KEGG   ORTHOLOGY: K04527Help
Entry
K04527                      KO                                     

Name
INSR, CD220
Definition
insulin receptor [EC:2.7.10.1]
Pathway
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04066  HIF-1 signaling pathway
ko04068  FoxO signaling pathway
ko04072  Phospholipase D signaling pathway
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04212  Longevity regulating pathway - worm
ko04213  Longevity regulating pathway - multiple species
ko04520  Adherens junction
ko04910  Insulin signaling pathway
ko04913  Ovarian steroidogenesis
ko04923  Regulation of lipolysis in adipocytes
ko04930  Type II diabetes mellitus
ko04931  Insulin resistance
ko04932  Non-alcoholic fatty liver disease (NAFLD)
ko04960  Aldosterone-regulated sodium reabsorption
Module
M00676  PI3K-Akt signaling
Disease
H00719  Leprechaunism
H00942  Rabson-Mendenhall syndrome
H01228  Insulin-resistant diabetes mellitus with acanthosis nigricans (IRAN)
H01267  Familial hyperinsulinemic hypoglycemia (HHF)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K04527  INSR, CD220; insulin receptor
   04015 Rap1 signaling pathway
    K04527  INSR, CD220; insulin receptor
   04010 MAPK signaling pathway
    K04527  INSR, CD220; insulin receptor
   04066 HIF-1 signaling pathway
    K04527  INSR, CD220; insulin receptor
   04068 FoxO signaling pathway
    K04527  INSR, CD220; insulin receptor
   04072 Phospholipase D signaling pathway
    K04527  INSR, CD220; insulin receptor
   04022 cGMP - PKG signaling pathway
    K04527  INSR, CD220; insulin receptor
   04151 PI3K-Akt signaling pathway
    K04527  INSR, CD220; insulin receptor
   04152 AMPK signaling pathway
    K04527  INSR, CD220; insulin receptor
   04150 mTOR signaling pathway
    K04527  INSR, CD220; insulin receptor
 Cellular Processes
  Cellular community - eukaryotes
   04520 Adherens junction
    K04527  INSR, CD220; insulin receptor
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    K04527  INSR, CD220; insulin receptor
   04923 Regulation of lipolysis in adipocyte
    K04527  INSR, CD220; insulin receptor
   04913 Ovarian Steroidogenesis
    K04527  INSR, CD220; insulin receptor
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K04527  INSR, CD220; insulin receptor
  Aging
   04211 Longevity regulating pathway - mammal
    K04527  INSR, CD220; insulin receptor
   04212 Longevity regulating pathway - worm
    K04527  INSR, CD220; insulin receptor
   04213 Longevity regulating pathway - multiple species
    K04527  INSR, CD220; insulin receptor
 Human Diseases
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    K04527  INSR, CD220; insulin receptor
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K04527  INSR, CD220; insulin receptor
   04931 Insulin resistance
    K04527  INSR, CD220; insulin receptor
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00676  PI3K-Akt signaling
     K04527  INSR, CD220; insulin receptor
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K04527  INSR, CD220; insulin receptor
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  INSR family [OT]
   K04527  INSR, CD220; insulin receptor
CD molecules [BR:ko04090]
 Proteins
  K04527  CD220, INSR; insulin receptor
BRITE hierarchy
Other DBs
GO: 0005009
Genes
HSA: 3643(INSR)
PTR: 455649(INSR)
PPS: 100991905(INSR)
GGO: 101144696(INSR)
PON: 100451422(INSR)
NLE: 100597533(INSR)
MCC: 706009(INSR)
MCF: 102139081(INSR)
CSAB: 103234346(INSR)
RRO: 104679498(INSR)
RBB: 108534554(INSR)
CJC: 100403400(INSR)
SBQ: 101028986(INSR)
MMU: 16337(Insr)
RNO: 24954(Insr)
CGE: 100766818(Insr)
NGI: 103743312(Insr)
HGL: 101722168(Insr)
CCAN: 109694006(Insr)
OCU: 100008911(INSR)
TUP: 102469167(INSR)
CFA: 484990(INSR)
AML: 100473956(INSR)
UMR: 103676308(INSR)
ORO: 101363371(INSR)
FCA: 100127108(INSR)
PTG: 102967156(INSR)
AJU: 106979040(INSR)
BTA: 408017(INSR)
BOM: 102285317(INSR)
BIU: 109561633(INSR)
PHD: 102344118(INSR)
CHX: 102168996(INSR)
OAS: 443431(INSR)
SSC: 396755(INSR)
CFR: 102522017(INSR)
CDK: 105087555(INSR)
BACU: 103018249(INSR)
LVE: 103085622(INSR)
OOR: 101283355(INSR)
ECB: 100066248(INSR)
EPZ: 103540259(INSR) 103541768
EAI: 106844524(INSR)
MYB: 102252005(INSR)
MYD: 102766590(INSR)
HAI: 109396062(INSR)
RSS: 109461386(INSR)
PALE: 102879346(INSR)
LAV: 100668116(INSR)
TMU: 101360415
MDO: 100027215(INSR)
SHR: 100929204(INSR)
OAA: 100079104(INSR)
GGA: 420133(INSR)
MGP: 100550007(INSR)
CJO: 107325585(INSR)
APLA: 101795803(INSR)
ACYG: 106044962(INSR)
TGU: 100228094(INSR)
GFR: 102036061(INSR)
FAB: 101813861(INSR)
PHI: 102105828(INSR)
PMAJ: 107215564(INSR)
CCW: 104696982(INSR)
FPG: 101914421(INSR)
FCH: 102056291(INSR)
CLV: 102085804(INSR)
EGZ: 104124372(INSR)
AAM: 106495607(INSR)
ASN: 102378715(INSR)
AMJ: 102558884(INSR)
PSS: 102459083(INSR)
CMY: 102935205(INSR)
CPIC: 101947783(INSR)
ACS: 100567954(insr) 103282842
PVT: 110072679(INSR)
PBI: 103051000 103067466(INSR)
GJA: 107121673(INSR)
XLA: 100158430 398006(insr.L)
XTR: 100492718(insr)
NPR: 108785893(INSR)
DRE: 245699(insra) 245700(insrb)
TRU: 101074083(insr) 101074430
NCC: 104961264(insr) 104965319
XMA: 102227076 102238226(insr)
LCM: 102345167(INSR) 102358202
CMK: 103181967(insr)
CIN: 778651(insulinr)
SPU: 579152(ir)
APLC: 110990313
SKO: 100329033
AGA: AgaP_AGAP012424(INR)
AME: 411297(IR-B) 725827(InR-2)
SOC: 105195102(InR-2) 105207962(InR-1)
NVI: 100122567(INSR)
TCA: 661524(InR) 664271(ilr2)
BMOR: 692560(InR)
PRAP: 111003916
PXY: 105397590
TUT: 107365291
CEL: CELE_Y55D5A.5(daf-2)
CBR: CBG15732(Cbr-daf-2)
BMY: Bm1_19395
TSP: Tsp_06967
CRG: 105348544
MYI: 110455012
OBI: 106876722
LAK: 106153706
EPA: 110243170
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2859121
  Authors
Ebina Y, Ellis L, Jarnagin K, Edery M, Graf L, Clauser E, Ou JH, Masiarz F, Kan YW, Goldfine ID, et al.
  Title
The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling.
  Journal
Cell 40:747-58 (1985)
DOI:10.1016/0092-8674(85)90334-4
  Sequence
[hsa:3643]
Reference
  Authors
Youngren JF
  Title
Regulation of insulin receptor function.
  Journal
Cell Mol Life Sci 64:873-91 (2007)
DOI:10.1007/s00018-007-6359-9
  Sequence
[rno:24954]
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