KEGG ORTHOLOGY: K04416

ORTHOLOGY: K04416

Entry

K04416                      KO

Symbol

MAP3K1, MEKK1

Name

mitogen-activated protein kinase kinase kinase 1 [EC:2.7.11.25]

Pathway

map04010

MAPK signaling pathway

map04120

Ubiquitin mediated proteolysis

map04530

Tight junction

map04622

RIG-I-like receptor signaling pathway

map04722

Neurotrophin signaling pathway

map04912

GnRH signaling pathway

map04935

Growth hormone synthesis, secretion and action

map05161

Hepatitis B

map05166

Human T-cell leukemia virus 1 infection

Disease

H00607

46,XY gonadal dysgenesis

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
09150 Organismal Systems
  09151 Immune system
   04622 RIG-I-like receptor signaling pathway
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
  09152 Endocrine system
   04912 GnRH signaling pathway
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
   04935 Growth hormone synthesis, secretion and action
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
   05161 Hepatitis B
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
Protein kinases [BR:ko01001]
Serine/threonine kinases: STE group
  STE11 family
   K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
  Single Ring-finger type E3
   Other single Ring-finger type E3
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1

Other DBs

GO:

0004709

Genes

HSA:	4214(MAP3K1)

PTR:	471543(MAP3K1)

PPS:	100994796(MAP3K1)

GGO:	101136722(MAP3K1)

PON:	100453309(MAP3K1)

NLE:	100606554(MAP3K1)

HMH:	116462248(MAP3K1)

MCC:	710979(MAP3K1)

MCF:	102123041(MAP3K1)

MTHB:

126957142

MNI:	105499405(MAP3K1)

CSAB:

103221701(MAP3K1)

CATY:

105599635(MAP3K1)

PANU:

100137396(MAP3K1)

TGE:	112626113(MAP3K1)

MLEU:

105553734(MAP3K1)

RRO:	104657086(MAP3K1)

RBB:	108530959(MAP3K1)

TFN:	117065147(MAP3K1)

PTEH:

111541624(MAP3K1)

CANG:

105512468(MAP3K1)

CJC:	100389500(MAP3K1)

SBQ:	101054366(MAP3K1)

CIMI:

108317984(MAP3K1)

CSYR:

103277203(MAP3K1)

MMUR:

105877272(MAP3K1)

LCAT:

123647994(MAP3K1)

PCOQ:

105819135(MAP3K1)

OGA:	100957675(MAP3K1)

MMU:	26401(Map3k1)

MCAL:

110307741(Map3k1)

MPAH:

110328949(Map3k1)

RNO:	116667(Map3k1)

MCOC:

116083778(Map3k1)

ANU:	117723859(Map3k1)

MUN:	110546648(Map3k1)

CGE:	100770540(Map3k1)

MAUA:

101843009(Map3k1)

PROB:

127221136(Map3k1)

PLEU:

114702950(Map3k1)

MORG:

121455832(Map3k1)

MFOT:

126507983

AAMP:

119809929(Map3k1)

NGI:	103739909(Map3k1)

HGL:	101720769(Map3k1)

CPOC:

100723456(Map3k1)

CCAN:

109695531(Map3k1)

DORD:

105987286(Map3k1)

DSP:	122117204(Map3k1)

PLOP:

125367414(Map3k1)

NCAR:

124986862

MMMA:

107151930(Map3k1)

OCU:

100348484

OPI:	101528866(MAP3K1)

TUP:	102483890(MAP3K1)

GVR:	103600330(MAP3K1)

CFA:	478061(MAP3K1)

CLUD:

112659920(MAP3K1)

VVP:	112935233(MAP3K1)

VLG:	121497450(MAP3K1)

NPO:	129513743(MAP3K1)

AML:	100466442(MAP3K1)

UMR:	103663891(MAP3K1)

UAH:	113255319(MAP3K1)

UAR:	123790179(MAP3K1)

ELK:

111156879

LLV:

125101058

MPUF:

101689561(MAP3K1)

MNP:	132028649(MAP3K1)

MLK:	131832249(MAP3K1)

NVS:	122889387(MAP3K1)

ORO:	101366511(MAP3K1)

EJU:	114221009(MAP3K1)

ZCA:	113929708(MAP3K1)

MLX:	118016799(MAP3K1)

NSU:	110591252(MAP3K1)

LWW:	102748780(MAP3K1)

FCA:	101090328(MAP3K1)

PYU:	121015675(MAP3K1)

PCOO:

112860595(MAP3K1)

PBG:	122489134(MAP3K1)

PVIV:

125155054(MAP3K1)

LRUF:

124517338

PTG:	102971191(MAP3K1)

PPAD:

109246346(MAP3K1)

PUC:

125935639

AJU:

106975243

HHV:	120239952(MAP3K1)

BTA:	523962(MAP3K1)

BOM:	102267592(MAP3K1)

BIU:	109574889(MAP3K1)

BBUB:

102399327(MAP3K1)

BBIS:

104998375(MAP3K1)

CHX:	102187530(MAP3K1)

OAS:	101112260(MAP3K1)

BTAX:

128065982(MAP3K1)

ODA:	120879530(MAP3K1)

CCAD:

122454236(MAP3K1)

MBEZ:

129553244(MAP3K1)

SSC:	396617(MAP3K1)

CFR:	102505358(MAP3K1)

CBAI:

105077858(MAP3K1)

CDK:	105087133(MAP3K1)

VPC:	102530799(MAP3K1)

BACU:

103002185(MAP3K1)

BMUS:

118892091(MAP3K1)

LVE:	103083385(MAP3K1)

OOR:	101288918(MAP3K1)

DLE:	111186550(MAP3K1)

PCAD:

102979076(MAP3K1)

PSIU:

116750695(MAP3K1)

NASI:

112413424(MAP3K1)

ECB:	100061688(MAP3K1)

EPZ:	103548212(MAP3K1)

EAI:	106843371(MAP3K1)

MYB:	102258632(MAP3K1)

MYD:	102763786(MAP3K1)

MMYO:

118656004(MAP3K1)

MLF:	102425420(MAP3K1)

PKL:	118702681(MAP3K1)

EFUS:

103303283(MAP3K1)

MNA:	107527145(MAP3K1)

DRO:	112315269(MAP3K1)

SHON:

118981725(MAP3K1)

AJM:	119039781(MAP3K1)

PDIC:

114512339(MAP3K1)

PHAS:

123819501(MAP3K1)

MMF:	118642468(MAP3K1)

PPAM:

129071974(MAP3K1)

HAI:	109385705(MAP3K1)

RFQ:	117025303(MAP3K1)

PALE:

102886741(MAP3K1)

PGIG:

120608191(MAP3K1)

PVP:	105299360(MAP3K1)

RAY:	107518617(MAP3K1)

MJV:	108384016(MAP3K1)

TOD:	119261148(MAP3K1)

SARA:

101554394(MAP3K1)

SETR:

126001850(MAP3K1)

LAV:	100655149(MAP3K1)

TMU:

101361190

ETF:	101645836(MAP3K1)

DNM:	101446968(MAP3K1)

MDO:	100032065(MAP3K1)

GAS:	123251773(MAP3K1)

SHR:	100913571(MAP3K1)

AFZ:

127557574

PCW:	110215703(MAP3K1)

OAA:	100076612(MAP3K1)

GGA:	427144(MAP3K1)

PCOC:

116239413(MAP3K1)

MGP:	100550623(MAP3K1)

CJO:	107306009(MAP3K1)

TPAI:

128074502(MAP3K1)

LMUT:

125686479(MAP3K1)

NMEL:

110390387(MAP3K1)

APLA:

101793656(MAP3K1)

ACYG:

106035615(MAP3K1)

CATA:

118251484(MAP3K1)

AFUL:

116501197(MAP3K1) 116501286

TGU:	100225825(MAP3K1)

LSR:	110472556(MAP3K1)

SCAN:

103821035(MAP3K1)

PMOA:

120502387(MAP3K1)

OTC:	121341271(MAP3K1)

PRUF:

121355416(MAP3K1)

GFR:	102044899(MAP3K1)

FAB:	101807669(MAP3K1)

OMA:	130264693(MAP3K1)

PHI:	102103765(MAP3K1)

PMAJ:

107216401(MAP3K1)

CCAE:

111941445(MAP3K1)

CCW:	104686679(MAP3K1)

CBRC:

103623840(MAP3K1)

ETL:	114055129(MAP3K1)

ZAB:	102064872(MAP3K1)

ACHL:

103802285(MAP3K1)

SVG:	106859615(MAP3K1)

MMEA:

130588760(MAP3K1)

HRT:	120765209(MAP3K1)

FPG:	101911178(MAP3K1)

FCH:	102045898(MAP3K1)

CLV:	102097744(MAP3K1)

EGZ:	104134700(MAP3K1)

NNI:	104011958(MAP3K1)

PCRI:

104027050(MAP3K1)

PLET:

104624748(MAP3K1)

EHS:	104506271(MAP3K1)

PCAO:

104051671(MAP3K1)

ACUN:

113489657(MAP3K1)

TALA:

104368466(MAP3K1)

PADL:

103919424(MAP3K1)

AFOR:

103893397(MAP3K1)

ACHC:

115336915(MAP3K1) 121232898

HALD:

104319316(MAP3K1)

HLE:	104839945(MAP3K1)

AGEN:

126035238 126036143

GCL:	127027572 127027897

CCRI:

104157655(MAP3K1)

CSTI:

104555906(MAP3K1)

CMAC:

104486221(MAP3K1)

MUI:	104539629(MAP3K1)

BREG:

104629986(MAP3K1)

FGA:	104070375(MAP3K1)

GSTE:

104256897(MAP3K1)

LDI:	104344750(MAP3K1)

MNB:	103781380(MAP3K1)

OHA:	104337710(MAP3K1)

NNT:	104404511(MAP3K1)

SHAB:

115619838(MAP3K1)

DPUB:

104306360(MAP3K1)

PGUU:

104472227(MAP3K1)

ACAR:

104526017(MAP3K1)

CPEA:

104395629(MAP3K1)

AVIT:

104267069(MAP3K1)

CVF:	104287132 104294997(MAP3K1)

RTD:	128902090 128902447(MAP3K1)

CUCA:

104054786(MAP3K1)

TEO:	104377698(MAP3K1)

BRHI:

104497099(MAP3K1)

AROW:

112970357(MAP3K1)

NPD:	112945646(MAP3K1)

TGT:	104571239(MAP3K1)

DNE:	112995770(MAP3K1)

SCAM:

104146859(MAP3K1)

ASN:	102376941(MAP3K1)

AMJ:	102562794(MAP3K1)

CPOO:

109307929(MAP3K1)

GGN:	109297803(MAP3K1)

PSS:	102463619(MAP3K1)

CMY:	102938448(MAP3K1)

CCAY:

125636790(MAP3K1)

DCC:	119855899(MAP3K1)

CPIC:

101933464(MAP3K1)

TST:	117878807(MAP3K1)

CABI:

116821886(MAP3K1)

MRV:	120407790(MAP3K1)

ACS:	100561745(map3k1)

ASAO:

132766999(MAP3K1)

PVT:	110085400(MAP3K1)

SUND:

121922484(MAP3K1)

PBI:	103048285(MAP3K1)

PMUR:

107292307(MAP3K1)

CTIG:

120313485(MAP3K1)

TSR:	106540861(MAP3K1)

PGUT:

117679202(MAP3K1)

PTEX:

113446900(MAP3K1)

NSS:	113413899(MAP3K1)

VKO:	123031252(MAP3K1)

PMUA:

114606892(MAP3K1)

PRAF:

128423443(MAP3K1)

ZVI:	118077342(MAP3K1)

HCG:	128346246(MAP3K1)

GJA:	107123377(MAP3K1)

STOW:

125436396(MAP3K1)

EMC:	129334303(MAP3K1)

XLA:	108704427(map3k1.S) 108718321(map3k1.L)

XTR:	100490504(map3k1)

NPR:	108792018(MAP3K1)

RTEM:

120928469(MAP3K1)

BBUF:

120992144(MAP3K1)

BGAR:

122925179(MAP3K1)

MUO:	115461877 115462999(MAP3K1)

GSH:	117366354(MAP3K1)

DRE:	100334486(map3k1)

SRX:	107715839 107737160

SANH:

107670047 107702559

SGH:	107558252 107560413(map3k1)

CCAR:

109097257 109097258

CAUA:

113053991 113109546

CGIB:

127965952 128021431

PTET:

122352837(map3k1)

LROH:

127171924(map3k1)

OMC:	131547897(map3k1)

PPRM:

120481914(map3k1)

RKG:	130069364(map3k1)

MAMB:

125255879(map3k1)

CIDE:

127520635

MASI:

127432324 127433272

TROS:

130545902(map3k1)

TDW:	130411393(map3k1)

MANU:

129445826 129446170

IPU:

108277254

IFU:	128620211(map3k1)

PHYP:

113543563(map3k1)

SMEO:

124393433(map3k1)

TFD:	113639281(map3k1)

TVC:	132863073(map3k1)

AMEX:

103042517(map3k1)

CMAO:

118825293(map3k1)

EEE:	113576764(map3k1)

CHAR:

105894653(map3k1)

SASA:

106562896 106571505(map3k1)

STRU:

115160088(map3k1)

OTW:	112220130(map3k1) 112230734

OMY:	110523170(map3k1)

OGO:	123989496(map3k1)

ONE:	115118152(map3k1) 115147124

OKI:	109868623(map3k1) 109875910

OKE:	118385561 118387265

SALP:

111961944(map3k1) 111963818

SNH:	120020909 120026372(map3k1)

CCLU:

121541398 121581971(map3k1)

ELS:	105021721(map3k1)

SFM:	108929962(map3k1)

PKI:	111834485(map3k1)

AANG:

118206649 118212807(map3k1)

LOC:	102683229(map3k1)

PSPA:

121300913 121316750

ARUT:

117425788 117963658

PSEX:

120532605(map3k1)

LCM:	102355070(MAP3K1)

CMK:	103177870(map3k1)

CPLA:

122549355(map3k1)

HOC:	132814043(map3k1)

LERI:

129696539(map3k1)

PMRN:

116943573 116948801

LRJ:	133346374 133351879

BFO:

BBEL:

SCLV:

SPU:

APLC:

SKO:

FOC:

TPAL:

ZNE:

CSEC:

PVM:

PJA:

PCHN:

HAME:

PCLA:

PTRU:

HAZT:

EAF:

LSM:

DSV:

RSAN:

RMP:

LGI:	LOTGIDRAFT_162448

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MMER:

OBI:

OSN:

LAK:	106170548 106177880

SMM:	Smp_050380

OVI:	T265_07440

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

TAD:	TRIADDRAFT_28738

SRE:	PTSG_10004

» show all

Reference

PMID:12049732

Authors

Lu Z, Xu S, Joazeiro C, Cobb MH, Hunter T

Title

The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2.

Journal

Mol Cell 9:945-56 (2002)
DOI:10.1016/S1097-2765(02)00519-1

Reference

PMID:9808624

Authors

Xia Y, Wu Z, Su B, Murray B, Karin M

Title

JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension.

Journal

Genes Dev 12:3369-81 (1998)
DOI:10.1101/gad.12.21.3369

Sequence

[hsa:4214]

LinkDB

DBGET integrated database retrieval system