KEGG   ORTHOLOGY: K04249
Entry
K04249                      KO                                     

Name
TSHR
Definition
thyrotropin receptor
Pathway
ko04024  cAMP signaling pathway
ko04080  Neuroactive ligand-receptor interaction
ko04918  Thyroid hormone synthesis
ko04923  Regulation of lipolysis in adipocytes
ko05320  Autoimmune thyroid disease
Disease
H00250  Congenital nongoitrous hypothyroidism (CHNG)
H01269  Congenital hyperthyroidism
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    K04249  TSHR; thyrotropin receptor
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K04249  TSHR; thyrotropin receptor
 09150 Organismal Systems
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    K04249  TSHR; thyrotropin receptor
   04918 Thyroid hormone synthesis
    K04249  TSHR; thyrotropin receptor
 09160 Human Diseases
  09163 Immune disease
   05320 Autoimmune thyroid disease
    K04249  TSHR; thyrotropin receptor
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors
    K04249  TSHR; thyrotropin receptor
G protein-coupled receptors [BR:ko04030]
 Rhodopsin family
  Peptide
   Thyrotropin
    K04249  TSHR; thyrotropin receptor
Other DBs
GO: 0004996
Genes
HSA: 7253(TSHR)
PTR: 453077(TSHR)
PPS: 100972767(TSHR)
GGO: 101125784(TSHR)
PON: 100937088(TSHR)
NLE: 100607314(TSHR)
MCC: 574251(TSHR)
MCF: 102127039(TSHR)
CSAB: 103229438(TSHR)
RRO: 104663334(TSHR)
RBB: 108530805(TSHR)
CJC: 100407112(TSHR)
SBQ: 101037988(TSHR)
MMU: 22095(Tshr)
MCAL: 110306948(Tshr)
MPAH: 110324476(Tshr)
RNO: 25360(Tshr)
MUN: 110561821(Tshr)
CGE: 100775040(Tshr)
NGI: 103736397(Tshr)
HGL: 101718949(Tshr)
CCAN: 109680770
OCU: 100353965(TSHR)
TUP: 102481319(TSHR)
CFA: 403968(TSHR)
VVP: 112934899(TSHR)
AML: 100476960(TSHR)
UMR: 103670618(TSHR)
UAH: 113270272(TSHR)
ORO: 101370481(TSHR)
ELK: 111148625
FCA: 493842(TSHR)
PTG: 102962400(TSHR)
PPAD: 109274402(TSHR)
AJU: 106983585(TSHR)
BTA: 281553(TSHR)
BOM: 102273230(TSHR)
BIU: 109565398(TSHR)
BBUB: 102403395(TSHR)
CHX: 102174848(TSHR)
OAS: 443428(TSHR)
SSC: 397560(TSHR)
CFR: 102506391(TSHR)
CDK: 105086050(TSHR)
BACU: 103007910(TSHR)
LVE: 103074120(TSHR)
OOR: 101276553(TSHR)
DLE: 111175908(TSHR)
PCAD: 102992777(TSHR)
ECB: 100052603(TSHR) 111770367(TSHR) 111772111
EPZ: 103561891(TSHR)
EAI: 106834829(TSHR)
MYB: 102247607(TSHR)
MYD: 102757126(TSHR)
MNA: 107542654(TSHR)
HAI: 109384686(TSHR)
DRO: 112311491(TSHR)
PALE: 102879305(TSHR)
RAY: 107506702(TSHR)
MJV: 108407926(TSHR)
LAV: 100659046(TSHR)
TMU: 101342131
MDO: 100021427(TSHR)
SHR: 100918071(TSHR)
PCW: 110200916(TSHR)
OAA: 100073918(TSHR)
GGA: 428900(TSHR)
MGP: 100548187(TSHR)
CJO: 107315169(TSHR)
NMEL: 110401706(TSHR)
APLA: 101798978(TSHR)
ACYG: 106044543(TSHR)
TGU: 100221875(TSHR)
LSR: 110477263(TSHR)
SCAN: 103826493(TSHR)
GFR: 102042388(TSHR)
FAB: 101812703(TSHR)
PHI: 102111924(TSHR)
PMAJ: 107205537(TSHR)
CCAE: 111929929(TSHR)
CCW: 104685667(TSHR)
ETL: 114068347(TSHR)
FPG: 101919866(TSHR)
FCH: 102049876(TSHR)
CLV: 102092407(TSHR)
EGZ: 104133261(TSHR)
NNI: 104023418(TSHR)
ACUN: 113480649(TSHR)
PADL: 103912982(TSHR)
AAM: 106483120(TSHR)
ASN: 102379889(TSHR)
AMJ: 102559305(TSHR)
PSS: 102448787(TSHR)
CMY: 102935714(TSHR)
CPIC: 101934096(TSHR)
ACS: 100565546(tshr)
PVT: 110089516(TSHR)
PBI: 103060796(TSHR)
PMUR: 107295475(TSHR)
TSR: 106547172
PMUA: 114591338(TSHR)
GJA: 107123703(TSHR)
XLA: 108698960 108700487
XTR: 100492843(tshr)
NPR: 108803865
DRE: 560609(tshr)
SRX: 107728338 107742823
SANH: 107657214 107681439
SGH: 107549347 107569215
CCAR: 109069715 109081289
IPU: 100304626(TSH-R)
PHYP: 113528721
AMEX: 103024692(tshr)
EEE: 113571056(tshr)
TRU: 101078625(tshr)
TNG: GSTEN00018427G001
LCO: 104934989 104940353(tshr)
NCC: 104946220 104967186
MZE: 101484362 101487214(tshr)
ONL: 100534416(tshr) 100700258
OLA: 101170361 101170888(tshr)
XMA: 102226272(tshr) 102227717
XCO: 114149033 114158998(tshr)
PRET: 103457814(tshr) 103473163
CVG: 107090086(tshr) 107098490
NFU: 107378162(tshr) 107395090
KMR: 108231850(tshr) 108246452
ALIM: 106522181 106525133
AOCE: 111569120(tshr) 111579141
CSEM: 103380719(tshr)
POV: 109632395(tshr) 109637608
LCF: 108877751 108895785
SDU: 111221097 111235988(tshr)
SLAL: 111659638 111672643(tshr)
HCQ: 109508158
BPEC: 110161534 110162775
MALB: 109960698 109970542(tshr)
SASA: 100136379 100136382 106592147
OTW: 112217944 112236091 112250461
SALP: 111954188 112071556 112072153
ELS: 105015439 105017687
SFM: 108922264(tshr)
PKI: 111841762
LCM: 102351480(TSHR)
CMK: 103186808(tshr)
RTP: 109925594(tshr)
BFO: 118409455
SPU: 115929506 576902
APLC: 110979502
SKO: 100377796
DME: Dmel_CG7665(Lgr1)
DER: 6552118
DSE: 6616693
DSI: Dsimw501_GD19184(Dsim_GD19184)
DYA: Dyak_GE25496
DSR: 110188216
DPO: Dpse_GA23116 Dpse_GA27492
DPE: 6594527
DMN: 108157437
DWI: 6649415
DGR: Dgri_GH17283
DMO: Dmoj_GI23956
DAZ: 108621498
DNV: 108652111
DHE: 111598500
DVI: 6632944
MDE: 101893701
LCQ: 111675991
AGA: AgaP_AGAP004035(GPRFSH)
AAG: 5564685
AALB: 109429338
CQU: CpipJ_CPIJ007712
TCA: 657350 662553
DPA: 109544186
NVL: 108566343
BMOR: 692585(Lgr)
BMAN: 114247249
DPL: KGM_200833
PMAC: 106719292
PRAP: 110997159
HAW: 110383514
TNL: 113491988
PXY: 105384429 105390736
API: 100163512
DNX: 107166703
AGS: 114122071
RMD: 113556237 113559318
CLEC: 106666164 106668561
PHU: Phum_PHUM452330
ZNE: 110833841 110839199 110840456
FCD: 110843509
DPX: DAPPUDRAFT_290661(LGR1)
PVM: 113799920 113805006
ISC: IscW_ISCW007539
TUT: 107367504
DPTE: 113789329
CSCU: 111634507
PTEP: 107439628 107457327
BMY: Bm1_17785
LOA: LOAG_18180
LGI: LOTGIDRAFT_92538
PCAN: 112570446
CRG: 105329517
MYI: 110442374
LAK: 106161863
NVE: 116601924 116619253 5499598 5515296 5520473 5520478 5520858 5521705
EPA: 110236734 110251387
ADF: 107339069
AMIL: 114952861 114954285 114970254 114974523
PDAM: 113665803 113679604 113687003
SPIS: 111327611 111342307 111347013
TAD: TRIADDRAFT_12963
AQU: 100636996
 » show all
Reference
PMID:2610690
  Authors
Libert F, Lefort A, Gerard C, Parmentier M, Perret J, Ludgate M, Dumont JE, Vassart G
  Title
Cloning, sequencing and expression of the human thyrotropin (TSH) receptor: evidence for binding of autoantibodies.
  Journal
Biochem Biophys Res Commun 165:1250-5 (1989)
DOI:10.1016/0006-291X(89)92736-8
  Sequence
[hsa:7253]
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