KEGG   ORTHOLOGY: K03993
Entry
K03993                      KO                                     

Name
MASP2
Definition
mannan-binding lectin serine protease 2 [EC:3.4.21.104]
Pathway
ko04610  Complement and coagulation cascades
ko05150  Staphylococcus aureus infection
ko05171  Coronavirus disease - COVID-19
Disease
H00105  Mannose-binding lectin pathway component defects
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    K03993  MASP2; mannan-binding lectin serine protease 2
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    K03993  MASP2; mannan-binding lectin serine protease 2
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K03993  MASP2; mannan-binding lectin serine protease 2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K03993  MASP2; mannan-binding lectin serine protease 2
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.104  mannan-binding lectin-associated serine protease-2
     K03993  MASP2; mannan-binding lectin serine protease 2
Peptidases and inhibitors [BR:ko01002]
 Serine peptidases
  Family S1: chymotrypsin family
   K03993  MASP2; mannan-binding lectin serine protease 2
Genes
HSA: 10747(MASP2)
PTR: 107974877(MASP2)
PPS: 100981899(MASP2)
GGO: 101126677(MASP2)
PON: 100458242(MASP2)
NLE: 100593253(MASP2)
MCC: 722714(MASP2)
MCF: 102131322(MASP2)
CSAB: 103225618(MASP2)
RRO: 104654364(MASP2)
RBB: 108539381(MASP2)
CJC: 100408774(MASP2)
SBQ: 101047723(MASP2)
MMU: 17175(Masp2)
MCAL: 110292278(Masp2)
MPAH: 110323473(Masp2)
RNO: 64459(Masp2)
MUN: 110548141(Masp2)
NGI: 103733193(Masp2)
HGL: 101696699(Masp2) 101706103
CCAN: 109689658(Masp2)
TUP: 102488905(MASP2)
CFA: 487447(MASP2)
VVP: 112929686(MASP2)
AML: 100466924(MASP2)
UMR: 103666866(MASP2)
UAH: 113270516(MASP2)
ORO: 101362776(MASP2)
FCA: 101099568(MASP2)
PPAD: 109274100(MASP2)
AJU: 106984902(MASP2)
BTA: 505819(MASP2)
BOM: 102280596(MASP2)
BIU: 109570390(MASP2)
BBUB: 102414667(MASP2)
CHX: 102169785(MASP2)
SSC: 100302537(MASP2)
CFR: 102513488(MASP2)
CDK: 105107020(MASP2)
BACU: 103005678(MASP2)
LVE: 103083615(MASP2)
OOR: 101283337(MASP2)
DLE: 111187114(MASP2)
PCAD: 102973281(MASP2)
ECB: 100056770(MASP2)
EPZ: 103552243(MASP2)
EAI: 106836680(MASP2)
MYB: 102255311
MYD: 102764933(MASP2)
MNA: 107540993(MASP2)
HAI: 109381284(MASP2)
DRO: 112299103(MASP2)
PALE: 102885750(MASP2)
RAY: 107513106(MASP2)
MJV: 108395496(MASP2) 108401888
LAV: 100662293(MASP2)
TMU: 101342871
MDO: 100018957(MASP2)
SHR: 100932261(MASP2)
OAA: 100079601(MASP2)
GGA: 407089(MASP2)
MGP: 100547191(MASP2)
CJO: 107323403(MASP2)
NMEL: 110408613(MASP2)
APLA: 101801331(MASP2)
ACYG: 106040226(MASP2)
TGU: 100232734(MASP2)
GFR: 102032737(MASP2)
PHI: 102110924(MASP2)
EGZ: 104133133(MASP2)
PADL: 103917979(MASP2)
AAM: 106482473(MASP2)
ASN: 102370755(MASP2)
PSS: 102453425(MASP2)
CMY: 102929438(MASP2)
CPIC: 101950973(MASP2)
PVT: 110073231(MASP2)
PBI: 103053568(MASP2)
PMUR: 107295524(MASP2) 107301108
TSR: 106548091(MASP2)
PMUA: 114602450(MASP2)
GJA: 107124364(MASP2)
XLA: 108696362(masp2.L) 373654(masp2.S)
XTR: 496446(masp2)
NPR: 108789090
DRE: 560277(masp2)
SRX: 107708846
SANH: 107681988(masp2)
SGH: 107571531
CCAR: 109048441
PHYP: 113530393(masp2)
AMEX: 103023364(masp2)
EEE: 113581290(masp2)
TRU: 101078225(masp2)
NCC: 104954130(masp2)
MZE: 101487177(masp2)
ONL: 100703975(masp2)
OLA: 101160657(masp2)
XMA: 102226518(masp2) 102236233
XCO: 114141728(masp2) 114142162
PRET: 103467229(masp2)
CVG: 107086886
NFU: 107379963 107390742(masp2)
KMR: 108236764(masp2)
ALIM: 106536928
AOCE: 111566407(masp2)
CSEM: 103384955(masp2)
POV: 109630666(masp2)
LCF: 108876586(masp2)
SDU: 111219203(masp2)
SLAL: 111670573(masp2)
HCQ: 109526567(masp2)
BPEC: 110164865(masp2)
MALB: 109968959(masp2)
SALP: 111966480(masp2)
ELS: 105022975(masp2)
SFM: 108923279(masp2)
PKI: 111834328(masp2)
LCM: 102360645(MASP2)
PTEP: 107450699
 » show all
Reference
  Authors
Matsushita M, Thiel S, Jensenius JC, Terai I, Fujita T.
  Title
Proteolytic activities of two types of mannose-binding lectin-associated serine protease.
  Journal
J Immunol 165:2637-42 (2000)
DOI:10.4049/jimmunol.165.5.2637
  Sequence
[hsa:10747]
Reference
PMID:9087411
  Authors
Thiel S, Vorup-Jensen T, Stover CM, Schwaeble W, Laursen SB, Poulsen K, Willis AC, Eggleton P, Hansen S, Holmskov U, Reid KB, Jensenius JC.
  Title
A second serine protease associated with mannan-binding lectin that activates complement.
  Journal
Nature 386:506-10 (1997)
DOI:10.1038/386506a0
  Sequence
[hsa:10747]
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