID:16181324

Authors

Strehl B, Seifert U, Kruger E, Heink S, Kuckelkorn U, Kloetzel PM

Title

Interferon-gamma, the functional plasticity of the ubiquitin-proteasome system, and MHC class I antigen processing.

Journal

Immunol Rev 207:19-30 (2005)
DOI:10.1111/j.0105-2896.2005.00308.x

Reference

PMID:21881205

Authors

Kitamura A, Maekawa Y, Uehara H, Izumi K, Kawachi I, Nishizawa M, Toyoshima Y, Takahashi H, Standley DM, Tanaka K, Hamazaki J, Murata S, Obara K, Toyoshima I, Yasutomo K

Title

A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans.

Journal

J Clin Invest 121:4150-60 (2011)
DOI:10.1172/JCI58414

Sequence

[hsa:5696]

LinkDB

DBGET integrated database retrieval system