KEGG   ORTHOLOGY: K03362
Entry
K03362                      KO                                     

Symbol
FBXW1_11, BTRC, beta-TRCP
Name
F-box and WD-40 domain protein 1/11
Pathway
map04114  Oocyte meiosis
map04120  Ubiquitin mediated proteolysis
map04218  Cellular senescence
map04310  Wnt signaling pathway
map04340  Hedgehog signaling pathway
map04341  Hedgehog signaling pathway - fly
map04390  Hippo signaling pathway
map04624  Toll and Imd signaling pathway
map04710  Circadian rhythm
map05131  Shigellosis
map05170  Human immunodeficiency virus 1 infection
Disease
H02460  Neurodevelopmental disorder with dysmorphic facies and skeletal anomalies
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
   04340 Hedgehog signaling pathway
    K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
   04341 Hedgehog signaling pathway - fly
    K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
   04390 Hippo signaling pathway
    K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
   04218 Cellular senescence
    K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
 09150 Organismal Systems
  09151 Immune system
   04624 Toll and Imd signaling pathway
    K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
  09159 Environmental adaptation
   04710 Circadian rhythm
    K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
 09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
   03036 Chromosome and associated proteins
    K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Multi subunit Ring-finger type E3
   SCF complex
    Target recognizing subunit (F-box)
     K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Centrosome duplication proteins
    Regulators of centriole replication
     K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
Genes
HSA: 23291(FBXW11) 8945(BTRC)
PTR: 450685(BTRC) 462263(FBXW11)
PPS: 100976100(FBXW11) 100977066(BTRC)
GGO: 101142383(FBXW11) 101152319(BTRC)
PON: 100171847(BTRC) 100432610(FBXW11)
NLE: 100583099(BTRC) 100605260(FBXW11)
MCC: 708990(FBXW11) 711843(BTRC)
MCF: 102136827(BTRC) 102143687(FBXW11)
CSAB: 103216409(BTRC) 103244971(FBXW11)
CATY: 105581652(FBXW11) 105581859(BTRC)
PANU: 101010993(BTRC) 101025156(FBXW11)
RRO: 104656496(BTRC) 104670124(FBXW11)
RBB: 108513614(FBXW11) 108515136(BTRC)
TFN: 117065452(FBXW11) 117067981(BTRC)
PTEH: 111538928(BTRC) 111547216(FBXW11)
CJC: 100389218(BTRC) 100402300(FBXW11)
SBQ: 101035000(BTRC) 101044866(FBXW11)
MMUR: 105871854(FBXW11) 105873891(BTRC)
MMU: 103583(Fbxw11) 12234(Btrc)
MCAL: 110285422(Btrc) 110304634(Fbxw11)
MPAH: 110331061(Fbxw11) 110337956(Btrc)
RNO: 303024(Fbxw11) 361765(Btrc)
MCOC: 116078965(Fbxw11) 116103918(Btrc)
MUN: 110547815(Fbxw11) 110556200(Btrc)
CGE: 100750426(Btrc) 100753568 100772242(Fbxw11)
PLEU: 114683476(Fbxw11) 114708125(Btrc)
NGI: 103744000(Btrc) 103748186(Fbxw11)
HGL: 101718253(Fbxw11) 101726740(Btrc)
CCAN: 109691321(Btrc) 109696980(Fbxw11)
OCU: 100340737(FBXW11) 100350519(BTRC)
TUP: 102485164(BTRC)
CFA: 479291(FBXW11) 486851(BTRC)
VVP: 112915141(BTRC) 112926170(FBXW11)
VLG: 121484364(BTRC) 121488189(FBXW11)
AML: 100470916(BTRC) 100479018(FBXW11)
UMR: 103664495(FBXW11) 103678776(BTRC)
UAH: 113251850(BTRC) 113264086(FBXW11)
ORO: 101371793(BTRC) 101378003(FBXW11)
ELK: 111140861 111145162
MPUF: 101671054(FBXW11) 101692220(BTRC)
EJU: 114205332(BTRC) 114208616(FBXW11) 114221539
MLX: 118016673(FBXW11) 118025164(BTRC)
FCA: 101094156(FBXW11) 101097596(BTRC)
PYU: 121010989(FBXW11) 121037135(BTRC)
PTG: 102953972(BTRC) 102962015(FBXW11)
PPAD: 109267495(FBXW11) 109272793(BTRC)
AJU: 106966878(BTRC) 106989251(FBXW11)
HHV: 120234082(FBXW11) 120243193(BTRC)
BTA: 534072(BTRC) 540642(FBXW11)
BOM: 102273208(FBXW11) 102280912(BTRC)
BIU: 109553040(BTRC) 109574833(FBXW11)
BBUB: 102402023(BTRC) 102408511(FBXW11)
CHX: 102184871(BTRC) 102187079(FBXW11)
OAS: 101101939(BTRC) 101107136(FBXW11)
ODA: 120873542(BTRC) 120879679(FBXW11)
CCAD: 122446012(BTRC) 122454491(FBXW11)
SSC: 100157842(BTRC) 100523218(FBXW11)
CFR: 102509669(BTRC) 102521888(FBXW11)
CBAI: 105081727(BTRC) 105082644(FBXW11)
CDK: 105084335(BTRC) 105089376(FBXW11)
BACU: 103003148(BTRC) 103005978(FBXW11)
LVE: 103070169(BTRC) 103072434(FBXW11)
OOR: 101276846(FBXW11) 101286442(BTRC)
DLE: 111172377(BTRC) 111185480(FBXW11)
PCAD: 102975666(BTRC)
ECB: 100069972(FBXW11) 100070200(BTRC)
EPZ: 103542811(FBXW11) 103551399(BTRC)
EAI: 106828852(BTRC) 106837358(FBXW11)
MYB: 102250477(BTRC) 102262850(FBXW11)
MYD: 102752909(BTRC) 102759029(FBXW11)
MMYO: 118658168(FBXW11) 118669829(BTRC)
MNA: 107535702(FBXW11) 107542570(BTRC)
HAI: 109379398(FBXW11) 109379675(BTRC)
DRO: 112300376(BTRC) 112319740(FBXW11)
SHON: 118994949(FBXW11) 118999496(BTRC)
AJM: 119036231(FBXW11) 119059661(BTRC)
MMF: 118631987(BTRC) 118643697(FBXW11)
PALE: 102893556(FBXW11) 102895058(BTRC)
PGIG: 120609176(BTRC) 120614879(FBXW11)
RAY: 107497788(BTRC) 107511023(FBXW11)
MJV: 108383975(FBXW11) 108408519(BTRC)
TOD: 119234284(BTRC) 119236342(FBXW11)
LAV: 100657114(FBXW11) 100661816(BTRC)
TMU: 101345935 101354147
MDO: 100029508(BTRC) 100031160(FBXW11)
SHR: 100923383(FBXW11) 100925642(BTRC)
PCW: 110194552(BTRC) 110212306(FBXW11)
OAA: 100076818(FBXW11) 100080584(BTRC)
GGA: 416181(FBXW11) 423854(BTRC)
PCOC: 116231690(BTRC) 116231968(FBXW11)
MGP: 100545331(BTRC) 100551173(FBXW11)
CJO: 107316011(BTRC) 107320428(FBXW11)
NMEL: 110399216(BTRC) 110405169(FBXW11)
APLA: 101795851(BTRC) 101796951(FBXW11)
ACYG: 106034370(FBXW11) 106034939(BTRC)
TGU: 100220854(BTRC) 100227408(FBXW11)
LSR: 110473660(BTRC) 110478308(FBXW11)
SCAN: 103813867(BTRC) 103823778(FBXW11)
PMOA: 120497674(FBXW11) 120501945(BTRC)
GFR: 102038820(BTRC) 102045368(FBXW11)
FAB: 101812833(BTRC) 101812846(FBXW11)
PHI: 102101586(BTRC) 102103643(FBXW11)
PMAJ: 107198553(FBXW11) 107206950(BTRC)
CCAE: 111931254(BTRC) 111935686(FBXW11)
CCW: 104695699(BTRC) 104696044(FBXW11)
ETL: 114070460(BTRC)
FPG: 101914153(FBXW11) 101920782(BTRC)
FCH: 102054729(BTRC) 102057588(FBXW11)
CLV: 102083982(BTRC) 102096361(FBXW11)
EGZ: 104125612(BTRC) 104135945(FBXW11)
NNI: 104012614(BTRC) 104016560(FBXW11)
ACUN: 113481483(BTRC) 113485119(FBXW11)
PADL: 103916272(BTRC) 103921960(FBXW11)
AAM: 106484672(BTRC) 106488073(FBXW11)
NPD: 112944317(FBXW11) 112957014(BTRC)
ASN: 102370841(FBXW11) 102381867
AMJ: 102569199(BTRC) 102572700(FBXW11)
CPOO: 109309939(FBXW11) 109324068(BTRC)
GGN: 109287546(BTRC) 109290155(FBXW11)
PSS: 102449762(BTRC) 102460007(FBXW11)
CMY: 102932779(FBXW11) 102937665(BTRC)
CPIC: 101936069(BTRC) 101936220(FBXW11)
TST: 117881050(BTRC) 117881595(FBXW11)
CABI: 116818061(FBXW11) 116833949(BTRC)
ACS: 100555677(btrc) 100566594(fbxw11)
PVT: 110077581(BTRC) 110078955(FBXW11)
PBI: 103052099(BTRC) 103055313(FBXW11)
PMUR: 107285262(BTRC)
TSR: 106549005(FBXW11) 106549208(BTRC)
PGUT: 117674329(FBXW11) 117678631(BTRC)
PMUA: 114593637(FBXW11) 114597556(BTRC)
ZVI: 118082518(FBXW11) 118093883(BTRC)
GJA: 107106744(FBXW11) 107114452(BTRC)
XLA: 394362(btrc.S) 397988(btrc.L)
XTR: 549140(btrc)
NPR: 108798513
DRE: 334373(fbxw11a) 406825(fbxw11b)
SRX: 107720711 107742374 107747095 107754486
SANH: 107655672 107660901 107678030 107687420
SGH: 107552016 107586136 107588312
CCAR: 109098998 109102506
CAUA: 113054240 113069547 113109765 113113643
IPU: 108275024(Fbxw11) 108277126
PHYP: 113529705 113544724
AMEX: 103028966 103029337
EEE: 113575584 113590515
TRU: 101067263(fbxw11)
TNG: GSTEN00005198G001
LCO: 104934047
NCC: 104953613
CGOB: 115014396
ELY: 117260997(fbxw11a)
PLEP: 121947873(fbxw11a)
SLUC: 116052496(fbxw11a)
ECRA: 117951202(fbxw11a)
PFLV: 114562291
GAT: 120817401(fbxw11a)
MSAM: 119889150
CUD: 121516266(fbxw11a)
MZE: 101473198
ONL: 100703880
OAU: 116336021(fbxw11a)
OLA: 101174029(fbxw11)
OML: 112153159(fbxw11a)
XMA: 102230173(fbxw11)
XCO: 114138794
XHE: 116714245
PRET: 103471323(fbxw11)
CVG: 107088238(fbxw11)
CTUL: 119794329
NFU: 107376245(fbxw11)
KMR: 108242388(fbxw11a)
ALIM: 106517031(fbxw11)
AOCE: 111577455(fbxw11)
CSEM: 103390898(fbxw11)
POV: 109627371(fbxw11)
LCF: 108899221(fbxw11)
SDU: 111239443(fbxw11)
SLAL: 111646646(fbxw11)
XGL: 120785405(fbxw11a)
HCQ: 109518762(fbxw11)
BPEC: 110160676(fbxw11)
MALB: 109951205(fbxw11)
SASA: 106568099(FBW1B) 106603254(FBW1B) 106604789 106611815(FBW1B)
OTW: 112220820 112228773 112250296 112256132 112257606
OMY: 110488702(fbxw11a) 110504897 110533895 110537224
SALP: 111950483 111965609 111980848 112073251
SNH: 120045059 120048172 120057210 120062303
ELS: 105026178 105029256
SFM: 108925478 108934063
PKI: 111834692 111859864
AANG: 118223625 118234824
LOC: 102686544 102688445(btrc)
PSPA: 121297128 121321847 121324395 121326084
ARUT: 117413404 117415480 117418534 117431581
LCM: 102350584(FBXW11) 102363698(BTRC)
CMK: 103177316(fbxw11)
RTP: 109915133(fbxw11) 109920037
BFO: 118413023
BBEL: 109485276
CIN: 445628(betaTrCP)
SCLV: 120338929
SPU: 578954
APLC: 110983423
SKO: 100329075
DME: Dmel_CG3412(slmb)
DER: 6553494
DSE: 6620053
DSI: Dsimw501_GD20006(Dsim_GD20006)
DYA: Dyak_GE25013
DAN: 6501287
DSR: 110190865
DPO: Dpse_GA27349
DPE: 6591415
DMN: 108155681
DWI: 6650398
DGR: 6568248
DMO: Dmoj_GI23727
DAZ: 108621765
DNV: 115561846
DHE: 111601297
DVI: 6629648
CCAT: 101448432
MDE: 101893248
LCQ: 111686993
AGA: AgaP_AGAP001944
ACOZ: 120952295
AARA: 120904058
AAG: 5578007
CQU: CpipJ_CPIJ017102 CpipJ_CPIJ017907
CPII: 120432353
AME: 551517
ACER: 107996315 114577626
BIM: 100744475
BBIF: 117209405
BTER: 100647997
CCAL: 108630717
OBB: 114877417
MGEN: 117221111
NMEA: 116431519
CGIG: 122394827
SOC: 105193827
MPHA: 105835128
AEC: 105152271
ACEP: 105617865
PBAR: 105432375
VEM: 105557340
HST: 105184823
DQU: 106749764
CFO: 105256506
FEX: 115240474
LHU: 105672519
PGC: 109853840
OBO: 105280109
PCF: 106785883
NVI: 100122997
CSOL: 105367293
MDL: 103571718
CCIN: 107267545
TCA: 664308(slmb)
DPA: 109546948
ATD: 109594444
AGB: 108917882
LDC: 111507496
NVL: 108565276
APLN: 108733401
PPYR: 116166544
OTU: 111419675
BMOR: 101738795
BMAN: 114243504
MSEX: 115453810
DPL: KGM_201583
BANY: 112056212
PPOT: 106110650
PXU: 106122819
ZCE: 119839315
TNL: 113492310
PXY: 105392356 105393673
API: 100166937
DNX: 107163009
AGS: 114124315
RMD: 113555913
BTAB: 109042902
DCI: 103511689 103520112
CLEC: 106661820
HHAL: 106677292 106683989 106690594
NLU: 111049173
PHU: Phum_PHUM317850
ZNE: 110829662
CSEC: 111861980
FCD: 110847655
DPX: DAPPUDRAFT_302263
DMK: 116916695 116921689 116922876 116922909 116927072 116928050 116929451 116934319
PVM: 113809160
HAME: 121863506
HAZT: 108669865
EAF: 111694954 111700382 111701805 111703554 111706700 111715108 111716907
DSV: 119461447
RSAN: 119379032
RMP: 119175984
VDE: 111254465
VJA: 111262322
TUT: 107359583
DPTE: 113795657
CSCU: 111618464
PTEP: 107438611 107452997
SDM: 118183498 118194134
CEL: CELE_K10B2.1(lin-23)
CBR: CBG02640(Cbr-lin-23)
BMY: BM_BM4966(Bma-lin-23)
LOA: LOAG_03465
NAI: NECAME_02805
TSP: Tsp_05213
HRO: HELRODRAFT_112326
LGI: LOTGIDRAFT_238545
PCAN: 112563747
BGT: 106061116
GAE: 121382574
CRG: 105349031
MYI: 110459150
PMAX: 117340071
OBI: 106884274
LAK: 106160796
SMM: Smp_099930
OVI: T265_10654 T265_12595
EGL: EGR_09165
NVE: 5521070
EPA: 110239842
ATEN: 116308969
ADF: 107351693
AMIL: 114961761
PDAM: 113676471
SPIS: 111331780
DGT: 114515968
HMG: 100199403(fbxw11)
TAD: TRIADDRAFT_50617
AQU: 100634006
QSU: 111983610 112014819 112018980
YLI: YALI0F21901g
SLB: AWJ20_1162(MET30)
NCR: NCU04540(fwd-1) NCU07521(fwd-2)
NTE: NEUTE1DRAFT122582(NEUTE1DRAFT_122582) NEUTE1DRAFT147873(NEUTE1DRAFT_147873)
SMP: SMAC_06089 SMAC_09515
PAN: PODANSg1857 PODANSg4690
TTT: THITE_2117904 THITE_2118362
MTM: MYCTH_2305406 MYCTH_2308005
CTHR: CTHT_0019790 CTHT_0021870
MGR: MGG_00261 MGG_09696
TMN: UCRPA7_2345 UCRPA7_8421
SSCK: SPSK_00700 SPSK_02984
FGR: FGSG_06615 FGSG_13776
FPU: FPSE_01636 FPSE_03387
FVR: FVEG_03223 FVEG_05506
FOX: FOXG_02332 FOXG_04918
NHE: NECHADRAFT_100263 NECHADRAFT_31774
TRE: TRIREDRAFT_47971 TRIREDRAFT_79756
TRR: M419DRAFT_142312 M419DRAFT_99567
MAW: MAC_01706 MAC_09532
MAJ: MAA_05486 MAA_09672
CMT: CCM_02758 CCM_08618
PLJ: VFPFJ_03949 VFPFJ_05936
VAL: VDBG_02862
VDA: VDAG_03775 VDAG_09743
CFJ: CFIO01_02549 CFIO01_05299
SAPO: SAPIO_CDS5990 SAPIO_CDS7823
ELA: UCREL1_1650 UCREL1_7887
PFY: PFICI_08146 PFICI_08837
SSL: SS1G_05720
BFU: BCIN_05g00750 BCIN_10g04620
MBE: MBM_04143 MBM_09442
PSCO: LY89DRAFT_427899 LY89DRAFT_726517
GLZ: GLAREA_01815 GLAREA_07323
ANI: AN2861.2 AN5593.2
AFM: AFUA_3G11870 AFUA_4G11440
ACT: ACLA_039760 ACLA_050510
NFI: NFIA_065450 NFIA_104760
AOR: AO090003000750 AO090003001079
ANG: ANI_1_1076024(An02g07700) ANI_1_1890184(An04g05180)
AFV: AFLA_000594 AFLA_000933
PCS: Pc18g00540 Pc22g05900
PDP: PDIP_34040 PDIP_74950
TMF: PMAA_023870 PMAA_041390
TRG: TRUGW13939_02845 TRUGW13939_03812
CIM: CIMG_01565 CIMG_03748
CPW: CPC735_005560 CPC735_048970
PBL: PAAG_02706 PAAG_07190
PBN: PADG_00949 PADG_01734
URE: UREG_05266 UREG_07532
ABE: ARB_02341 ARB_05691
TVE: TRV_03694 TRV_04682
AJE: HCAG_01562 HCAG_06606
BGH: BDBG_02901 BDBG_07212
PNO: SNOG_06163 SNOG_11667
PTE: PTT_01335 PTT_09911
BZE: COCCADRAFT_25595 COCCADRAFT_97819
BSC: COCSADRAFT_244591 COCSADRAFT_268864
BOR: COCMIDRAFT_100048 COCMIDRAFT_106445
AALT: CC77DRAFT_678591 CC77DRAFT_935255
ZTR: MYCGRDRAFT_104452 MYCGRDRAFT_38013
PFJ: MYCFIDRAFT_148775 MYCFIDRAFT_214822
BCOM: BAUCODRAFT_32216 BAUCODRAFT_61218
NPA: UCRNP2_1634 UCRNP2_1758
TML: GSTUM_00005683001 GSTUM_00007331001
SPO: SPAC29E6.01(pof11)
CNE: CNN01080
CNB: CNBN1070
CGI: CGB_N1480C
TVS: TRAVEDRAFT_134364
DSQ: DICSQDRAFT_85749
PCO: PHACADRAFT_172766
SHS: STEHIDRAFT_78183
HIR: HETIRDRAFT_326886
PSQ: PUNSTDRAFT_124012
ADL: AURDEDRAFT_181412
FME: FOMMEDRAFT_124173
GTR: GLOTRDRAFT_140812
MRR: Moror_14192
CCI: CC1G_06922
SCM: SCHCODRAFT_68501
ABP: AGABI1DRAFT76048(AGABI1DRAFT_76048)
ABV: AGABI2DRAFT209689(AGABI2DRAFT_209689)
UMA: UMAG_10341
PFP: PFL1_05021
MGL: MGL_2979
MRT: MRET_3585
PGR: PGTG_14767 PGTG_18882
MLR: MELLADRAFT_27234
MBR: MONBRDRAFT_15157
SRE: PTSG_01223
 » show all
Reference
  Authors
Shirogane T, Jin J, Ang XL, Harper JW
  Title
SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein.
  Journal
J Biol Chem 280:26863-72 (2005)
DOI:10.1074/jbc.M502862200
  Sequence
[hsa:23291]
Reference
  Authors
Suzuki H, Chiba T, Suzuki T, Fujita T, Ikenoue T, Omata M, Furuichi K, Shikama H, Tanaka K
  Title
Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination.
  Journal
J Biol Chem 275:2877-84 (2000)
DOI:10.1074/jbc.275.4.2877
  Sequence
[hsa:8945 23291]
Reference
PMID:9859996
  Authors
Yaron A, Hatzubai A, Davis M, Lavon I, Amit S, Manning AM, Andersen JS, Mann M, Mercurio F, Ben-Neriah Y
  Title
Identification of the receptor component of the IkappaBalpha-ubiquitin ligase.
  Journal
Nature 396:590-4 (1998)
DOI:10.1038/25159
  Sequence
[hsa:8945]
Reference
  Authors
Koike J, Sagara N, Kirikoshi H, Takagi A, Miwa T, Hirai M, Katoh M
  Title
Molecular cloning and genomic structure of the betaTRCP2 gene on chromosome 5q35.1.
  Journal
Biochem Biophys Res Commun 269:103-9 (2000)
DOI:10.1006/bbrc.2000.2241
  Sequence
[hsa:23291]
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