KEGG ORTHOLOGY: K04675

ORTHOLOGY: K04675

Entry

K04675 KO

Name

ACVR1, ALK2

Definition

activin receptor type-1 [EC:2.7.11.30]

Pathway

ko04060

Cytokine-cytokine receptor interaction

ko04350

TGF-beta signaling pathway

ko04550

Signaling pathways regulating pluripotency of stem cells

ko05418

Fluid shear stress and atherosclerosis

Disease

H00430

Fibrodysplasia ossificans progressiva

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    K04675  ACVR1, ALK2; activin receptor type-1
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04675  ACVR1, ALK2; activin receptor type-1
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K04675  ACVR1, ALK2; activin receptor type-1
09160 Human Diseases
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K04675  ACVR1, ALK2; activin receptor type-1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04675  ACVR1, ALK2; activin receptor type-1
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.30  receptor protein serine/threonine kinase
     K04675  ACVR1, ALK2; activin receptor type-1
Protein kinases [BR:ko01001]
Receptor serine/threonine kinases (RSTK): TKL group
  TGFBR1 family [OT]
   K04675  ACVR1, ALK2; activin receptor type-1

Other DBs

GO:

0016361

Genes

HSA:

90(ACVR1)

PTR:	470565(ACVR1)

PPS:	100967435(ACVR1)

GGO:	101124161(ACVR1)

PON:	100455728(ACVR1)

NLE:	100594249(ACVR1)

MCC:	697935(ACVR1)

MCF:	102134051(ACVR1)

CSAB:

103217143(ACVR1)

RRO:	104654252(ACVR1)

RBB:	108544116(ACVR1)

CJC:	100406595(ACVR1)

SBQ:	101051443(ACVR1)

MMU:	11477(Acvr1)

MCAL:

110284153(Acvr1)

MPAH:

110317764(Acvr1)

RNO:	79558(Acvr1)

MUN:	110549524(Acvr1)

CGE:	100758565(Acvr1)

NGI:	103741053(Acvr1)

HGL:	101711343(Acvr1)

CCAN:

109688929(Acvr1)

OCU:	100355119(ACVR1)

TUP:	102471973(ACVR1)

CFA:	478757(ACVR1)

VVP:	112916491(ACVR1)

AML:	100476325(ACVR1)

UMR:	103659482(ACVR1)

UAH:	113250864(ACVR1)

ORO:	101363476(ACVR1)

ELK:

111156874

FCA:	101091298(ACVR1)

PTG:	102955784(ACVR1)

PPAD:

109271504(ACVR1)

AJU:	106978932(ACVR1)

BTA:	338068(ACVR1)

BOM:	102275369(ACVR1)

BIU:	109567478(ACVR1)

BBUB:

102393535(ACVR1)

CHX:	100860926(ACVR1)

OAS:	443161(ACVR1)

SSC:	100152307(ACVR1)

CFR:	102512007(ACVR1)

CDK:	105093706(ACVR1)

BACU:

102998999(ACVR1)

LVE:	103085459(ACVR1)

OOR:	101285877(ACVR1)

DLE:	111172774(ACVR1)

PCAD:

102981211(ACVR1)

ECB:	100050899(ACVR1)

EPZ:	103554403(ACVR1)

EAI:	106842688(ACVR1)

MYB:	102263759(ACVR1)

MYD:	102767973(ACVR1)

MNA:	107529258(ACVR1)

HAI:	109379868(ACVR1)

DRO:	112322201(ACVR1)

PALE:

102880880(ACVR1)

RAY:	107513429(ACVR1)

MJV:	108392510(ACVR1)

LAV:	100666899(ACVR1)

TMU:

101357210

MDO:	100021438(ACVR1)

SHR:	100928279(ACVR1)

PCW:	110220739(ACVR1)

OAA:	100077006(ACVR1)

GGA:	395246(ACVR1)

MGP:	100546560(ACVR1)

CJO:	107316966(ACVR1)

NMEL:

110399301(ACVR1)

APLA:

101793792(ACVR1)

ACYG:

106043900(ACVR1)

TGU:	100230545(ACVR1)

LSR:	110477578(ACVR1)

SCAN:

103814244(ACVR1)

GFR:	102040859(ACVR1)

FAB:	101818057(ACVR1)

PHI:	102109524(ACVR1)

PMAJ:

107207654(ACVR1)

CCAE:

111932401(ACVR1)

CCW:	104694116(ACVR1)

ETL:

114071380

FPG:	101911977(ACVR1)

FCH:	102053092(ACVR1)

CLV:	102087076(ACVR1)

EGZ:	104126443(ACVR1)

NNI:	104012353(ACVR1)

ACUN:

113482360(ACVR1)

PADL:

103925325(ACVR1)

AAM:	106486557(ACVR1)

ASN:	102378519(ACVR1) 102385749

AMJ:	102559894 102569539(ACVR1)

PSS:	102455326(ACVR1)

CMY:	102948189(ACVR1)

CPIC:

101937747(ACVR1)

ACS:	100552279(acvr1)

PVT:	110083054(ACVR1)

PBI:	103049229(ACVR1)

PMUR:

107289583(ACVR1)

TSR:

106537843

PMUA:

114605253(ACVR1)

GJA:	107110765(ACVR1)

XLA:	108708536(acvrl1.L) 108708988(acvrl1.S) 399083(acvr1.S) 399103(acvr1.L)

XTR:	100493282(acvrl1) 550111(acvr1)

NPR:	108784364(ACVR1)

DRE:	30615(acvr1l)

SRX:	107708857 107716208 107721710 107734497 107745260 107749086

SANH:

107657409 107678695 107681938 107685428 107690001 107695804

SGH:	107548806 107563639 107567977 107570535 107588871 107602619

CCAR:

109054164 109054165 109069205 109077091 109083144 109093773

IPU:	108266766(acvr1) 108267867 108275854(ACVR1)

PHYP:

113525658(acvr1) 113530630 113540098

AMEX:

103027706 103030586 103041954

EEE:	113574636(acvr1) 113584249

TRU:	101064229 101072160(acvr1)

TNG:	GSTEN00000089G001 GSTEN00002127G001 GSTEN00030564G001

LCO:	104920073(acvr1) 104926585

NCC:

104965961

MZE:	101467323 101472561(acvr1) 101486234

ONL:	100706216(acvr1) 100706480 100711913

OLA:	101166428 101173900(acvr1)

XMA:	102235577(acvr1) 102236735 102237610

XCO:	114134098 114144944 114148164(acvr1)

PRET:

103458472 103461685(acvr1) 103467352

CVG:	107087143(acvr1) 107093036

NFU:	107390086(acvr1) 107390883 107392117

KMR:	108235705(acvr1l) 108240788

ALIM:

106518471 106524896 106536539

AOCE:

111577012 111580336

CSEM:

103380097 103392173(acvr1)

POV:	109631350(acvr1) 109636415

LCF:	108874998 108876551 108901063(acvr1)

SDU:	111218267(acvr1) 111225557

SLAL:

111647399 111651254(acvr1)

HCQ:	109514817(acvr1) 109517367

BPEC:

110155079 110166565(acvr1)

MALB:

109957102(acvr1) 109968016

SASA:

100196610(acvr1) 106574510 106581817(acvr1) 106586172(ACVR1)

OTW:	112225176(acvr1) 112234149 112235726 112266400

SALP:

111959572(acvr1) 111970840 111974512 112076965

ELS:	105019986 105022431(acvr1)

SFM:	108918472 108927951(acvr1) 108928974 108936721

PKI:	111847357 111849720 111856538(acvr1)

LCM:	102345137(ACVR1) 102356523 102363253(ACVRL1)

CMK:	103176404(acvr1) 103181553 103189515

RTP:	109912785(acvr1) 109922718

BFO:

118405722

CIN:	778776(tgfbr-ia)

SPU:	115919015 590282

APLC:

110986020

SKO:

100370104

DME:	Dmel_CG1891(sax)

DER:

6541171

DSE:

6608061

DSI:	Dsimw501_GD15359(Dsim_GD15359)

DYA:	Dyak_GE19150

DAN:

6496473

DSR:

110191580

DPO:	Dpse_GA15112

DPE:

6590839

DMN:	108158968 117189839

DWI:

6643404

DGR:	Dgri_GH20320

DMO:	Dmoj_GI19992

DAZ:

DNV:

DHE:

DVI:

MDE:

LCQ:

AGA:	AgaP_AGAP007729

AAG:

5566323

AALB:

109423295

CQU:	CpipJ_CPIJ014117

AME:

BIM:

BTER:

CCAL:

OBB:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

LHU:

PGC:

OBO:

PCF:

NVI:

CSOL:

MDL:

TCA:	658545(sax)

DPA:

ATD:

NVL:

BMOR:

BMAN:

DPL:	KGM_213346

PMAC:

PRAP:

HAW:

TNL:

PXY:

API:

DNX:

AGS:

RMD:

BTAB:

CLEC:

PHU:	Phum_PHUM551530

ZNE:

110830842

FCD:

110858442

DPX:	DAPPUDRAFT_347227(SAX)

PVM:

113808802

ISC:	IscW_ISCW011054

TUT:

DPTE:

CSCU:

PTEP:

HRO:	HELRODRAFT_107560

LGI:	LOTGIDRAFT_53518

PCAN:

CRG:

MYI:

OBI:

LAK:

SHX:

OVI:	T265_02579 T265_12512

EGL:	EGR_00134 EGR_00451

NVE:

EPA:

PDAM:

DGT:

HMG:

TAD:	TRIADDRAFT_22452

» show all

Reference

PMID:8389764

Authors

Matsuzaki K, Xu J, Wang F, McKeehan WL, Krummen L, Kan M

Title

A widely expressed transmembrane serine/threonine kinase that does not bind activin, inhibin, transforming growth factor beta, or bone morphogenic factor.

Journal

J Biol Chem 268:12719-23 (1993)

Sequence

[hsa:90]

LinkDB

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