KEGG   ORTHOLOGY: K04421Help
Entry
K04421                      KO                                     

Name
MAP3K3, MEKK3
Definition
mitogen-activated protein kinase kinase kinase 3 [EC:2.7.11.25]
Pathway
ko04010  MAPK signaling pathway
ko04722  Neurotrophin signaling pathway
ko04912  GnRH signaling pathway
ko05166  Human T-cell leukemia virus 1 infection
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04421  MAP3K3, MEKK3; mitogen-activated protein kinase kinase kinase 3
 09150 Organismal Systems
  09152 Endocrine system
   04912 GnRH signaling pathway
    K04421  MAP3K3, MEKK3; mitogen-activated protein kinase kinase kinase 3
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04421  MAP3K3, MEKK3; mitogen-activated protein kinase kinase kinase 3
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04421  MAP3K3, MEKK3; mitogen-activated protein kinase kinase kinase 3
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04421  MAP3K3, MEKK3; mitogen-activated protein kinase kinase kinase 3
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04421  MAP3K3, MEKK3; mitogen-activated protein kinase kinase kinase 3
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     K04421  MAP3K3, MEKK3; mitogen-activated protein kinase kinase kinase 3
Protein kinases [BR:ko01001]
 Serine/threonine kinases: STE group
  STE11 family
   K04421  MAP3K3, MEKK3; mitogen-activated protein kinase kinase kinase 3
BRITE hierarchy
Other DBs
GO: 0004709
Genes
HSA: 4215(MAP3K3)
PTR: 468286(MAP3K3)
PPS: 100969705(MAP3K3)
GGO: 101148044(MAP3K3)
PON: 100444678(MAP3K3)
NLE: 100601763(MAP3K3)
MCC: 717866(MAP3K3)
MCF: 102132095(MAP3K3)
CSAB: 103243225(MAP3K3)
RRO: 104675466(MAP3K3)
RBB: 108536280(MAP3K3)
CJC: 100409608(MAP3K3)
SBQ: 101035755(MAP3K3) 101043439
MMU: 26406(Map3k3)
MCAL: 110305762(Map3k3)
MPAH: 110331495(Map3k3)
RNO: 303604(Map3k3)
MUN: 110547048(Map3k3)
CGE: 100753508(Map3k3)
NGI: 103744757(Map3k3)
HGL: 101704335(Map3k3)
CCAN: 109703189(Map3k3)
OCU: 100355324(MAP3K3)
TUP: 102477673(MAP3K3)
CFA: 480481(MAP3K3)
VVP: 112920702(MAP3K3)
AML: 100475740(MAP3K3)
UMR: 103665628(MAP3K3)
UAH: 113265289(MAP3K3)
ORO: 101375291(MAP3K3)
FCA: 101083633(MAP3K3)
PTG: 102966576(MAP3K3)
PPAD: 109277107(MAP3K3)
AJU: 106978686(MAP3K3)
BTA: 508943(MAP3K3)
BOM: 102275307(MAP3K3)
BIU: 109573385(MAP3K3)
BBUB: 102413611(MAP3K3)
CHX: 102173036(MAP3K3)
OAS: 101122537(MAP3K3)
SSC: 100513491(MAP3K3)
CFR: 102505759(MAP3K3)
CDK: 105090412(MAP3K3)
BACU: 102999255(MAP3K3)
LVE: 103076636(MAP3K3)
OOR: 101273961(MAP3K3)
DLE: 111182605(MAP3K3)
PCAD: 102985586(MAP3K3)
ECB: 100064751(MAP3K3)
EPZ: 103549765(MAP3K3)
EAI: 106835525(MAP3K3)
MYB: 102242308(MAP3K3)
MYD: 102762787(MAP3K3)
MNA: 107530487(MAP3K3)
HAI: 109380266(MAP3K3)
DRO: 112316249(MAP3K3)
PALE: 102889570(MAP3K3)
RAY: 107501901(MAP3K3)
MJV: 108401834(MAP3K3)
LAV: 100662122(MAP3K3)
TMU: 101341472
MDO: 100025970(MAP3K3)
SHR: 100933837(MAP3K3)
PCW: 110215942(MAP3K3)
OAA: 100083301 100092024(MAP3K3)
GGA: 419954(MAP3K3) 420419(MAPKKK3L)
MGP: 100542691 100542719(MAP3K3)
CJO: 107308787 107325133(MAP3K3)
NMEL: 110388470(MAP3K3) 110394259
APLA: 101795869 101801284(MAP3K3)
ACYG: 106036842 106045975(MAP3K3)
TGU: 100223633(MAP3K3) 100226503
LSR: 110474827(MAP3K3) 110484542
SCAN: 103812700 103821658(MAP3K3)
GFR: 102032306(MAP3K3) 102044243
FAB: 101813992(MAP3K3) 101817004
PHI: 102108460 102112033(MAP3K3)
PMAJ: 107200237 107215258(MAP3K3)
CCAE: 111925531 111939927(MAP3K3)
CCW: 104686414 104698629(MAP3K3)
ETL: 114065134 114066926(MAP3K3)
FCH: 102047801(MAP3K3) 102050351
CLV: 102085060(MAP3K3) 102088147
EGZ: 104130961 104134638(MAP3K3)
NNI: 104009891(MAP3K3) 104021753
ACUN: 113477214 113489126(MAP3K3)
PADL: 103913871(MAP3K3) 103924744
AAM: 106497426(MAP3K3)
ASN: 102368863 102374958(MAP3K3)
AMJ: 102572648 106736961(MAP3K3)
PSS: 102454634(MAP3K3) 102454880
CMY: 102930570(MAP3K3) 102931859
CPIC: 101948589 101953672(MAP3K3)
ACS: 100557698(map3k3) 100562159
PVT: 110080317(MAP3K3) 110085837
PBI: 103064885 103066986(MAP3K3)
PMUR: 107284356 107302364(MAP3K3)
TSR: 106540521(MAP3K3) 106545629
PMUA: 114581713(MAP3K3) 114607438
GJA: 107116392
XTR: 100488360 100490021(map3k3)
NPR: 108784622 108802493(MAP3K3)
DRE: 560211(map3k3)
IPU: 108256020(map3k3) 108256334
PHYP: 113528353(map3k3) 113541066
AMEX: 103034596(map3k3) 103044968
EEE: 113580221(map3k3) 113581205
TRU: 101061953 101072543(map3k3)
LCO: 104930222(map3k3) 104937092
NCC: 104943590(map3k3)
MZE: 101468082(map3k3) 101475626
ONL: 100692691(map3k3) 100711264
OLA: 101156127 101169290(map3k3)
XMA: 102228349 102234853(map3k3)
XCO: 114136809 114160172(map3k3)
PRET: 103456566 103468920(map3k3)
CVG: 107084751(map3k3) 107100967
NFU: 107378534(map3k3) 107382822
ALIM: 106513381 106534689(map3k3)
AOCE: 111565972 111588903(map3k3)
CSEM: 103392663(map3k3)
LCF: 108880564(map3k3) 108881705
SDU: 111217593(map3k3) 111221016
SLAL: 111656266 111660589(map3k3)
HCQ: 109519483 109532434(map3k3)
BPEC: 110160986 110167886(map3k3)
MALB: 109961492 109963171(map3k3)
SALP: 111980991(map3k3)
ELS: 105007693 105012974(map3k3)
LCM: 102350357 102353974(MAP3K3)
CMK: 103187711(map3k3) 103189852
HMG: 100205297
ATH: AT1G53570(MAP3KA)
CRB: 17898011
BRP: 103860382
BOE: 106335806
RSZ: 108863113
CIT: 102607672
DZI: 111299762
EGR: 104415891
LJA: Lj1g3v1316910.1(Lj1g3v1316910.1) Lj1g3v1316910.2(Lj1g3v1316910.2) Lj1g3v1318210.1(Lj1g3v1318210.1) Lj1g3v1318220.1(Lj1g3v1318220.1) Lj4g3v2742830.1(Lj4g3v2742830.1) Lj4g3v2742850.1(Lj4g3v2742850.1)
ADU: 107480227
AIP: 107630938
FVE: 101313251
RCN: 112187320
PPER: 18780007
PMUM: 103327145
PAVI: 110756513
CSV: 101203907(MAP3Ka)
CMO: 103485282
MCHA: 111005414
VVI: 100243772
SLY: 101243985 543918(MAPKKKalpha)
SIND: 105178081
CCAV: 112511697
DCR: 108204080
BVG: 104895397
SOE: 110775554
DOSA: Os11t0207200-01(Os11g0207200)
ATS: 109750728(LOC109750728) 109758282(LOC109758282)
AOF: 109830282
ATR: 18448262
SMO: SELMODRAFT_449560(MAP3K_2)
SMIN: v1.2.002573.t1(symbB.v1.2.002573.t1)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Craig EA, Stevens MV, Vaillancourt RR, Camenisch TD
  Title
MAP3Ks as central regulators of cell fate during development.
  Journal
Dev Dyn 237:3102-14 (2008)
DOI:10.1002/dvdy.21750
Reference
PMID:9006902
  Authors
Ellinger-Ziegelbauer H, Brown K, Kelly K, Siebenlist U
  Title
Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated  protein Kinase/ERK kinase kinase 3 (MEKK) derivative.
  Journal
J Biol Chem 272:2668-74 (1997)
DOI:10.1074/jbc.272.5.2668
  Sequence
[hsa:4215]
LinkDB All DBs

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