KEGG   ORTHOLOGY: K04707Help
Entry
K04707                      KO                                     

Name
CBL
Definition
E3 ubiquitin-protein ligase CBL [EC:2.3.2.27]
Pathway
ko04012  ErbB signaling pathway
ko04120  Ubiquitin mediated proteolysis
ko04144  Endocytosis
ko04910  Insulin signaling pathway
ko05100  Bacterial invasion of epithelial cells
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05220  Chronic myeloid leukemia
Disease
H00523  Noonan syndrome and related disorders
H02190  CBL syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K04707  CBL; E3 ubiquitin-protein ligase CBL
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K04707  CBL; E3 ubiquitin-protein ligase CBL
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K04707  CBL; E3 ubiquitin-protein ligase CBL
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K04707  CBL; E3 ubiquitin-protein ligase CBL
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04707  CBL; E3 ubiquitin-protein ligase CBL
   05205 Proteoglycans in cancer
    K04707  CBL; E3 ubiquitin-protein ligase CBL
  09162 Cancer: specific types
   05220 Chronic myeloid leukemia
    K04707  CBL; E3 ubiquitin-protein ligase CBL
  09171 Infectious disease: bacterial
   05100 Bacterial invasion of epithelial cells
    K04707  CBL; E3 ubiquitin-protein ligase CBL
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K04707  CBL; E3 ubiquitin-protein ligase CBL
   04121 Ubiquitin system
    K04707  CBL; E3 ubiquitin-protein ligase CBL
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     K04707  CBL; E3 ubiquitin-protein ligase CBL
Membrane trafficking [BR:ko04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Ubiquitin E3 ligases
    K04707  CBL; E3 ubiquitin-protein ligase CBL
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   CBL proteins
    K04707  CBL; E3 ubiquitin-protein ligase CBL
BRITE hierarchy
Genes
HSA: 867(CBL)
PTR: 451690(CBL)
PPS: 100988815(CBL)
GGO: 101140325(CBL)
PON: 100462634(CBL)
NLE: 100607272(CBL)
MCC: 704311(CBL)
MCF: 102137660(CBL)
CSAB: 103248629(CBL)
RRO: 104657236(CBL)
RBB: 108528599(CBL) 108542282
CJC: 100408313(CBL)
SBQ: 101053489(CBL)
MMU: 12402(Cbl)
MCAL: 110301174(Cbl)
MPAH: 110327640(Cbl)
RNO: 500985(Cbl)
MUN: 110562581(Cbl)
CGE: 100754737(Cbl)
NGI: 103727895(Cbl)
HGL: 101710004(Cbl)
CCAN: 109696224(Cbl)
OCU: 100342595(CBL)
TUP: 102469580(CBL)
CFA: 489369(CBL)
VVP: 112920322(CBL)
AML: 100470573(CBL)
UMR: 103662312(CBL)
UAH: 113259962(CBL)
ORO: 101377544(CBL)
PTG: 102960753(CBL)
PPAD: 109278523(CBL)
AJU: 106983886(CBL)
BTA: 527418(CBL)
BOM: 102279176(CBL)
BIU: 109568806(CBL)
BBUB: 102409714(CBL)
CHX: 102185385(CBL)
OAS: 101115401(CBL)
SSC: 100518854(CBL)
CFR: 102504124(CBL)
CDK: 105090203(CBL)
BACU: 103016132(CBL)
LVE: 103082495(CBL)
OOR: 101270049(CBL)
DLE: 111167490(CBL)
PCAD: 102994124(CBL)
ECB: 100071403(CBL)
EPZ: 103546643(CBL)
EAI: 106840308(CBL)
MYB: 102242908(CBL)
MYD: 102763080(CBL)
MNA: 107533071(CBL)
HAI: 109393876(CBL)
DRO: 112314205(CBL)
PALE: 102895335(CBL)
RAY: 107507930(CBL)
MJV: 108409307(CBL)
LAV: 100658892(CBL)
TMU: 101342874
MDO: 100031184(CBL)
SHR: 100920890(CBL)
PCW: 110207221(CBL)
OAA: 100091424(CBL)
GGA: 374038(CBL)
MGP: 100549952(CBL)
CJO: 107324207(CBL)
NMEL: 110387634(CBL)
APLA: 101789789(CBL)
ACYG: 106039784(CBL)
TGU: 100227293(CBL)
LSR: 110475970(CBL)
SCAN: 103823039(CBL)
GFR: 102036440(CBL)
FAB: 101810639(CBL)
PHI: 102103093(CBL)
PMAJ: 107214346(CBL)
CCAE: 111939301(CBL)
CCW: 104692188(CBL)
ETL: 114067820(CBL)
FPG: 101919050(CBL)
FCH: 102058724(CBL)
CLV: 102096530(CBL)
EGZ: 104125948(CBL)
ACUN: 113488489(CBL)
PADL: 103921583(CBL)
AAM: 106495869(CBL)
ASN: 102372644(CBL)
AMJ: 106737050(CBL)
PSS: 102450818(CBL)
CMY: 102937369(CBL)
CPIC: 101937375(CBL)
ACS: 100568145(cbl)
PVT: 110078535(CBL)
PBI: 103056422(CBL)
PMUR: 107285391(CBL)
TSR: 106542966
PMUA: 114585772(CBL)
GJA: 107105501(CBL)
XLA: 108705407(cbl.S) 398194(cbl.L)
XTR: 594900(cbl)
NPR: 108797509(CBL)
DRE: 492364(cbl)
SANH: 107683813(cbl) 107690460
SGH: 107585540(cbl) 107601723
IPU: 108277804(cbl)
PHYP: 113532779(cbl)
AMEX: 103032411(cbl)
EEE: 113579444(cbl)
TRU: 101070370 101078613(cbl)
LCO: 104921108 104936425(cbl)
ONL: 100692645 100710684(cbl)
OLA: 101163758 101170289(cbl)
XMA: 102233950 102234614(cbl)
XCO: 114133667(cbl) 114153038
PRET: 103474573(cbl) 103476312
CVG: 107088320(cbl) 107098202
NFU: 107380353(cbl) 107387219
KMR: 108238085 108246038(cbl)
ALIM: 106515461(cbl) 106525419
CSEM: 103378406(cbl) 103395395
POV: 109630213(cbl) 109635803
LCF: 108886386(cbl) 108893685
SDU: 111217085 111228025(cbl)
SLAL: 111651622 111652625(cbl)
HCQ: 109517915 109529378(cbl)
BPEC: 110154105(cbl) 110174966
MALB: 109959267 109960188(cbl)
ELS: 105011087 105012434(cbl)
LCM: 102345712(CBL) 102349292(CBLC)
CMK: 103191373
RTP: 109922666(cbl) 109924873
CIN: 100176362
APLC: 110989191
DME: Dmel_CG7037(Cbl)
DER: 6545674
DSI: Dsimw501_GD14094(Dsim_GD14094)
DSR: 110190648
DPE: 6601222
DMN: 108152690
DWI: 6646101
DAZ: 108612806
DNV: 108652306
DHE: 111602911
LCQ: 111677441
AAG: 5572351
AME: 411982
BIM: 100745466
BTER: 100642596
CCAL: 108629821
OBB: 114880297
SOC: 105202310
AEC: 105147762
ACEP: 105620476
PBAR: 105429426
VEM: 105568325
HST: 105191070
DQU: 106751772
CFO: 105249224
LHU: 105673746
OBO: 105282007
PCF: 106788578
NVI: 100119672
MDL: 103577747
TCA: 656167
DPA: 109541931
ATD: 109607009
NVL: 108569006
BMOR: 101740182
PMAC: 106709441
PRAP: 110993846
HAW: 110381365
TNL: 113505180
PXY: 105391330
API: 100159071
DNX: 107164289
AGS: 114127579
RMD: 113556449
BTAB: 109040444
CLEC: 106665709
ZNE: 110833897
FCD: 110842987
PVM: 113799956
TUT: 107370090
PTEP: 107450406
CEL: CELE_M02A10.3(sli-1)
CBR: CBG08124(Cbr-sli-1)
BMY: Bm1_05660
TSP: Tsp_01088
PCAN: 112567631
CRG: 105342258
MYI: 110444983
OBI: 106869207
LAK: 106177307
SHX: MS3_04067
EGL: EGR_02348
SPIS: 111338656
DGT: 114524433
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Wehrle C, Van Slyke P, Dumont DJ
  Title
Angiopoietin-1-induced ubiquitylation of Tie2 by c-Cbl is required for internalization and degradation.
  Journal
Biochem J 423:375-80 (2009)
DOI:10.1042/BJ20091010
Reference
  Authors
Joazeiro CA, Wing SS, Huang H, Leverson JD, Hunter T, Liu YC
  Title
The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase.
  Journal
Science 286:309-12 (1999)
DOI:10.1126/science.286.5438.309
  Sequence
[hsa:867]
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